Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach.

abstract：:A metabolic mechanism for oxalic acid biosynthesis in the wood-rotting basidiomycete Fomitopsis palustris has been proposed on the basis of biochemical analyses of glucose metabolism. There was a strong correlation between glucose consumption and oxalate production. Oxalic acid was found to accumulate in the culture f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munir E,Yoon JJ,Tokimatsu T,Hattori T,Shimada M

更新日期：2001-09-25 00:00:00

abstract：:Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical outcome remain controversial. It is currently not known whether the soluble alternatively spliced TF form (asTF) is expressed in BrCa or impacts BrCa progression....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kocatürk B,Van den Berg YW,Tieken C,Mieog JS,de Kruijf EM,Engels CC,van der Ent MA,Kuppen PJ,Van de Velde CJ,Ruf W,Reitsma PH,Osanto S,Liefers GJ,Bogdanov VY,Versteeg HH

更新日期：2013-07-09 00:00:00

abstract：:In a significant fraction of the Escherichia coli cytosolic proteins, the N-terminal methionine residue incorporated during the translation initiation step is excised. The N-terminal methionine excision is catalyzed by methionyl-aminopeptidase (MAP). Previous studies have suggested that the action of this enzyme could...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirel PH,Schmitter MJ,Dessen P,Fayat G,Blanquet S

更新日期：1989-11-01 00:00:00

abstract：:Insects living in the temperate zone enter a physiological state of arrested or slowed development to overcome an adverse season, such as winter. Developmental arrest, called diapause, occurs at a species-specific developmental stage, and embryonic and pupal diapauses have been extensively studied in mostly holometabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miki T,Shinohara T,Chafino S,Noji S,Tomioka K

更新日期：2020-03-10 00:00:00

abstract：:In order to define the protease domain of human immunodeficiency virus 1, various regions of the pol open reading frame were cloned and expressed in Escherichia coli. Antiserum directed against the conserved retroviral protease active site was used to identify pol precursor and processed species containing the presume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves MC,Lim JJ,Heimer EP,Kramer RA

更新日期：1988-04-01 00:00:00

abstract：:PIK3CA mutations are reported to be present in approximately 25% of breast cancer (BC), particularly the estrogen receptor-positive (ER+) and HER2-overexpressing (HER2+) subtypes, making them one of the most common genetic aberrations in BC. In experimental models, these mutations have been shown to activate AKT and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loi S,Haibe-Kains B,Majjaj S,Lallemand F,Durbecq V,Larsimont D,Gonzalez-Angulo AM,Pusztai L,Symmans WF,Bardelli A,Ellis P,Tutt AN,Gillett CE,Hennessy BT,Mills GB,Phillips WA,Piccart MJ,Speed TP,McArthur GA,Sotiriou

更新日期：2010-06-01 00:00:00

abstract：:Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates. Crucial for rapidly dividing cells, RNR is a target for cancer therapy. In eukaryotes, RNR comprises a heterooligomer of alpha(2) and beta(2) subunits. Rnr1, the alpha subunit, contains regulatory and ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu H,Faber C,Uchiki T,Racca J,Dealwis C

更新日期：2006-03-14 00:00:00

abstract：:Neural crest cell derivatives have been suggested to be involved in thymus development. We established nonlymphoid thymic stromal cell cultures capable of supporting T-cell differentiation. In these nonlymphoid cell cultures, we identified cells with phenotypic and biochemical markers specific for neuronal cells. Neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Screpanti I,Meco D,Scarpa S,Morrone S,Frati L,Gulino A,Modesti A

更新日期：1992-04-15 00:00:00

abstract：:Life-long protection from disease through immunization can be accomplished through individual or community protection. Individual protection is the goal for vaccination against diseases that have inanimate or animal reservoirs or that pose risks for certain populations. Community protection is the goal for vaccination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowdle WR,Orenstein WA

更新日期：1994-03-29 00:00:00

abstract：:The low-energy conformations for a series of peptides based on the sequence of the ras P21 protein from position 55 to position 67 have been computed using conformational energy analysis. These sequences differed at position 61 and contained Gln, Pro, Leu, Lys, and Arg at this position. P21 proteins with Gln, Glu, or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus MR,Brandt-Rauf PW,Carty RP,Lubowsky J,Avitable M,Gibson KD,Scheraga HA

更新日期：1987-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV), an oncogenic herpesvirus, encodes two small RNAs (EBERs) that are expressed at high levels during latent transformation of human B lymphocytes. Here we report that a 15-kDa cellular protein called EAP (for EBER associated protein), previously shown to bind EBER1, is in fact the ribosomal prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toczyski DP,Matera AG,Ward DC,Steitz JA

更新日期：1994-04-12 00:00:00

abstract：:Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gee DG,Gabard-Durnam LJ,Flannery J,Goff B,Humphreys KL,Telzer EH,Hare TA,Bookheimer SY,Tottenham N

更新日期：2013-09-24 00:00:00

abstract：:By the combined use of DNase I footprinting, electrophoretic mobility-shift assay, and methylation interference analysis, we have identified a series of sequence-specific protein-DNA interactions in the 5' flanking region of the rat osteocalcin gene. Stimulation of osteocalcin gene expression by 1,25-dihydroxyvitamin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markose ER,Stein JL,Stein GS,Lian JB

更新日期：1990-03-01 00:00:00

abstract：:Although most nuclear hormone receptors are ligand-dependent transcriptional activators, certain members of this superfamily, such as thyroid hormone receptor (TR) and retinoic acid receptor (RAR), are involved in transcriptional repression. The silencing function of these receptors has been localized to the ligand bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nawaz Z,Tsai MJ,O'Malley BW

更新日期：1995-12-05 00:00:00

abstract：:We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu A,Tepler I,Benfey PN,Berenstein EH,Siraganian RP,Leder P

更新日期：1988-03-01 00:00:00

abstract：:Gene regulatory networks (GRNs) provide a transformation function between the static genomic sequence and the primary spatial specification processes operating development. The regulatory information encompassed in developmental GRNs thus goes far beyond the control of individual genes. We here address regulatory info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peter IS,Davidson EH

更新日期：2017-06-06 00:00:00

abstract：:Crystals of myosin subfragment 1 from avian skeletal muscle have been grown reproducibly. They diffract x-rays to at least 4.5-A resolution. The subfragment 1 crystallizes in space group P2(1)2(1)2(1) where a = 107 A, b = 117 A, and c = 278 A. The cell dimensions and intensity distribution on x-ray diffraction photogr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayment I,Winkelmann DA

更新日期：1984-07-01 00:00:00

abstract：:Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1 protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified cholesterol and other lipids in lysosomal storage organelles. We report the use of a series of small molecule histone deacetylase (HDAC) in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pipalia NH,Cosner CC,Huang A,Chatterjee A,Bourbon P,Farley N,Helquist P,Wiest O,Maxfield FR

更新日期：2011-04-05 00:00:00

abstract：:The deadly symptoms of malaria occur as Plasmodium parasites replicate within blood cells. Members of several variant surface protein families are expressed on infected blood cell surfaces. Of these, the largest and most ubiquitous are the Plasmodium-interspersed repeat (PIR) proteins, with more than 1,000 variants in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrison TE,Reid AJ,Cunningham D,Langhorne J,Higgins MK

更新日期：2020-12-15 00:00:00

abstract：:Evolution of new enzymatic activities is believed to require a period of gene sharing in which a single enzyme must serve both its original function and a new function that has become advantageous to the organism. Subsequent gene duplication allows one copy to maintain the original function, while the other diverges t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLoughlin SY,Copley SD

更新日期：2008-09-09 00:00:00

abstract：:Protein-protein interactions allow the retinoid X receptor (RXR) to bind to cognate DNA as a homo- or a heterodimer and to participate in mediating the effects of a variety of hormones on gene transcription. Here we report a systematic study of the oligomeric state of RXR in the absence of a DNA template. We have used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kersten S,Kelleher D,Chambon P,Gronemeyer H,Noy N

更新日期：1995-09-12 00:00:00

abstract：:Elucidating the lineage relationships among different cell types is key to understanding human brain development. Here we developed parallel RNA and DNA analysis after deep sequencing (PRDD-seq), which combines RNA analysis of neuronal cell types with analysis of nested spontaneous DNA somatic mutations as cell lineag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang AY,Li P,Rodin RE,Kim SN,Dou Y,Kenny CJ,Akula SK,Hodge RD,Bakken TE,Miller JA,Lein ES,Park PJ,Lee EA,Walsh CA

更新日期：2020-06-23 00:00:00

abstract：:Ho endonuclease of Saccharomyces cerevisiae is a homing endonuclease that makes a site-specific double-strand break in the MAT gene in late G(1). Here we show that Ho is rapidly degraded via the ubiquitin-26S proteasome system through two ubiquitin-conjugating enzymes UBC2(Rad6) and UBC3(Cdc34). UBC2(Rad6) is complexe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplun L,Ivantsiv Y,Kornitzer D,Raveh D

更新日期：2000-08-29 00:00:00

abstract：:Genetic manipulation of the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in mice has revealed the role of this subtype in numerous responses, including agonist-induced hypotension and sedation. Unexpectedly, alpha(2)-agonist treatment of mice heterozygous for the alpha(2A)-AR (alpha(2A)-AR(+/-)) lowers blood pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan CM,Wilson MH,MacMillan LB,Kobilka BK,Limbird LE

更新日期：2002-09-17 00:00:00

abstract：:Previous studies have shown that Arthrobacter pyridinolis can transport D-fructose or L-rhamnose using either a phosphoenolpyruvate:hexose phosphotransferase (phosphoenolpyruvate:protein phosphotransferase, EC 2.7.3.9) system or a respiration-coupled transport system which requires the presence of exogenous L-malate. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolfson EB,Krulwich TA

更新日期：1974-05-01 00:00:00

abstract：:Metabolic engineering seeks to reprogram microbial cells to efficiently and sustainably produce value-added compounds. Since chemical production can be at odds with the cell's natural objectives, strategies have been developed to balance conflicting goals. For example, dynamic regulation modulates gene expression to f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinh CV,Prather KLJ

更新日期：2019-12-17 00:00:00

abstract：:Biochemical evidence is presented for the disintegration of the lens fiber plasma membrane in human cataracts. The intrinsic membrane proteins are found in both the water-soluble and water-insoluble nonmembrane fractions of the cataract lens but not in the normal tissue. Furthermore, in contrast to the normal lens, no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garner MH,Roy D,Rosenfeld L,Garner WH,Spector A

更新日期：1981-03-01 00:00:00

abstract：:Friction is caused by dissipative lateral forces that act between macroscopic objects. An improved understanding of friction is therefore expected from measurements of dissipative lateral forces acting between individual atoms. Here we establish atomic resolution of both conservative and dissipative forces by lateral ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giessibl FJ,Herz M,Mannhart J

更新日期：2002-09-17 00:00:00

abstract：:The presence of an amino acid other than aspartic acid at position 57 of the HLA-DQ beta chain (non-Asp-57) is highly associated with susceptibility to insulin-dependent diabetes mellitus (IDDM), whereas an aspartic acid at this position (Asp-57) appears to confer resistance to the disease. We hypothesize that the 30-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorman JS,LaPorte RE,Stone RA,Trucco M

更新日期：1990-10-01 00:00:00

abstract：:Donor DNA molecules carrying Tn1 or Tn3 deletion mutants do not need to replicate in order to participate in replicon fusion recombination events during which the Tn1/Tn3 element is duplicated. We have assayed Tn1 delta Ap-mediated replicon fusion events involving plasmid R388 and the bacteriophage lambda-derived plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muster CJ,Shapiro JA,MacHattie LA

更新日期：1983-04-01 00:00:00