Coherent modulation of the electron temperature and electron-phonon couplings in a 2D material.

abstract：:With current concerns of antibiotic-resistant bacteria and biodefense, it has become important to rapidly identify infectious bacteria. Traditional technologies involving isolation and amplification of the pathogenic bacteria are time-consuming. We report a rapid and simple method that combines in vivo biotinylation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edgar R,McKinstry M,Hwang J,Oppenheim AB,Fekete RA,Giulian G,Merril C,Nagashima K,Adhya S

更新日期：2006-03-28 00:00:00

abstract：:How do regions acquire the knowledge they need to diversify their economic activities? How does the migration of workers among firms and industries contribute to the diffusion of that knowledge? Here we measure the industry-, occupation-, and location-specific knowledge carried by workers from one establishment to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jara-Figueroa C,Jun B,Glaeser EL,Hidalgo CA

更新日期：2018-12-11 00:00:00

abstract：:We have isolated two genes, Hox-2.8 and Hox-2.9, from the mouse homeobox cluster Hox-2, located on chromosome 11. A 120-kilobase yeast artificial chromosome (YAC) containing a large region of the murine Hox-2 cluster, including 45 kilobases of sequence upstream of the most 5' gene, was cloned. The DNA sequence of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubock MJ,Larin Z,Cook M,Papalopulu N,Krumlauf R,Lehrach H

更新日期：1990-06-01 00:00:00

abstract：:The increasing threat of pathogen resistance to antibiotics requires the development of novel antimicrobial strategies. Here we present a proof of concept for a genetic strategy that aims to sensitize bacteria to antibiotics and selectively kill antibiotic-resistant bacteria. We use temperate phages to deliver a funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yosef I,Manor M,Kiro R,Qimron U

更新日期：2015-06-09 00:00:00

abstract：:Controlling the effects of proactive interference (PI), the deleterious effect of prior mental activity on current memory representations, is believed to be a key function of the prefrontal cortex. This view is supported by neuroimaging evidence for a correlation between the longer reaction times caused by high PI con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feredoes E,Tononi G,Postle BR

更新日期：2006-12-19 00:00:00

abstract：:Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oda S,Toyoshima Y,de Bono M

更新日期：2017-06-06 00:00:00

abstract：:This paper examines the relationship between various treatment parameters within a latent variable model when the effects of treatment depend on the recipient's observed and unobserved characteristics. We show how this relationship can be used to identify the treatment parameters when they are identified and to bound ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heckman JJ,Vytlacil EJ

更新日期：1999-04-13 00:00:00

abstract：:Accounting for enzyme-mediated active sliding, disassembly, and sequence-dependent positioning of nucleosomes, we simulate nucleosome occupancy over cell-cycle-scale times using a stochastic kinetic model. We show that ATP-dependent active nucleosome sliding and nucleosome removal processes are essential to obtain in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padinhateeri R,Marko JF

更新日期：2011-05-10 00:00:00

abstract：:Histone mRNAs are naturally intronless and accumulate efficiently in the cytoplasm. To learn whether there are cis-acting sequences within histone genes that allow efficient cytoplasmic accumulation of RNAs, we made recombinant constructs in which sequences from the mouse H2a gene were cloned into a human beta-globin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang Y,Carmichael GG

更新日期：1997-09-16 00:00:00

abstract：:Microprocessor [Drosha-DGCR8 (DiGeorge syndrome critical region gene 8) complex] processing of primary microRNA (pri-miRNA) is the critical first step in miRNA biogenesis, but how the Drosha cleavage site is determined has been unclear. Previous models proposed that the Drosha-DGCR8 complex measures either ~22 nt from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma H,Wu Y,Choi JG,Wu H

更新日期：2013-12-17 00:00:00

abstract：:In this note the Weierstrass integral J is taken as L, the Riemann integral of length. Here M(n), n > 1, is a compact, connected manifold of class C(infinity) with a positive definite Riemann structure. Presentations (phi, U(phi)) in M(n) and geodesics (with the aid of the Euler-Riemann equations) are defined in Morse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse M

更新日期：1977-06-01 00:00:00

abstract：:Aposematic coloration, or warning coloration, is a visual signal that acts to minimize contact between predator and unprofitable prey. The conditions favoring the evolution of aposematic coloration remain largely unidentified. Recent work suggests that diet specialization and resultant toxicity may play a role in faci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prudic KL,Oliver JC,Sperling FA

更新日期：2007-12-04 00:00:00

abstract：:Variable regions of Ig chains provide the antigen recognition portion of B-cell receptors and derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally from V, D, J gene segments. Each variable region contains three antigen-contacting complementarity-determining regions (CDRs), with CDR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang JK,Wang C,Du Z,Meyers RM,Kepler TB,Neuberg D,Kwong PD,Mascola JR,Joyce MG,Bonsignori M,Haynes BF,Yeap LS,Alt FW

更新日期：2017-08-08 00:00:00

abstract：:Cytochrome c (cyt c) is a stable protein that functions in a monomeric state as an electron donor for cytochrome c oxidase. It is also released to the cytosol when permeabilization of the mitochondrial outer membrane occurs at the early stage of apoptosis. For nearly half a century, it has been known that cyt c forms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirota S,Hattori Y,Nagao S,Taketa M,Komori H,Kamikubo H,Wang Z,Takahashi I,Negi S,Sugiura Y,Kataoka M,Higuchi Y

更新日期：2010-07-20 00:00:00

abstract：:Mapping posttranslational modifications (PTMs), which diversely modulate biological functions, represents a significant analytical challenge. The centerpiece technology for PTM site identification, mass spectrometry (MS), requires proteolytic cleavage in the vicinity of a PTM to yield peptides for sequencing. This req...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tran DT,Cavett VJ,Dang VQ,Torres HL,Paegel BM

更新日期：2016-12-20 00:00:00

abstract：:In enzyme catalysis, where exquisitely positioned functionality is the sine qua non, atomic coordinates for a Michaelis complex can provide powerful insights into activation of the substrate. We focus here on the initial proton transfer of the isomerization reaction catalyzed by triosephosphate isomerase and present t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jogl G,Rozovsky S,McDermott AE,Tong L

更新日期：2003-01-07 00:00:00

abstract：:Nuclear RNA of high molecular weight, approximately 15 to 30 x 10(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were inters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes DS,Bonner J

更新日期：1974-04-01 00:00:00

abstract：:We have screened a large number of isolated human genomic clones that hybridize to a cloned HLA cDNA probe for their ability to direct the synthesis of HLA-A, -B, and -C surface antigens on mouse L cells following DNA-mediated gene transfer. The surface expression of human histocompatibility antigens, monitored by ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbosa JA,Kamarck ME,Biro PA,Weissman SM,Ruddle FH

更新日期：1982-10-01 00:00:00

abstract：:The size of an organism reflects its metabolic rate, growth rate, mortality, and other important characteristics; therefore, the distribution of body size is a major determinant of ecosystem structure and function. Body-size distributions often are multimodal, with several peaks of abundant sizes, and previous studies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampert A,Tlusty T

更新日期：2013-01-02 00:00:00

abstract：:Innate immunity can facilitate nervous system regeneration, yet the underlying cellular and molecular mechanisms are not well understood. Here we show that intraocular injection of lipopolysaccharide (LPS), a bacterial cell wall component, or the fungal cell wall extract zymosan both lead to rapid and comparable intra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baldwin KT,Carbajal KS,Segal BM,Giger RJ

更新日期：2015-02-24 00:00:00

abstract：:Lymphatic vessel growth or lymphangiogenesis occurs during embryonic development and wound healing and plays an important role in tumor metastasis and inflammatory diseases. However, the possibility of noninvasive detection and quantification of lymphangiogenesis has been lacking. Here, we present the Vegfr3(EGFPLuc) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martínez-Corral I,Olmeda D,Diéguez-Hurtado R,Tammela T,Alitalo K,Ortega S

更新日期：2012-04-17 00:00:00

abstract：:In rod photoreceptors, several phototransduction components display light-dependent translocation between cellular compartments. Notably, the G protein transducin translocates from rod outer segments to inner segments/spherules in bright light, but the functional consequences of translocation remain unclear. We genera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majumder A,Pahlberg J,Boyd KK,Kerov V,Kolandaivelu S,Ramamurthy V,Sampath AP,Artemyev NO

更新日期：2013-07-23 00:00:00

abstract：:The F-box protein Skp2 (S-phase kinase-associated protein 2) positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. We show here that Skp2 expression correlates directly with grade of malignancy and inversely with p27 levels in human ly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Latres E,Chiarle R,Schulman BA,Pavletich NP,Pellicer A,Inghirami G,Pagano M

更新日期：2001-02-27 00:00:00

abstract：:Integrin alphanubeta3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an alphanubeta3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the alphanubeta3-expressing tumor vasculature. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy EA,Majeti BK,Barnes LA,Makale M,Weis SM,Lutu-Fuga K,Wrasidlo W,Cheresh DA

更新日期：2008-07-08 00:00:00

abstract：:The nucleosomal repeat lengths of bulk chromatin and the chromatin of transcriptionally active and inactive genes were analyzed in two mouse cell lines and adult mouse spleens. The adult beta-globin gene exhibits a nucleosomal repeat length approximately 11 base pairs longer than (i) an inactive embryonic globin gene,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith RD,Seale RL,Yu J

更新日期：1983-09-01 00:00:00

abstract：:pRK212.2, a derivative of the broad host range plasmid RK2, contains two EcoRI cleavage fragments, A and B, neither of which can replicate by itself in Escherichia coli. Fragment A (41.7 kilobases), but not fragment B (14.4 kilobases), can be cloned by insertion into the unrelated plasmids mini-F and ColE1. Fragment B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Figurski DH,Helinski DR

更新日期：1979-04-01 00:00:00

abstract：:Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hyporheic zone sediment. To assess the fate of As during discharge, surface (0-5 cm) and subsurface (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Mailloux B,Jung HB,Hoque MA,Stute M,Ahmed KM,Zheng Y

更新日期：2009-10-06 00:00:00

abstract：:Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in Arabidopsis during leaf aging. The most evident characteristic of these time-dependent networks w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HJ,Park JH,Kim J,Kim JJ,Hong S,Kim J,Kim JH,Woo HR,Hyeon C,Lim PO,Nam HG,Hwang D

更新日期：2018-05-22 00:00:00

abstract：:Insects living in the temperate zone enter a physiological state of arrested or slowed development to overcome an adverse season, such as winter. Developmental arrest, called diapause, occurs at a species-specific developmental stage, and embryonic and pupal diapauses have been extensively studied in mostly holometabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miki T,Shinohara T,Chafino S,Noji S,Tomioka K

更新日期：2020-03-10 00:00:00

abstract：:The nucleotide sequence of a 1,163-base-pair fragment that encodes the entire thyA gene of Escherichia coli K-12 was determined. The strategy involved sequence determination of both DNA strands by using overlapping deletions that had been generated in vitro from the two ends of the fragment with BAL-31 nuclease. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belfort M,Maley G,Pedersen-Lane J,Maley F

更新日期：1983-08-01 00:00:00