Components of histidine transport: histidine-binding proteins and hisP protein.

abstract：:Diabetes is now the most common cause of progressive kidney failure leading to dialysis or transplantation. The central pathological feature of diabetic nephropathy is accumulation of extracellular matrix within the glomeruli. The factors in the diabetic milieu responsible for extracellular matrix accumulation are not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto T,Nakamura T,Noble NA,Ruoslahti E,Border WA

更新日期：1993-03-01 00:00:00

abstract：:The retinoblastoma gene product (the RB protein) is phosphorylated in a cell cycle-dependent manner and this modification is believed to be important for cells to progress through the cell cycle. We found that purified cdk2 (cyclin-dependent kinase/cell division kinase 2) can phosphorylate the RB protein in vitro at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama T,Ohuchi T,Sumida S,Matsumoto K,Toyoshima K

更新日期：1992-09-01 00:00:00

abstract：:The transcription of genes encoding gluconeogenic enzymes is tightly regulated during the perinatal period. These genes are induced by glucagon (cAMP) and glucocorticoids and repressed by insulin. To address the role of cAMP and glucocorticoids in the physiological activation of genes encoding gluconeogenic enzymes in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montoliu L,Blendy JA,Cole TJ,Schütz G

更新日期：1995-05-09 00:00:00

abstract：:Eye blinking is one of the most frequent human actions. The control of blinking is thought to reflect complex interactions between maintaining clear and healthy vision and influences tied to central dopaminergic functions including cognitive states, psychological factors, and medical conditions. The most imminent cons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoppe D,Helfmann S,Rothkopf CA

更新日期：2018-02-27 00:00:00

abstract：:The delta-subspecies of protein kinase C (delta PKC) was purified to near homogeneity from the Triton X-100 extract of the rat brain particulate fraction by successive chromatographies on S-Sepharose fast flow, phenyl 5PW, heparin 5PW, hydroxyapatite, and Mono Q columns. The purified enzyme was a doublet with molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogita K,Miyamoto S,Yamaguchi K,Koide H,Fujisawa N,Kikkawa U,Sahara S,Fukami Y,Nishizuka Y

更新日期：1992-03-01 00:00:00

abstract：:Dynamic fluxes of s-block metals like potassium, sodium, and calcium are of broad importance in cell signaling. In contrast, the concept of mobile transition metals triggered by cell activation remains insufficiently explored, in large part because metals like copper and iron are typically studied as static cellular n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodani SC,Domaille DW,Nam CI,Miller EW,Finney LA,Vogt S,Chang CJ

更新日期：2011-04-12 00:00:00

abstract：:The extensive refolding of the membrane-anchoring chain of hemagglutinin (HA) of influenza virus (termed HA2) in cellular endosomes, which initiates viral entry by membrane fusion, suggests that viral HA is meta-stable. HA2 polypeptide residues 38-175 expressed in Escherichia coli are reported here to fold in vivo int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Wharton SA,Weissenhorn W,Calder LJ,Hughson FM,Skehel JJ,Wiley DC

更新日期：1995-12-19 00:00:00

abstract：:The c-Jun NH(2)-terminal kinase (JNK) is activated when cells are exposed to environmental stress, including UV radiation. Gene disruption studies demonstrate that JNK is essential for UV-stimulated apoptosis mediated by the mitochondrial pathway by a Bax/Bak-dependent mechanism. Here, we demonstrate that JNK phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lei K,Davis RJ

更新日期：2003-03-04 00:00:00

abstract：:From 1980 to 1992, a series of influential papers reported on the discovery, genetics, and evolution of a periodic cycling of the interval between Drosophila male courtship song pulses. The molecular mechanisms underlying this periodicity were never described. To reinitiate investigation of this phenomenon, we previou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern DL,Clemens J,Coen P,Calhoun AJ,Hogenesch JB,Arthur BJ,Murthy M

更新日期：2017-09-12 00:00:00

abstract：:Neurotrophins are potent survival factors for developing and injured neurons. However, they are not being used to treat neurodegenerative diseases because of difficulties in administration and numerous side effects that have been encountered in previous clinical trials. Their biological activities use Trk (tropomyosin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiese S,Jablonka S,Holtmann B,Orel N,Rajagopal R,Chao MV,Sendtner M

更新日期：2007-10-23 00:00:00

abstract：:Distribution studies disclosed that all major cerebral arteries and cortical arterioles of the cat were invested with fine varicose nerve fibers that contained calcitonin gene-related peptide (CGRP)-like immunoreactivity; the trigeminal ganglia likewise contained CGRP immunoreactivity. Sequential immunostaining with a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCulloch J,Uddman R,Kingman TA,Edvinsson L

更新日期：1986-08-01 00:00:00

abstract：:During reverse transcription of retroviral RNA, synthesis of (-) strand DNA is primed by a cellular tRNA that anneals to an 18-nt primer binding site within the 5' long terminal repeat. For (+) strand synthesis using a (-) strand DNA template linked to the tRNA primer, only the first 18 nt of tRNA are replicated to re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burnett BP,McHenry CS

更新日期：1997-07-08 00:00:00

abstract：:Infection by certain human papillomavirus types is regarded as the major risk factor in the development of cervical cancer, one of the most common cancers of women worldwide. Analysis of the immunogenic and structural features of papillomavirus virions has been hampered by the inability to efficiently propagate the vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirnbauer R,Booy F,Cheng N,Lowy DR,Schiller JT

更新日期：1992-12-15 00:00:00

abstract：:Therapeutics for cerebral ischemia/hypoxia, which often results in ischemic stroke in humans, are a global unmet medical need. Here, we report that bryostatin-1, a highly potent protein kinase C (PKC) activator, interrupts pathophysiological molecular cascades and apoptosis triggered by cerebral ischemia/hypoxia, enha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun MK,Hongpaisan J,Alkon DL

更新日期：2009-08-25 00:00:00

abstract：:Type 2 diabetes is preceded by the development of insulin resistance, in which the action of insulin is impaired, largely in skeletal muscles. Caveolin-3 (Cav3) is a muscle-specific subtype of caveolin, an example of a scaffolding protein found within membranes. Cav is also known as growth signal inhibitor, although i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oshikawa J,Otsu K,Toya Y,Tsunematsu T,Hankins R,Kawabe J,Minamisawa S,Umemura S,Hagiwara Y,Ishikawa Y

更新日期：2004-08-24 00:00:00

abstract：:Several polypeptides contained in the coat and the core of adenovirus type 2 particles have been identified as virus gene products. They are synthesized in vitro by a cell-free protein-making system programmed by adenovirus type 2 messenger RNA that has been hybridized with and eluted from virus DNA. Fractionation by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eron L,Westphal H

更新日期：1974-09-01 00:00:00

abstract：:Neurofibromin gene (NF1) mutation causes neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss in adult oligodendrocytes causes myelin decompaction and increases oligodendrocyte nitric oxide (NO) levels...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asleh J,Shofty B,Cohen N,Kavushansky A,López-Juárez A,Constantini S,Ratner N,Kahn I

更新日期：2020-09-08 00:00:00

abstract：:Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unkn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ristow M,Zarse K,Oberbach A,Klöting N,Birringer M,Kiehntopf M,Stumvoll M,Kahn CR,Blüher M

更新日期：2009-05-26 00:00:00

abstract：:Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one pore domain. Because of high-level structural flexibility, the first mammalian Kv structure, Kv1.2 at 2.9 A, has about 37% molecular mass of the transmembrane portion not resolved. In this study, by applying a novel no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Wang Q,Ni F,Ma J

更新日期：2010-06-22 00:00:00

abstract：:We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce synaptic potentiation will instead cause a specific synaptic depression. To realize this situation experimentally, the Schaffer collateral projection to area CA1 in rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dudek SM,Bear MF

更新日期：1992-05-15 00:00:00

abstract：:The protooncogene c-fps/fes is a single vertebrate locus homologous to both the fps transforming gene of Fujinami avian sarcoma virus and the fes transforming gene of two feline sarcoma virus isolates. The human c-fps/fes locus has been previously cloned and characterized. We report that a recombinant gene in which 3'...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sodroski JG,Goh WC,Haseltine WA

更新日期：1984-05-01 00:00:00

abstract：:Subcortical structures play a critical role in brain function. However, options for assessing electrophysiological activity in these structures are limited. Electromagnetic fields generated by neuronal activity in subcortical structures can be recorded noninvasively, using magnetoencephalography (MEG) and electroencep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krishnaswamy P,Obregon-Henao G,Ahveninen J,Khan S,Babadi B,Iglesias JE,Hämäläinen MS,Purdon PL

更新日期：2017-11-28 00:00:00

abstract：:The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3' OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by DNA primase. The primase of archaea and eukaryotes, despite having varying subunit compositions, share sequence and struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan J,Holzer S,Pellegrini L,Bell SD

更新日期：2018-06-26 00:00:00

abstract：:Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miao RQ,Gao Y,Harrison KD,Prendergast J,Acevedo LM,Yu J,Hu F,Strittmatter SM,Sessa WC

更新日期：2006-07-18 00:00:00

abstract：:Allergies are highly prevalent, and allergic responses can be triggered even in the absence of allergens due to Pavlovian conditioning to a specific cue. Here we show in humans suffering from allergic rhinitis that merely reencountering the environmental context in which an allergen was administered a week earlier is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Besedovsky L,Benischke M,Fischer J,Yazdi AS,Born J

更新日期：2020-05-19 00:00:00

abstract：:Five different selectively deuterated analogs of staphylococcal nuclease (Foggi) were prepared having all but a selected few hydrogen atoms in the enzyme molecule replaced by deuterium. The (1)H-NMR spectra of these analogs are extremely simplified, since they consist of lines arising only from the remaining protonate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putter I,Barreto A,Markley JL,Jardetzky O

更新日期：1969-12-01 00:00:00

abstract：:Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy. As a model for changes induced in nonmalignant cells by cancer, we examined T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorgun G,Ramsay AG,Holderried TA,Zahrieh D,Le Dieu R,Liu F,Quackenbush J,Croce CM,Gribben JG

更新日期：2009-04-14 00:00:00

abstract：:The preferential inactivation of the paternal X chromosome in extraembryonic cells during early mouse development is an example of parental imprinting, but it has not been studied at the transcriptional level because standard methods of measuring RNA levels do not allow detection of allele-specific RNAs in individual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singer-Sam J,Chapman V,LeBon JM,Riggs AD

更新日期：1992-11-01 00:00:00

abstract：:Antigen-induced activation of T cells can be specifically inhibited by antigen analogs that have been termed T-cell receptor peptide antagonists. These antagonists appear to act by inducing the formation of nonstimulatory or partially stimulatory complexes between T-cell receptors and the major histocompatibility comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Page DM,Alexander J,Snoke K,Appella E,Sette A,Hedrick SM,Grey HM

更新日期：1994-04-26 00:00:00

abstract：:The 26S proteasome, a molecular machine responsible for regulated protein degradation, consists of a proteolytic core particle (20S CP) associated with 19S regulatory particles (19S RPs) subdivided into base and lid subcomplexes. The assembly of 19S RP base subcomplex is mediated by multiple dedicated chaperones. Amon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrault MB,Richet N,Godard C,Murciano B,Le Tallec B,Rousseau E,Legrand P,Charbonnier JB,Le Du MH,Guérois R,Ochsenbein F,Peyroche A

更新日期：2012-04-24 00:00:00