Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.

abstract：:Daytime sleepiness impairs cognitive ability, but recent evidence suggests it is also an important driver of human motivation and behavior. We aimed to investigate the relationship between sleepiness and a behavior strongly associated with better health: social activity. We additionally aimed to investigate whether a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holding BC,Sundelin T,Schiller H,Åkerstedt T,Kecklund G,Axelsson J

更新日期：2020-09-01 00:00:00

abstract：:The AAA-ATPase thyroid hormone receptor interacting protein 13 (TRIP13), jointly with the Mad2-binding protein p31(comet), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC). This checkpoint system ensures the accuracy of chromosome segregation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miniowitz-Shemtov S,Eytan E,Kaisari S,Sitry-Shevah D,Hershko A

更新日期：2015-09-15 00:00:00

abstract：:Natural products have long served as both a source and inspiration for pharmaceuticals. Modifying the structure of a natural product often improves the biological activity of the compound. Metabolic engineering strategies to ferment "unnatural" products have been enormously successful in microbial organisms. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Runguphan W,Maresh JJ,O'Connor SE

更新日期：2009-08-18 00:00:00

abstract：:In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubin AS,Coons AH

更新日期：1971-08-01 00:00:00

abstract：:There is currently an unmet need for versatile techniques to monitor the assembly and dynamics of ternary complexes in live cells. Here we describe bioluminescence resonance energy transfer with fluorescence enhancement by combined transfer (BRETFect), a high-throughput technique that enables robust spectrometric dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cotnoir-White D,El Ezzy M,Boulay PL,Rozendaal M,Bouvier M,Gagnon E,Mader S

更新日期：2018-03-13 00:00:00

abstract：:Gecko and many insects have adopted nanoscale fibrillar structures on their feet as adhesion devices. Here, we consider adhesion between a single fiber and a substrate by van der Waals or electrostatic interactions. For a given contact area A, the theoretical pull-off force of the fiber is sigma(th)A where sigma(th) i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao H,Yao H

更新日期：2004-05-25 00:00:00

abstract：:The yeast SIN1 protein is a nuclear protein that together with other proteins behaves as a transcriptional repressor of a family of genes. In addition, sin1 mutants are defective in proper mitotic chromosome segregation. In an effort to understand the basis for these phenotypes, we employed the yeast two-hybrid system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shpungin S,Liberzon A,Bangio H,Yona E,Katcoff DJ

更新日期：1996-08-06 00:00:00

abstract：:Adult human brains retain the capacity to undergo tissue reorganization during second-language learning. Brain-imaging studies show a relationship between neuroanatomical properties and learning for adults exposed to a second language. However, the role of genetic factors in this relationship has not been investigated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mamiya PC,Richards TL,Coe BP,Eichler EE,Kuhl PK

更新日期：2016-06-28 00:00:00

abstract：:When encountering unexpected event changes, memories of relevant past experiences must be updated to form new representations. Current models of memory updating propose that people must first generate memory-based predictions to detect and register that features of the environment have changed, then encode the new eve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stawarczyk D,Wahlheim CN,Etzel JA,Snyder AZ,Zacks JM

更新日期：2020-11-24 00:00:00

abstract：:Genomic RNA from the human prototype strain H of the hepatitis C virus (HCV-H) has been molecularly cloned and sequenced. The HCV-H sequence reported consists of 9416 nucleotides including the 5' and 3' untranslated regions. HCV-H shows 96% amino acid identity with the American isolate HCV-1 but only 84.9% with the Ja...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inchauspe G,Zebedee S,Lee DH,Sugitani M,Nasoff M,Prince AM

更新日期：1991-11-15 00:00:00

abstract：:Temporal integration in visual perception is thought to occur within cycles of occipital alpha-band (8-12 Hz) oscillations. Successive stimuli may be integrated when they fall within the same alpha cycle and segregated for different alpha cycles. Consequently, the speed of alpha oscillations correlates with the tempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wutz A,Melcher D,Samaha J

更新日期：2018-02-06 00:00:00

abstract：:Variation in the multiplication rate of blood stage malaria parasites is often positively correlated with the severity of the disease they cause. The rodent malaria parasite Plasmodium yoelii yoelii has strains with marked differences in multiplication rate and pathogenicity in the blood. We have used genetic analysis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pattaradilokrat S,Culleton RL,Cheesman SJ,Carter R

更新日期：2009-04-28 00:00:00

abstract：:Optimal infectivity of HIV-1 virions requires synthesis of the HIV-1 regulatory protein Nef in some producer cells but not others. A survey of 18 lymphoid cell lines found that Nef was dispensable in three, each of which harbored gammaretroviruses. Nef-dependent cell lines were rendered Nef-independent by a cell-free ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pizzato M

更新日期：2010-05-18 00:00:00

abstract：:We have shown that cellular inhibitor of apoptosis proteins (cIAPs) impair clearance of hepatitis B virus (HBV) infection by preventing TNF-mediated killing/death of infected cells. A key question, with profound therapeutic implications, is whether this finding can be translated to the development of drugs that promot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ebert G,Allison C,Preston S,Cooney J,Toe JG,Stutz MD,Ojaimi S,Baschuk N,Nachbur U,Torresi J,Silke J,Begley CG,Pellegrini M

更新日期：2015-05-05 00:00:00

abstract：:Id2 is a natural inhibitor of the basic helix-loop-helix transcription factors and the retinoblastoma tumor suppressor protein. Active Id2 prevents differentiation and promotes cell-cycle progression and tumorigenesis in the nervous system. A key event that regulates Id2 activity during differentiation is translocatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lasorella A,Iavarone A

更新日期：2006-03-28 00:00:00

abstract：:An unprecedented, spontaneous, and complete cleavage of the triple bond of N2 in the thermal reaction of 15N2 with Ta214N+ was observed experimentally by Fourier transform ion cyclotron resonance mass spectrometry; mechanistic aspects of the degenerate ligand exchange were addressed by high-level quantum chemical calc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geng C,Li J,Weiske T,Schwarz H

更新日期：2019-10-22 00:00:00

abstract：:Seemingly similar individuals often experience drastically different success trajectories, with some repeatedly failing and others consistently succeeding. One explanation is preexisting variability along unobserved fitness dimensions that is revealed gradually through differential achievement. Alternatively, positive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van de Rijt A,Kang SM,Restivo M,Patil A

更新日期：2014-05-13 00:00:00

abstract：:In photosynthetic systems, the absorbed light energy is used to generate electron transport or it is lost in the form of fluorescence and thermal emission. While fluorescence can be readily measured, the detection of thermal deactivation processes can be achieved by the photoacoustic technique. In that case, the press...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allakhverdiev SI,Klimov VV,Carpentier R

更新日期：1994-01-04 00:00:00

abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

更新日期：1995-09-12 00:00:00

abstract：:CDK7 is a cyclin-dependent kinase proposed to function in two essential cellular processes: transcription and cell cycle regulation. CDK7 is the kinase subunit of the general transcription factor TFIIH that phosphorylates the C-terminal domain (CTD) of RNA polymerase II, and has been shown to be broadly required for t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallenfang MR,Seydoux G

更新日期：2002-04-16 00:00:00

abstract：:A sensitive assay for detection of eukaryotic RNA polymerase II has been developed. This assay depends on the ability of polymerase II to elongate a small RNA primer, oligo(U), hybridized to a single-stranded homopolymeric DNA template, poly(dA). The poly(dA).oligo(U)-dependent RNA polymerase II from calf thymus has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fradkin LG,Leong K,Morrow CD,Berk AJ,Dasgupta A

更新日期：1985-12-01 00:00:00

abstract：:If X(1), X(2),... are independent random variables with zero expectation and finite variances, the cumulative sums S(n) are, on the average, of the order of magnitude S(n), where S(n) (2) = E(S(n) (2)). The occasional maxima of the ratios S(n)/S(n) are surprisingly large and the problem is to estimate the extent of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feller W

更新日期：1969-07-01 00:00:00

abstract：:The environmental topology of complex structures is used by Escherichia coli to create traveling waves of high cell density, a prelude to quorum sensing. When cells are grown to a moderate density within a confining microenvironment, these traveling waves of cell density allow the cells to find and collapse into confi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Wolanin PM,Yuzbashyan EA,Lin H,Darnton NC,Stock JB,Silberzan P,Austin R

更新日期：2003-11-25 00:00:00

abstract：:Plasmids have been constructed to generate substrates for the study of proteinases 2A and 3C of poliovirus. They contain the P1 (capsomer precursor) region of the poliovirus genome or P1 and part of P2 (a nonstructural precursor), which can be transcribed and translated in vitro. A transcript containing the entire 5' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicklin MJ,Kräusslich HG,Toyoda H,Dunn JJ,Wimmer E

更新日期：1987-06-01 00:00:00

abstract：:A stable complex between pentaammineruthenium(III) and histidine-33 in horse heart ferricytochrome c is formed in the reaction between aquopentaammineruthenium(II) and the protein at pH 7. HPLC of the tryptic hydrolysate of the modified protein was employed to identify the pentaammineruthenium binding site. Spectrosco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yocom KM,Shelton JB,Shelton JR,Schroeder WA,Worosila G,Isied SS,Bordignon E,Gray HB

更新日期：1982-11-01 00:00:00

abstract：:Compartmentalization of biomolecules within lipid membranes is a fundamental requirement of living systems and an essential feature of many pharmaceutical therapies. However, applications of membrane-enclosed solutions of proteins, DNA, and other biologically active compounds have been limited by the difficulty of for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stachowiak JC,Richmond DL,Li TH,Liu AP,Parekh SH,Fletcher DA

更新日期：2008-03-25 00:00:00

abstract：:How do firing patterns in a cortical circuit change when inhibitory neurons are excited? We virally expressed an excitatory designer receptor exclusively activated by a designer drug (Gq-DREADD) in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. While clozapine N-oxide (CNO) activatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers S,Rozman PA,Valero M,Doyle WK,Buzsáki G

更新日期：2021-01-12 00:00:00

abstract：:The E6 oncoprotein of human papillomaviruses (HPVs) that are associated with cervical cancer utilizes the cellular ubiquitin-protein ligase E6-AP to target the tumor suppressor p53 for degradation. In normal cells (i.e., in the absence of E6), p53 is also a target of the ubiquitin-proteasome pathway. Under these condi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hengstermann A,Linares LK,Ciechanover A,Whitaker NJ,Scheffner M

更新日期：2001-01-30 00:00:00

abstract：:TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53-/-) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also functions as a Ral ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awasthi S,Tompkins J,Singhal J,Riggs AD,Yadav S,Wu X,Singh S,Warden C,Liu Z,Wang J,Slavin TP,Weitzel JN,Yuan YC,Awasthi M,Srivastava SK,Awasthi YC,Singhal SS

更新日期：2018-04-10 00:00:00

abstract：:The distribution of dopamine-containing processes in the striatum of fetal and neonatal cats was studied by immunohistochemical and glyoxylic acid histofluorescence methods and compared to the distribution of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) observed by thiocholine histochemistry in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graybiel AM,Pickel VM,Joh TH,Reis DJ,Ragsdale CW Jr

更新日期：1981-09-01 00:00:00