Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly.

abstract：:REPRESSOR OF SILENCING 1 (ROS1) is a DNA demethylation enzyme that was previously identified during a genetic screen for the silencing of both RD29A-LUC and 35S-NPTII transgenes on a T-DNA construct. Here we performed a genetic screen to identify additional mutants in which the 35S-NPTII transgene is silenced. We iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Qian W,Zhao Y,Wang C,Shen J,Zhu JK,Gong Z

更新日期：2012-07-10 00:00:00

abstract：:Achieving label-free, molecular-specific imaging with high spatial resolution in deep tissue is often considered the grand challenge of optical imaging. To accomplish this goal, significant optical scattering in tissues has to be overcome while achieving molecular specificity without resorting to extrinsic labeling. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yakovlev VV,Zhang HF,Noojin GD,Denton ML,Thomas RJ,Scully MO

更新日期：2010-11-23 00:00:00

abstract：:Prions are composed solely of an alternatively folded isoform of the prion protein (PrP), designated PrP(Sc). N-terminally truncated PrP(Sc), denoted PrP 27-30, retains infectivity and polymerizes into rods with the ultrastructural and tinctorial properties of amyloid. We report here that some polyoxometalates (POMs) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wille H,Shanmugam M,Murugesu M,Ollesch J,Stubbs G,Long JR,Safar JG,Prusiner SB

更新日期：2009-03-10 00:00:00

abstract：:The human chemokine receptors CCR5 and CXCR4 have emerged as the predominant cofactors, along with CD4, for cellular entry of HIV-1 in vivo whereas the contribution of other chemokine receptors to HIV disease has not been yet determined. CCR5-specific (R5) viruses predominate during primary HIV-1 infection whereas vir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penn ML,Grivel JC,Schramm B,Goldsmith MA,Margolis L

更新日期：1999-01-19 00:00:00

abstract：:Sheep antibodies directed against an AMP-bovine serum albumin conjugate exhibit highly specific binding toward AMP. These antibodies bind to the AMP moiety of adenylylated glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] from Escherichia coli and to no other antigenic determinant on the prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohman RJ,Rhee SG,Stadtman ER

更新日期：1980-12-01 00:00:00

abstract：:The effective management of marine fisheries is an ongoing challenge at the intersection of biology, economics, and policy. One way in which fish stocks-and their habitats-can be protected is through the establishment of marine reserves, areas that are closed to fishing. Although the potential economic benefits of suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herrera GE,Moeller HV,Neubert MG

更新日期：2016-04-05 00:00:00

abstract：:Preliminary x-ray diffraction data from single crystals of the MoFe proteins of nitrogenase from Clostridium pasteurianum and Azotobacter vinelandii have been obtained. Both protein crystals belong to the P2(1) space group. The MoFe protein crystals from C. pasteurianum and A. vinelandii diffract to angles correspondi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weininger MS,Mortenson LE

更新日期：1982-01-01 00:00:00

abstract：:The ability to modulate the collective properties of correlated electron systems at their interfaces and surfaces underpins the burgeoning field of "designer" quantum materials. Here, we show how an electronic reconstruction driven by surface polarity mediates a Stoner-like magnetic instability to itinerant ferromagne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazzola F,Sunko V,Khim S,Rosner H,Kushwaha P,Clark OJ,Bawden L,Marković I,Kim TK,Hoesch M,Mackenzie AP,King PDC

更新日期：2018-12-18 00:00:00

abstract：:After more than a decade of experiments generating and studying the physics of quantized vortices in atomic gas Bose-Einstein condensates, research is beginning to focus on the roles of vortices in quantum turbulence, as well as other measures of quantum turbulence in atomic condensates. Such research directions have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White AC,Anderson BP,Bagnato VS

更新日期：2014-03-25 00:00:00

abstract：:Two chlorophyll-protein complexes associated with photosystem II (PSII) of the cyanobacterium Anacystis nidulans R2 have been detected. The larger of the two complexes, CPVI-1, contained a 71-kDa and a 42-kDa protein. The 71-kDa protein was determined to be the anchor protein of the phycobilisomes (the light-harvestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pakrasi HB,Riethman HC,Sherman LA

更新日期：1985-10-01 00:00:00

abstract：:Exposure of cholera toxin to membrane particles prepared from sarcoma 180 cells gives rise to a variety of fragments which are capable of activating adenylate cyclase [ATP:pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. A major component of these fragments has an apparent molecular weight in the 8,000-10,000 range. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matuo Y,Wheeler MA,Bitensky MW

更新日期：1976-08-01 00:00:00

abstract：:Rev-Erbβ is a nuclear receptor that couples circadian rhythm, metabolism, and inflammation. Heme binding to the protein modulates its function as a repressor, its stability, its ability to bind other proteins, and its activity in gas sensing. Rev-Erbβ binds Fe3+-heme more tightly than Fe2+-heme, suggesting its activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar A,Carter EL,Harland JB,Speelman AL,Lehnert N,Ragsdale SW

更新日期：2021-01-19 00:00:00

abstract：:Growth of 3T3-L2 fibroblasts in medium containing 5-bromo-2'-deoxyuridine prevents the spontaneous cytodifferentiation of these cells into adipose cells. Treatment of bromodeoxyuridine-suppressed cultures at confluence with 1-methyl-3-isobutylxanthine, a promoter of the adipose conversion, results in differentiation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell TR

更新日期：1979-09-01 00:00:00

abstract：:One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display a CR. To investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welters MJ,Kenter GG,de Vos van Steenwijk PJ,Löwik MJ,Berends-van der Meer DM,Essahsah F,Stynenbosch LF,Vloon AP,Ramwadhdoebe TH,Piersma SJ,van der Hulst JM,Valentijn AR,Fathers LM,Drijfhout JW,Franken KL,Oostendorp J,Fle

更新日期：2010-06-29 00:00:00

abstract：:The human pathogen Mycobacterium tuberculosis encodes a proteasome that carries out regulated degradation of bacterial proteins. It has been proposed that the proteasome contributes to nitrogen metabolism in M. tuberculosis, although this hypothesis had not been tested. Upon assessing M. tuberculosis growth in several...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker SH,Jastrab JB,Dhabaria A,Chaton CT,Rush JS,Korotkov KV,Ueberheide B,Darwin KH

更新日期：2019-02-19 00:00:00

abstract：:Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. Here we report that disrupting the Slc4a10 gene, which encodes the Na(+)-coupled Cl(-)-HCO(3)(-) exchanger Slc4a10 (NCBE), drastically reduces brain ventricle volume and protects against fatal epileptic seizures in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobs S,Ruusuvuori E,Sipilä ST,Haapanen A,Damkier HH,Kurth I,Hentschke M,Schweizer M,Rudhard Y,Laatikainen LM,Tyynelä J,Praetorius J,Voipio J,Hübner CA

更新日期：2008-01-08 00:00:00

abstract：:Noncanonical DNA structures that stall DNA replication can cause errors in genomic DNA. Here, we investigated how the noncanonical structures formed by sequences in genes associated with a number of diseases impacted DNA polymerization by the Klenow fragment of DNA polymerase. Replication of a DNA sequence forming an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi S,Brazier JA,Sugimoto N

更新日期：2017-09-05 00:00:00

abstract：:Capable of inducing antigen-specific immune responses in both systemic and mucosal compartments without the use of syringe and needle, mucosal vaccination is considered ideal for the global control of infectious diseases. In this study, we developed a rice-based oral vaccine expressing cholera toxin B subunit (CTB) un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nochi T,Takagi H,Yuki Y,Yang L,Masumura T,Mejima M,Nakanishi U,Matsumura A,Uozumi A,Hiroi T,Morita S,Tanaka K,Takaiwa F,Kiyono H

更新日期：2007-06-26 00:00:00

abstract：:Allergies are highly prevalent, and allergic responses can be triggered even in the absence of allergens due to Pavlovian conditioning to a specific cue. Here we show in humans suffering from allergic rhinitis that merely reencountering the environmental context in which an allergen was administered a week earlier is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Besedovsky L,Benischke M,Fischer J,Yazdi AS,Born J

更新日期：2020-05-19 00:00:00

abstract：:An exact treatment of adsorption from a one-dimensional lattice gas is used to eliminate and correct a well-known inconsistency in the Brunauer-Emmett-Teller (B.E.T.) equation-namely, Gibbs excess adsorption is not taken into account and the Gibbs integral diverges at the transition point. However, neither model shoul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1996-12-10 00:00:00

abstract：:In phylogenetic reconstruction, two types of bacterial tyrosyl-tRNA synthetases (TyrRS) form distinct clades with many bacterial phyla represented in both clades. Very few taxa possess both forms, and maximum likelihood analysis of the distribution of TyrRS types suggests horizontal gene transfer (HGT), rather than an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andam CP,Williams D,Gogarten JP

更新日期：2010-06-08 00:00:00

abstract：:To successfully colonize the human gut, enteric bacteria must activate acid resistance systems to survive the extreme acidity (pH 1.5-3.5) of the stomach. The antiporter AdiC is the master orchestrator of the arginine-dependent system. Upon acid shock, it imports extracellular arginine (Arg) into the cytoplasm, provid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai MF,Miller C

更新日期：2013-04-09 00:00:00

abstract：:The self-association of gene-32 protein has been studied by sedimentation equilibrium centrifugation and polyacrylamide gel electrophoresis, in order to better understand its role in DNA replication and genetic recombination. The monomer molecular weight of gene-32 protein is 38,000 in guanidine hydrochloride and 34,0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carroll RB,Neet KE,Goldthwait DA

更新日期：1972-09-01 00:00:00

abstract：:A detailed conformational analysis of the known crystal structures of vitamin A, carotenoid, and xanthenoid derivatives has been made. These studies suggest that the visual chromophore 11-cis retinal and its isomers may each occur in several different conformational states, which would be expected to have different li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sundaralingam M,Beddell C

更新日期：1972-06-01 00:00:00

abstract：:Bacterial chemotaxis receptors can detect a small concentration gradient of attractants and repellents in the environment over a wide range of background concentration. The clustering of these receptors to form patches observed in vivo and in vitro has been suspected as a reason for the high sensitivity, and such wide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Wang W,Kim KK

更新日期：2002-09-03 00:00:00

abstract：:Gyrate atrophy (GA), a recessive eye disease involving progressive loss of vision due to chorioretinal degeneration, is associated with a deficiency of the mitochondrial enzyme ornithine aminotransferase (OATase; ornithine-oxo-acid aminotransferase; L-ornithine:2-oxo-acid aminotransferase, EC 2.6.1.13) with consequent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramesh V,McClatchey AI,Ramesh N,Benoit LA,Berson EL,Shih VE,Gusella JF

更新日期：1988-06-01 00:00:00

abstract：:Organ graft rejection is a T-cell-dependent process. The activation of alloreactive T cells requires stimulation of the T-cell receptor/CD3 complex by foreign major histocompatibility complex (MHC)-encoded gene products. However, accumulating evidence suggests that, in addition to T-cell receptor occupancy, other cost...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turka LA,Linsley PS,Lin H,Brady W,Leiden JM,Wei RQ,Gibson ML,Zheng XG,Myrdal S,Gordon D

更新日期：1992-11-15 00:00:00

abstract：:Psoralens linked to triplex-forming oligonucleotides (psoTFOs) have been used in conjunction with laser-induced two-photon excitation (TPE) to damage a specific DNA target sequence. To demonstrate that TPE can initiate photochemistry resulting in psoralen-DNA photoadducts, target DNA sequences were incubated with psoT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oh DH,King BA,Boxer SG,Hanawalt PC

更新日期：2001-09-25 00:00:00

abstract：:Policy folklists present a set of alleged historical facts seen as relevant to some social issue. Although the validity of these folklists is dubious, leaders and writers circulate them in the media, variants arise, and the lists continue on, sometimes for decades. Folklists are repeated because their messages are app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill B

更新日期：2014-07-22 00:00:00

abstract：:Here, we describe the identification and characterization of a nuclear body (matrix-associated deacetylase body) whose formation and integrity depend on deacetylase activity. Typically, there are 20-40 0.5-microM bodies per nucleus, although the size and number can vary substantially. The structure appears to contain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Downes M,Ordentlich P,Kao HY,Alvarez JG,Evans RM

更新日期：2000-09-12 00:00:00