DNA sequence of the lactose operon: the lacA gene and the transcriptional termination region.

abstract：:U2 snRNP auxiliary factor 65 kDa (U2AF(65)) is a general splicing factor that contacts polypyrimidine (Py) tract and promotes prespliceosome assembly. In this report, we show that U2AF(65) stimulates alternative exon skipping in spinal muscular atrophy (SMA)-related survival motor neuron (SMN) pre-mRNA. A stronger 5' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho S,Moon H,Loh TJ,Jang HN,Liu Y,Zhou J,Ohn T,Zheng X,Shen H

更新日期：2015-08-11 00:00:00

abstract：:We compared folding properties of designed protein Top7 and natural protein S6 by using coarse-grained chain models with a mainly native-centric construct that accounted also for nonnative hydrophobic interactions and desolvation barriers. Top7 and S6 have similar secondary structure elements and are approximately equ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Chan HS

更新日期：2010-02-16 00:00:00

abstract：:Interpretation of empirical results based on a taxa's lifetime distribution shows apparently conflicting results. Species' lifetime is reported to be exponentially distributed, whereas higher-order taxa, such as families or genera, follow a broader distribution, compatible with power-law decay. We show that both forms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pigolotti S,Flammini A,Marsili M,Maritan A

更新日期：2005-11-01 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:Disruption of the nucleotide excision repair (NER) pathway by mutations can cause xeroderma pigmentosum, a syndrome predisposing affected individuals to development of skin cancer. The xeroderma pigmentosum C (XPC) protein is essential for initiating global genome NER by recognizing the DNA lesion and recruiting downs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ming M,Shea CR,Guo X,Li X,Soltani K,Han W,He YY

更新日期：2010-12-28 00:00:00

abstract：:Obesity is associated with increased risk for developing pancreatic cancer, and it is suggested that insulin resistance provides the missing link. Here we demonstrate that under the context of genetic susceptibility, a high fat diet (HFD) predisposes mice with oncogenic K-ras activation to accelerated pancreatic intra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khasawneh J,Schulz MD,Walch A,Rozman J,Hrabe de Angelis M,Klingenspor M,Buck A,Schwaiger M,Saur D,Schmid RM,Klöppel G,Sipos B,Greten FR,Arkan MC

更新日期：2009-03-03 00:00:00

abstract：:Research on global patterns of diversity has been dominated by studies seeking explanations for the equator-to-poles decline in richness of most groups of organisms, namely the latitudinal diversity gradient. A problem with this gradient is that it conflates two key explanations, namely biome stability (age and area) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colville JF,Beale CM,Forest F,Altwegg R,Huntley B,Cowling RM

更新日期：2020-08-18 00:00:00

abstract：:The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimulating activity. We have raised rabbit antisera to a bacterially synthe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeClue JE,Cohen BD,Lowy DR

更新日期：1991-11-15 00:00:00

abstract：:A chimeric transforming growth factor beta (TGF-beta) molecule has been synthesized to map the amino acids responsible for the substantially greater activity of TGF-beta 1 than TGF-beta 2 on growth and migration of endothelial cells. This chimera consists of a dimer of a monomeric unit composed of amino acids 1-39 of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian SW,Burmester JK,Merwin JR,Madri JA,Sporn MB,Roberts AB

更新日期：1992-07-15 00:00:00

abstract：:Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-1, miR-133 and miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao PK,Kumar RM,Farkhondeh M,Baskerville S,Lodish HF

更新日期：2006-06-06 00:00:00

abstract：:Structural symmetry is a hallmark of homomeric ion channels. Nonobligatory regulatory proteins can also critically define the precise functional role of such channels. For instance, the pore-forming subunit of the large conductance voltage and calcium-activated potassium (BK, Slo1, or KCa1.1) channels encoded by a sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Perez V,Ben Johny M,Xia XM,Lingle CJ

更新日期：2018-10-02 00:00:00

abstract：:DNA restriction fragments of the genes encoding HLA class II-beta antigens were compared in 34 patients with insulin-dependent diabetes mellitus and 34 HLA-DR-matched healthy individuals. Ninety-three fragments, determined by six restriction enzymes (EcoRI, EcoRV, HindIII, BamHI, Pvu II, and Taq I), were analyzed: (i)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen-Haguenauer O,Robbins E,Massart C,Busson M,Deschamps I,Hors J,Lalouel JM,Dausset J,Cohen D

更新日期：1985-05-01 00:00:00

abstract：:After primary infection, human cytomegalovirus (HCMV) persists as a life-long latent infection, with host immunosuppression often resulting in clinical reactivation. During lytic infection, major changes in the expression of secreted cellular proteins (the secretome) occur that have profound effects on host-cell inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason GM,Poole E,Sissons JG,Wills MR,Sinclair JH

更新日期：2012-09-04 00:00:00

abstract：:We find that histidine residues in proteins are major targets for reaction with the lipid peroxidation product 4-hydroxynon-2-enal (HNE). Reaction of insulin (which contains no sulfhydryl groups) with HNE leads to the generation of HNE-protein adducts, which are converted to radioactive derivatives upon subsequent tre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida K,Stadtman ER

更新日期：1992-05-15 00:00:00

abstract：:We present a mandible recovered in 2003 from the Aurora Stratum of the TD6 level of the Gran Dolina site (Sierra de Atapuerca, northern Spain). The specimen, catalogued as ATD6-96, adds to the hominin sample recovered from this site in 1994-1996, and assigned to Homo antecessor. ATD6-96 is the left half of a gracile m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carbonell E,Bermúdez de Castro JM,Arsuaga JL,Allue E,Bastir M,Benito A,Cáceres I,Canals T,Díez JC,van der Made J,Mosquera M,Ollé A,Pérez-González A,Rodríguez J,Rodríguez XP,Rosas A,Rosell J,Sala R,Vallverdú J,Vergés

更新日期：2005-04-19 00:00:00

abstract：:Laser-polarized gases (3He and 129Xe) are currently being used in magnetic resonance imaging as strong signal sources that can be safely introduced into the lung. Recently, researchers have been investigating other tissues using 129Xe. These studies use xenon dissolved in a carrier such as lipid vesicles or blood. Sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chawla MS,Chen XJ,Möller HE,Cofer GP,Wheeler CT,Hedlund LW,Johnson GA

更新日期：1998-09-01 00:00:00

abstract：:The importance of core histones in the regulation of DNA function by chromatin is clear. However, little is known about the role of the linker histone. We investigated the role of H1 in Saccharomyces cerevisiae during extensive transcriptional reprogramming in stationary phase. Although the levels of linker histone Hh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer G,McEvoy CR,Patterton HG

更新日期：2008-09-30 00:00:00

abstract：:Intrinsic horizontal axon collaterals in the striate cortex of adult cats specifically link columns having the same preferred orientation; consequently, retrograde tracer injections result in intrinsic labeling that is sharply clustered. We have previously shown that the normal development of this circuitry involves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callaway EM,Katz LC

更新日期：1991-02-01 00:00:00

abstract：:The role played by oligodendrocytes (OLs), the myelinating cells of the CNS, during brain development has not been fully explored. We have addressed this question by inducing a temporal and reversible ablation of OLs on postnatal CNS development. OL ablation in newborn mice leads to a profound alteration in the struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collin L,Usiello A,Erbs E,Mathis C,Borrelli E

更新日期：2004-01-06 00:00:00

abstract：:Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadkarni S,Smith J,Sferruzzi-Perri AN,Ledwozyw A,Kishore M,Haas R,Mauro C,Williams DJ,Farsky SH,Marelli-Berg FM,Perretti M

更新日期：2016-12-27 00:00:00

abstract：:In choanoflagellates, the closest living relatives of animals, multicellular rosette development is regulated by environmental bacteria. The simplicity of this evolutionarily relevant interaction provides an opportunity to identify the molecules and regulatory logic underpinning bacterial regulation of development. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woznica A,Cantley AM,Beemelmanns C,Freinkman E,Clardy J,King N

更新日期：2016-07-12 00:00:00

abstract：:We have investigated the differentiation potential of precursor cells within the developing spinal cord of mice and have shown that spinal cord cells from embryonic day 10 specifically give rise to neurons when plated onto an astrocytic monolayer, Ast-1. These neurons had the morphology of motor neurons and > 83% expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richards LJ,Murphy M,Dutton R,Kilpatrick TJ,Puche AC,Key B,Tan SS,Talman PS,Bartlett PF

更新日期：1995-10-24 00:00:00

abstract：:Development of spatial patterns in multicellular organisms depends on gradients in the concentration of signaling molecules that control gene expression. In the Drosophila embryo, Bicoid (Bcd) morphogen controls cell fate along 70% of the anteroposterior axis but is translated from mRNA localized at the anterior pole....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregor T,Bialek W,de Ruyter van Steveninck RR,Tank DW,Wieschaus EF

更新日期：2005-12-20 00:00:00

abstract：:Break-induced replication (BIR) refers to recombination-dependent DNA synthesis initiated from one end of a DNA double-strand break and can extend for more than 100 kb. BIR initiates by Rad51-catalyzed strand invasion, but the mechanism for DNA synthesis is not known. Here, we used BrdU incorporation to track DNA synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donnianni RA,Symington LS

更新日期：2013-08-13 00:00:00

abstract：:The recent development of HIV-1 lentiviral vectors is especially useful for gene transfer because they achieve efficient integration into nondividing cell genomes and successful long-term expression of the transgene. These attributes make the vector useful for gene delivery, mutagenesis, and other applications in mamm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Z,Han I,Park M,Brady RO

更新日期：2002-03-19 00:00:00

abstract：:This paper presents insights and action proposals to better harness technological innovation for sustainable development. We begin with three key insights from scholarship and practice. First, technological innovation processes do not follow a set sequence but rather emerge from complex adaptive systems involving many...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anadon LD,Chan G,Harley AG,Matus K,Moon S,Murthy SL,Clark WC

更新日期：2016-08-30 00:00:00

abstract：:Cerebellar granule cells grown in the presence of a serum complex differentiate but are resistant to the lethal action of excitatory amino acids. When these cells are grown also in the presence of insulin-like growth factor I (IGF-I) they become fully susceptible to the toxic, lethal action of glutamate. The glutamate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calissano P,Ciotti MT,Battistini L,Zona C,Angelini A,Merlo D,Mercanti D

更新日期：1993-09-15 00:00:00

abstract：:Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathesius U,Mulders S,Gao M,Teplitski M,Caetano-Anolles G,Rolfe BG,Bauer WD

更新日期：2003-02-04 00:00:00

abstract：:The sparking of cut grape hemispheres in a household microwave oven has been a poorly explained Internet parlor trick for over two decades. By expanding this phenomenon to whole spherical dimers of various grape-sized fruit and hydrogel water beads, we demonstrate that the formation of plasma is due to electromagnetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khattak HK,Bianucci P,Slepkov AD

更新日期：2019-03-05 00:00:00

abstract：:Islet transplantation offers a potential therapy to restore glucose homeostasis in type 1 diabetes patients. However, islet transplantation is not routinely successful because most islet recipients gradually lose graft function. Furthermore, serological markers of islet function are insensitive to islet loss until the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Y,Dang H,Middleton B,Zhang Z,Washburn L,Stout DB,Campbell-Thompson M,Atkinson MA,Phelps M,Gambhir SS,Tian J,Kaufman DL

更新日期：2006-07-25 00:00:00