Abstract:
:Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we investigated its possible involvement in the brain's response to focal cerebral ischemia. Ischemia was induced by occlusion of the middle cerebral artery in the rat for 90 min, and proliferating cells were labeled with 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdUrd) over 2-day periods before sacrificing animals 1, 2 or 3 weeks after ischemia. Ischemia increased the incorporation of BrdUrd into cells in two neuroproliferative regions-the subgranular zone of the dentate gyrus and the rostral subventricular zone. Both effects were bilateral, but that in the subgranular zone was more prominent on the ischemic side. Cells labeled with BrdUrd coexpressed the immature neuronal markers doublecortin and proliferating cell nuclear antigen but did not express the more mature cell markers NeuN and Hu, suggesting that they were nascent neurons. These results support a role for ischemia-induced neurogenesis in what may be adaptive processes that contribute to recovery after stroke.
journal_name
Proc Natl Acad Sci U S Aauthors
Jin K,Minami M,Lan JQ,Mao XO,Batteur S,Simon RP,Greenberg DAdoi
10.1073/pnas.081011098keywords:
subject
Has Abstractpub_date
2001-04-10 00:00:00pages
4710-5issue
8eissn
0027-8424issn
1091-6490pii
98/8/4710journal_volume
98pub_type
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