Nature and evolution of incommensurate charge order in manganites visualized with cryogenic scanning transmission electron microscopy.

abstract：:Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation and are tumor specific. Unexpectedly, added glycans terminate at high ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coelho V,Krysov S,Ghaemmaghami AM,Emara M,Potter KN,Johnson P,Packham G,Martinez-Pomares L,Stevenson FK

更新日期：2010-10-26 00:00:00

abstract：:Permanent transfer of genetic information from chromosomes isolated from human diploid cells to recipient cells has been demonstrated. Human metaphase chromosomes were incubated with mouse A9 fibroblasts deficient in hypoxanthine phosphoribosyltransferase (IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) and a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burch JW,McBride OW

更新日期：1975-05-01 00:00:00

abstract：:The TATA box-binding activity of transcription factor IID (TFIID) is autoinhibited by the N-terminal domain of the Drosophila TATA box-binding protein- (TBP) associated factor 230/yeast TBP-associated factor 145 subunit, which binds to the TATA box-binding domain of TBP by mimicking the TATA box structure. Here, we pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotani T,Banno K,Ikura M,Hinnebusch AG,Nakatani Y,Kawaichi M,Kokubo T

更新日期：2000-06-20 00:00:00

abstract：:Mitochondria isolated from maize plants with S-type male-sterile cytoplasms are capable of synthesizing four species of RNA at concentrations of actinomycin D that eliminate all DNA-directed RNA synthesis. No RNA synthesis occurs under the same conditions with mitochondria from plants possessing normal (N) cytoplasm o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finnegan PM,Brown GG

更新日期：1986-07-01 00:00:00

abstract：:The impact of projected global warming on crop yields has been evaluated by indirect methods using simulation models. Direct studies on the effects of observed climate change on crop growth and yield could provide more accurate information for assessing the impact of climate change on crop production. We analyzed weat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng S,Huang J,Sheehy JE,Laza RC,Visperas RM,Zhong X,Centeno GS,Khush GS,Cassman KG

更新日期：2004-07-06 00:00:00

abstract：:Antibodies have been prepared to the core protein of cartilage chondroitin sulfate proteoglycan from clones isolated after fusion of rat spleen cells and mouse myeloma cell lines. Antibodies produced by five clones were studied in detail by a radioimmunoassay utilizing 35SO42-labeled hyaluronidase-digested chondroitin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorfman A,Hall T,Ho PL,Fitch F

更新日期：1980-07-01 00:00:00

abstract：:The fluorescence of the supposedly buried tryptophan in ribonuclease T1 has been found to be collisionally quenched by acrylamide with a rate constant of 3 X 10(8) M--1 sec--1. Only a slight decrease in the quenching rate is observed upon a 5-fold increase in the viscosity of the solution. For this to be the case, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eftink MR,Ghiron CA

更新日期：1975-09-01 00:00:00

abstract：:The compact steep-spectrum sources (CSSs) are an interesting class of objects which are of subgalactic dimensions; they occur more frequently in high-frequency surveys because their spectra often turn over at lower frequencies. We have estimated the symmetry parameters of a well-defined sample of CSSs and compared the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saikia DJ

更新日期：1995-12-05 00:00:00

abstract：:Supported metal catalysts are extensively used in industrial and environmental applications. To improve their performance, it is crucial to identify the most active sites. This identification is, however, made challenging by the presence of a large number of potential surface structures that complicate such an assignm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang AC,Choksi T,Streibel V,Aljama H,Wrasman CJ,Roling LT,Goodman ED,Thomas D,Bare SR,Sánchez-Carrera RS,Schäfer A,Li Y,Abild-Pedersen F,Cargnello M

更新日期：2020-06-30 00:00:00

abstract：:Summertime Arctic shipboard observations of oxygenated volatile organic compounds (OVOCs) such as organic acids, key precursors of climatically active secondary organic aerosol (SOA), are consistent with a novel source of OVOCs to the marine boundary layer via chemistry at the sea surface microlayer. Although this sou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mungall EL,Abbatt JPD,Wentzell JJB,Lee AKY,Thomas JL,Blais M,Gosselin M,Miller LA,Papakyriakou T,Willis MD,Liggio J

更新日期：2017-06-13 00:00:00

abstract：:The different isoforms of PDGF bind with different affinities to two different receptor types. Previously, these receptors have been demonstrated mainly on mesenchymal and glial cells. We show here that PDGF beta-type receptors are present also on rat brain neurons in vivo as well as in vitro. Immunohistochemical anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smits A,Kato M,Westermark B,Nistér M,Heldin CH,Funa K

更新日期：1991-09-15 00:00:00

abstract：:N-Acetylaspartylglutamate, an endogenous brain peptide that binds with high affinity to a subpopulation of glutamate-binding sites in rat brain, is excitatory on rat piriform cortex pyramidal cells studied in a perfused brain slice. Both the monosynaptic excitation of the pyramidal cells elicited by stimulation of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ffrench-Mullen JM,Koller K,Zaczek R,Coyle JT,Hori N,Carpenter DO

更新日期：1985-06-01 00:00:00

abstract：:The evolution of cadherins, which are essential for metazoan multicellularity and restricted to metazoans and their closest relatives, has special relevance for understanding metazoan origins. To reconstruct the ancestry and evolution of cadherin gene families, we analyzed the genomes of the choanoflagellate Salpingoe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nichols SA,Roberts BW,Richter DJ,Fairclough SR,King N

更新日期：2012-08-07 00:00:00

abstract：:The effects of predator intimidation on habitat use and behavior of prey species are rarely quantified for large marine vertebrates over ecologically relevant scales. Using state space movement models followed by a series of step selection functions, we analyzed movement data of concurrently tracked prey, bowhead whal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matthews CJD,Breed GA,LeBlanc B,Ferguson SH

更新日期：2020-03-24 00:00:00

abstract：:When animals move, respiration increases to adapt for increased energy demands; the underlying mechanisms are still not understood. We investigated the neural substrates underlying the respiratory changes in relation to movement in lampreys. We showed that respiration increases following stimulation of the mesencephal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariépy JF,Missaghi K,Chevallier S,Chartré S,Robert M,Auclair F,Lund JP,Dubuc R

更新日期：2012-01-10 00:00:00

abstract：:Major changes in global rainfall patterns accompanied a northward shift of Earth's thermal equator at the onset of an abrupt climate change 14.6 kya. This northward pull of Earth's wind and rain belts stemmed from disintegration of North Atlantic winter sea ice cover, which steepened the interhemispheric meridional te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broecker WS,Putnam AE

更新日期：2013-10-15 00:00:00

abstract：:Two monoclonal antibodies directed against the native beta 2 subunit of Escherichia coli tryptophan synthase [L-serine hydro-lyase (adding indoleglycerol-phosphate), EC 4.2.1.20], one recognizing the C-terminal F1 domain and the other the N-terminal F2 domain, were used to detect immunoreactive intermediates in the fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blond S,Goldberg M

更新日期：1987-03-01 00:00:00

abstract：:Exposure of murine hepatoma (Hepa 1c1c7) cells to a variety of chemical agents known to protect animals against the neoplastic, mutagenic, and other toxic effects of chemical carcinogens results in dose- and time-dependent inductions of NAD(P)H:quinone reductase (EC 1.6.99.2). This enzyme protects against quinone toxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Long MJ,Prochaska HJ,Talalay P

更新日期：1986-02-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential to class-switch recombination (CSR) and somatic hypermutation (SHM) in both V region SHM and S region SHM (s-SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair (BER) complex, is required for CSR. Strikingly, however, UNG deficiency causes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yousif AS,Stanlie A,Mondal S,Honjo T,Begum NA

更新日期：2014-03-18 00:00:00

abstract：:Ligand-specific molecular switches composed of RNA were created by coupling preexisting catalytic and receptor domains via structural bridges. Binding of ligand to the receptor triggers a conformational change within the bridge, and this structural reorganization dictates the activity of the adjoining ribozyme. The mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soukup GA,Breaker RR

更新日期：1999-03-30 00:00:00

abstract：:The human T cell leukemia virus I basic leucine zipper protein (HTLV-1 HBZ) maintains chronic viral infection and promotes leukemogenesis through poorly understood mechanisms involving interactions with the KIX domain of the transcriptional coactivator CBP and its paralog p300. The KIX domain binds regulatory proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang K,Stanfield RL,Martinez-Yamout MA,Dyson HJ,Wilson IA,Wright PE

更新日期：2018-10-02 00:00:00

abstract：:Metallic nanoscale structures are capable of supporting surface plasmon polaritons (SPPs), propagating collective electron oscillations with tight spatial confinement at the metal surface. SPPs represent one of the most promising structures to beat the diffraction limit imposed by conventional dielectric optics. Ag na...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Pausauskie P,Huang J,Yang P

更新日期：2009-12-15 00:00:00

abstract：:Plasma levels of corticosterone are often used as a measure of "stress" in wild animal populations. However, we lack conclusive evidence that different stress levels reflect different survival probabilities between populations. Galápagos marine iguanas offer an ideal test case because island populations are affected d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romero LM,Wikelski M

更新日期：2001-06-19 00:00:00

abstract：:Recent theory suggests that animals should switch facultatively among canonical movement modes as a complex function of internal state, landscape characteristics, motion capacity, and navigational capacity. We tested the generality of this paradigm for free-ranging elk (Cervus elaphus) over 5 orders of magnitude in ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fryxell JM,Hazell M,Börger L,Dalziel BD,Haydon DT,Morales JM,McIntosh T,Rosatte RC

更新日期：2008-12-09 00:00:00

abstract：:A short, highly stereoselective (over 97%) synthesis of all-trans squalene is described. Starting with succinaldehyde, a tetraenedichlorodione having the complete squalene skeleton with the four internal trans olefinic bonds has been developed in four steps involving a sequence of two double Claisen rearrangements. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Werthemann L,Johnson WS

更新日期：1970-11-01 00:00:00

abstract：:AB5 bacterial toxins and polyomaviruses induce membrane curvature as a mechanism to facilitate their entry into host cells. How membrane bending is accomplished is not yet fully understood but has been linked to the simultaneous binding of the pentameric B subunit to multiple copies of glycosphingolipid receptors. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kabbani AM,Raghunathan K,Lencer WI,Kenworthy AK,Kelly CV

更新日期：2020-06-30 00:00:00

abstract：:Class I major histocompatibility complex (MHC) antigens are confronted with an apparently insurmountable dilemma. Each should show a binding preference to a common enough variety of nonapeptides, so that one relevant nonapeptide can be found in at least every other viral protein to provoke a cytotoxic T-cell response....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno S

更新日期：1992-05-15 00:00:00

abstract：:A detailed model of the G(2) DNA damage checkpoint (G2DDC) system is presented that includes complex regulatory networks of the mitotic kinase Cdc2, phosphatase Cdc25, Wee1 kinase, and damage signal transduction pathways involving Chk1 and p53. Assumptions on the kinetic equations of the G2DDC are made, and computer s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aguda BD

更新日期：1999-09-28 00:00:00

abstract：:The cheA locus of Escherichia coli, which is required for chemotactic behavior, encodes two polypeptide products designated p[cheA]L and p[cheA]S. The mode of synthesis of these two proteins was investigated by transferring various missense and nonsense mutations to a lambda transducing phage and observing the mutant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith RA,Parkinson JS

更新日期：1980-09-01 00:00:00

abstract：:We describe a procedure for predicting the tertiary folds of alpha-helical proteins from their primary sequences. The central component of the procedure is a method for predicting interhelical contacts that is based on a helix-packing model. Instead of predicting the individual contacts, our method attempts to identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Hou J,Kim SH

更新日期：2002-03-19 00:00:00