Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization.

abstract：:Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation through the acetylation of cyclooxygenase II. These aspirin-triggered lipoxins (ATL) may mediate some of ASA's beneficial actions and therefore are of interest in the search...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clish CB,O'Brien JA,Gronert K,Stahl GL,Petasis NA,Serhan CN

更新日期：1999-07-06 00:00:00

abstract：:Cell walls of Mycobacterium leprae, prepared by differential solvent extraction, were shown to contain arabinogalactan, mycolates, and peptidoglycan. In addition, amino acid analysis revealed the unexpected presence of large amounts of protein that retained potent immunological reactivity. Purified cell walls stimulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melancon-Kaplan J,Hunter SW,McNeil M,Stewart C,Modlin RL,Rea TH,Convit J,Salgame P,Mehra V,Bloom BR

更新日期：1988-03-01 00:00:00

abstract：:The central limit theorem is applied to group foraging to show an automatic and universal benefit to group living. This may explain the paradoxical inverse correlation between group size and per capita brood production in primitively eusocial insects and why only one of the five major lineages of social insects contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wenzel JW,Pickering J

更新日期：1991-01-01 00:00:00

abstract：:Three fluorescein-labeled lectins have been shown to exhibit specificity for the surface of cells in different layers of the epidermis in the newborn rat. An isolectin from seeds of Bandeiraea simplicifolia with specificity for alpha-D-galactosyl end groups labeled the basal and lower spinous cells; a lectin from Ulex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brabec RK,Peters BP,Bernstein IA,Gray RH,Goldstein IJ

更新日期：1980-01-01 00:00:00

abstract：:Programmed cell death (PCD) of mammary alveolar cells during involution commences within hours of the end of suckling. Locally, milk accumulates within alveolar lumens; systemically, levels of lactogenic hormones fall. Four experimental models were used to define the role of local factors as compared with systemic hor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li M,Liu X,Robinson G,Bar-Peled U,Wagner KU,Young WS,Hennighausen L,Furth PA

更新日期：1997-04-01 00:00:00

abstract：:A series of small peptides corresponding to the amino termini of the fibrin alpha- and beta-chains has been synthesized. The peptides glycyl-L-prolyl-L-arginyl-L-proline and glycyl-L-prolyl-L-arginylsarcosine are potent inhibitors of fibrin polymerization. Moreover, these peptides have a natural stability stemming fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laudano AP,Doolittle RF

更新日期：1978-07-01 00:00:00

abstract：:The first step in the replication of the adenovirus genome is the covalent attachment of the 5'-terminal nucleotide, dCMP, to the virus-encoded terminal protein precursor (pTP). This reaction can be observed in vitro and has been previously shown to be dependent upon either viral DNA or linearized plasmid DNA containi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Challberg MD,Rawlins DR

更新日期：1984-01-01 00:00:00

abstract：:HLA-G is the putative natural killer (NK) cell inhibitory ligand expressed on the extravillous cytotrophoblast of the human placenta. Killing of the class I negative human B cell line 721.221 by NK cells is inhibited by the expression of HLA-G. This inhibition is dependent on a high level of HLA-G expression. In the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandelboim O,Pazmany L,Davis DM,Valés-Gómez M,Reyburn HT,Rybalov B,Strominger JL

更新日期：1997-12-23 00:00:00

abstract：:The functional capacities of CD8(+) T cells important for virus clearance are influenced by interactions with antigen presenting cells (APCs) and CD4(+) T cells during initial selection, subsequent expansion, and development of memory. Recently, investigators have shown that polyfunctional T cells correlate best with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ndhlovu ZM,Oelke M,Schneck JP,Griffin DE

更新日期：2010-02-23 00:00:00

abstract：:Site-specific recombination is responsible for a broad range of biological phenomena, including DNA inversion, resolution of transposition intermediates, and the integration and excision of bacteriophage genomes. Integration of mycobacteriophage L5 is catalyzed by a phage-encoded integrase with recombination occurring...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peña CE,Kahlenberg JM,Hatfull GF

更新日期：2000-07-05 00:00:00

abstract：:Cell-based therapies are attractive for revascularizing and regenerating tissues and organs, but clinical trials of endothelial progenitor cell transplantation have not resulted in consistent benefit. We propose a different approach in which a material delivery system is used to create a depot of vascular progenitor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva EA,Kim ES,Kong HJ,Mooney DJ

更新日期：2008-09-23 00:00:00

abstract：:There is great interest in understanding the mechanisms of expression underlying long-term potentiation (LTP). They are agreed to involve an increase in synaptic efficacy, which is described by three multiplicative parameters: p, the probability of neurotransmitter release; n, the number of active release sites; and q...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz PE

更新日期：1997-05-27 00:00:00

abstract：:Plants frequently respond to herbivorous insect attack by synthesizing defense proteins that deter insect feeding and prevent additional herbivory. Maize (Zea mays L.) lines, resistant to feeding by a number of lepidopteran species, rapidly mobilize a unique 33-kDa cysteine protease in response to caterpillar feeding....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pechan T,Cohen A,Williams WP,Luthe DS

更新日期：2002-10-01 00:00:00

abstract：:An analysis of taxonomic longevity for species of the two Cenozoic radiations of Caribbean planktonic foraminifera shows strong similarity in longevity for extinct taxa, though extant species of the latter radiation are biased towards longer-lived forms. In this case, the present is not the key to the past. A simple o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinton JS,Ginzburg L

更新日期：1984-09-01 00:00:00

abstract：:Unlike normal cells, malignant rat and two simian virus 40-transformed human cell lines can neither grow nor survive in B12-and folate-supplemented media in which methionine is replaced by homocysteine. Yet three lines of evidence indicate that the malignant and transformed cells synthesize large amounts of methionine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman RM,Erbe RW

更新日期：1976-05-01 00:00:00

abstract：:Many neurodegenerative diseases are characterized by the accumulation of amyloid fibers in the brain, which can occur when a protein misfolds into an extended beta-sheet conformation. The nucleation of these beta-sheet aggregates is of particular interest, not only because it is the rate-determining step toward fiber ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petty SA,Decatur SM

更新日期：2005-10-04 00:00:00

abstract：:KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain. Electrostatic interactions have been envisaged as the primary determinant of interactions between KRAS and membranes. Here, we integrated molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Prakash PS,Liang H,Gorfe AA,Hancock JF

更新日期：2021-02-09 00:00:00

abstract：:Nitrogen limitation imposes a major transition in the lifestyle of nondiazotrophic cyanobacteria that is controlled by a complex interplay of regulatory factors involving the pervasive signal processor PII Immediately upon nitrogen limitation, newly fixed carbon is redirected toward glycogen synthesis. How the metabol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orthwein T,Scholl J,Spät P,Lucius S,Koch M,Macek B,Hagemann M,Forchhammer K

更新日期：2021-02-09 00:00:00

abstract：:Transcription, splicing, and translation are potentially coordinately regulatable in a temporospatial-dependent manner, although supporting experimental evidence for this notion is scarce. Yeast two-hybrid screening of a mammary gland cDNA library with human p21-activated kinase 1 (Pak1) as bait identified polyC-RNA-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng Q,Rayala SK,Gururaj AE,Talukder AH,O'Malley BW,Kumar R

更新日期：2007-04-03 00:00:00

abstract：:The commitment of differentiating cells to a specialized fate is fundamental to the correct assembly of tissues within a multicellular organism. Because commitment is often irreversible, entry into and progression through this phase of development must be tightly regulated. Under nitrogen-limiting conditions, the mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Videau P,Rivers OS,Hurd K,Ushijima B,Oshiro RT,Ende RJ,O'Hanlon SM,Cozy LM

更新日期：2016-11-08 00:00:00

abstract：:The genome of a thermophilic fungus, Thermomyces lanuginosus, contains a tandemly arranged cluster of sequences that are approximately equal to 50% homologous with the cytoplasmic 5S RNA and that are selectable by hybridization techniques. Unlike typical pseudogenes, these sequences are not truncated; rather, they bea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong WM,Abrahamson JL,Nazar RN

更新日期：1984-03-01 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:It is a well known fact that stirring keeps particles suspended in fluids. This is apparent, for instance, when shaking medicine flasks, when agitating tea deposits in a mug, or when heavy winds fill the air with dust particles. The commonplace nature of such observations makes it easy to accept that this feature will...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz J,Macías D,Peters F

更新日期：2004-12-21 00:00:00

abstract：:Rising sea levels and increased storminess are expected to accelerate the erosion of soft-cliff coastlines, threatening coastal infrastructure and livelihoods. To develop predictive models of future coastal change we need fundamentally to know how rapidly coasts have been eroding in the past, and to understand the dri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurst MD,Rood DH,Ellis MA,Anderson RS,Dornbusch U

更新日期：2016-11-22 00:00:00

abstract：:Coordinated changes in gene expression underlie the early patterning and cell-type specification of the central nervous system. However, much less is known about how such changes contribute to later stages of circuit assembly and refinement. In this study, we employ single-cell RNA sequencing to develop a detailed, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalish BT,Cheadle L,Hrvatin S,Nagy MA,Rivera S,Crow M,Gillis J,Kirchner R,Greenberg ME

更新日期：2018-01-30 00:00:00

abstract：:Nucleotide sequence analysis of one of several tRNA genes cloned from Tetrahymena thermophila macronuclear DNA indicated that it corresponds to a tRNA species having TTA as anticodon. Subsequently, the tRNA species corresponding to that gene was isolated and its nucleotide sequence was determined by post-labeling tech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuchino Y,Hanyu N,Tashiro F,Nishimura S

更新日期：1985-07-01 00:00:00

abstract：:Microorganisms have mechanisms to sense their environment and rapidly adapt to survive changes in conditions. In Streptomyces albus, various transcriptional repressors mediate the induction of heat shock genes. The RheA repressor regulates the synthesis of HSP18, a small heat shock protein, which plays a role in therm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Servant P,Grandvalet C,Mazodier P

更新日期：2000-03-28 00:00:00

abstract：:Linear growth delay (stunting) affects roughly 155 million children under the age of 5 years worldwide. Treatment has been limited by a lack of understanding of the underlying pathophysiological mechanisms. Stunting is most likely associated with changes in the microbial community of the small intestine, a compartment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonaesch P,Morien E,Andrianonimiadana L,Sanke H,Mbecko JR,Huus KE,Naharimanananirina T,Gondje BP,Nigatoloum SN,Vondo SS,Kaleb Kandou JE,Randremanana R,Rakotondrainipiana M,Mazel F,Djorie SG,Gody JC,Finlay BB,Rubbo PA,

更新日期：2018-09-04 00:00:00

abstract：:The ability of a specialized herbivore to overcome the chemical defense of a particular plant taxon not only makes it accessible as a food source but may also provide metabolites to be exploited for communication or chemical defense. Phyllotreta flea beetles are adapted to crucifer plants (Brassicales) that are defend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beran F,Pauchet Y,Kunert G,Reichelt M,Wielsch N,Vogel H,Reinecke A,Svatoš A,Mewis I,Schmid D,Ramasamy S,Ulrichs C,Hansson BS,Gershenzon J,Heckel DG

更新日期：2014-05-20 00:00:00

abstract：:Hepatocellular injury during hepatitis B virus (HBV) infection has been postulated to result from a human leukocyte antigen (HLA)-restricted T-lymphocyte host immune response against HBV antigens. Although HLA expression is enhanced in the presence of hepatic inflammation, whether HBV itself can induce HLA expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu KQ,Vierling JM,Siddiqui A

更新日期：1990-09-01 00:00:00