Metal-insulator quantum critical point beneath the high Tc superconducting dome.

abstract：:The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability. BRCA2 binds to RAD51 through 8 conserved BRC repeat motifs dispersed in an 1127-residue region (BRCA2([BRC1-8])). Here, we show that BRCA2([BRC1-8]) exerts opposing effects o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shivji MK,Mukund SR,Rajendra E,Chen S,Short JM,Savill J,Klenerman D,Venkitaraman AR

更新日期：2009-08-11 00:00:00

abstract：:High-resolution mapping of cofactor-specific photochemistry in photosynthetic reaction centers (RCs) from Rhodobacter sphaeroides was achieved by polarization selective ultrafast spectroscopy in single crystals at cryogenic temperature. By exploiting the fixed orientation of cofactors within crystals, we isolated a si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang L,Ponomarenko N,Wiederrecht GP,Tiede DM

更新日期：2012-03-27 00:00:00

abstract：:Dimers of bacteriochlorophyll a (Bchla) with optical absorption maximum at 853 nm and a nonconservative circular dichroism spectrum are formed in a solution of formamide/water that contains micelles of Triton X-100. The apparent equilibrium constant and the corresponding Gibbs energy change for the Bchl self-organizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherz A,Rosenbach-Belkin V

更新日期：1989-03-01 00:00:00

abstract：:The central questions of bacterial ecology and evolution require a method to consistently demarcate, from the vast and diverse set of bacterial cells within a natural community, the groups playing ecologically distinct roles (ecotypes). Because of a lack of theory-based guidelines, current methods in bacterial systema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koeppel A,Perry EB,Sikorski J,Krizanc D,Warner A,Ward DM,Rooney AP,Brambilla E,Connor N,Ratcliff RM,Nevo E,Cohan FM

更新日期：2008-02-19 00:00:00

abstract：:Binding and uptake of alpha-fetoprotein (AFP) by mouse T-lymphoma YAC-1 cells exhibited the characteristics of receptor-mediated endocytosis. The binding saturation curve obtained by incubating YAC-1 cells at 4 degrees C with 125I-labeled AFP at different concentrations (50 ng/ml to 2.5 mg/ml) showed three saturation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naval J,Villacampa MJ,Goguel AF,Uriel J

更新日期：1985-05-01 00:00:00

abstract：:Individual cell types are defined by architecturally and functionally specialized cortical domains. The Ezrin, Radixin, and Moesin (ERM) proteins play a major role in organizing cortical domains by assembling membrane protein complexes and linking them to the cortical actin cytoskeleton. Many studies have focused on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casaletto JB,Saotome I,Curto M,McClatchey AI

更新日期：2011-07-19 00:00:00

abstract：:A new model of an autoimmune disease of the neuromuscular junction was obtained by injection of acetylcholine receptor purified from rat denervated muscles into Balb/c mice. Anti-rat, then anti-mouse acetylcholine receptor antibodies, appear in mouse serum during the immunization procedure. Electrophysiological invest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granato DA,Fulpius BW,Moody JF

更新日期：1976-08-01 00:00:00

abstract：:A system is described for assembling infectious bacteriophage phi 6 nucleocapsids in vitro. Procapsids encoded by cDNA copies of genomic segment L in Escherichia coli were used to package and replicate viral RNA segments. The resulting filled particles were shown to be capable of infecting host cell spheroplasts after...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olkkonen VM,Gottlieb P,Strassman J,Qiao XY,Bamford DH,Mindich L

更新日期：1990-12-01 00:00:00

abstract：:The apparent detection of an exoplanet orbiting Fomalhaut was announced in 2008. However, subsequent observations of Fomalhaut b raised questions about its status: Unlike other exoplanets, it is bright in the optical and nondetected in the infrared, and its orbit appears to cross the debris ring around the star withou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gáspár A,Rieke GH

更新日期：2020-05-05 00:00:00

abstract：:Recent scholarship suggests that the genomes of those around us affect our own phenotypes. Much of the empirical evidence for such "metagenomic" effects comes from animal studies, where the socio-genetic environment can be easily manipulated. Among humans, it is more difficult to identify such effects given the nonran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sotoudeh R,Harris KM,Conley D

更新日期：2019-08-13 00:00:00

abstract：:Ferric uptake regulation protein (Fur) is a bacterial global regulator that uses iron as a cofactor to bind to specific DNA sequences. The function of Fur is not limited to iron homeostasis. A wide variety of genes involved in various mechanisms such as oxidative and acid stresses are under Fur control. Flavohemoglobi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Autreaux B,Touati D,Bersch B,Latour JM,Michaud-Soret I

更新日期：2002-12-24 00:00:00

abstract：:Combining genotypes across datasets is central in facilitating advances in genetics. Data aggregation efforts often face the challenge of record matching-the identification of dataset entries that represent the same individual. We show that records can be matched across genotype datasets that have no shared markers ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edge MD,Algee-Hewitt BFB,Pemberton TJ,Li JZ,Rosenberg NA

更新日期：2017-05-30 00:00:00

abstract：:Splice variants (SVs) of receptors for growth hormone-releasing hormone (GHRH) have been found in primary human prostate cancers and diverse human cancer cell lines. GHRH antagonists inhibit growth of various experimental human cancers, including pancreatic and colorectal, xenografted into nude mice or cultured in vit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busto R,Schally AV,Varga JL,Garcia-Fernandez MO,Groot K,Armatis P,Szepeshazi K

更新日期：2002-09-03 00:00:00

abstract：:Vibrational modes in mechanical resonators provide a promising candidate to interface and manipulate classical and quantum information. The observation of coherent dynamics between distant mechanical resonators can be a key step toward scalable phonon-based applications. Here we report tunable coherent phonon dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang ZZ,Song XX,Luo G,Su ZJ,Wang KL,Cao G,Li HO,Xiao M,Guo GC,Tian L,Deng GW,Guo GP

更新日期：2020-03-17 00:00:00

abstract：:Mature larvae of Sarcophaga argyrostoma fail to form puparia when kept in contact with water, but pupariate after having been subsequently exposed to dryness for 30 hr. They become increasingly more sensitive to injected ecdysone the longer the exposure to dry conditions. A second wet treatment halts the production of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zdarek J,Fraenkel G

更新日期：1970-09-01 00:00:00

abstract：:Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rall LB,Pictet RL,Williams RH,Rutter WJ

更新日期：1973-12-01 00:00:00

abstract：:The rRNA intervening sequence of Tetrahymena is a catalytic RNA molecule, or "ribozyme." A tertiary-structure model of the active site of this ribozyme has been constructed based on comparative sequence analysis of related group I intervening sequences, data on the accessibility of each nucleotide to chemical and enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Cech TR

更新日期：1987-12-01 00:00:00

abstract：:We have combined standard micrococcal nuclease (MNase) digestion of nuclei with a modified protocol for constructing paired-end DNA sequencing libraries to map both nucleosomes and subnucleosome-sized particles at single base-pair resolution throughout the budding yeast genome. We found that partially unwrapped nucleo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henikoff JG,Belsky JA,Krassovsky K,MacAlpine DM,Henikoff S

更新日期：2011-11-08 00:00:00

abstract：:The GTPase-activating protein (GAP) has been postulated to function either as a negative regulator or as a possible target protein of Ras in mammalian cells and Xenopus oocytes. Ras must be localized in the plasma membrane of vertebrate cells to function, but GAP is localized in the cytosol. To test whether Ras functi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibbs JB,Schaber MD,Schofield TL,Scolnick EM,Sigal IS

更新日期：1989-09-01 00:00:00

abstract：:Aggregation of the receptor for IgE on mast cells, basophils, and a tumor analog, rat basophilic leukemia (RBL) cells, induces a calcium-dependent degranulation of the cells. We have measured the membrane potential (delta psi) of RBL cells during this reaction by using the tetraphenylphosphonium ion (Ph4P+) equilibrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanner BI,Metzger H

更新日期：1983-09-01 00:00:00

abstract：:The low-energy conformations for a series of peptides based on the sequence of the ras P21 protein from position 55 to position 67 have been computed using conformational energy analysis. These sequences differed at position 61 and contained Gln, Pro, Leu, Lys, and Arg at this position. P21 proteins with Gln, Glu, or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus MR,Brandt-Rauf PW,Carty RP,Lubowsky J,Avitable M,Gibson KD,Scheraga HA

更新日期：1987-12-01 00:00:00

abstract：:Saccharomyces cerevisiae is an ideal host from which to obtain high levels of posttranslationally modified eukaryotic proteins for x-ray crystallography. However, extensive replacement of methionine by selenomethionine for anomalous dispersion phasing has proven intractable in yeast. We report a general method to inco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malkowski MG,Quartley E,Friedman AE,Babulski J,Kon Y,Wolfley J,Said M,Luft JR,Phizicky EM,DeTitta GT,Grayhack EJ

更新日期：2007-04-17 00:00:00

abstract：:Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes. Studies of such lethal albino deletion homozygotes in perinatal stages revealed a deficiency in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaret KS,Milos P,Lia M,Bali D,Gluecksohn-Waelsch S

更新日期：1992-07-15 00:00:00

abstract：:Experimental observations of unexpected shear rigidity in confined liquids, on very low frequency scales on the order of 0.01 to 0.1 Hz, call into question our basic understanding of the elasticity of liquids and have posed a challenge to theoretical models of the liquid state ever since. Here we combine the nonaffine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaccone A,Trachenko K

更新日期：2020-08-18 00:00:00

abstract：:As a dynamic property of folded proteins, protein compressibility provides important information about the forces that govern structural stability. We relate intrinsic compressibility to stability by using molecular dynamics to identify a molecular basis for the variation in compressibility among globular proteins. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dadarlat VM,Post CB

更新日期：2003-12-09 00:00:00

abstract：:Sensory information from the external world is inherently ambiguous, necessitating prior experience as a constraint on perception. Prolonged experience (adaptation) induces perception of ambiguous morph faces as a category different from the adapted category, suggesting sensitivity in underlying neural codes to differ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furl N,van Rijsbergen NJ,Treves A,Friston KJ,Dolan RJ

更新日期：2007-08-14 00:00:00

abstract：:Glutaredoxins (Grxs) have been identified across taxa as important mediators in various physiological functions. A chloroplastic monothiol glutaredoxin, AtGRXS16 from Arabidopsis thaliana, comprises two distinct functional domains, an N-terminal domain (NTD) with GlyIleTyr-TyrIleGly (GIY-YIG) endonuclease motif and a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Liu S,Feng Y,Liu JZ,Chen Y,Pham K,Deng H,Hirschi KD,Wang X,Cheng N

更新日期：2013-06-04 00:00:00

abstract：:The ability to be synchronized by light-dark cycles is a fundamental property of circadian clocks. Although there are indications that circadian clocks are extremely light-sensitive and that they can be set by the low irradiances that occur at dawn and dusk, this has not been shown on the cellular level. Here, we demo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachleitner W,Kempinger L,Wülbeck C,Rieger D,Helfrich-Förster C

更新日期：2007-02-27 00:00:00

abstract：:A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salerno W,Havlak P,Miller J

更新日期：2006-08-29 00:00:00

abstract：:Rad51 is the primary eukaryotic recombinase responsible for initiating DNA strand exchange during homologous recombination. Although the subject of intense study for over a decade, many molecular details of the reactions promoted by Rad51 and related recombinases remain unknown. Using total internal reflection fluores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granéli A,Yeykal CC,Robertson RB,Greene EC

更新日期：2006-01-31 00:00:00