Abstract:
:The high frequency, recent origin, and geographic distribution of the CCR5-Delta 32 deletion allele together indicate that it has been intensely selected in Europe. Although the allele confers resistance against HIV-1, HIV has not existed in the human population long enough to account for this selective pressure. The prevailing hypothesis is that the selective rise of CCR5-Delta 32 to its current frequency can be attributed to bubonic plague. By using a population genetic framework that takes into account the temporal pattern and age-dependent nature of specific diseases, we find that smallpox is more consistent with this historical role.
journal_name
Proc Natl Acad Sci U S Aauthors
Galvani AP,Slatkin Mdoi
10.1073/pnas.2435085100keywords:
subject
Has Abstractpub_date
2003-12-09 00:00:00pages
15276-9issue
25eissn
0027-8424issn
1091-6490pii
2435085100journal_volume
100pub_type
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