Reversal of DNA alkylation damage by two human dioxygenases.

abstract：:The rat brain increases >6x in mass from birth to adulthood, presumably through the addition of glial cells and increasing neuronal size, without the addition of neurons. To test this hypothesis, here we investigate quantitatively the postnatal changes in the total number of neuronal and non-neuronal cells in the deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bandeira F,Lent R,Herculano-Houzel S

更新日期：2009-08-18 00:00:00

abstract：:Watching someone scratch himself can induce feelings of itchiness in the perceiver. This provides a unique opportunity to characterize the neural basis of subjective experiences of itch, independent of changes in peripheral inputs. In this study, we first established that the social contagion of itch is essentially a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holle H,Warne K,Seth AK,Critchley HD,Ward J

更新日期：2012-11-27 00:00:00

abstract：:Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Zhu L,Dang M,Hu Z,Gao Q,Yuan S,Sun Y,Zhang B,Ren J,Kotecha A,Walter TS,Wang J,Fry EE,Stuart DI,Rao Z

更新日期：2017-01-24 00:00:00

abstract：:Escherichia coli phage N4 transcription is resistant to rifampicin, an inhibitor of the host RNA polymerase, even when the drug is added prior to infection. A rifampicin-resistant RNA polymerase has been detected in disrupted N4 virions. This enzyme shows a requirement for the four ribonucleoside 5'-triphosphates and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falco SC,Laan KV,Rothman-Denes LB

更新日期：1977-02-01 00:00:00

abstract：:Artificial two-dimensional biological habitats were prepared from porous polymer layers and inoculated with the fungus Penicillium roqueforti to provide a living material. Such composites of classical industrial ingredients and living microorganisms can provide a novel form of functional or smart materials with capabi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber LC,Koehler FM,Grass RN,Stark WJ

更新日期：2012-01-03 00:00:00

abstract：:We have studied the properties of r-eag voltage-activated potassium channels in a stably transfected human embryonic kidney cell line. It was found that r-eag channels are rapidly and reversibly inhibited by a rise in intracellular calcium from 30 to 300 nM. The inhibition does not appear to depend on the activity of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stansfeld CE,Röper J,Ludwig J,Weseloh RM,Marsh SJ,Brown DA,Pongs O

更新日期：1996-09-03 00:00:00

abstract：:Several Bradyrhizobium species nodulate the leguminous plant Aeschynomene indica in a type III secretion system-dependent manner, independently of Nod factors. To date, the underlying molecular determinants involved in this symbiotic process remain unknown. To identify the rhizobial effectors involved in nodulation, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teulet A,Busset N,Fardoux J,Gully D,Chaintreuil C,Cartieaux F,Jauneau A,Comorge V,Okazaki S,Kaneko T,Gressent F,Nouwen N,Arrighi JF,Koebnik R,Mergaert P,Deslandes L,Giraud E

更新日期：2019-10-22 00:00:00

abstract：:Synapsin I is a neuron-specific phosphoprotein associated with the membranes of small synaptic vesicles. Its function is not entirely clear, but evidence points to a possible role in the regulation of neurotransmitter release. Its biosynthesis is under developmental control. Assignment of the human synapsin I gene to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang-Feng TL,DeGennaro LJ,Francke U

更新日期：1986-11-01 00:00:00

abstract：:Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodson BM,Song Y,Taylor RE,Schepkin VD,Brennan KM,Chingas GC,Budinger TF,Navon G,Pines A

更新日期：1997-12-23 00:00:00

abstract：:Ribozymes are RNAs that possess the dual properties of RNA sequence-specific recognition, analogous to conventional antisense molecules, and RNA substrate destruction via site-specific cleavage. The cleavage reaction is catalytic in that more than one substrate molecule is processed per ribozyme molecule. We have desi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ojwang JO,Hampel A,Looney DJ,Wong-Staal F,Rappaport J

更新日期：1992-11-15 00:00:00

abstract：:Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive coiled-coils. The amino acid sequence of the motor domain of kinesin-73 protein is most closely related to the motor domains of Caenorhabditis elegans unc-104 and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li HP,Liu ZM,Nirenberg M

更新日期：1997-02-18 00:00:00

abstract：:We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into a large chromosome and 2 related minichromosomes. The Halobacterium NRC-1 genome codes for 2,630 predicted proteins, 36...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ng WV,Kennedy SP,Mahairas GG,Berquist B,Pan M,Shukla HD,Lasky SR,Baliga NS,Thorsson V,Sbrogna J,Swartzell S,Weir D,Hall J,Dahl TA,Welti R,Goo YA,Leithauser B,Keller K,Cruz R,Danson MJ,Hough DW,Maddocks DG,Jabl

更新日期：2000-10-24 00:00:00

abstract：:Reported effects of anti-CD154 treatment on autoimmunity, alloreactivity, and inflammatory events mediated by macrophages and endothelial cells indicated that it might be an ideal agent for the prevention of intrahepatic islet allograft failure. This hypothesis was tested in MHC-mismatched rhesus monkeys. Transplantat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kenyon NS,Chatzipetrou M,Masetti M,Ranuncoli A,Oliveira M,Wagner JL,Kirk AD,Harlan DM,Burkly LC,Ricordi C

更新日期：1999-07-06 00:00:00

abstract：:All proteins of this world are constructed in compliance with the same rule. Accordingly, two totally unrelated proteins, on the average, share 30 identical tripeptides, two tetrapeptides, and one pentapeptide per 500 residues. With this in mind, the 221-residue-long influenza virus hemagglutinin II (IVHA-II), as a re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno S

更新日期：1991-04-15 00:00:00

abstract：:Insulin resistance, obesity, diabetes, dyslipidemia, and nonalcoholic fatty liver are components of the metabolic syndrome, a disease complex that is increasing at epidemic rates in westernized countries. Although proinflammatory cytokines have been suggested to contribute to the development of these disorders, the mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueki K,Kondo T,Tseng YH,Kahn CR

更新日期：2004-07-13 00:00:00

abstract：:Intracellular bacterial pathogens evade the bactericidal functions of mammalian cells by physical escape from their phagosome and replication into the cytoplasm or through the modulation of phagosome maturation and biogenesis of a membrane-bound replicative organelle. Here, we detail in murine primary macrophages the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Checroun C,Wehrly TD,Fischer ER,Hayes SF,Celli J

更新日期：2006-09-26 00:00:00

abstract：:Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of single-molecule fluorescence studies that characterize the ligand-dependent cotranscriptional folding of the Escherichia coli thiM riboswitch that regulates translation. We found that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uhm H,Kang W,Ha KS,Kang C,Hohng S

更新日期：2018-01-09 00:00:00

abstract：:C1q, a member of the immune complement cascade, is implicated in the selective pruning of synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown to occur during brain development, while increased activation and complement-dependent synapse loss is observed in neurodegenerative diseases. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Györffy BA,Kun J,Török G,Bulyáki É,Borhegyi Z,Gulyássy P,Kis V,Szocsics P,Micsonai A,Matkó J,Drahos L,Juhász G,Kékesi KA,Kardos J

更新日期：2018-06-12 00:00:00

abstract：:Simulations with a regional chemical transport model show that anthropogenic emissions of volatile organic compounds and nitrogen oxides (NO(x) = NO + NO(2)) lead to a dramatic diurnal variation of surface ozone (O(3)) in Houston, Texas. During the daytime, photochemical oxidation of volatile organic compounds catalyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Lei W,Tie X,Hess P

更新日期：2004-04-27 00:00:00

abstract：:The amino acid sequence of rabbit skeletal muscle heat-stable inhibitor of the cAMP-dependent protein kinase has been determined by microsequencing techniques. Proof of the structure involved a series of nonoverlapping tryptic fragments for primary identification of 86% of the amino acids. Complementary fragments gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scott JD,Fischer EH,Takio K,Demaille JG,Krebs EG

更新日期：1985-09-01 00:00:00

abstract：:The Taq DNA polymerase is the most commonly used enzyme in DNA sequencing. However, all versions of Taq polymerase are deficient in two respects: (i) these enzymes incorporate each of the four dideoxynucleoside 5' triphosphates (ddNTPs) at widely different rates during sequencing (ddGTP, for example, is incorporated 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Mitaxov V,Waksman G

更新日期：1999-08-17 00:00:00

abstract：:Classic physiology studies dating to the 1930s demonstrate that moderate or transient glucocorticoid (GC) exposure improves muscle performance. The ergogenic properties of GCs are further evidenced by their surreptitious use as doping agents by endurance athletes and poorly understood efficacy in Duchenne muscular dys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morrison-Nozik A,Anand P,Zhu H,Duan Q,Sabeh M,Prosdocimo DA,Lemieux ME,Nordsborg N,Russell AP,MacRae CA,Gerber AN,Jain MK,Haldar SM

更新日期：2015-12-08 00:00:00

abstract：:Human diploid fibroblasts (HDFs) possess Ca(2+)-dependent membrane currents. These currents were suppressed in late-passage normal (senescent) HDFs and prematurely senescent HDFs derived from a subject with Werner syndrome (WS), compared with early-passage normal (young) HDFs. When young HDFs were microinjected with m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Thweatt R,Lumpkin CK Jr,Goldstein S

更新日期：1994-03-15 00:00:00

abstract：:We previously characterized a methionine aminopeptidase (EC 3.4.11.18; Met-AP1; also called peptidase M) in Saccharomyces cerevisiae, which differs from its prokaryotic homologues in that it (i) contains an N-terminal zinc-finger domain and (ii) does not produce lethality when disrupted, although it does slow growth d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Chang YH

更新日期：1995-12-19 00:00:00

abstract：:The efficacy of active immunization with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-administration reinstatement was assessed in rats. An animal model of relapse was used where rats were trained to self-administer cocaine, subjected to a period of extinction by substituting th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrera MR,Ashley JA,Zhou B,Wirsching P,Koob GF,Janda KD

更新日期：2000-05-23 00:00:00

abstract：:Because most human squamous carcinoma cell lines of the aerodigestive and genital tracts are refractory to the antiproliferative action of transforming growth factor beta 1 (TGF beta 1) in vitro, we have begun to identify the causes for resistance of squamous carcinoma cell lines to TGF beta 1 by using somatic cell ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reiss M,Muñoz-Antonia T,Cowan JM,Wilkins PC,Zhou ZL,Vellucci VF

更新日期：1993-07-01 00:00:00

abstract：:Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens, induced activation characterized by proliferation and the expression of surface CD5. In contrast, B cells induced to proliferate in response to thymus-dependent inductive signals provided by eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wortis HH,Teutsch M,Higer M,Zheng J,Parker DC

更新日期：1995-04-11 00:00:00

abstract：:SUMO, a small ubiquitin-related modifier, is known to covalently attach to a number of nuclear regulatory proteins such as p53, IkappaB, promyelocytic leukemia protein and c-Jun. The sumoylation reaction is catalyzed by the SUMO protease, which exposes the C-terminal active glycine residue of the nascent SUMO, the het...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li T,Evdokimov E,Shen RF,Chao CC,Tekle E,Wang T,Stadtman ER,Yang DC,Chock PB

更新日期：2004-06-08 00:00:00

abstract：:Antiapoptotic Bcl-2 family members interact with inositol trisphosphate receptor (InsP3R) Ca(2+)release channels in the endoplasmic reticulum to modulate Ca(2+)signals that affect cell viability. However, the molecular details and consequences of their interactions are unclear. Here, we found that Bcl-xL activates sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Vais H,Gu W,Foskett JK

更新日期：2016-03-29 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00