Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors.

abstract：:The reversible phosphorylation of tyrosine residues is an important mechanism for modulating biological processes such as cellular signaling, differentiation, and growth, and if deregulated, can result in various types of cancer. Therefore, an understanding of these dynamic cellular processes at the molecular level re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salomon AR,Ficarro SB,Brill LM,Brinker A,Phung QT,Ericson C,Sauer K,Brock A,Horn DM,Schultz PG,Peters EC

更新日期：2003-01-21 00:00:00

abstract：:This paper provides transcendental and algebraic framework for the classification of identities expressing pi and other logarithms of algebraic numbers as rapidly convergent generalized hypergeometric series in rational parameters. Algebraic and arithmetic relations between values of p+1Fp hypergeometric functions and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chudnovsky DV,Chudnovsky GV

更新日期：1998-03-17 00:00:00

abstract：:The isolated beta subunit of hemoglobin Kansas has an oxygen affinity that is as low relative to the oxygen affinity of the beta(A) subunit as the affinity of hemoglobin Kansas is low relative to hemoglobin A. Thus the low affinity properties of hemoglobin Kansas are almost completely reflected in the properties of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Riggs A,Gibson QH

更新日期：1973-06-01 00:00:00

abstract：:Thioredoxin (Trx) is an intracellular redox protein with extracellular cytokine-like and chemokine-like activities. We show here that, although plasma Trx levels are unrelated to survival of HIV-infected individuals with CD4 cell counts above 200/microl blood, survival is significantly impaired (P = 0.003) when plasma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura H,De Rosa SC,Yodoi J,Holmgren A,Ghezzi P,Herzenberg LA,Herzenberg LA

更新日期：2001-02-27 00:00:00

abstract：:Impaired regulatory T-cell function results in a severe chronic autoimmune disease affecting multiple organs in Scurfy mice and humans with the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Previous studies have shown that T helper cells but not cytotoxic T cells are critical for the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aschermann S,Lehmann CH,Mihai S,Schett G,Dudziak D,Nimmerjahn F

更新日期：2013-11-19 00:00:00

abstract：:SsrA/SsrB is a primary two-component system that mediates the survival and replication of Salmonella within host cells. When activated, the SsrB response regulator directly promotes the transcription of multiple genes within Salmonella pathogenicity island 2 (SPI-2). As expression of the SsrB protein is promoted by se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi J,Shin D,Yoon H,Kim J,Lee CR,Kim M,Seok YJ,Ryu S

更新日期：2010-11-23 00:00:00

abstract：:Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA). Here, we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts using immunoblotting, molecular imaging, and [(35)S]methionine pulse-chase experiments, tog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng AC,Miyake T,Yokoe S,Zhang L,Rezende LM Jr,Sharma P,MacLennan DH,Liu PP,Gramolini AO

更新日期：2015-06-09 00:00:00

abstract：:Marine ecosystems are in decline. New transformational changes in governance are urgently required to cope with overfishing, pollution, global changes, and other drivers of degradation. Here we explore social, political, and ecological aspects of a transformation in governance of Chile's coastal marine resources, from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelcich S,Hughes TP,Olsson P,Folke C,Defeo O,Fernández M,Foale S,Gunderson LH,Rodríguez-Sickert C,Scheffer M,Steneck RS,Castilla JC

更新日期：2010-09-28 00:00:00

abstract：:The maytansinoid drug DM1 is 100- to 1000-fold more cytotoxic than anticancer drugs that are currently in clinical use. The immunoconjugate C242-DM1 was prepared by conjugating DM1 to the monoclonal antibody C242, which recognizes a mucin-type glycoprotein expressed to various extents by human colorectal cancers. C242...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Tadayoni BM,Bourret LA,Mattocks KM,Derr SM,Widdison WC,Kedersha NL,Ariniello PD,Goldmacher VS,Lambert JM,Blättler WA,Chari RV

更新日期：1996-08-06 00:00:00

abstract：:The O(2)-reaction chemistry of 1:1 mixtures of (F(8))Fe(II) (1; F(8) = tetrakis(2,6-diflurorophenyl)porphyrinate) and [(L(Me(2))N)Cu(I)](+) (2; L(Me(2))N = N,N-bis(2-[2-(N',N'-4-dimethylamino)pyridyl]ethyl)methylamine) is described, to model aspects of the chemistry occurring in cytochrome c oxidase. Spectroscopic inv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim E,Helton ME,Wasser IM,Karlin KD,Lu S,Huang HW,Moenne-Loccoz P,Incarvito CD,Rheingold AL,Honecker M,Kaderli S,Zuberbuhler AD

更新日期：2003-04-01 00:00:00

abstract：:Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel gene, cause chromosome 7-linked LQT. Heterologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanguinetti MC,Curran ME,Spector PS,Keating MT

更新日期：1996-03-05 00:00:00

abstract：:Feasting is one of humanity's most universal and unique social behaviors. Although evidence for feasting is common in the early agricultural societies of the Neolithic, evidence in pre-Neolithic contexts is more elusive. We found clear evidence for feasting on wild cattle and tortoises at Hilazon Tachtit cave, a Late ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munro ND,Grosman L

更新日期：2010-08-31 00:00:00

abstract：:Although the mechanisms of anterior-posterior axis formation are well understood in Drosophila, both embryological and molecular studies suggest significant variation in the mechanisms generating this axis within the Insecta class as a whole. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel NH

更新日期：2000-04-25 00:00:00

abstract：:Nuclear factor kappaB (NF-kappaB) transcription factors regulate genes responsible for critical cellular processes. IkappaBalpha, -beta, and -epsilon bind to NF-kappaBs and inhibit their transcriptional activity. The NF-kappaB-binding domains of IkappaBs contain six ankyrin repeats (ARs), which adopt a beta-hairpin/al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Truhlar SM,Torpey JW,Komives EA

更新日期：2006-12-12 00:00:00

abstract：:Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. Isoform-specific differences have been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strittmatter WJ,Roses AD

更新日期：1995-05-23 00:00:00

abstract：:A recombinant plasmid containing a DNA segment complementary to rat liver albumin mRNA has been constructed, cloned, and used to examine the organization of albumin gene. The 18S fraction of total liver poly(A)-containing RNA was copied into a double-stranded cDNA by avian myeloblastosis virus reverse transcriptase an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kioussis D,Hamilton R,Hanson RW,Tilghman SM,Taylor JM

更新日期：1979-09-01 00:00:00

abstract：:Untargeted metabolomics of environmental samples routinely detects thousands of small molecules, the vast majority of which cannot be identified. Meta-mass shift chemical (MeMSChem) profiling was developed to identify mass differences between related molecules using molecular networks. This approach illuminates metabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartmann AC,Petras D,Quinn RA,Protsyuk I,Archer FI,Ransome E,Williams GJ,Bailey BA,Vermeij MJA,Alexandrov T,Dorrestein PC,Rohwer FL

更新日期：2017-10-31 00:00:00

abstract：:The AML1 gene, located on chromosome 21, is involved in several distinct chromosomal translocations in human leukemia. In t(8;21) acute myelogenous leukemia (AML), the AML1 gene is juxtaposed to the ETO gene located on chromosome 8, generating an AML1/ETO fusion protein. Both AML1/ETO and the AML1 proteins recognize t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klampfer L,Zhang J,Zelenetz AO,Uchida H,Nimer SD

更新日期：1996-11-26 00:00:00

abstract：:Type IV pili (Tfp), which are key virulence factors in many bacterial pathogens, define a large group of multipurpose filamentous nanomachines widespread in Bacteria and Archaea. Tfp biogenesis is a complex multistep process, which relies on macromolecular assemblies composed of 15 conserved proteins in model gram-neg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goosens VJ,Busch A,Georgiadou M,Castagnini M,Forest KT,Waksman G,Pelicic V

更新日期：2017-06-20 00:00:00

abstract：:A pluripotent cell line, C3H10T1/2, is induced to undergo adipogenesis by a mixture of factors that includes a glucocorticoid such as dexamethasone. We found that expression of myostatin (MSTN), a TGF-beta family member extensively studied in muscle, was induced by dexamethasone under those differentiation conditions....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman BJ,Streeper RS,Farese RV Jr,Yamamoto KR

更新日期：2006-10-17 00:00:00

abstract：:Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to immune-dependent and conventional therapeutic modalities. As a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50% of the brain tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Miska J,Lee-Chang C,Rashidi A,Panek WK,An S,Zannikou M,Lopez-Rosas A,Han Y,Xiao T,Pituch KC,Kanojia D,Balyasnikova IV,Lesniak MS

更新日期：2019-11-19 00:00:00

abstract：:Myosin V, a double-headed molecular motor, transports organelles within cells by walking processively along actin, a process that requires coordination between the heads. To understand the mechanism underlying this coordination, processive runs of single myosin V molecules were perturbed by varying nucleotide content....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baker JE,Krementsova EB,Kennedy GG,Armstrong A,Trybus KM,Warshaw DM

更新日期：2004-04-13 00:00:00

abstract：:In the manufacture of chemical feedstocks and subsequent processing into derivatives and materials, the U.S. chemical industry sets the current standard of excellence for technological competitiveness. This world-class leadership is attributed to the innovation and advancement of chemical engineering process technolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell JW

更新日期：1992-02-01 00:00:00

abstract：:Alveolar type II (AT2) cell dysfunction contributes to a number of significant human pathologies including respiratory distress syndrome, lung adenocarcinoma, and debilitating fibrotic diseases, but the critical transcription factors that maintain AT2 cell identity are unknown. Here we show that the E26 transformation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Newton K,Kummerfeld SK,Webster J,Kirkpatrick DS,Phu L,Eastham-Anderson J,Liu J,Lee WP,Wu J,Li H,Junttila MR,Dixit VM

更新日期：2017-04-11 00:00:00

abstract：:Low phosphate (Pi) availability constrains plant development and seed production in both natural and agricultural ecosystems. When Pi is scarce, modifications of root system architecture (RSA) enhance the soil exploration ability of the plant and lead to an increase in Pi uptake. In Arabidopsis, an iron-dependent mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mora-Macías J,Ojeda-Rivera JO,Gutiérrez-Alanís D,Yong-Villalobos L,Oropeza-Aburto A,Raya-González J,Jiménez-Domínguez G,Chávez-Calvillo G,Rellán-Álvarez R,Herrera-Estrella L

更新日期：2017-04-25 00:00:00

abstract：:We have cloned and identified a DNA sequence complementary to the mRNA of creatine kinase (CK) isozyme M, although the mRNA is a minor species of the total mRNA in developing myoblasts. Poly(A)+RNA from breast and thigh muscle of 5-week-old chicks was enriched for CK mRNA by a novel procedure of sucrose gradient centr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweinfest CW,Kwiatkowski RW,Dottin RP

更新日期：1982-08-01 00:00:00

abstract：:Efficient single nucleotide polymorphism (SNP) genotyping methods are necessary to accomplish many current gene discovery goals. A crucial element in large-scale SNP genotyping is the number of individual biochemical reactions that must be performed. An efficient method that can be used to simultaneously amplify a set...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan B,Charest A,Dowd JF,Blumenstiel JP,Yeh Rf RF,Osman A,Housman DE,Landers JE

更新日期：2002-03-05 00:00:00

abstract：:We examined the distributions of short tandemly repeated DNAs (microsatellites) in nine complete microbial genomes (Saccharomyces cerevisiae, Archaeoglobus fulgidus, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Methanococcus jannaschii, Mycoplasma pneumoniae, M. genitalium, and Synechocystis PCC6803....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Field D,Wills C

更新日期：1998-02-17 00:00:00

abstract：:Magnetotactic bacteria synthesize highly uniform intracellular magnetite nanoparticles through the action of several key biomineralization proteins. These proteins are present in a unique lipid-bound organelle (the magnetosome) that functions as a nanosized reactor in which the particle is formed. A master regulator p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawlings AE,Bramble JP,Walker R,Bain J,Galloway JM,Staniland SS

更新日期：2014-11-11 00:00:00

abstract：:We obtain a general connection between a large quantum advantage in communication complexity and Bell nonlocality. We show that given any protocol offering a sufficiently large quantum advantage in communication complexity, there exists a way of obtaining measurement statistics that violate some Bell inequality. Our m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buhrman H,Czekaj Ł,Grudka A,Horodecki M,Horodecki P,Markiewicz M,Speelman F,Strelchuk S

更新日期：2016-03-22 00:00:00