A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

abstract：:An ability to safely harness the powerful regenerative potential of adult stem cells for clinical applications is critically dependent on a comprehensive understanding of the underlying mechanisms regulating their activity. Epithelial organoid cultures accurately recapitulate many features of in vivo stem cell-driven ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami K,Terakado Y,Saito K,Jomen Y,Takeda H,Oshima M,Barker N

更新日期：2021-01-26 00:00:00

abstract：:The membrane glycoproteins specified by herpes simplex virus are synthesized concurrently with structural viral proteins and accumulate in the cytoplasm and in the membranes lining it. Analyses of free and membranebound polyribosomes, the cytoplasmic pool of soluble proteins, and purified smooth membranes showed that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spear PG,Roizman B

更新日期：1970-07-01 00:00:00

abstract：:Before the origin of simple cellular life, the building blocks of RNA (nucleotides) had to form and polymerize in favorable environments on early Earth. At this time, meteorites and interplanetary dust particles delivered organics such as nucleobases (the characteristic molecules of nucleotides) to warm little ponds w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearce BKD,Pudritz RE,Semenov DA,Henning TK

更新日期：2017-10-24 00:00:00

abstract：:Dynamic coupling of blood supply with energy demand is a natural brain property that requires signaling between synapses and endothelial cells. Our previous work showed that cortical arteriole lumen diameter is regulated by N-methyl-d-aspartate receptors (NMDARs) expressed by brain endothelial cells. The purpose of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hogan-Cann AD,Lu P,Anderson CM

更新日期：2019-05-21 00:00:00

abstract：:Protein phosphatase 2C (PP2C) is a class of ubiquitous and evolutionarily conserved serine/threonine PP involved in stress responses in yeasts, mammals, and plants. Here, I present mutational analysis of two Arabidopsis thaliana PP2Cs, encoded by ABI1 and AtPP2C, involved in the plant stress hormone abscisic acid (ABA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheen J

更新日期：1998-02-03 00:00:00

abstract：:Progress toward understanding the biology of prostate cancer has been slow due to the few animal research models available to study the spectrum of this uniquely human disease. To develop an animal model for prostate cancer, several lines of transgenic mice were generated by using the prostate-specific rat probasin pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenberg NM,DeMayo F,Finegold MJ,Medina D,Tilley WD,Aspinall JO,Cunha GR,Donjacour AA,Matusik RJ,Rosen JM

更新日期：1995-04-11 00:00:00

abstract：:Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shim AH,Liu H,Focia PJ,Chen X,Lin PC,He X

更新日期：2010-06-22 00:00:00

abstract：:Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death. The majority of affected individuals harbor a loss-of-function mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richards KL,Milligan CJ,Richardson RJ,Jancovski N,Grunnet M,Jacobson LH,Undheim EAB,Mobli M,Chow CY,Herzig V,Csoti A,Panyi G,Reid CA,King GF,Petrou S

更新日期：2018-08-21 00:00:00

abstract：:The recognition of carrier proteins by multiple catalytic partners occurs in every cycle of chain elongation in the biosynthesis of fatty acids and of the pharmacologically important polyketide and nonribosomal peptide natural products. To dissect the features of carrier proteins that determine specific recognition at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Z,Lai JR,Walsh CT

更新日期：2007-07-10 00:00:00

abstract：:Pore-forming toxins (PFTs) are a class of proteins implicated in a wide range of virulent bacterial infections and diseases. These toxins bind to target membranes and subsequently oligomerize to form functional pores that eventually lead to cell lysis. While the protein undergoes large conformational changes on the bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ponmalar II,Cheerla R,Ayappa KG,Basu JK

更新日期：2019-06-25 00:00:00

abstract：:Obesity affects over 2 billion people worldwide and is accompanied by peripheral neuropathy (PN) and an associated poorer quality of life. Despite high prevalence, the molecular mechanisms underlying the painful manifestations of PN are poorly understood, and therapies are restricted to use of painkillers or other dru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonomo RR,Cook TM,Gavini CK,White CR,Jones JR,Bovo E,Zima AV,Brown IA,Dugas LR,Zakharian E,Aubert G,Alonzo F 3rd,Calcutt NA,Mansuy-Aubert V

更新日期：2020-10-20 00:00:00

abstract：:Selective lodgement or homing of transplanted hemopoietic stem cells in the recipient's bone marrow (BM) is a critical step in the establishment of long-term hemopoiesis after BM transplantation. However, despite its biologic and clinical significance, little is understood about the process of homing. In the present s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papayannopoulou T,Craddock C,Nakamoto B,Priestley GV,Wolf NS

更新日期：1995-10-10 00:00:00

abstract：:The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is removed from cullins by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein G,Ganoth D,Hershko A

更新日期：2006-08-01 00:00:00

abstract：:Loss or reduction in function of tumor suppressor genes contributes to tumorigenesis. Here, by allelic DNA copy number analysis using single-nucleotide polymorphism genotyping array and mass spectrometry, we report homozygous deletion in glioblastoma multiformes at chromosome 13q21, where DACH1 gene is located. We fou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe A,Ogiwara H,Ehata S,Mukasa A,Ishikawa S,Maeda D,Ueki K,Ino Y,Todo T,Yamada Y,Fukayama M,Saito N,Miyazono K,Aburatani H

更新日期：2011-07-26 00:00:00

abstract：:A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salerno W,Havlak P,Miller J

更新日期：2006-08-29 00:00:00

abstract：:A hitherto unknown Neoproterozoic orogenic system, the Saharides, is described in North Africa. It formed during the 900-500-Ma interval. The Saharides involved large subduction accretion complexes occupying almost the entire Arabian Shield and much of Egypt and parts of the small Precambrian inliers in the Sahara inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Şengör AMC,Lom N,Zabcı C,Sunal G,Öner T

更新日期：2020-12-22 00:00:00

abstract：:Synaptic transmission depends on the continued availability of neurotransmitter-filled synaptic vesicles (SVs) for triggered release from presynaptic boutons. Surprisingly, small boutons in the brain, that already contain comparatively few SVs, are thought to retain the majority of these SVs in a "reserve" pool that i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikeda K,Bekkers JM

更新日期：2009-02-24 00:00:00

abstract：:High-throughput biological data, whether generated as sequencing, transcriptional microarrays, proteomic, or other means, continues to require analytic methods that address its high dimensional aspects. Because the computational part of data analysis ultimately identifies shape characteristics in the organization of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicolau M,Levine AJ,Carlsson G

更新日期：2011-04-26 00:00:00

abstract：:We have isolated a lymphoid cell line, MDS, from the pleural exudate of a patient with chronic myelomonocytic leukemia. The cells are biphenotypic, containing various T-cell and myeloid markers, and are surface negative for CD4 and CD8 but have low CD4 mRNA. The cells grow in suspension with a doubling time of 15 hr, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee R,Bekesi JG,Tarcsafalvi A,Sperber K,Deak G,Choi HS,Paronetto F,Holland JF,Acs G

更新日期：1992-11-01 00:00:00

abstract：:The relationship between performance and ability is a central concern in the social sciences: Are the most successful much more able than others, and are failures unskilled? Prior research has shown that noise and self-reinforcing dynamics make performance unpredictable and lead to a weak association between ability a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denrell J,Liu C

更新日期：2012-06-12 00:00:00

abstract：:We have cloned one of the two human alpha-globin genes and report its complete nucleotide sequence. The gene is 832 base pairs (bp) long from the 5'-cap site to the 3'-polyadenylylation site. The amino acid coding sequences are separated into three segments (exons) by two short (117 and 140 bp) intervening sequences. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liebhaber SA,Goossens MJ,Kan YW

更新日期：1980-12-01 00:00:00

abstract：:Free gangliosides bind fibroblast growth factor 2 (FGF2), thus preventing cell interaction and biological activity of the growth factor in endothelial cells. Here we investigated the role of cell-associated gangliosides in mediating the biological activity of FGF2. Treatment of endothelial cells of different origin wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rusnati M,Urbinati C,Tanghetti E,Dell'Era P,Lortat-Jacob H,Presta M

更新日期：2002-04-02 00:00:00

abstract：:In skeletal muscle, transcription of the gene encoding the mouse type Ialpha (RIalpha) subunit of the cAMP-dependent protein kinase is initiated from the alternative noncoding first exons 1a and 1b. Here, we report that activity of the promoter upstream of exon 1a (Pa) depends on two adjacent E boxes (E1 and E2) in NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barradeau S,Imaizumi-Scherrer T,Weiss MC,Faust DM

更新日期：2001-04-24 00:00:00

abstract：:Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodson BM,Song Y,Taylor RE,Schepkin VD,Brennan KM,Chingas GC,Budinger TF,Navon G,Pines A

更新日期：1997-12-23 00:00:00

abstract：:A panel of 20 recombinant Fab fragments reactive with the surface glycoprotein gp120 of human type 1 immunodeficiency virus (HIV-1) were examined for their ability to neutralize MN and IIIB strains of the virus. Neutralization was determined as the ability of the Fab fragments to inhibit infection as measured in both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbas CF 3rd,Björling E,Chiodi F,Dunlop N,Cababa D,Jones TM,Zebedee SL,Persson MA,Nara PL,Norrby E

更新日期：1992-10-01 00:00:00

abstract：:Seasonal epidemics and periodic worldwide pandemics caused by influenza A viruses are of continuous concern. The viral nonstructural (NS1) protein is a multifunctional virulence factor that antagonizes several host innate immune defenses during infection. NS1 also directly stimulates class IA phosphoinositide 3-kinase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hale BG,Kerry PS,Jackson D,Precious BL,Gray A,Killip MJ,Randall RE,Russell RJ

更新日期：2010-02-02 00:00:00

abstract：:Multiple paleoclimate proxies are required for robust assessment of past hydroclimatic conditions. Currently, estimates of drought variability over the past several thousand years are based largely on tree-ring records. We produced a 1,500-y record of winter precipitation in the Pacific Northwest using a physical mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinman BA,Abbott MB,Mann ME,Stansell ND,Finney BP

更新日期：2012-07-17 00:00:00

abstract：:Microorganisms must sense their environment and rapidly tune their metabolism to ambient conditions to efficiently use available resources. We have identified a gene encoding a response regulator, NblR, that complements a cyanobacterial mutant unable to degrade its light-harvesting complex (phycobilisome), in response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwarz R,Grossman AR

更新日期：1998-09-01 00:00:00

abstract：:Blot hybridization analysis that used labeled tubulin cDNA probes revealed that N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate [dibutyryl cyclic AMP (Bt2cAMP)] initially increases and later decreases the level of tubulin mRNA in a neuroblastoma-glioma hybrid cell line as well as in the parent cells. A significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ginzburg I,Rybak S,Kimhi Y,Littauer UZ

更新日期：1983-07-01 00:00:00

abstract：:The conditional lifetime expectancy function (LEF) is the expected lifetime of a subject given survival past a certain time point and the values of a set of explanatory variables. This function is attractive to researchers because it summarizes the entire residual life distribution and has an easy interpretation compa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong J,Klein BE,Klein R,Wahba G

更新日期：2015-09-29 00:00:00