Ice-core evidence of abrupt climate changes.

Abstract:

:Ice-core records show that climate changes in the past have been large, rapid, and synchronous over broad areas extending into low latitudes, with less variability over historical times. These ice-core records come from high mountain glaciers and the polar regions, including small ice caps and the large ice sheets of Greenland and Antarctica.

authors

Alley RB

doi

10.1073/pnas.97.4.1331

keywords:

subject

Has Abstract

pub_date

2000-02-15 00:00:00

pages

1331-4

issue

4

eissn

0027-8424

issn

1091-6490

pii

97/4/1331

journal_volume

97

pub_type

杂志文章
  • Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

    abstract::The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1811727115

    authors: Shen K,Sabatini DM

    更新日期:2018-09-18 00:00:00

  • Topology of the RNA polymerase active center probed by chimeric rifampicin-nucleotide compounds.

    abstract::Spatial organization of the binding sites for the priming substrate, the template DNA, and the transcription inhibitor rifampicin (Rif) in Escherichia coli RNA polymerase (EC 2.7.7.6) was probed with chimeric compounds in which Rif is covalently attached to a ribonucleotide. The compounds bind to RNA polymerase in bif...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.91.25.12036

    authors: Mustaev A,Zaychikov E,Severinov K,Kashlev M,Polyakov A,Nikiforov V,Goldfarb A

    更新日期:1994-12-06 00:00:00

  • Early extracellular events in infection of competent Bacillus subtilis by DNA of bacteriophage SP82G.

    abstract::Analysis, by the recovery of specific genetic "markers," of the effects of DNase I, physical shear, and temperature shock on DNA-cell complexes demonstrates that sequential attachment of both ends of bacteriophage SP82G DNA to Bacillus subtilis precedes entry of the DNA molecule into the cell, and that each attachment...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.69.6.1545

    authors: Williams GL,Green DM

    更新日期:1972-06-01 00:00:00

  • Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins.

    abstract::Metal-catalyzed oxidation results in loss of function and structural alteration of proteins. The oxidative process affects a variety of side amino acid groups, some of which are converted to carbonyl compounds. Spectrophotometric measurement of these moieties, after their reaction with 2,4-dinitrophenylhydrazine, is a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.011526698

    authors: Requena JR,Chao CC,Levine RL,Stadtman ER

    更新日期:2001-01-02 00:00:00

  • Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish.

    abstract::In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0811186106

    authors: Qin Z,Barthel LK,Raymond PA

    更新日期:2009-06-09 00:00:00

  • Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits.

    abstract::The prefrontal cortex plays a fundamental role in the working memory functions of the cerebral cortex and is also the site of dysfunction in several neurological and psychiatric disorders, including schizophrenia. Prefrontal neurons are distinguished by their capacity for sustained activity during the time a stimulus ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.011524298

    authors: Gao WJ,Krimer LS,Goldman-Rakic PS

    更新日期:2001-01-02 00:00:00

  • Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm.

    abstract::Cryptococcus neoformans (CN), an encapsulated, ubiquitous environmental yeast, is pathogenic for humans, primarily those with compromised immune function. CN is believed to be a facultative intracellular pathogen. Time-lapsed video microscopy revealed that yeast began to replicate and divide 2 hours after ingestion by...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.052702799

    authors: Tucker SC,Casadevall A

    更新日期:2002-03-05 00:00:00

  • Histone octamer dissociation is not required for transcript elongation through arrays of nucleosome cores by phage T7 RNA polymerase in vitro.

    abstract::We have examined whether dissociation of the histone octamer is required for elongation of RNA transcripts through arrays of nucleosome cores in vitro. Control or dimethyl suberimidate-crosslinked histone octamers were reconstituted onto supercoiled, closed circular pT207-18 DNA, which contains tandemly repeated 207-b...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.13.6203

    authors: O'Neill TE,Smith JG,Bradbury EM

    更新日期:1993-07-01 00:00:00

  • Inferring identify from DNA profile evidence.

    abstract::The controversy over the interpretation of DNA profile evidence in forensic identification can be attributed in part to confusion over the mode(s) of statistical inference appropriate to this setting. Although there has been substantial discussion in the literature of, for example, the role of population genetics issu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.25.11741

    authors: Balding DJ,Donnelly P

    更新日期:1995-12-05 00:00:00

  • Killing niche competitors by remote-control bacteriophage induction.

    abstract::A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by Streptococcus pneumoniae in the nasopharynx, which is of considerable clinical significance. How it i...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0809600106

    authors: Selva L,Viana D,Regev-Yochay G,Trzcinski K,Corpa JM,Lasa I,Novick RP,Penadés JR

    更新日期:2009-01-27 00:00:00

  • Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.

    abstract::To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody pr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.12.4460

    authors: Watanabe N,Katakura K,Kobayashi A,Okumura K,Ovary Z

    更新日期:1988-06-01 00:00:00

  • Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain.

    abstract::Neurogenesis has recently been observed in the adult human brain, suggesting the possibility of endogenous neural repair. However, the augmentation of neurogenesis in the adult human brain in response to neuronal cell loss has not been demonstrated. This study was undertaken to investigate whether neurogenesis occurs ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1532244100

    authors: Curtis MA,Penney EB,Pearson AG,van Roon-Mom WM,Butterworth NJ,Dragunow M,Connor B,Faull RL

    更新日期:2003-07-22 00:00:00

  • Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes.

    abstract::A computational model is presented that can be used as a tool in the design of safer chemicals. This model predicts the rate of hydrogen-atom abstraction by cytochrome P450 enzymes. Excellent correlations between biotransformation rates and the calculated activation energies (delta Hact) of the cytochrome P450-mediate...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.24.11076

    authors: Yin H,Anders MW,Korzekwa KR,Higgins L,Thummel KE,Kharasch ED,Jones JP

    更新日期:1995-11-21 00:00:00

  • Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva.

    abstract::When T cells become infected by the parasite Theileria parva, they acquire a transformed phenotype and no longer require antigen-specific stimulation or exogenous growth factors. This is accompanied by constitutive interleukin 2 (IL-2) and IL-2 receptor expression. Transformation can be reversed entirely by eliminatio...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.10.5119

    authors: Galley Y,Hagens G,Glaser I,Davis W,Eichhorn M,Dobbelaere D

    更新日期:1997-05-13 00:00:00

  • Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.

    abstract::Environmental cues are transmitted to the interior of the cell via a complex network of signaling hubs. Receptor tyrosine kinases (RTKs) and trimeric G proteins are two such major signaling hubs in eukaryotes. Conventionally, canonical signal transduction via trimeric G proteins is thought to be triggered exclusively ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1420140112

    authors: Midde KK,Aznar N,Laederich MB,Ma GS,Kunkel MT,Newton AC,Ghosh P

    更新日期:2015-03-03 00:00:00

  • Paleogenomics of echinoids reveals an ancient origin for the double-negative specification of micromeres in sea urchins.

    abstract::Establishing a timeline for the evolution of novelties is a common, unifying goal at the intersection of evolutionary and developmental biology. Analyses of gene regulatory networks (GRNs) provide the ability to understand the underlying genetic and developmental mechanisms responsible for the origin of morphological ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1610603114

    authors: Thompson JR,Erkenbrack EM,Hinman VF,McCauley BS,Petsios E,Bottjer DJ

    更新日期:2017-06-06 00:00:00

  • Distinct facial expressions represent pain and pleasure across cultures.

    abstract::Real-world studies show that the facial expressions produced during pain and orgasm-two different and intense affective experiences-are virtually indistinguishable. However, this finding is counterintuitive, because facial expressions are widely considered to be a powerful tool for social interaction. Consequently, de...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1807862115

    authors: Chen C,Crivelli C,Garrod OGB,Schyns PG,Fernández-Dols JM,Jack RE

    更新日期:2018-10-23 00:00:00

  • A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF.

    abstract::We have cloned a murine cDNA encoding a tyrosine kinase receptor with about 90% similarity to the chicken fibroblast growth factor (FGF) receptor and the human fms-like gene (FLG) tyrosine kinase. This mouse receptor lacks 88 amino acids in the extracellular portion, leaving only two immunoglobulin-like domains compar...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.11.4378

    authors: Mansukhani A,Moscatelli D,Talarico D,Levytska V,Basilico C

    更新日期:1990-06-01 00:00:00

  • Primary structural evidence that the H-2Dq region encodes at least three distinct gene products: Dq, Lq, and Rq.

    abstract::Class I gene products D, L, and R encoded by the D region of the H-2q haplotype were isolated by sequential immunoprecipitation from Nonidet P-40 extracts of B10.AKM murine spleen cells. Primary structural comparisons of these molecules were made by tryptic peptide map analyses and radiochemical amino acid sequence de...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.8.2499

    authors: Lillehoj EP,Hansen TH,Sachs DH,Coligan JE

    更新日期:1984-04-01 00:00:00

  • X-ray Raman scattering study of MgSiO3 glass at high pressure: implication for triclustered MgSiO3 melt in Earth's mantle.

    abstract::Silicate melts at the top of the transition zone and the core-mantle boundary have significant influences on the dynamics and properties of Earth's interior. MgSiO3-rich silicate melts were among the primary components of the magma ocean and thus played essential roles in the chemical differentiation of the early Eart...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0802667105

    authors: Lee SK,Lin JF,Cai YQ,Hiraoka N,Eng PJ,Okuchi T,Mao HK,Meng Y,Hu MY,Chow P,Shu J,Li B,Fukui H,Lee BH,Kim HN,Yoo CS

    更新日期:2008-06-10 00:00:00

  • Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression.

    abstract::Adoptive cellular immunotherapy, infusions of interleukin 2 (IL-2) in conjunction with in vitro-activated killer cells, has brought new hope to patients with cancer. The broad application of this strategy, however, is constrained by the need for repeated leukapheresis and by the labor-intensive process of in vitro act...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.91.17.7889

    authors: Nakajima F,Khanna A,Xu G,Lagman M,Haschemeyer R,Mouradian J,Wang JC,Stenzel KH,Rubin AL,Suthanthiran M

    更新日期:1994-08-16 00:00:00

  • Molecular cloning of developmentally regulated, low-abundance mRNA sequences from embryonic muscle.

    abstract::To study the role of low-abundance, embryonic muscle-specific gene transcripts, we have developed a method to screen cDNA clones from embryonic muscle for such sequences. The protocol involves two stages: first, partial enrichment for cDNA clones carrying possible embryo-specific sequences by selecting clones of low-a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.77.8.4519

    authors: Ordahl CP,Kioussis D,Tilghman SM,Ovitt CE,Fornwald J

    更新日期:1980-08-01 00:00:00

  • Resolution of a spectrum of nucleoprotein species in sonicated chromatin.

    abstract::Sonicated rabbit-liver chromatin is fractionated by ion-exchange chromatography on ECTHAM-cellulose, a weakly cationic adsorbent. The chromatographic procedure provides a series of fractions having a spectrum of thermal denaturation profiles. The earliest-eluting fractions melt cooperatively at a significantly higher ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.69.8.2317

    authors: Reeck GR,Simpson RT,Sober HA

    更新日期:1972-08-01 00:00:00

  • Rapid upslope shifts in New Guinean birds illustrate strong distributional responses of tropical montane species to global warming.

    abstract::Temperate-zone species have responded to warming temperatures by shifting their distributions poleward and upslope. Thermal tolerance data suggests that tropical species may respond to warming temperatures even more strongly than temperate-zone species, but this prediction has yet to be tested. We addressed this data ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1318190111

    authors: Freeman BG,Class Freeman AM

    更新日期:2014-03-25 00:00:00

  • Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.

    abstract::Antibiotic resistance in bacteria has emerged as a global challenge over the past 90 years, compromising our ability to effectively treat infections. There has been a dramatic increase in antibiotic resistance-associated determinants in bacterial populations, driven by the mobility and infectious nature of such determ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1717162115

    authors: Klemm EJ,Wong VK,Dougan G

    更新日期:2018-12-18 00:00:00

  • The karrikin signaling regulator SMAX1 controls Lotus japonicus root and root hair development by suppressing ethylene biosynthesis.

    abstract::An evolutionarily ancient plant hormone receptor complex comprising the α/β-fold hydrolase receptor KARRIKIN INSENSITIVE 2 (KAI2) and the F-box protein MORE AXILLARY GROWTH 2 (MAX2) mediates a range of developmental responses to smoke-derived butenolides called karrikins (KARs) and to yet elusive endogenous KAI2 ligan...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2006111117

    authors: Carbonnel S,Das D,Varshney K,Kolodziej MC,Villaécija-Aguilar JA,Gutjahr C

    更新日期:2020-09-01 00:00:00

  • 5'-CGA sequence is a strong motif for homo base-paired parallel-stranded DNA duplex as revealed by NMR analysis.

    abstract::The structure of the non-self-complementary DNA heptamer d(CGACGAC) at low pH has been determined by the quantitative NMR refinement procedure designated SPEDREF (SPEctral-Driven REFinement). Acid-base titration of the molecule indicated a prominent n = 2 pKa near 6.8. In the pH range up to 6.0, the heptamer forms a r...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.11.5224

    authors: Robinson H,Wang AH

    更新日期:1993-06-01 00:00:00

  • Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity.

    abstract::Neurotrophins (NTs) have recently been found to regulate synaptic transmission in the hippocampus. Whole-cell and single-channel recordings from cultured hippocampal neurons revealed a mechanism responsible for enhanced synaptic strength. Specifically, brain-derived neurotrophic factor augmented glutamate-evoked, but ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.17.10235

    authors: Levine ES,Crozier RA,Black IB,Plummer MR

    更新日期:1998-08-18 00:00:00

  • Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

    abstract::I have determined the nucleotide sequence of the ampicillin resistance gene of pBR322, an Escherichia coli plasmid that encodes a penicillin beta-lactamase. This gene codes for a protein of 286 amino acid residues. The first 23 amino acids presumably form a signal for secretion, because they do not appear in the matur...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.75.8.3737

    authors: Sutcliffe JG

    更新日期:1978-08-01 00:00:00

  • Partition congruences and the Andrews-Garvan-Dyson crank.

    abstract::In 1944, Freeman Dyson conjectured the existence of a "crank" function for partitions that would provide a combinatorial proof of Ramanujan's congruence modulo 11. Forty years later, Andrews and Garvan successfully found such a function and proved the celebrated result that the crank simultaneously "explains" the thre...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0506702102

    authors: Mahlburg K

    更新日期:2005-10-25 00:00:00