Compact steep-spectrum sources and the unified scheme.

abstract：:Bone morphogenetic protein 9 (BMP9) promotes the acquisition of the cholinergic phenotype in basal forebrain cholinergic neurons (BFCN) during development and protects these neurons from cholinergic dedifferentiation following axotomy when administered in vivo. A decline in BFCN function occurs in patients with Alzhei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burke RM,Norman TA,Haydar TF,Slack BE,Leeman SE,Blusztajn JK,Mellott TJ

更新日期：2013-11-26 00:00:00

abstract：:A hierarchy of residue density assessments and packing properties in protein structures are contrasted, including a regular density, a variety of charge densities, a hydrophobic density, a polar density, and an aromatic density. These densities are investigated by alternative distance measures and also at the interfac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baud F,Karlin S

更新日期：1999-10-26 00:00:00

abstract：:Genetic manipulation of the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in mice has revealed the role of this subtype in numerous responses, including agonist-induced hypotension and sedation. Unexpectedly, alpha(2)-agonist treatment of mice heterozygous for the alpha(2A)-AR (alpha(2A)-AR(+/-)) lowers blood pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan CM,Wilson MH,MacMillan LB,Kobilka BK,Limbird LE

更新日期：2002-09-17 00:00:00

abstract：:Pertussis toxin (PT), a protein produced by Bordetella pertussis, was studied for its effect on lipolysis in isolated rat epididymal adipocytes. Exposure of adipocytes to pertussis toxin resulted in a significant increase in cyclic AMP levels and lipolysis after a lag of 1-2 hr. Both the maximal rate of lipolysis and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olansky L,Myers GA,Pohl SL,Hewlett EL

更新日期：1983-11-01 00:00:00

abstract：:Metals in one spatial dimension are described at the lowest energy scales by the Luttinger liquid theory. It is well understood that this free theory, and even interacting integrable models, can support ballistic transport of conserved quantities including energy. In contrast, realistic one-dimensional metals, even wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulchandani VB,Karrasch C,Moore JE

更新日期：2020-06-09 00:00:00

abstract：:The skeletal muscle L-type Ca2+ channel is a complex of five subunits that is specifically localized in the triad. Its primary function is the rapid activation of Ca2+ release from cytoplasmic stores in a process called excitation-contraction coupling. To study the role of alpha1S-beta1a interactions in the incorporat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neuhuber B,Gerster U,Döring F,Glossmann H,Tanabe T,Flucher BE

更新日期：1998-04-28 00:00:00

abstract：:Observers have found a small number of lithium-depleted halo stars in the temperature range of the Spite plateau. The current status of the mass-loss hypothesis for producing the observed lithium dip in Population (Pop) I stars is briefly discussed and extended to Pop II stars as a possible explanation for these halo ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dearborn DS,Schramm DN

更新日期：1997-05-13 00:00:00

abstract：:The hepatic uptake of cholephilic organic anions is a carrier-mediated process. Three distinct proteins [bilitranslocase (BTL), sulfobromophthalein (BSP)/bilirubin-binding protein (BBBP), and organic anion-binding protein] have been isolated from the basolateral plasma-membrane domain of the hepatocyte. To investigate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torres AM,Lunazzi GC,Stremmel W,Tiribelli C

更新日期：1993-09-01 00:00:00

abstract：:A remarkable property of tetrapod bone is its ability to detect and remodel areas where damage has accumulated through prolonged use. This process, believed vital to the long-term health of bone, is considered to be initiated and orchestrated by osteocytes, cells within the bone matrix. It is therefore surprising that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atkins A,Dean MN,Habegger ML,Motta PJ,Ofer L,Repp F,Shipov A,Weiner S,Currey JD,Shahar R

更新日期：2014-11-11 00:00:00

abstract：:The major Hsp70 of the mitochondrial matrix (Ssc1 in yeast) is critically important for the translocation of proteins from the cytosol, across the mitochondrial inner membrane, and into the matrix. Tim44, a peripheral inner membrane protein with limited sequence similarity to the J domain of J-type cochaperones, tethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Silva PD,Schilke B,Walter W,Andrew A,Craig EA

更新日期：2003-11-25 00:00:00

abstract：:Most of the activities of IFN-gamma are the result of STAT1-mediated transcriptional responses. In this study, we show that the BRCA1 tumor suppressor acts in concert with STAT1 to differentially activate transcription of a subset of IFN-gamma target genes and mediates growth inhibition by this cytokine. After IFN-gam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouchi T,Lee SW,Ouchi M,Aaronson SA,Horvath CM

更新日期：2000-05-09 00:00:00

abstract：:An obstacle in the utilization of catalytic Abs for selective prodrug activation in cancer therapy has been systemic tumor targeting. Here we report the generation of catalytic Abs that effectively target tumor cells with undiminished prodrug activation capability. Ab conjugates were prepared by covalent conjugation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abraham S,Guo F,Li LS,Rader C,Liu C,Barbas CF 3rd,Lerner RA,Sinha SC

更新日期：2007-03-27 00:00:00

abstract：:Chlamydia trachomatis R2c is the prototype for a recently discovered group of ribonucleotide reductase R2 proteins that use a heterodinuclear Mn/Fe redox cofactor for radical generation and storage. Here, we show that the Mycobacterium tuberculosis protein Rv0233, an R2 homologue and a potential virulence factor, cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andersson CS,Högbom M

更新日期：2009-04-07 00:00:00

abstract：:Pro-Leu-Gly-NH2 (MIF) and several structural analogues, all injected in 50-microgram doses daily in mice receiving morphine chronically, were found to prevent development of physical dependence as measured by changes in body temperature associated with naloxone-induced withdrawal. Dose-response studies, using again a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Ritzmann RF,Bhargava HN,Flexner LB

更新日期：1979-01-01 00:00:00

abstract：:There is not a single pharmaceutical that halts or even slows any neurodegenerative disease. Mounting evidence shows that prions cause many neurodegenerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targets. We report here that the previously identified 2-amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry DB,Lu D,Geva M,Watts JC,Bhardwaj S,Oehler A,Renslo AR,DeArmond SJ,Prusiner SB,Giles K

更新日期：2013-10-29 00:00:00

abstract：:The requirement for protein synthesis in the mechanism of a circadian pacemaker was investigated by using inhibitors of protein synthesis. Continuous treatment of the ocular circadian pacemaker of the mollusc Bulla gouldiana with anisomycin or cycloheximide substantially lengthened (up to 39 and 52 hr, respectively) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khalsa SB,Whitmore D,Block GD

更新日期：1992-11-15 00:00:00

abstract：:The role of the intradiscal polypeptide loops in bovine rhodopsin has been investigated by deletions in the N-terminal tail and in loops B-C, D-E, and E-F as well as by single amino acid substitutions in the D-E loop. Mutants with three types of phenotypes were observed. Type I mutants showed a rhodopsin-like chromoph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doi T,Molday RS,Khorana HG

更新日期：1990-07-01 00:00:00

abstract：:Infants born prematurely risk significant life-long cognitive disability, representing a major pediatric health crisis. The neuropathology of this cohort is accurately modeled in mice subjected to sublethal postnatal hypoxia. Massively parallel transcriptome analysis using cDNA microchips (9,262 genes), combined with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curristin SM,Cao A,Stewart WB,Zhang H,Madri JA,Morrow JS,Ment LR

更新日期：2002-11-26 00:00:00

abstract：:We have isolated a cDNA clone, called Dmyd for Drosophila myogenic-determination gene, that encodes a protein with structural and functional characteristics similar to the members of the vertebrate MyoD family. Dmyd clone encodes a polypeptide of 332 amino acids with 82% identity to MyoD in the 41 amino acids of the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paterson BM,Walldorf U,Eldridge J,Dübendorfer A,Frasch M,Gehring WJ

更新日期：1991-05-01 00:00:00

abstract：:The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination, as occurs in multiple sclerosis. However, remyelination-the re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMurran CE,Guzman de la Fuente A,Penalva R,Ben Menachem-Zidon O,Dombrowski Y,Falconer J,Gonzalez GA,Zhao C,Krause FN,Young AMH,Griffin JL,Jones CA,Hollins C,Heimesaat MM,Fitzgerald DC,Franklin RJM

更新日期：2019-12-10 00:00:00

abstract：:Synapse formation at the neuromuscular junction (NMJ) requires an alternatively spliced variant of agrin (Z(+) agrin) that is produced only by neurons. Here, we show that Nova1 and Nova2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) agrin. Nova1/N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruggiu M,Herbst R,Kim N,Jevsek M,Fak JJ,Mann MA,Fischbach G,Burden SJ,Darnell RB

更新日期：2009-03-03 00:00:00

abstract：:Introduction of a sequence encoding 147 amino acids from human immunodeficiency virus type I (HIV-1) strain MN glycoprotein gp120 into the RNA genome of the stably attenuated Mengo virus strain vM16 yielded an infectious recombinant virus, vMLN450, which expressed the heterologous HIV-1 sequence along with the normal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altmeyer R,Escriou N,Girard M,Palmenberg A,van der Werf S

更新日期：1994-10-11 00:00:00

abstract：:Cyclic AMP levels increase abruptly in the secondary palatal shelf (mesenchyme plus a two- to three-cell-layered epithelium) between day 15 and 16 of gestation in the rat embryo. The addition of dibutyryl cyclic AMP to the media in which immature palatal shelves (day 14) are cultured causes a precocious decrease in DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pratt RM,Martin GR

更新日期：1975-03-01 00:00:00

abstract：:After pollen grains germinate on the stigma, pollen tubes traverse the extracellular matrix of the style on their way to the ovules. We previously characterized two pollen-specific, receptor-like kinases, LePRK1 and LePRK2, from tomato (Lycopersicon esculentum). Their structure and immunolocalization pattern and the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wengier D,Valsecchi I,Cabanas ML,Tang WH,McCormick S,Muschietti J

更新日期：2003-05-27 00:00:00

abstract：:Life-long protection from disease through immunization can be accomplished through individual or community protection. Individual protection is the goal for vaccination against diseases that have inanimate or animal reservoirs or that pose risks for certain populations. Community protection is the goal for vaccination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowdle WR,Orenstein WA

更新日期：1994-03-29 00:00:00

abstract：:We report a combined thermodynamic and structural characterization of a DNA tetraplex. Using spectroscopic and calorimetric techniques, we demonstrate that d(TG3T) and d(TG3T2G3T), in the presence of K+, form stable tetramolecular complexes. From differential scanning calorimetry measurements, we obtain the following ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin R,Gaffney BL,Wang C,Jones RA,Breslauer KJ

更新日期：1992-09-15 00:00:00

abstract：:In this paper is presented the theory of a class of locally convex lattices (L-lattices) of real functions which generalize the classical Lebesgue spaces. The monotone and dominated convergence theorems for convergence almost everywhere and sequential and order completeness of such lattices are established. These resu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogdanowicz WM

更新日期：1970-06-01 00:00:00

abstract：:A cDNA for parafusin, an evolutionarily conserved phosphoglycoprotein involved in exocytosis, has been cloned and sequenced from a unicellular eukaryote, Paramecium tetraurelia. A Paramecium cDNA library was screened with an oligonucleotide probe synthesized to an internal amino acid sequence of isolated parafusin. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subramanian SV,Wyroba E,Andersen AP,Satir BH

更新日期：1994-10-11 00:00:00

abstract：:Complex gene regulatory circuits contain many interacting components. In principle, all of these components and interactions may be essential to the function of the circuit. Alternatively, some of them may be refinements to a simpler version of the circuit that improve its fitness. In this work, we have tested whether...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Babić AC,Little JW

更新日期：2007-11-06 00:00:00

abstract：:Genomes exhibit diverse patterns of species-specific GC content, GC and AT skews, codon bias, and mutation bias. Despite intensive investigations and the rapid accumulation of sequence data, the causes of these a priori different genome biases have not been agreed on and seem multifactorial and idiosyncratic. We show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vetsigian K,Goldenfeld N

更新日期：2009-01-06 00:00:00