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Temperature-sensitive mutations in Drosophila melanogaster. V. A mutation affecting concentrations of pteridines.

Abstract：

:A temperature-sensitive ras allele has an effective lethal phase at 29 degrees C about 12 hr after pupation and a temperature-sensitive period for lethality beginning midway through the third larval instar and ending around pupation. The mutation also alters the quantity of pteridines present in the eyes, testes, and Malpighian tubules at 29 degrees C. The temperature-sensitive period for pigment production in the Malpighian tubules occurs in the egg and first instar larvae, and in eyes and testes after pupation. The demonstrated autonomy of the mutant in the eyes implies the tissue-specific functioning of the gene. We suggest that the different temperature-sensitive periods for a single mutation indicate tissue-specific activation of a gene at different times during development, although the possibility of activation of preformed polypeptides has not been eliminated.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Grigliatti T,Suzuki DT

doi

10.1073/pnas.67.3.1101

subject

Has Abstract

pub_date

1970-11-01 00:00:00

pages

1101-8

issue

3

eissn

0027-8424

issn

1091-6490

journal_volume

67

pub_type

杂志文章

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