Evidence of asymmetric cell division and centrosome inheritance in human neuroblastoma cells.

abstract：:The presence of an amino acid other than aspartic acid at position 57 of the HLA-DQ beta chain (non-Asp-57) is highly associated with susceptibility to insulin-dependent diabetes mellitus (IDDM), whereas an aspartic acid at this position (Asp-57) appears to confer resistance to the disease. We hypothesize that the 30-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorman JS,LaPorte RE,Stone RA,Trucco M

更新日期：1990-10-01 00:00:00

abstract：:Two genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells with an activate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molenaar JJ,Ebus ME,Geerts D,Koster J,Lamers F,Valentijn LJ,Westerhout EM,Versteeg R,Caron HN

更新日期：2009-08-04 00:00:00

abstract：:Anxiety disorders are the most prevalent mental disorders in developed societies. Although roles for the prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus in anxiety disorders are well documented, molecular mechanisms contributing to the functions of these structures are poorly understood. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tekinay AB,Nong Y,Miwa JM,Lieberam I,Ibanez-Tallon I,Greengard P,Heintz N

更新日期：2009-03-17 00:00:00

abstract：:The three-dimensional structures of RNA enzymes form catalytic centers that include specific substrate binding sites. High-resolution determination of these and other RNA structures is essential for a detailed understanding of the function of RNA in biological systems. The crystal structures of only a few RNA molecule...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doudna JA,Grosshans C,Gooding A,Kundrot CE

更新日期：1993-08-15 00:00:00

abstract：:In the troposphere, methanol (CH3OH) is present ubiquitously and second in abundance among organic gases after methane. In the surface ocean, methanol represents a supply of energy and carbon for marine microbes. Here we report direct measurements of air-sea methanol transfer along a ∼10,000-km north-south transect of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang M,Nightingale PD,Beale R,Liss PS,Blomquist B,Fairall C

更新日期：2013-12-10 00:00:00

abstract：:Septins assemble into filaments and higher-order structures that act as scaffolds for diverse cell functions including cytokinesis, cell polarity, and membrane remodeling. Despite their conserved role in cell organization, little is known about how septin filaments elongate and are knitted together into higher-order a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridges AA,Zhang H,Mehta SB,Occhipinti P,Tani T,Gladfelter AS

更新日期：2014-02-11 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang HJ,Kokrashvili Z,Theodorakis MJ,Carlson OD,Kim BJ,Zhou J,Kim HH,Xu X,Chan SL,Juhaszova M,Bernier M,Mosinger B,Margolskee RF,Egan JM

更新日期：2007-09-18 00:00:00

abstract：:Infection of BALB/3T3 cells by polyoma virus causes an alteration in the cell surface, characterized by enhanced agglutination of the cells by wheat germ agglutinin or concanavalin A. Infection by the thermosensitive mutant of polyoma, ts-3, causes the cell surface alteration at the permissive temperature, but not at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eckhart W,Dulbecco R,Burger MM

更新日期：1971-02-01 00:00:00

abstract：:Transcriptional network evolution is central to the development of complex biological systems. Networks can evolve through variation of master regulators and/or by changes in regulation of genes within networks. To gain insight into meaningful evolutionary differences in large networks, it is essential to address the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jegga AG,Inga A,Menendez D,Aronow BJ,Resnick MA

更新日期：2008-01-22 00:00:00

abstract：:A line of nonobese diabetic (NOD) mice expressing the human diabetes-associated HLA-DQ8 transgene in the absence of mouse IAbeta failed to show spontaneous insulitis or diabetes, but rather developed dilated cardiomyopathy, leading to early death from heart failure. Pathology in these animals results from an organ- an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elliott JF,Liu J,Yuan ZN,Bautista-Lopez N,Wallbank SL,Suzuki K,Rayner D,Nation P,Robertson MA,Liu G,Kavanagh KM

更新日期：2003-11-11 00:00:00

abstract：:Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai SY,Pokrass MJ,Klauer NR,Nohara H,Su TP

更新日期：2015-05-26 00:00:00

abstract：:The sphinganine analog mycotoxin, AAL-toxin, induces a death process in plant and animal cells that shows apoptotic morphology. In nature, the AAL-toxin is the primary determinant of the Alternaria stem canker disease of tomato, thus linking apoptosis to this disease caused by Alternaria alternata f. sp. lycopersici. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lincoln JE,Richael C,Overduin B,Smith K,Bostock R,Gilchrist DG

更新日期：2002-11-12 00:00:00

abstract：:Artificially aminoacylated suppressor tRNAs were used to introduce photoreactive amino acids into model mitochondrial precursor proteins to probe the environment along the protein import pathway. Amino acids with benzophenone side chains of various lengths [DL-2-amino-3-(p-benzoylphenyl)propanoic acid (1) and DL-2-ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanamori T,Nishikawa S,Shin I,Schultz PG,Endo T

更新日期：1997-01-21 00:00:00

abstract：:Wild-type p53 protein is a growth modulator whose inactivation has been found to be a key event in malignant transformation. Reconstitution of wild-type p53 in the p53-nonproducer, Abelson murine leukemia virus-transformed pre-B-cell line L12 gave rise to stably growing clones. Wild-type p53-producer derived cell line...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaulsky G,Goldfinger N,Peled A,Rotter V

更新日期：1991-10-15 00:00:00

abstract：:Protein prenylation with farnesyl or geranylgeranyl moieties is an important posttranslational modification that affects the activity of such diverse proteins as the nuclear lamins, the yeast mating factor mata, and the ras oncogene products. In this article, we show that whole retinal cultures incorporate radioactive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai RK,Perez-Sala D,Cañada FJ,Rando RR

更新日期：1990-10-01 00:00:00

abstract：:Phosphorylation of ADP to ATP was induced in nonrespiring submitochondrial particles (SMP) from rat liver by the application of electric pulses with field strengths of 10-35 kV/cm and a decay time of 60 mus. In all cases respiration was inhibited completely by using cyanide or rotenone. Newly formed ATP was measured b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teissie J,Knox BE,Tsong TY,Wehrle J

更新日期：1981-12-01 00:00:00

abstract：:c-myc, N-myc, and L-myc genes are subject to highly variable degrees of tissue-specific regulation. Their aberrant expression has also been implicated in the pathogenesis of a variety of malignant tumors. The recently identified max protein dimerizes with c-myc to promote its sequence-specific DNA binding. max exists ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prochownik EV,VanAntwerp ME

更新日期：1993-02-01 00:00:00

abstract：:Measures of complexity derived from ergodic theory of dynamical systems were developed and applied to an exemplary data set describing locomotor movements of rats in a bounded space. A symbolic dynamical system was obtained by partitioning the event space into equally probable partition elements, using a k-dimensional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulus MP,Geyer MA,Gold LH,Mandell AJ

更新日期：1990-01-01 00:00:00

abstract：:The genetic evolution of altruism (i.e., a behavior resulting in a net reduction of the survival and/or reproduction of an actor to benefit a recipient) once perplexed biologists because it seemed paradoxical in a Darwinian world. More than half a century ago, W. D. Hamilton explained that when interacting individuals...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay T,Keller L,Lehmann L

更新日期：2020-11-17 00:00:00

abstract：:Laminin, an ∼800-kDa heterotrimeric protein, is a major functional component of the extracellular matrix, contributing to tissue development and maintenance. The unique architecture of laminin is not currently amenable to determination at high resolution, as its flexible and narrow segments complicate both crystalliza...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armony G,Jacob E,Moran T,Levin Y,Mehlman T,Levy Y,Fass D

更新日期：2016-11-22 00:00:00

abstract：:Left ventricular remodeling that occurs after myocardial infarction (MI) and pressure overload is generally accepted as a determinant of the clinical course of heart failure. The molecular mechanism of this process, however, remains to be elucidated. Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi O,Higuchi Y,Hirotani S,Kashiwase K,Nakayama H,Hikoso S,Takeda T,Watanabe T,Asahi M,Taniike M,Matsumura Y,Tsujimoto I,Hongo K,Kusakari Y,Kurihara S,Nishida K,Ichijo H,Hori M,Otsu K

更新日期：2003-12-23 00:00:00

abstract：:In myocardial ischemia, adrenergic nerves release excessive amounts of norepinephrine (NE), causing dysfunction and arrhythmias. With anoxia and the concomitant ATP depletion, vesicular storage of NE is impaired, resulting in accumulation of free NE in the axoplasm of sympathetic nerves. Intraneuronal acidosis activat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silver RB,Mackins CJ,Smith NC,Koritchneva IL,Lefkowitz K,Lovenberg TW,Levi R

更新日期：2001-02-27 00:00:00

abstract：:Tracing interisland and interarchipelago movements of people and artifacts in prehistoric Polynesia has posed a challenge to archaeologists due to the lack of pottery and obsidian, two materials most readily used in studies of prehistoric trade or exchange. Here we report the application of nondestructive energy-dispe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weisler MI,Kirch PV

更新日期：1996-02-20 00:00:00

abstract：:Real-time visualization of intracellular calcium concentration ([Ca2+]i) changes in mammalian Purkinje cells in vitro, utilizing the dye Fura-2, indicates that calcium action potentials are generated in the dendritic tree and follow a particular activation sequence. During spontaneous oscillations or after direct curr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugimori M,Llinás RR

更新日期：1990-07-01 00:00:00

abstract：:The AG dinucleotide at the 3' splice sites of metazoan nuclear pre-mRNAs plays a critical role in catalytic step II of the splicing reaction. Previous studies have shown that replacement of the guanine by adenine in the AG (AG --> GG) inhibits this step. We find that the second step was even more severely inhibited by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaur RK,Beigelman L,Haeberli P,Maniatis T

更新日期：2000-01-04 00:00:00

abstract：:Cell-free extracts of Arbacia eggs (Arbacia punctulata) apparently do not contain an enzymatic system for the reduction of ribonucleotides to deoxyribonucleotides. However, during an interval of 5 hr after fertilization at 23 degrees , an enzymatic system is produced that is capable of catalyzing the reduction of CDP ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noronha JM,Sheys GH,Buchanan JM

更新日期：1972-08-01 00:00:00

abstract：:The actions of various opioids were examined on calcium action potentials in the cell somata of guinea pig myenteric neurones and on the release of acetylcholine at synapses onto these cells. The opioids morphine, normorphine, and [D-Ala2, MePhe4, Met5(O)]enkephalin-ol caused membrane hyperpolarizations resulting from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherubini E,North RA

更新日期：1985-03-01 00:00:00

abstract：:In the normal development of retinotectal connections, the site in the tectum at which an optic fiber synapses is related to the position of its ganglion-cell body in the retina. How and when the ganglion cells acquire information about their positions is unknown, but the positional information that each ganglion cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-10-01 00:00:00

abstract：:Ankyrin-G (AnkG), a highly enriched scaffold protein in the axon initial segment (AIS) of neurons, functions to maintain axonal polarity and the integrity of the AIS. At the AIS, AnkG regulates selective intracellular cargo trafficking between soma and axons via interaction with the dynein regulator protein Ndel1, but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye J,Li J,Ye F,Zhang Y,Zhang M,Wang C

更新日期：2020-01-14 00:00:00

abstract：:Magnetic ground states in solids often arise as a result of a delicate balance between competing factors. One currently active area of research in magnetic materials involves compounds in which long-range magnetic ordering at low temperatures is frustrated by the geometry of the crystalline lattice, a situation known ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karunadasa H,Huang Q,Ueland BG,Schiffer P,Cava RJ

更新日期：2003-07-08 00:00:00