Longevity and transposon defense, the case of termite reproductives.

abstract：:Serotonin (5-hydroxytryptamine; 0.5 microM and above) stimulated the synthesis of prostacyclin (as measured by radioimmunoassay of 6-ketoprostaglandin F1 alpha) by bovine aortic smooth muscle cells in culture. This effect was structurally specific; a similar response was not elicited by the other indoles (tryptophan, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coughlin SR,Moskowitz MA,Antoniades HN,Levine L

更新日期：1981-11-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85alpha regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although PI3K enzymatic a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taniguchi CM,Tran TT,Kondo T,Luo J,Ueki K,Cantley LC,Kahn CR

更新日期：2006-08-08 00:00:00

abstract：:A DNA-dependent RNA polymerase has been purified from disrupted virions of the Escherichia coli bacteriophage N4. The RNA polymerase is phage-coded and is required for class I N4 RNA synthesis, which is defined as RNA synthesized in vivo in the absence of post-infection protein synthesis. A polypeptide of molecular we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falco SC,Zivin R,Rothman-Denes LB

更新日期：1978-07-01 00:00:00

abstract：:We examine how the polypeptide chain in protein crystal structures exploits the multivalent hydrogen-bonding potential of bound water molecules. This shows that multiple interactions with a single water molecule tend to occur locally along the chain. A distinctive internal-coordinate representation of the local water-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robert CH,Ho PS

更新日期：1995-08-01 00:00:00

abstract：:Bacterial outer membrane porins have a robust beta-barrel structure and therefore show potential for use as stochastic sensors based on single-molecule detection. The monomeric porin OmpG is especially attractive compared with multisubunit proteins because appropriate modifications of the pore can be easily achieved b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen M,Khalid S,Sansom MS,Bayley H

更新日期：2008-04-29 00:00:00

abstract：:Induction of transcription of the GAL genes of yeast by galactose is a multistep process: Galactose frees the activator Gal4 of its inhibitor, Gal80, allowing Gal4 to recruit proteins required to transcribe the GAL genes. Here, we show that deletion of components of either the HSP90 or the HSP70 chaperone machinery de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Floer M,Bryant GO,Ptashne M

更新日期：2008-02-26 00:00:00

abstract：:Human serum albumin (HSA) derivatized with cis-aconitic anhydride was covalently coupled to liposomes with a size of approximately 100 nm [polyaconitylated HSA (Aco-HSA) liposomes]. Within 30 min after injection into a rat, Aco-HSA liposomes were completely cleared from the blood and almost exclusively taken up by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamps JA,Morselt HW,Swart PJ,Meijer DK,Scherphof GL

更新日期：1997-10-14 00:00:00

abstract：:The molecular mechanism of growth hormone release by synthetic somatocrinin was investigated on purified hog anterior pituitary secretory granules; the granules were found to contain a cAMP-dependent protein kinase that catalyzed [gamma-32P]-ATP histone phosphorylation with maximal rates ranging from 1 to 5 nmol of Pi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewin MJ,Reyl-Desmars F,Ling N

更新日期：1983-11-01 00:00:00

abstract：:Mechanisms for controlling symbiont populations are critical for maintaining the associations that exist between a host and its microbial partners. We describe here the transcriptional, metabolic, and ultrastructural characteristics of a diel rhythm that occurs in the symbiosis between the squid Euprymna scolopes and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wier AM,Nyholm SV,Mandel MJ,Massengo-Tiassé RP,Schaefer AL,Koroleva I,Splinter-Bondurant S,Brown B,Manzella L,Snir E,Almabrazi H,Scheetz TE,Bonaldo Mde F,Casavant TL,Soares MB,Cronan JE,Reed JL,Ruby EG,McFall-Ngai MJ

更新日期：2010-02-02 00:00:00

abstract：:Electron spin echo electron-nuclear double resonance (ESE-ENDOR) experiments performed on a broad radical electron paramagnetic resonance (EPR) signal observed in photosystem II particles depleted of Ca2+ indicate that this signal arises from the redox-active tyrosine YZ. The tyrosine EPR signal width is increased rel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilchrist ML Jr,Ball JA,Randall DW,Britt RD

更新日期：1995-10-10 00:00:00

abstract：:Cellular wound healing or the repair of plasma membrane/cell wall damage (plasma membrane damage) occurs frequently in nature. Although various cellular perturbations, such as DNA damage, spindle misalignment, and impaired daughter cell formation, are monitored by cell cycle checkpoint mechanisms in budding yeast, whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kono K,Al-Zain A,Schroeder L,Nakanishi M,Ikui AE

更新日期：2016-06-21 00:00:00

abstract：:The nucleotide sequence of the recognition site for the restriction-modification enzyme of Escherichia coli B (SB site) has been determined. The recognition site is a 15-nucleotide sequence consisting of the trimer 5'TGA3', followed by an 8-nucleotide domain of variable sequence, which in turn is followed by tetramer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ravetch JV,Horiuchi K,Zinder ND

更新日期：1978-05-01 00:00:00

abstract：:The global financial crisis has precipitated an increasing appreciation of the need for a systemic perspective toward financial stability. For example: What role do large banks play in systemic risk? How should capital adequacy standards recognize this role? How is stability shaped by concentration and diversification...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arinaminpathy N,Kapadia S,May RM

更新日期：2012-11-06 00:00:00

abstract：:We have developed Differential Specificity and Energy Landscape (DiSEL) analysis to comprehensively compare DNA-protein interactomes (DPIs) obtained by high-throughput experimental platforms and cutting edge computational methods. While high-affinity DNA binding sites are identified by most methods, DiSEL uncovered nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhimsaria D,Rodríguez-Martínez JA,Pan J,Roston D,Korkmaz EN,Cui Q,Ramanathan P,Ansari AZ

更新日期：2018-11-06 00:00:00

abstract：:During or immediately after synthesis in vertebrate cells, the oncogenic protein-tyrosine kinase pp60v-src associates with the approximately 90-kDa heat-shock protein (hsp90). In this complex, pp60v-src is not functional as a kinase. When pp60v-src is subsequently found inserted into the plasma membrane, it is active ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Y,Lindquist S

更新日期：1993-08-01 00:00:00

abstract：:Patchy particles with shape complementarity can serve as building blocks for assembling colloidal superstructures. Alternatively, encoding information on patches using DNA can direct assembly into a variety of crystalline or other preprogrammed structures. Here, we present a tool where DNA is used both to engineer sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diaz A JA,Oh JS,Yi GR,Pine DJ

更新日期：2020-05-19 00:00:00

abstract：:The current epidemic of infections caused by antibiotic-resistant gram-positive bacteria requires the discovery of new drug targets and the development of new therapeutics. Lipoteichoic acid (LTA), a cell wall polymer of gram-positive bacteria, consists of 1,3-polyglycerol-phosphate linked to glycolipid. LTA synthase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter SG,Elli D,Kim HK,Hendrickx AP,Sorg JA,Schneewind O,Missiakas D

更新日期：2013-02-26 00:00:00

abstract：:Peroxisome proliferators cause rapid and coordinated transcriptional activation of genes encoding peroxisomal beta-oxidation system enzymes by activating peroxisome proliferator-activated receptor (PPAR) isoform(s). Since the thyroid hormone (T3; 3,3',5-triiodothyronine) receptor (TR), another member of the nuclear ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu R,Madison LD,Lin Y,Kopp P,Rao MS,Jameson JL,Reddy JK

更新日期：1995-12-05 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:Twelve zeolitic imidazolate frameworks (ZIFs; termed ZIF-1 to -12) have been synthesized as crystals by copolymerization of either Zn(II) (ZIF-1 to -4, -6 to -8, and -10 to -11) or Co(II) (ZIF-9 and -12) with imidazolate-type links. The ZIF crystal structures are based on the nets of seven distinct aluminosilicate zeo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KS,Ni Z,Côté AP,Choi JY,Huang R,Uribe-Romo FJ,Chae HK,O'Keeffe M,Yaghi OM

更新日期：2006-07-05 00:00:00

abstract：:A five-helix secondary structural model is proposed for eukaryotic cytoplasmic 5S rRNA. All available sequence data are consistent with this model including those from Chlorella 5S rRNA whose sequence is revised by data included here. Various architectural features of eukaryotic 5S rRNA are summarized in terms of this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luehrsen KR,Fox GE

更新日期：1981-04-01 00:00:00

abstract：:The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of sharks. Here, we report 2.2- and 2.8-A structures of the type 2 IgNAR variable domains 12Y-1 and 12Y-2. Structural features include, first, an Ig superfamily topology transitional between cell adhesion molecules, antibodies, and T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streltsov VA,Varghese JN,Carmichael JA,Irving RA,Hudson PJ,Nuttall SD

更新日期：2004-08-24 00:00:00

abstract：:In experiments originally designed to examine selective turnover of methylated "caps" in renal mRNA, we observed that [3H]methyl label decayed from mRNA containing poly(A) with a half-life of 1-2 hr. (Caps are blocked, methylated mRNA sequences of the general structure m7GpppNm p(1 or 2)Np.). To distinguish between me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouellette AJ,Reed SL,Malt RA

更新日期：1976-08-01 00:00:00

abstract：:People who are more avoidant of pathogens are more politically conservative, as are nations with greater parasite stress. In the current research, we test two prominent hypotheses that have been proposed as explanations for these relationships. The first, which is an intragroup account, holds that these relationships ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tybur JM,Inbar Y,Aarøe L,Barclay P,Barlow FK,de Barra M,Becker DV,Borovoi L,Choi I,Choi JA,Consedine NS,Conway A,Conway JR,Conway P,Adoric VC,Demirci DE,Fernández AM,Ferreira DC,Ishii K,Jakšić I,Ji T,van Leeuwen

更新日期：2016-11-01 00:00:00

abstract：:For disordered proteins, the dimensions of the chain are an important property that is sensitive to environmental conditions. We have used single-molecule Förster resonance energy transfer to probe the temperature-induced chain collapse of five unfolded or intrinsically disordered proteins. Because this behavior is se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wuttke R,Hofmann H,Nettels D,Borgia MB,Mittal J,Best RB,Schuler B

更新日期：2014-04-08 00:00:00

abstract：:The mechanism of contrast enhancement of tumors using magnetic resonance imaging was investigated in MCF7 human breast cancer implanted in nude mice. Dynamic contrast-enhanced images recorded at high spatial resolution were analyzed by an image analysis method based on a physiological model, which included the blood c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furman-Haran E,Margalit R,Grobgeld D,Degani H

更新日期：1996-06-25 00:00:00

abstract：:Recombinant plasmids containing mutant or wild-type adenovirus serotype 2 EIa genes that produce the 12S mRNA alone, the 13S mRNA alone, or both mRNAs were cotransfected into HeLa cells with plasmids containing the viral EIIa or EIII transcription units. The amount of RNA produced from the EIIa and EIII promoters was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leff T,Elkaim R,Goding CR,Jalinot P,Sassone-Corsi P,Perricaudet M,Kédinger C,Chambon P

更新日期：1984-07-01 00:00:00

abstract：:Fibrinogen binding to receptors on stimulated platelets is a prerequisite for platelet aggregation. To gain further insight into the role of fibrinogen in platelet aggregation and to identify the platelet fibrinogen receptor, we developed a monoclonal anti-platelet antibody that inhibited platelet aggregation. The pur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett JS,Hoxie JA,Leitman SF,Vilaire G,Cines DB

更新日期：1983-05-01 00:00:00

abstract：:Peace River is one of the few shocked members of the L-chondrites clan that contains both high-pressure polymorphs of olivine, ringwoodite and wadsleyite, in diverse textures and settings in fragments entrained in shock-melt veins. Among these settings are complete olivine porphyritic chondrules. We encountered few sq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyahara M,El Goresy A,Ohtani E,Nagase T,Nishijima M,Vashaei Z,Ferroir T,Gillet P,Dubrovinsky L,Simionovici A

更新日期：2008-06-24 00:00:00

abstract：:Healthy ocean ecosystems are needed to sustain people and livelihoods and to achieve the United Nations Sustainable Development Goals. Using the ocean sustainably requires overcoming many formidable challenges: overfishing, climate change, ocean acidification, and pollution. Despite gloomy forecasts, there is reason f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lubchenco J,Cerny-Chipman EB,Reimer JN,Levin SA

更新日期：2016-12-20 00:00:00