Parasite stress and pathogen avoidance relate to distinct dimensions of political ideology across 30 nations.

abstract：:The Tol2 element of the medaka fish Oryzias latipes belongs to the hAT family of transposons (hobo/Ac/Tam3). We report here identification of a functional transposase of Tol2 that is capable of catalyzing its transposition in the germ line of zebrafish Danio rerio. A transcript produced from Tol2 encodes a putative tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami K,Shima A,Kawakami N

更新日期：2000-10-10 00:00:00

abstract：:L-type Ca(2+) currents conducted by CaV1.2 channels initiate excitation-contraction coupling in the heart. Their activity is increased by β-adrenergic/cAMP signaling via phosphorylation by PKA in the fight-or-flight response, but the sites of regulation are unknown. We describe the functional role of phosphorylation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Y,Westenbroek RE,Scheuer T,Catterall WA

更新日期：2013-11-26 00:00:00

abstract：:Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of structural remodelin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czéh B,Michaelis T,Watanabe T,Frahm J,de Biurrun G,van Kampen M,Bartolomucci A,Fuchs E

更新日期：2001-10-23 00:00:00

abstract：:Previous work has shown that serotonin induces an increase in membrane K+ conductance in Aplysia neuron R15 and that this response is mediated by cAMP. The present study examines the role of protein phosphorylation in the response to serotonin. A specific inhibitor of cAMP-dependent protein kinase was injected intrace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams WB,Levitan IB

更新日期：1982-06-01 00:00:00

abstract：:The Met mutant of Drosophila melanogaster is highly resistant to juvenile hormone III (JH III) or its chemical analog, methoprene, an insect growth regulator. Five major mechanisms of insecticide resistance were examined in Met and susceptible Met+ flies. These two strains showed only minor differences when penetratio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shemshedini L,Wilson TG

更新日期：1990-03-01 00:00:00

abstract：:Without a fully developed initial segment, the most proximal region of the epididymis, male infertility results. Therefore, it is important to understand the development and regulation of this crucial region. In addition to distinctively high activity levels of the components of the ERK pathway, which are essential fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu B,Washington AM,Hinton BT

更新日期：2014-12-30 00:00:00

abstract：:The structure of DNA toroids made of individual DNA molecules of various lengths (3,000 to 55,000 bp) was studied, by using partially filled bacteriophage capsids in conjunction with cryoelectron microscopy. The tetravalent cation spermine was diffused through the capsid to condense the DNA under conditions that were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leforestier A,Livolant F

更新日期：2009-06-09 00:00:00

abstract：:Cells in the brain act as components of extended networks. Therefore, to understand neurobiological processes in a physiological context, it is essential to study them in vivo. Super-resolution microscopy has spatial resolution beyond the diffraction limit, thus promising to provide structural and functional insights ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turcotte R,Liang Y,Tanimoto M,Zhang Q,Li Z,Koyama M,Betzig E,Ji N

更新日期：2019-05-07 00:00:00

abstract：:Experimental lemurs either were infected orally with the agent of bovine spongiform encephalopathy (BSE) or were maintained as uninfected control animals. Immunohistochemical examination for proteinase-resistant protein (prion protein or PrP) was performed on tissues from two infected but still asymptomatic lemurs, ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bons N,Mestre-Frances N,Belli P,Cathala F,Gajdusek DC,Brown P

更新日期：1999-03-30 00:00:00

abstract：:Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for primary mammary tumor growth but is required ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Zhang W,Font-Burgada J,Palmer T,Hamil AS,Biswas SK,Poidinger M,Borcherding N,Xie Q,Ellies LG,Lytle NK,Wu LW,Fox RG,Yang J,Dowdy SF,Reya T,Karin M

更新日期：2014-09-23 00:00:00

abstract：:Human cells express thousands of different surface proteins that can be used for cell classification, or to distinguish healthy and disease conditions. A method capable of profiling a substantial fraction of the surface proteome simultaneously and inexpensively would enable more accurate and complete classification of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pollock SB,Hu A,Mou Y,Martinko AJ,Julien O,Hornsby M,Ploder L,Adams JJ,Geng H,Müschen M,Sidhu SS,Moffat J,Wells JA

更新日期：2018-03-13 00:00:00

abstract：:In eukaryotes, ubiquitination is an important posttranslational process achieved through a cascade of ubiquitin-activating (E1), conjugating (E2), and ligase (E3) enzymes. Many pathogenic bacteria deliver virulence factors into the host cell that function as E3 ligases. How these bacterial "Trojan horses" integrate in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin DY,Diao J,Chen J

更新日期：2012-02-07 00:00:00

abstract：:Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence Asn-[unk]-Ser/Thr was at the site of carbohydrate attachment in all light chains. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sox HC Jr,Hood L

更新日期：1970-07-01 00:00:00

abstract：:Several cDNA clones encoding the human immunoglobulin G receptor CD16 were isolated from human lung or peripheral blood leukocyte cDNA libraries. Nucleotide sequence comparisons revealed that the cDNAs could be divided into two groups. cDNA clones in one group encode a protein that terminates 4 amino acids after the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scallon BJ,Scigliano E,Freedman VH,Miedel MC,Pan YC,Unkeless JC,Kochan JP

更新日期：1989-07-01 00:00:00

abstract：:The NMR structures of three single-amino acid variants of the C-terminal domain of the human prion protein, hPrP(121-230), are presented. In hPrP(M166V) and hPrP(R220K) the substitution is with the corresponding residue in murine PrP, and in hPrP(S170N) it is with the corresponding Syrian hamster residue. All three su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calzolai L,Lysek DA,Guntert P,von Schroetter C,Riek R,Zahn R,Wüthrich K

更新日期：2000-07-18 00:00:00

abstract：:The mechanism of Ca2+-dependent protein-protein interaction and enzyme activation by calmodulin was investigated with the phosphoprotein phosphatase, calcineurin. Dimethylaminonaphthalene (dansyl)-calmodulin, a fluorescent derivative used to monitor complex formation, produced similar maximal activation (10- to 12-fol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kincaid RL,Vaughan M

更新日期：1986-03-01 00:00:00

abstract：:Molecular modeling and two-dimensional NMR techniques enable us to identify structural features in the third variable region (V3) loop of the human immunodeficiency virus (HIV) surface glycoprotein gp120, in particular the principal neutralizing determinant (PND), that remain conserved despite the sequence variation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontenot JD,Gatewood JM,Mariappan SV,Pau CP,Parekh BS,George JR,Gupta G

更新日期：1995-01-03 00:00:00

abstract：:A major part of the present understanding of the molecular basis of signal transduction has been gained from in vitro studies using classical biochemical methods. In this study, we used 31P NMR spectroscopy to investigate the response of live M2R mouse melanoma cells to stimulation by melanocyte-stimulating hormone (M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Degani H,DeJordy JO,Salomon Y

更新日期：1991-02-15 00:00:00

abstract：:In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates Nδ and Nω' of Nω-methyl-l-arginine before oxidatively rearranging the triply modified guanidine to the N-methyl-N-nitrosourea pharmacophore. A previously published structure visualized the monoiron cofa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McBride MJ,Pope SR,Hu K,Okafor CD,Balskus EP,Bollinger JM Jr,Boal AK

更新日期：2021-01-26 00:00:00

abstract：:The design, realization, and test performances of an electronic junction based on single-electron phenomena that works in the air at room temperature are hereby reported. The element consists of an electrochemically etched sharp tungsten stylus over whose tip a nanometer-size crystal was synthesized. Langmuir-Blodgett...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Facci P,Erokhin V,Carrara S,Nicolini C

更新日期：1996-10-01 00:00:00

abstract：:The Tap protein mediates the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element (CTE). Previously, the structures of individual Tap subdomains, including ribonucleoprotein and leucine-rich repeat domains, have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho DN,Coburn GA,Kang Y,Cullen BR,Georgiadis MM

更新日期：2002-02-19 00:00:00

abstract：:The completion of the human genome draft has taken several years and is only the beginning of a period in which large amounts of DNA and RNA sequence information will be required from many individuals and species. Conventional sequencing technology has limitations in cost, speed, and sensitivity, with the result that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braslavsky I,Hebert B,Kartalov E,Quake SR

更新日期：2003-04-01 00:00:00

abstract：:The six members of the contactin (CNTN) family of neural cell adhesion molecules are involved in the formation and maintenance of the central nervous system (CNS) and have been linked to mental retardation and neuropsychiatric disorders such as autism. Five of the six CNTNs bind to the homologous receptor protein tyro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamprianou S,Chatzopoulou E,Thomas JL,Bouyain S,Harroch S

更新日期：2011-10-18 00:00:00

abstract：:The transcription factor retinoic acid receptor beta(2) (RARbeta(2)) is a potent inhibitor of breast cancer cells in vitro, and studies suggest that RARbeta expression is lost in primary breast cancer. Although RARbeta(2) is selectively down-regulated at the mRNA level in breast tumor cells, we show that expression of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommer KM,Chen LI,Treuting PM,Smith LT,Swisshelm K

更新日期：1999-07-20 00:00:00

abstract：:RsbR is a regulator of sigma(B), the RNA polymerase sigma factor subunit responsible for transcribing the general stress response genes when environmental stress is imposed on Bacillus subtilis. The C-terminal domain of RsbR and its paralogues is a substrate for the kinase function of another sigma(B) regulator, RsbT,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray JW,Delumeau O,Lewis RJ

更新日期：2005-11-29 00:00:00

abstract：:Far-red radiation (FR) reflected by green tissues is a key signal that plants use to detect the proximity of future competitors. Perception of increased levels of FR elicits a suite of responses collectively known as the shade-avoidance syndrome, which includes increased stem elongation, production of erect leaves, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Izaguirre MM,Mazza CA,Biondini M,Baldwin IT,Ballaré CL

更新日期：2006-05-02 00:00:00

abstract：:The environmental topology of complex structures is used by Escherichia coli to create traveling waves of high cell density, a prelude to quorum sensing. When cells are grown to a moderate density within a confining microenvironment, these traveling waves of cell density allow the cells to find and collapse into confi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Wolanin PM,Yuzbashyan EA,Lin H,Darnton NC,Stock JB,Silberzan P,Austin R

更新日期：2003-11-25 00:00:00

abstract：:High molecular weight proteins extracted from the walking nerves of the shore crab (Carcinus maenas) exhibit a cycle of phosphorylation-dephosphorylation that is influenced by neurotropic compounds and inorganic ions. The net phosphorylation state of the proteins is increased in the presence of K+ ions and decreased w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoffeniels E,Dandrifosse G

更新日期：1980-02-01 00:00:00

abstract：:Somatic hypermutation (SHM) and class-switch recombination (CSR) of the Ig gene require both the transcription of the locus and the expression of activation-induced cytidine deaminase (AID). During CSR, AID decreases the amount of topoisomerase I (Top1); this decrease alters the DNA structure and induces cleavage in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi M,Sabouri Z,Sabouri S,Kitawaki Y,Pommier Y,Abe T,Kiyonari H,Honjo T

更新日期：2011-11-29 00:00:00

abstract：:Differences between early and late passage cell cultures on the organelle and macromolecular levels have been attributed to cellular "aging". However, concern has been expressed over whether changes in diploid cell populations after serial passage in vitro accurately reflect human cellular aging in vivo. Studies were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider EL,Mitsui Y

更新日期：1976-10-01 00:00:00