Actin stress in cell reprogramming.

abstract：:Copper is an essential metal nutrient that is tightly regulated in the body because loss of its homeostasis is connected to severe diseases such as Menkes and Wilson diseases, Alzheimer's disease, prion disorders, and amyotrophic lateral sclerosis. The complex relationships between copper status and various stages of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirayama T,Van de Bittner GC,Gray LW,Lutsenko S,Chang CJ

更新日期：2012-02-14 00:00:00

abstract：:By adapting to sustained stimuli, hair cells in the internal ear retain their sensitivity to minute transient displacements. Because one model for adaptation asserts that this process is mediated by a myosin isozyme, we reasoned that we should be able to arrest adaptation by interfering with myosin's ATPase cycle thou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillespie PG,Hudspeth AJ

更新日期：1993-04-01 00:00:00

abstract：:To prevent the spread of coronavirus disease 2019 (COVID-19), some types of public spaces have been shut down while others remain open. These decisions constitute a judgment about the relative danger and benefits of those locations. Using mobility data from a large sample of smartphones, nationally representative cons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benzell SG,Collis A,Nicolaides C

更新日期：2020-06-30 00:00:00

abstract：:8-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts by directing incorporation of an incorrect nucleotide during transcription. Such transcriptional mutagenesis (TM) may produce a pool of mutant proteins. In contrast, transcription-couple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saxowsky TT,Meadows KL,Klungland A,Doetsch PW

更新日期：2008-12-02 00:00:00

abstract：:The fact that animal introns are not spliced out in plants suggests that recognition of pre-mRNA splice sites differs between the two kingdoms. In plants, little is known about proteins required for splicing, as no plant in vitro splicing system is available. Several essential splicing factors from animals, such as SF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopato S,Mayeda A,Krainer AR,Barta A

更新日期：1996-04-02 00:00:00

abstract：:Even in the absence of sensory stimulation, the neocortex shows complex spontaneous activity patterns, often consisting of alternating "DOWN" states of generalized neural silence and "UP" states of massive, persistent network activity. To investigate how this spontaneous activity propagates through neuronal assemblies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luczak A,Barthó P,Marguet SL,Buzsáki G,Harris KD

更新日期：2007-01-02 00:00:00

abstract：:Esterase 6 is a polymorphic carboxylesterase (carboxylic-ester hydrolase, EC 3.1.1.1) localized to the reproductive tract of male Drosophila melanogaster and transferred to females at copulation. The reproductive fitness of males is strongly affected by temperature and the esterase 6 alleles (active versus null) that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilbert DG,Richmond RC

更新日期：1982-05-01 00:00:00

abstract：:Natural selection does not necessarily favor maximal reproduction because reproduction imposes fitness costs, reducing parental survival, and offspring quality. Here, we show that parents in a preindustrial population in North America incurred fitness costs from reproduction, and women incurred greater costs than men....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penn DJ,Smith KR

更新日期：2007-01-09 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause fluid secretion, inflammation, and cell death. Using a gene-trap insertional mutagenesis scre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaFrance ME,Farrow MA,Chandrasekaran R,Sheng J,Rubin DH,Lacy DB

更新日期：2015-06-02 00:00:00

abstract：:The high-affinity (K(m) = 3 x 10(-8) M) transport system for histidine in Salmonella typhimurium has been resolved into three components: J, K, and P. J, which is a histidine-binding protein released by osmotic shock, is specified by the hisJ gene: hisJ mutants lack the binding protein and are defective in histidine t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ames GF,Lever J

更新日期：1970-08-01 00:00:00

abstract：:Active matter, both synthetic and biological, demonstrates complex spatiotemporal self-organization and the emergence of collective behavior. A coherent rotational motion, the vortex phase, is of great interest because of its ability to orchestrate well-organized motion of self-propelled particles over large distances...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han K,Kokot G,Tovkach O,Glatz A,Aranson IS,Snezhko A

更新日期：2020-05-05 00:00:00

abstract：:Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin antibodies composed of Leucine-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SC,Park K,Han J,Lee JJ,Kim HJ,Hong S,Heu W,Kim YJ,Ha JS,Lee SG,Cheong HK,Jeon YH,Kim D,Kim HS

更新日期：2012-02-28 00:00:00

abstract：:DNA extracted from Dane particles has been characterized by gel electrophoresis and restriction enzyme cleavage with endonuclease R-HaeIII (from Hemophilus aegyptius). Dane particle DNA is proposed to be a double-stranded circular DNA approximately 3600 nucleotides in length containing a single-stranded gap of 600-210...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Summers J,O'Connell A,Millman I

更新日期：1975-11-01 00:00:00

abstract：:Metaphase checkpoint controls sense abnormalities of chromosome alignment during mitosis and prevent progression to anaphase until proper alignment has been attained. A number of proteins, including mad2, bub1, and bubR1, have been implicated in the metaphase checkpoint control in mammalian cells. Metaphase checkpoint...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skoufias DA,Andreassen PR,Lacroix FB,Wilson L,Margolis RL

更新日期：2001-04-10 00:00:00

abstract：:Amphibian eggs and embryos as well as mammalian cells have been reported to contain an activity that unwinds double-stranded RNA. We have now found that adenosine residues have been modified in the RNA products of this unwinding activity. Although the modified RNA remains double-stranded, the modification causes the R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner RW,Smith JE,Cooperman BS,Nishikura K

更新日期：1989-04-01 00:00:00

abstract：:A cloned Bacillus subtilis gene (sprE) expressed only during the stationary growth phase is shown to encode the subtilisin E protease, an enzyme associated with sporulation. We have determined the DNA sequence of the sprE promoter region and the promoter-proximal half of the structural gene. The sprE gene codes for a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong SL,Price CW,Goldfarb DS,Doi RH

更新日期：1984-02-01 00:00:00

abstract：:Precise, quantitative measurements of the hydration status of skin can yield important insights into dermatological health and skin structure and function, with additional relevance to essential processes of thermoregulation and other features of basic physiology. Existing tools for determining skin water content expl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon K,Wang H,Lim J,Chun KS,Jang H,Yoo I,Wu D,Chen AJ,Gu CG,Lipschultz L,Kim JU,Kim J,Jeong H,Luan H,Park Y,Su CJ,Ishida Y,Madhvapathy SR,Ikoma A,Kwak JW,Yang DS,Banks A,Xu S,Huang Y,Chang JK,Rogers JA

更新日期：2021-02-02 00:00:00

abstract：:A longstanding problem in the social, biological, and computational sciences is to determine how groups of distributed individuals can form intelligent collective judgments. Since Galton's discovery of the "wisdom of crowds" [Galton F (1907) Nature 75:450-451], theories of collective intelligence have suggested that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker J,Brackbill D,Centola D

更新日期：2017-06-27 00:00:00

abstract：:Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating hormone) from the pituitary. This reproductive circuit is sensitive to metabolic perturbations. When challenged with starvation, insufficient en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padilla SL,Qiu J,Nestor CC,Zhang C,Smith AW,Whiddon BB,Rønnekleiv OK,Kelly MJ,Palmiter RD

更新日期：2017-02-28 00:00:00

abstract：:Circumnutation and winding in plants are universal growth movements that allow plants to survive despite their sessile nature. However, the detailed molecular mechanisms controlling these phenomena remain unclear. We previously found that a gravitropic mutant of Japanese morning glory (Pharbitis nil or Ipomoea nil), S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitazawa D,Hatakeda Y,Kamada M,Fujii N,Miyazawa Y,Hoshino A,Iida S,Fukaki H,Morita MT,Tasaka M,Suge H,Takahashi H

更新日期：2005-12-20 00:00:00

abstract：:Human platelets stimulated by epinephrine undergo enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulate inositol trisphosphate, diacylglycerol, and phosphatidic acid, and phosphorylate a 47-kDa protein. All of these phenomena indicate stimulation of phospholipase C. These responses are blocked complet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banga HS,Simons ER,Brass LF,Rittenhouse SE

更新日期：1986-12-01 00:00:00

abstract：:Two issues long debated among Pacific and American prehistorians are (i) whether there was a pre-Columbian introduction of chicken (Gallus gallus) to the Americas and (ii) whether Polynesian contact with South America might be identified archaeologically, through the recovery of remains of unquestionable Polynesian or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Storey AA,Ramírez JM,Quiroz D,Burley DV,Addison DJ,Walter R,Anderson AJ,Hunt TL,Athens JS,Huynen L,Matisoo-Smith EA

更新日期：2007-06-19 00:00:00

abstract：:Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seybold BA,Stanco A,Cho KK,Potter GB,Kim C,Sohal VS,Rubenstein JL,Schreiner CE

更新日期：2012-08-21 00:00:00

abstract：:After decades of robust growth, the rise in US life expectancy stalled after 2010. Explanations for the stall have focused on rising drug-related deaths. Here we show that a stagnating decline in cardiovascular disease (CVD) mortality was the main culprit, outpacing and overshadowing the effects of all other causes of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehta NK,Abrams LR,Myrskylä M

更新日期：2020-03-31 00:00:00

abstract：:CCR5 (R5)-tropic, but not CXCR4 (X4)-tropic, HIV-1 is associated with primary HIV-1 infection and transmission. Recent studies have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, restrict a broad range of viruses. Here, we demonstrate that an IFITM2 isoform (Δ20 IFITM2) la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu WL,Grotefend CR,Tsai MT,Wang YL,Radic V,Eoh H,Huang IC

更新日期：2017-07-03 00:00:00

abstract：:The Na,K-ATPase contains a binding site for cardiac glycosides, such as ouabain, digoxin, and digitoxin, which is highly conserved among species ranging from Drosophila to humans. Although advantage has been taken of this site to treat congestive heart failure with drugs such as digoxin, it is unknown whether this sit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dostanic-Larson I,Van Huysse JW,Lorenz JN,Lingrel JB

更新日期：2005-11-01 00:00:00

abstract：:Despite early speculation to the contrary, all tropical forests studied to date display seasonal variations in the presence of new leaves, flowers, and fruits. Past studies were focused on the timing of phenological events and their cues but not on the accompanying changes in leaf area that regulate vegetation-atmosph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Myneni RB,Yang W,Nemani RR,Huete AR,Dickinson RE,Knyazikhin Y,Didan K,Fu R,Negrón Juárez RI,Saatchi SS,Hashimoto H,Ichii K,Shabanov NV,Tan B,Ratana P,Privette JL,Morisette JT,Vermote EF,Roy DP,Wolfe RE,Friedl MA,

更新日期：2007-03-20 00:00:00

abstract：:Whole-genome duplication (WGD) is believed to be a significant source of major evolutionary innovation. Redundant genes resulting from WGD are thought to be lost or acquire new functions. However, the rates of gene loss and thus temporal process of genome reshaping after WGD remain unclear. The WGD shared by all teleo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue J,Sato Y,Sinclair R,Tsukamoto K,Nishida M

更新日期：2015-12-01 00:00:00

abstract：:Small molecules of biological origin continue to yield the most promising leads for drug design, but systematic approaches for exploring nature's cache of structural diversity are lacking. Here, we demonstrate the use of 2D NMR spectroscopy to screen a library of biorationally selected insect metabolite samples for pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deyrup ST,Eckman LE,McCarthy PH,Smedley SR,Meinwald J,Schroeder FC

更新日期：2011-06-14 00:00:00

abstract：:The embryonic neuroepithelium gives rise to the components of the central nervous system in the mature animal. To study the early development of the murine central nervous system we have sought to isolate growth factor receptors from the neuroepithelium of the neural tube of 10-day-old mouse embryos. Because many grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid HH,Wilks AF,Bernard O

更新日期：1990-02-01 00:00:00