当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation.

Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation.

Abstract：

:Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes. MHC-I-bound peptides originate from protein degradation by the proteasome, suggesting that stably folded, long-lived proteins could evade monitoring. Here, we investigate the role in antigen presentation of the ribosome-associated quality control (RQC) pathway for the degradation of nascent polypeptides that are encoded by defective messenger RNAs and undergo stalling at the ribosome during translation. We find that degradation of model proteins by RQC results in efficient MHC-I presentation, independent of their intrinsic folding properties. Quantitative profiling of MHC-I peptides in wild-type and RQC-deficient cells by mass spectrometry showed that RQC substantially contributes to the composition of the immunopeptidome. Our results also identify endogenous substrates of the RQC pathway in human cells and provide insight into common principles causing ribosome stalling under physiological conditions.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Trentini DB,Pecoraro M,Tiwary S,Cox J,Mann M,Hipp MS,Hartl FU

doi

10.1073/pnas.1914401117

subject

Has Abstract

pub_date

2020-02-25 00:00:00

pages

4099-4108

issue

8

eissn

0027-8424

issn

1091-6490

pii

1914401117

journal_volume

117

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Biosynthesis of vitamin B12: structure of precorrin-6x octamethyl ester.

    abstract：:13C-labeled precorrin-6x is biosynthesized by cell-free protein preparations from Pseudomonas denitrificans in separate experiments using delta-amino[5-13C]levulinic acid and the corresponding delta-amino[4-13C]- and delta-amino[3-13C]levulinic acid-labeled forms in conjunction with S-[methyl-13C]adenosylmethionine fo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.22.8800

    authors： Thibaut D,Blanche F,Debussche L,Leeper FJ,Battersby AR

    更新日期：1990-11-01 00:00:00

  • RNA virus microRNA that mimics a B-cell oncomiR.

    abstract：:MicroRNAs (miRNAs) are small RNAs that play a regulatory role in numerous and diverse eukaryotic cellular processes. Virus-encoded miRNAs have garnered much interest, although the functions of most remain to be deciphered. To date, readily detectable, evolutionarily conserved natural miRNAs have only been identified f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1116107109

    authors： Kincaid RP,Burke JM,Sullivan CS

    更新日期：2012-02-21 00:00:00

  • Language universals at birth.

    abstract：:The evolution of human languages is driven both by primitive biases present in the human sensorimotor systems and by cultural transmission among speakers. However, whether the design of the language faculty is further shaped by linguistic biological biases remains controversial. To address this question, we used near-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1318261111

    authors： Gómez DM,Berent I,Benavides-Varela S,Bion RA,Cattarossi L,Nespor M,Mehler J

    更新日期：2014-04-22 00:00:00

  • LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.

    abstract：:Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression is universal, and tumors with AR-independent resistance mechanisms appear to be increasing in frequency. Consequently, there is an urgent need to develop new tr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1719168115

    authors： Sehrawat A,Gao L,Wang Y,Bankhead A 3rd,McWeeney SK,King CJ,Schwartzman J,Urrutia J,Bisson WH,Coleman DJ,Joshi SK,Kim DH,Sampson DA,Weinmann S,Kallakury BVS,Berry DL,Haque R,Van Den Eeden SK,Sharma S,Bearss J,Beer

    更新日期：2018-05-01 00:00:00

  • False beliefs about fattening foods can have healthy consequences.

    abstract：:We suggested to 228 subjects in two experiments that, as children, they had had negative experiences with a fattening food. An additional 107 subjects received no such suggestion and served as controls. In Experiment 1, a minority of subjects came to believe that they had felt ill after eating strawberry ice cream as ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0504869102

    authors： Bernstein DM,Laney C,Morris EK,Loftus EF

    更新日期：2005-09-27 00:00:00

  • Bioactive alkaloids of frog skin: combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source.

    abstract：:Nearly 500 alkaloids have been detected in skin extracts from frogs of the family Dendrobatidae. All seem to have been sequestered unchanged into skin glands from alkaloid-containing arthropods. Ants, beetles, and millipedes seem to be the source of decahydroquinolines, certain izidines, coccinellines, and spiropyrrol...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.222551599

    authors： Daly JW,Kaneko T,Wilham J,Garraffo HM,Spande TF,Espinosa A,Donnelly MA

    更新日期：2002-10-29 00:00:00

  • Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals.

    abstract：:Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryoti...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.262672599

    authors： Mathesius U,Mulders S,Gao M,Teplitski M,Caetano-Anolles G,Rolfe BG,Bauer WD

    更新日期：2003-02-04 00:00:00

  • Novel plasticity rule can explain the development of sensorimotor intelligence.

    abstract：:Grounding autonomous behavior in the nervous system is a fundamental challenge for neuroscience. In particular, self-organized behavioral development provides more questions than answers. Are there special functional units for curiosity, motivation, and creativity? This paper argues that these features can be grounded...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1508400112

    authors： Der R,Martius G

    更新日期：2015-11-10 00:00:00

  • Direct observation of hole transfer through double-helical DNA over 100 A.

    abstract：:Mechanism of photo-induced electron transfer and the subsequent hole transfer in DNA has been studied extensively, but so far we are not aware of any reliable report of the observation of the long-distance hole-transfer process. In this article, we demonstrate the results of direct observation for the long-distance ho...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0402756101

    authors： Takada T,Kawai K,Fujitsuka M,Majima T

    更新日期：2004-09-28 00:00:00

  • A long-range attraction between aggregating 3T3 cells mediated by near-infrared light scattering.

    abstract：:At what range can a mammalian cell sense the presence of another cell and through what medium? To approach these questions, the formation of aggregates of a 3T3 cell variant (3T3x cells) grown on solid substrates was studied. Each of the aggregates consisted of cells that, at the time of their seeding, were single and...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0407763102

    authors： Albrecht-Buehler G

    更新日期：2005-04-05 00:00:00

  • Functional characterization of piggyBat from the bat Myotis lucifugus unveils an active mammalian DNA transposon.

    abstract：:A revelation of the genomic age has been the contributions of the mobile DNA segments called transposable elements to chromosome structure, function, and evolution in virtually all organisms. Substantial fractions of vertebrate genomes derive from transposable elements, being dominated by retroelements that move via R...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1217548110

    authors： Mitra R,Li X,Kapusta A,Mayhew D,Mitra RD,Feschotte C,Craig NL

    更新日期：2013-01-02 00:00:00

  • Macrophage activation by monosaccharide precursors of Escherichia coli lipid A.

    abstract：:Certain Escherichia coli mutants defective in phosphatidylglycerol biosynthesis accumulate two novel glycolipids, designated X and Y. Lipid X is a diacylglucosamine 1-phosphate bearing beta-hydroxymyristoyl groups at positions 2 and 3, and lipid Y has the same structure as X, except for the additional presence of a pa...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.2.282

    authors： Nishijima M,Amano F,Akamatsu Y,Akagawa K,Tokunaga T,Raetz CR

    更新日期：1985-01-01 00:00:00

  • CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention.

    abstract：:The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear. Here, we demonstrate that a 79-aa region within the CTCF N terminus is essential for cohesin positioning at CTCF bi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1911708117

    authors： Pugacheva EM,Kubo N,Loukinov D,Tajmul M,Kang S,Kovalchuk AL,Strunnikov AV,Zentner GE,Ren B,Lobanenkov VV

    更新日期：2020-01-28 00:00:00

  • Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins.

    abstract：:Retroviral entry into cells depends on envelope glycoproteins, whereby receptor binding to the surface-exposed subunit triggers membrane fusion by the transmembrane protein (TM) subunit. We determined the crystal structure at 2.5-A resolution of the ectodomain of gp21, the TM from human T cell leukemia virus type 1. T...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.8.4319

    authors： Kobe B,Center RJ,Kemp BE,Poumbourios P

    更新日期：1999-04-13 00:00:00

  • Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.

    abstract：:The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A-retinol-binding protein complex. Mutations with...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1121005109

    authors： Bulawa CE,Connelly S,Devit M,Wang L,Weigel C,Fleming JA,Packman J,Powers ET,Wiseman RL,Foss TR,Wilson IA,Kelly JW,Labaudinière R

    更新日期：2012-06-12 00:00:00

  • Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.

    abstract：:Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we report that activatio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1918950117

    authors： Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR

    更新日期：2020-03-17 00:00:00

  • Nonplanar peptide bonds in proteins are common and conserved but not biased toward active sites.

    abstract：:The planarity of peptide bonds is an assumption that underlies decades of theoretical modeling of proteins. Peptide bonds strongly deviating from planarity are considered very rare features of protein structure that occur for functional reasons. Here, empirical analyses of atomic-resolution protein structures reveal t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1107115108

    authors： Berkholz DS,Driggers CM,Shapovalov MV,Dunbrack RL Jr,Karplus PA

    更新日期：2012-01-10 00:00:00

  • Master curve of boosted diffusion for 10 catalytic enzymes.

    abstract：:Molecular agitation more rapid than thermal Brownian motion is reported for cellular environments, motor proteins, synthetic molecular motors, enzymes, and common chemical reactions, yet that chemical activity coupled to molecular motion contrasts with generations of accumulated knowledge about diffusion at equilibriu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2019810117

    authors： Jee AY,Tlusty T,Granick S

    更新日期：2020-11-24 00:00:00

  • beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.

    abstract：:The members of the chimaerin family of Rac-GTPase-activating proteins possess a single C1 domain with high homology to those present in protein kinase C (PKC) isozymes. This domain in PKCs is involved in phorbol ester and diacylglycerol (DAG) binding. We previously have demonstrated that one of the chimaerin isoforms,...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.21.11854

    authors： Caloca MJ,Garcia-Bermejo ML,Blumberg PM,Lewin NE,Kremmer E,Mischak H,Wang S,Nacro K,Bienfait B,Marquez VE,Kazanietz MG

    更新日期：1999-10-12 00:00:00

  • Perturbation of the T cell repertoire in rheumatoid arthritis.

    abstract：:Aberrations in the T cell repertoire with the emergence of oligoclonal populations have been described in patients with rheumatoid arthritis (RA). However, the extent of the repertoire perturbations as well as the underlying mechanisms are not known. We now have examined the diversity of the peripheral CD4 T cell repe...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.24.14447

    authors： Wagner UG,Koetz K,Weyand CM,Goronzy JJ

    更新日期：1998-11-24 00:00:00

  • Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

    abstract：:ADP ribosylation factor (ARF) is a small guanosine triphosphate (GTP)-binding protein that regulates the binding of coat proteins to membranes and is required for several stages of vesicular transport. ARF also stimulates phospholipase D (PLD) activity, which can alter the lipid content of membranes by conversion of p...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.11.4952

    authors： Ktistakis NT,Brown HA,Sternweis PC,Roth MG

    更新日期：1995-05-23 00:00:00

  • Theory of a class of locally convex vector lattices which include the lebesgue spaces.

    abstract：:In this paper is presented the theory of a class of locally convex lattices (L-lattices) of real functions which generalize the classical Lebesgue spaces. The monotone and dominated convergence theorems for convergence almost everywhere and sequential and order completeness of such lattices are established. These resu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.66.2.275

    authors： Bogdanowicz WM

    更新日期：1970-06-01 00:00:00

  • A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.

    abstract：:The region of the murine major histocompatibility complex (MHC) between the Pb (A beta 3) and Ob (A beta 2) genes controls the expression of an intracellular complex named the LMP (low molecular weight polypeptide) complex. DNA probes for at least seven different genes mapping to this region were isolated. These hybri...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.12.5197

    authors： Cho S,Attaya M,Brown MG,Monaco JJ

    更新日期：1991-06-15 00:00:00

  • Regulation of p53 is critical for vertebrate limb regeneration.

    abstract：:Extensive regeneration of the vertebrate body plan is found in salamander and fish species. In these organisms, regeneration takes place through reprogramming of differentiated cells, proliferation, and subsequent redifferentiation of adult tissues. Such plasticity is rarely found in adult mammalian tissues, and this ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1310519110

    authors： Yun MH,Gates PB,Brockes JP

    更新日期：2013-10-22 00:00:00

  • From residue matching patterns to protein folding topographies: general model and bovine pancreatic trypsin inhibitor.

    abstract：:A coarse-grained model for protein-folding dynamics is introduced based on a discretized representation of torsional modes. The model, based on the Ramachandran map of the local torsional potential surface and the class (hydrophobic/polar/neutral) of each residue, recognizes patterns of both torsional conformations an...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.23.12991

    authors： Fernández A,Kostov K,Berry RS

    更新日期：1999-11-09 00:00:00

  • Quality control of ribosomal RNA mediated by polynucleotide phosphorylase and RNase R.

    abstract：:Despite their overall accuracy, errors in macromolecular processes, such as rRNA synthesis and ribosome assembly, inevitably occur. However, whether these errors are remediated and how this might be accomplished is not known. In previous work, we showed that a double mutant strain lacking both polynucleotide phosphory...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1231041100

    authors： Cheng ZF,Deutscher MP

    更新日期：2003-05-27 00:00:00

  • Integrated logic circuits using single-atom transistors.

    abstract：:Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. S...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1109935108

    authors： Mol JA,Verduijn J,Levine RD,Remacle F,Rogge S

    更新日期：2011-08-23 00:00:00

  • Statistical methods for characterizing similarities and differences between semantic structures.

    abstract：:This paper describes a variety of statistical methods for obtaining precise quantitative estimates of the similarities and differences in the structures of semantic domains in different languages. The methods include comparing mean correlations within and between groups, principal components analysis of interspeaker c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.1.518

    authors： Romney AK,Moore CC,Batchelder WH,Hsia TL

    更新日期：2000-01-04 00:00:00

  • Synchronized renal tubular cell death involves ferroptosis.

    abstract：:Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the pathophysiologically predominant pathway that leads to regulated necrosis of parenchymal cells in ischemia-reperfusion injury (IRI), and loss of either Fas-associated protein with death domain (FADD) or caspase-8 is known to sensit...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1415518111

    authors： Linkermann A,Skouta R,Himmerkus N,Mulay SR,Dewitz C,De Zen F,Prokai A,Zuchtriegel G,Krombach F,Welz PS,Weinlich R,Vanden Berghe T,Vandenabeele P,Pasparakis M,Bleich M,Weinberg JM,Reichel CA,Bräsen JH,Kunzendorf U,An

    更新日期：2014-11-25 00:00:00

  • Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.

    abstract：:Improper function of voltage-gated sodium channels (NaVs), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target NaVs hold considerable promise for treatment of chronic disease. Absent a comprehensive understanding of channel struc...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1603486113

    authors： Thomas-Tran R,Du Bois J

    更新日期：2016-05-24 00:00:00