Role of the intradiscal domain in rhodopsin assembly and function.

abstract：:Here, we highlight the potential translational benefits of delivering FLASH radiotherapy using ultra-high dose rates (>100 Gy⋅s-1). Compared with conventional dose-rate (CONV; 0.07-0.1 Gy⋅s-1) modalities, we showed that FLASH did not cause radiation-induced deficits in learning and memory in mice. Moreover, 6 months a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montay-Gruel P,Acharya MM,Petersson K,Alikhani L,Yakkala C,Allen BD,Ollivier J,Petit B,Jorge PG,Syage AR,Nguyen TA,Baddour AAD,Lu C,Singh P,Moeckli R,Bochud F,Germond JF,Froidevaux P,Bailat C,Bourhis J,Vozenin MC

更新日期：2019-05-28 00:00:00

abstract：:Stroke patients with small central nervous system infarcts often demonstrate an acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing speed, independent of lesion size or location. We use magnetoencephalography (MEG) to show that disruption of network dynamics may be res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsh EB,Brodbeck C,Llinas RH,Mallick D,Kulasingham JP,Simon JZ,Llinás RR

更新日期：2020-12-29 00:00:00

abstract：:Stepwise, synthetic alteration of oxytocin, guided by conformational and enzymological considerations, has led to analogs with specifically modified activity profiles and resistance to enzymatic inactivation. General requirements for the design of peptides with therapeutic value are discussed. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Yamanaka T,Sakakibara S

更新日期：1974-05-01 00:00:00

abstract：:Insects living in the temperate zone enter a physiological state of arrested or slowed development to overcome an adverse season, such as winter. Developmental arrest, called diapause, occurs at a species-specific developmental stage, and embryonic and pupal diapauses have been extensively studied in mostly holometabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miki T,Shinohara T,Chafino S,Noji S,Tomioka K

更新日期：2020-03-10 00:00:00

abstract：:In the retinae of many vertebrates, there are classes of horizontal cell that probably utilize gamma-aminobutyric acid (GABA) as a neurotransmitter. As with other amino acid transmitter agents, the postsynaptic action of GABA is thought to be terminated by uptake into neurons and glia surrounding the release site. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malchow RP,Ripps H

更新日期：1990-11-01 00:00:00

abstract：:Methyl groups placed on varphiXsB1 replicative form DNA by the Escherichia coli B modification enzyme are located in the overlap between fragments Mbo II-3 and Alu I-2, a 61-base-pair DNA segment. Mutations that led to loss of susceptibility to restriction by E. coli B occurred within this segment at three positions s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lautenberger JA,Kan NC,Lackey D,Linn S,Edgell MH,Hutchison CA 3rd

更新日期：1978-05-01 00:00:00

abstract：:The electronic absorption spectra of oxidized and reduced spinach ferredoxins have been measured between 1200 and 600 nm at low temperature in D(2)O/ethylene glycol glasses. Relatively weak absorption bands are observed at 720, 820, and 920 nm in oxidized ferredoxin, and at 652, 820, and 920 nm in reduced ferredoxin. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawlings J,Siiman O,Gray HB

更新日期：1974-01-01 00:00:00

abstract：:The recent completion of the deletion of essentially all of the ORFs in yeast is an important new resource for identifying the phenotypes of unknown genes. Each ORF is replaced with a cassette containing unique tag sequences that allow rapid parallel analysis of strains in a pool by using hybridization to a high-densi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birrell GW,Giaever G,Chu AM,Davis RW,Brown JM

更新日期：2001-10-23 00:00:00

abstract：:Functional reconstitution of membrane proteins within lipid bilayers is crucial for understanding their biological function in living cells. While this strategy has been extensively used with liposomes, reconstitution of membrane proteins in lipidic cubic mesophases presents significant challenges related to the struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Speziale C,Salvati Manni L,Manatschal C,Landau EM,Mezzenga R

更新日期：2016-07-05 00:00:00

abstract：:Thirty percent of the 189 tumors studied to date express DNA polymerase beta variants. One of these variants was identified in a prostate carcinoma and is altered from isoleucine to methionine at position 260, within the hydrophobic hinge region of the protein. Another variant was identified in a colon carcinoma and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sweasy JB,Lang T,Starcevic D,Sun KW,Lai CC,Dimaio D,Dalal S

更新日期：2005-10-04 00:00:00

abstract：:Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by the insulin receptor permits this docking protein to interact with signaling proteins that promote insulin action. Serine phosphorylation uncouples IRS-1 from the insulin receptor, thereby inhibiting its tyrosine phosphorylation and insulin signaling....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozes ON,Akca H,Mayo LD,Gustin JA,Maehama T,Dixon JE,Donner DB

更新日期：2001-04-10 00:00:00

abstract：:Two features make the tooth an excellent model in the study of evolutionary innovations: the relative simplicity of its structure and the fact that the major tooth-forming genes have been identified in eutherian mammals. To understand the nature of the innovation at the molecular level, it is necessary to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyosawa S,O'hUigin C,Figueroa F,Tichy H,Klein J

更新日期：1998-10-27 00:00:00

abstract：:Selection is usually considered to be the dominant force controlling viral variation; the large population sizes suggest that deterministic population genetic models are appropriate. To investigate their validity for HIV, samples of env gene sequences were tested for departure from neutrality because of mutation-selec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown AJ

更新日期：1997-03-04 00:00:00

abstract：:The recent observation of superconductivity in [Formula: see text] has raised fundamental questions about the hierarchy of the underlying electronic structure. Calculations suggest that this system falls in the Mott-Hubbard regime, rather than the charge-transfer configuration of other nickel oxides and the supercondu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodge BH,Li D,Lee K,Osada M,Wang BY,Sawatzky GA,Hwang HY,Kourkoutis LF

更新日期：2021-01-12 00:00:00

abstract：:The substrate specificity of the catalytic subunit of rabbit skeletal muscle 3': 5'-cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP: protein phosphotransferase) has been studied using the synthetic peptide Arg-Gly-Tyr-Ser-Leu-Gly corresponding to the sequence around serine 24, a phosphorylation site in reduced, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kemp BE,Benjamini E,Krebs EG

更新日期：1976-04-01 00:00:00

abstract：:Do people judge hurricane risks in the context of gender-based expectations? We use more than six decades of death rates from US hurricanes to show that feminine-named hurricanes cause significantly more deaths than do masculine-named hurricanes. Laboratory experiments indicate that this is because hurricane names lea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung K,Shavitt S,Viswanathan M,Hilbe JM

更新日期：2014-06-17 00:00:00

abstract：:Early forms of the genetic code likely generated "statistical" proteins, with similar side chains occupying the same sequence positions at different ratios. In this scenario, groups of related side chains were treated by aminoacyl-tRNA synthetases as a single molecular species until a discrimination mechanism develope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang XL,Otero FJ,Skene RJ,McRee DE,Schimmel P,Ribas de Pouplana L

更新日期：2003-12-23 00:00:00

abstract：:Although sexual selection theory has proved successful in explaining a wide array of male ornaments, the function of ornaments occurring in females is largely unknown. Traditionally, female ornaments have been considered nonfunctional, being merely a genetically correlated response to selection for male ornamentation....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amundsen T,Forsgren E

更新日期：2001-11-06 00:00:00

abstract：:A cloned segment of yeast DNA containing the structural gene for imidazoleglycerolphosphate dehydratase (D-erythro-imidazoleglycerolphosphate hydro-lase, EC 4.2.1.19) is transcribed and translated in Escherichia coli with sufficient fidelity to produce functional enzyme. This segment of yeast DNA was isolated as a via...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Struhl K,Davis RW

更新日期：1977-12-01 00:00:00

abstract：:Deficiency of acyl CoA:cholesterol acyltransferase 2 (ACAT2) in mice results in a reduction in cholesterol ester synthesis in the small intestine and liver, which in turn limits intestinal cholesterol absorption, hepatic cholesterol gallstone formation, and the accumulation of cholesterol esters in the plasma lipoprot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willner EL,Tow B,Buhman KK,Wilson M,Sanan DA,Rudel LL,Farese RV Jr

更新日期：2003-02-04 00:00:00

abstract：:Deep aquifers in South and Southeast Asia are increasingly exploited as presumed sources of pathogen- and arsenic-free water, although little is known of the processes that may compromise their long-term viability. We analyze a large area (>1,000 km(2)) of the Mekong Delta, Vietnam, in which arsenic is found pervasive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Erban LE,Gorelick SM,Zebker HA,Fendorf S

更新日期：2013-08-20 00:00:00

abstract：:The thesis is developed that a low oxygen level Precambrian atmosphere presented early-evolving metazoan organisms with physiological connective tissue priorities resulting from the important molecular oxygen requirements in the biosynthesis of collagen hydroxyproline. Shells, cuticles, and carapaces which are not man...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Towe KM

更新日期：1970-04-01 00:00:00

abstract：:Different splice variants of the proinflammatory cytokine IL-32 are found in various tissues; their putative differences in biological function remain unknown. In the present study, we report that IL-32γ is the most active isoform of the cytokine. Splicing to one less active IL-32β appears to be a salvage mechanism to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heinhuis B,Koenders MI,van de Loo FA,Netea MG,van den Berg WB,Joosten LA

更新日期：2011-03-22 00:00:00

abstract：:Transabdominal (Tab) is a dominant gain-of-function mutation that results in islands of sexually dimorphic abdominal cuticle in the dorsal thorax of the adult fly. This phenotype has complete penetrance and constant expressivity, and we show that it results from ectopic expression of ABD-BII, one of two proteins deriv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Celniker SE,Lewis EB

更新日期：1993-02-15 00:00:00

abstract：:The "kindling" phenomenon is associated with long-lasting facilitation of synaptic transmission. A possible mechanism of such facilitation could involve changes in the number of synaptic contacts. However, previous attempts to demonstrate a synaptic morphological alteration that could account for the long-term effects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geinisman Y,Morrell F,deToledo-Morrell L

更新日期：1988-05-01 00:00:00

abstract：:Stable isotope values of carbon (delta13C) and nitrogen (delta15N) in blood, feathers, eggshell, and bone have been used in seabird studies since the 1980s, providing a valuable source of information on diet, foraging patterns, and migratory behavior in these birds. These techniques can also be applied to fossil mater...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emslie SD,Patterson WP

更新日期：2007-07-10 00:00:00

abstract：:A major calmodulin-binding protein (CaM-BP) of Mr 240,000 was demonstrated in various rat tissues by using a 125I-labeled CaM gel overlay technique. This protein (designated p240) was detected in the particulate fraction and to a lesser extent in the cytosol of all tissues studied. Binding of CaM to p240 was completel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palfrey HC,Schiebler W,Greengard P

更新日期：1982-06-01 00:00:00

abstract：:What drives scientists' position taking on matters where empirical answers are unavailable or contradictory? We examined the contentious debate on whether to limit experiments involving the creation of potentially pandemic pathogens. Hundreds of scientists, including Nobel laureates, have signed petitions on the debat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelmann A,Moody J,Light R

更新日期：2017-06-13 00:00:00

abstract：:To use recombinant DNA technology to functionally analyze mutations introduced into cloned eukaryotic genes, a rapid procedure is necessary to assay the steps along the gene expression pathway. Since cloned rat insulin genes are not transcribed efficiently after transfection into various cell lines, I have asked wheth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lomedico PT

更新日期：1982-10-01 00:00:00

abstract：:In the filamentous fungus Neurospora crassa, several events in the process of conidiation are influenced by light. Two genes, con-6 and con-10, which were previously shown to be transcriptionally activated during conidiation and by exposure to light, were found to be unexpressed in mycelium maintained in constant dark...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lauter FR,Yanofsky C

更新日期：1993-09-01 00:00:00