Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria.

abstract：:Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by the insulin receptor permits this docking protein to interact with signaling proteins that promote insulin action. Serine phosphorylation uncouples IRS-1 from the insulin receptor, thereby inhibiting its tyrosine phosphorylation and insulin signaling....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozes ON,Akca H,Mayo LD,Gustin JA,Maehama T,Dixon JE,Donner DB

更新日期：2001-04-10 00:00:00

abstract：:The developmental plasticity of plants relies on the remarkable ability of the meristems to integrate nutrient and energy availability with environmental signals. Meristems in root and shoot apexes share highly similar molecular players but are spatially separated by soil. Whether and how these two meristematic tissue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Cai W,Liu Y,Li H,Fu L,Liu Z,Xu L,Liu H,Xu T,Xiong Y

更新日期：2017-03-07 00:00:00

abstract：:The template for transcription and replication of negative-stranded RNA viruses is a ribonucleoprotein structure, the nucleocapsid. We have developed a system that supports assembly of the negative-stranded RNA genome of a defective interfering (DI) particle of vesicular stomatitis virus (VSV) into a nucleocapsid in v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirakhur B,Peluso RW

更新日期：1988-10-01 00:00:00

abstract：:The λ exonuclease is an ATP-independent enzyme that binds to dsDNA ends and processively digests the 5'-ended strand to form 5' mononucleotides and a long 3' overhang. The crystal structure of λ exonuclease revealed a toroidal homotrimer with a central funnel-shaped channel for tracking along the DNA, and a mechanism ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,McCabe KA,Bell CE

更新日期：2011-07-19 00:00:00

abstract：:The labeled inorganic phosphate formed by enzymatic hydrolysis of [gamma-18O]ATP in normal water was derivatized to trimethyl phosphate and analyzed for the proportions of [18O3]Pi, [18O2]Pi, [18O1]Pi, and [18O0]Pi. The proportions observed were correlated with the kinetics of intermediate exchange by using a kinetic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Midelfort CF

更新日期：1981-04-01 00:00:00

abstract：:Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Yeuh MF,Radominska-Pandya A,Saini SP,Negishi Y,Bottroff BS,Cabrera GY,Tukey RH,Evans RM

更新日期：2003-04-01 00:00:00

abstract：:Members of the order Nidovirales express their structural protein ORFs from a nested set of 3' subgenomic mRNAs (sg mRNAs), and for most of these ORFs, a single genomic transcription regulatory sequence (TRS) was identified. Nine TRSs were previously reported for the arterivirus Simian hemorrhagic fever virus (SHFV). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di H,Madden JC Jr,Morantz EK,Tang HY,Graham RL,Baric RS,Brinton MA

更新日期：2017-10-17 00:00:00

abstract：:Swarming bacteria move in multicellular groups and exhibit adaptive resistance to multiple antibiotics. Analysis of this phenomenon has revealed the protective power of high cell densities to withstand exposure to otherwise lethal antibiotic concentrations. We find that high densities promote bacterial survival, even ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler MT,Wang Q,Harshey RM

更新日期：2010-02-23 00:00:00

abstract：:Psychopathy is associated with persistent antisocial behavior and a striking lack of regret for the consequences of that behavior. Although explanatory models for psychopathy have largely focused on deficits in affective responsiveness, recent work indicates that aberrant value-based decision making may also play a ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baskin-Sommers A,Stuppy-Sullivan AM,Buckholtz JW

更新日期：2016-12-13 00:00:00

abstract：:The distribution of oriented, polymerized sickle cell hemoglobin (hemoglobin S) in erythrocytes is visualized with a microscope that produces an image proportional to linear dichroism. Monochromatic light alternately polarized along two perpendicular directions is incident on the sample. The image is focused on a diod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mickols W,Maestre MF,Tinoco I Jr,Embury SH

更新日期：1985-10-01 00:00:00

abstract：:Von Willebrand protein is present in the extracellular matrix of endothelial cells where it codistributes with fibronectin and types IV and V collagen. Bacterial collagenase digestion of endothelial cells removed fibrillar collagen, but the pattern of fibronectin and of von Willebrand protein remained undisturbed. Exo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner DD,Urban-Pickering M,Marder VJ

更新日期：1984-01-01 00:00:00

abstract：:Dentinal repair in the postnatal organism occurs through the activity of specialized cells, odontoblasts, that are thought to be maintained by an as yet undefined precursor population associated with pulp tissue. In this study, we isolated a clonogenic, rapidly proliferative population of cells from adult human dental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gronthos S,Mankani M,Brahim J,Robey PG,Shi S

更新日期：2000-12-05 00:00:00

abstract：:The effects of urea and of guanidinium chloride on binding constants in water for 6-(4-tert-butylanilino)-naphthalene-2-sulfonate and of bis(p-tert-butylphenyl) phosphate binding to beta-cyclodextrin and to N,N'-bis(6-beta-cyclo-dextrinyl)imidazolium ion have been determined. Their effects on the water solubility of p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breslow R,Halfon S

更新日期：1992-08-01 00:00:00

abstract：:A unique property of the mammalian embryo is that stem cells can be derived from its early tissue lineages. These lineages will give rise to the fetus as well as essential extraembryonic tissues. Understanding how chromatin regulation participates in establishment of these lineages in the embryo and their derived stem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rugg-Gunn PJ,Cox BJ,Ralston A,Rossant J

更新日期：2010-06-15 00:00:00

abstract：:The integrin receptor alphavbeta5 controls two independent forms of interactions of the retinal pigment epithelium (RPE) with adjacent photoreceptor outer segments that are essential for vision. Alphavbeta5 localizes specifically to apical microvilli of the RPE and contributes to retinal adhesion that maintains RPE co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nandrot EF,Anand M,Almeida D,Atabai K,Sheppard D,Finnemann SC

更新日期：2007-07-17 00:00:00

abstract：:Epithelial growth factor-like 7 (EGFL7) is a protein that is secreted by endothelial cells and plays an important role in angiogenesis. Although EGFL7 is aberrantly overexpressed in solid tumors, its role in leukemia has not been evaluated. Here, we report that levels of both EGFL7 mRNA and EGFL7 protein are increased...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papaioannou D,Shen C,Nicolet D,McNeil B,Bill M,Karunasiri M,Burke MH,Ozer HG,Yilmaz SA,Zitzer N,Behbehani GK,Oakes CC,Steiner DJ,Marcucci G,Powell BL,Kolitz JE,Carter TH,Wang ES,Mrózek K,Croce CM,Caligiuri MA,Bl

更新日期：2017-06-06 00:00:00

abstract：:Invariant natural killer T (iNKT) cells recognize self lipid antigens presented by CD1d molecules. The nature of the self-antigens involved in the development and maturation of iNKT cells is poorly defined. Lysophospholipids are self-antigens presented by CD1d that are generated through the action of phospholipases A1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paduraru C,Bezbradica JS,Kunte A,Kelly R,Shayman JA,Veerapen N,Cox LR,Besra GS,Cresswell P

更新日期：2013-03-26 00:00:00

abstract：:Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merion M,Schlesinger P,Brooks RM,Moehring JM,Moehring TJ,Sly WS

更新日期：1983-09-01 00:00:00

abstract：:The L-A double-stranded RNA virus of Saccharomyces cerevisiae makes a gag-pol fusion protein by a -1 ribosomal frameshift. The pol amino acid sequence includes consensus patterns typical of the RNA-dependent RNA polymerases (EC 2.7.7.48) of (+) strand and double-stranded RNA viruses of animals and plants. We have carr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribas JC,Wickner RB

更新日期：1992-03-15 00:00:00

abstract：:Taz1 is a hybrid signal-transducing membrane receptor between Tar, an aspartate chemoreceptor, and EnvZ, an osmosensor of Escherichia coli that is able to induce ompC expression by phosphorylating OmpR (a transcriptional activator) in response to aspartate. When the Taz1 His-277, the proposed autophosphorylation site ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Inouye M

更新日期：1991-12-15 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction of the human proteome play important roles in numerous cellular functions. Prostate-Associated Gene 4 (PAGE4) is an IDP that acts as a potentiator of the Activator Protein-1 (AP-1) transcription factor. Homeodomain-I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kulkarni P,Jolly MK,Jia D,Mooney SM,Bhargava A,Kagohara LT,Chen Y,Hao P,He Y,Veltri RW,Grishaev A,Weninger K,Levine H,Orban J

更新日期：2017-03-28 00:00:00

abstract：:Biological polymers such as nucleic acids and proteins are constructed of only one-the d or l-of the two possible nonsuperimposable mirror images (enantiomers) of selected organic compounds. However, before the advent of life, it is generally assumed that chemical reactions produced 50:50 (racemic) mixtures of enantio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper G,Rios AC

更新日期：2016-06-14 00:00:00

abstract：:Molting or ecdysis is the most fundamentally important process in arthropod life history, because shedding of the exoskeleton is an absolute prerequisite for growth and metamorphosis. Although the hormonal mechanisms driving ecdysis in insects have been studied extensively, nothing is known about these processes in cr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung JS,Dircksen H,Webster SG

更新日期：1999-11-09 00:00:00

abstract：:CD4(+) T cells expand after transfer into lymphopenic H-2(b) A(beta)-/- mice (I-A(beta)-, I-E(alpha)-deficient mice) but not after transfer into lymphopenic MHC II(Delta/Delta) mice (I-A(alpha)-, I-A(beta)-, I-E(alpha)-, and I-E(beta)-deficient mice), implying that in H-2(b) A(beta)-/- mice, A(alpha) chain and E(beta)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin B,Bourgeois C,Dautigny N,Lucas B

更新日期：2003-05-13 00:00:00

abstract：:The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyons RP,Scholz CA,Cohen AS,King JW,Brown ET,Ivory SJ,Johnson TC,Deino AL,Reinthal PN,McGlue MM,Blome MW

更新日期：2015-12-22 00:00:00

abstract：:Despite the growing interest in collective phenomena such as "swarm intelligence" and "wisdom of the crowds," little is known about the mechanisms underlying decision-making in vertebrate animal groups. How do animals use the behavior of others to make more accurate decisions, especially when it is not possible to ide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ward AJ,Sumpter DJ,Couzin ID,Hart PJ,Krause J

更新日期：2008-05-13 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multigenic autoimmune disease, and the major histocompatibility complex (MHC) class II polymorphism serves as a key genetic element. In SLE-prone (NZB x NZW)F(1) mice, the MHC H-2(d/z) heterozygosity (H-2(d) of NZB and H-2(z) of NZW) has a strong impact on disease; thus, congeni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang D,Fujio K,Jiang Y,Zhao J,Tada N,Sudo K,Tsurui H,Nakamura K,Yamamoto K,Nishimura H,Shira T,Hirose S

更新日期：2004-09-21 00:00:00

abstract：:Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron microscopy of pure mitochondrial Lon from Saccharomyces cerevisiae identify Lon as a flexible ring-shaped heptamer. In the presence of ATP or 5'-adenylylimidodiphosphate, most of the rings are symmetric and resemble ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stahlberg H,Kutejová E,Suda K,Wolpensinger B,Lustig A,Schatz G,Engel A,Suzuki CK

更新日期：1999-06-08 00:00:00

abstract：:Over the past 50 years, the rising tree line along Jumpingpound Ridge in the Rocky Mountains of Alberta, Canada, has reduced the area of alpine meadows and isolated populations that reside within them. By analyzing an 11-year data set of butterfly population sizes for 17 subpopulations along the ridge, we show that fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roland J,Matter SF

更新日期：2007-08-21 00:00:00

abstract：:We have constructed a hybrid E beta gene by replacing the second exon of the Ed beta gene (which encodes the majority of the beta 1 protein domain) with the corresponding exon from the Eb beta gene. The hybrid gene has been introduced into a d haplotype host, the lymphoma beta-cell line A20-2J, and an E alpha E beta d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Folsom V,Gay D,Tonegawa S

更新日期：1985-03-01 00:00:00