Virion-associated RNA polymerase required for bacteriophage N4 development.

abstract：:Receptor-type protein tyrosine phosphatase D (PTPRD) is a neuronal cell-adhesion molecule/synaptic specifier that has been implicated in addiction vulnerability and stimulant reward by human genomewide association and mouse cocaine-conditioned place-preference data. However, there have been no reports of effects of re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uhl GR,Martinez MJ,Paik P,Sulima A,Bi GH,Iyer MR,Gardner E,Rice KC,Xi ZX

更新日期：2018-11-06 00:00:00

abstract：:We have used the 1.1 kilobases of the 5' upstream region of the platelet factor four (PF4) gene coupled to the prokaryotic beta-galactosidase gene to generate two lines of transgenic mice that express this construct. Studies of blood, bone marrow, spleen, and thymus reveal that platelets are the only circulating blood...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ravid K,Beeler DL,Rabin MS,Ruley HE,Rosenberg RD

更新日期：1991-02-15 00:00:00

abstract：:A DNA fragment homologous to U6 small nuclear RNA was isolated from a human genomic library and sequenced. The immediate 5'-flanking region of the U6 DNA clone had significant homology with a potential mouse U6 gene, including a "TATA box" at a position 26-29 nucleotides upstream from the transcription start site. Alt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kunkel GR,Maser RL,Calvet JP,Pederson T

更新日期：1986-11-01 00:00:00

abstract：:To specify when and where Ig class switch recombination (CSR) takes place, a good molecular marker closely associated with active CSR is required. CSR is accompanied by deletion of circular DNA from the Ig heavy chain locus. The circular DNA contains a DNA segment between Smu and a target S region including its I prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinoshita K,Harigai M,Fagarasan S,Muramatsu M,Honjo T

更新日期：2001-10-23 00:00:00

abstract：:Animals capable of regenerating multiple tissue types, organs, and appendages after injury are common yet sporadic and include some sponge, hydra, planarian, and salamander (i.e., newt and axolotl) species, but notably such regenerative capacity is rare in mammals. The adult MRL mouse strain is a rare exception to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedelbaeva K,Snyder A,Gourevitch D,Clark L,Zhang XM,Leferovich J,Cheverud JM,Lieberman P,Heber-Katz E

更新日期：2010-03-30 00:00:00

abstract：:Go is a specific class ("other") of signal-transducing heterotrimeric GTP-binding proteins (G proteins) that is expressed in high levels in mammalian brain. We have cloned two different rat cDNAs encoding the alpha subunit of Go (Go alpha-1 and Go alpha-2) and a human Go alpha chromosomal gene. The human Go alpha gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsukamoto T,Toyama R,Itoh H,Kozasa T,Matsuoka M,Kaziro Y

更新日期：1991-04-15 00:00:00

abstract：:The swelling of secretory vesicles has been implicated in exocytosis, but the underlying mechanism of vesicle swelling remains largely unknown. Zymogen granules (ZGs), the membrane-bound secretory vesicles in exocrine pancreas, swell in response to GTP mediated by a G(alpha)i3 protein. Evidence is presented here that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho SJ,Sattar AK,Jeong EH,Satchi M,Cho JA,Dash S,Mayes MS,Stromer MH,Jena BP

更新日期：2002-04-02 00:00:00

abstract：:Wild-type p53 protein is a growth modulator whose inactivation has been found to be a key event in malignant transformation. Reconstitution of wild-type p53 in the p53-nonproducer, Abelson murine leukemia virus-transformed pre-B-cell line L12 gave rise to stably growing clones. Wild-type p53-producer derived cell line...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaulsky G,Goldfinger N,Peled A,Rotter V

更新日期：1991-10-15 00:00:00

abstract：:High molecular weight RNA (35S) isolated from avian myeloblastosis virus directs the cell-free synthesis of two prominent polypeptides of 180,000 and 76,000 molecular weight. The latter polypeptide has previously been identified as the precursor to the group-specific antigens of the virus ("gag" proteins) [Vogt, V. M....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paterson BM,Marciani DJ,Papas TS

更新日期：1977-11-01 00:00:00

abstract：:Escherichia coli fMet-tRNAfMet alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6), affecting RNA synthesis from the rRNA, suIII+tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debenham PG,Pongs O,Travers AA

更新日期：1980-02-01 00:00:00

abstract：:The retrosplenial cortex (RSC) is part of a network of interconnected cortical, hippocampal, and thalamic structures harboring spatially modulated neurons. The RSC contains head direction cells and connects to the parahippocampal region and anterior thalamus. Manipulations of the RSC can affect spatial and contextual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czajkowski R,Jayaprakash B,Wiltgen B,Rogerson T,Guzman-Karlsson MC,Barth AL,Trachtenberg JT,Silva AJ

更新日期：2014-06-10 00:00:00

abstract：:Circumnutation and winding in plants are universal growth movements that allow plants to survive despite their sessile nature. However, the detailed molecular mechanisms controlling these phenomena remain unclear. We previously found that a gravitropic mutant of Japanese morning glory (Pharbitis nil or Ipomoea nil), S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitazawa D,Hatakeda Y,Kamada M,Fujii N,Miyazawa Y,Hoshino A,Iida S,Fukaki H,Morita MT,Tasaka M,Suge H,Takahashi H

更新日期：2005-12-20 00:00:00

abstract：:We recently showed that the mammalian genome encodes >1,000 large intergenic noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene expression patterns have implicated these lincRNAs in diverse biological processes, including cell-cycle regulation, immune surveillance, and embryonic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khalil AM,Guttman M,Huarte M,Garber M,Raj A,Rivea Morales D,Thomas K,Presser A,Bernstein BE,van Oudenaarden A,Regev A,Lander ES,Rinn JL

更新日期：2009-07-14 00:00:00

abstract：:A special methionine tRNA (tRNAi) is universally required to initiate translation. Amongst species a tRNAi structural conservation is most apparent in the anticodon and T arms of the molecule but extends into the variable loop and the 3' strand of the D stem. This suggested that they could share a similar ancestral or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ganoza MC,Marliere P,Kofoid EC,Louis BG

更新日期：1985-07-01 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are potent mitogens for various cancers, including carcinoma of the prostate. In several experimental cancers, treatment with antagonists of growth hormone-releasing hormone (GH-RH) produces a reduction in IGF-I and -II, concomitant to inhibition of tumor growth. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamharzi N,Schally AV,Koppán M,Groot K

更新日期：1998-07-21 00:00:00

abstract：:Climate change over the next century is predicted to cause widespread maladaptation in natural systems. This prediction, as well as many sustainable management and conservation practices, assumes that species are adapted to their current climate. However, this assumption is rarely tested. Using a large-scale common ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Browne L,Wright JW,Fitz-Gibbon S,Gugger PF,Sork VL

更新日期：2019-12-10 00:00:00

abstract：:Five DNA fragments have been cloned from yeast, chicken, and mouse DNA that titrate lac repressor in an Escherichia coli lac+ I+Z+ wild-type strain when on a multi-copy plasmid. The five repressor-binding sequences have been identified by DNA sequence determinations and DNase cleavage-inhibition patterns. They share t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons A,Tils D,von Wilcken-Bergmann B,Müller-Hill B

更新日期：1984-03-01 00:00:00

abstract：:Changes in levels of the newly discovered cytidine 3':5'-cyclic monophosphate (cyclic CMP) phosphodiesterase in some representative tissues (cerebral cortex, kidney, intestine, liver, heart, and lung) of guinea pigs from various developmental stages (fetus, neonate, pup, and adult) were studied and compared with those...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfman DM,Brackett NL,Kuo JF

更新日期：1978-09-01 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate added to exponentially growing cells of Hemophilus influenzae strain Rd increases competence for transformation 100- to 10,000-fold. Cyclic AMP added to near-stationary or stationary cells does not increase competence over the high level normally found in the early stationary phase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Alexander SP,Powers M

更新日期：1973-02-01 00:00:00

abstract：:The carboxy-terminal domain (CTD) code encrypted within the Y1S2P3T4S5P6S7 heptad repeats of RNA polymerase II (Pol2) is deeply rooted in eukaryal biology. Key steps to deciphering the code are identifying the events in gene expression that are governed by individual "letters" and then defining a vocabulary of multile...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez AM,Shuman S,Schwer B

更新日期：2018-11-06 00:00:00

abstract：:Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we report that activatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR

更新日期：2020-03-17 00:00:00

abstract：:Human settlement of Polynesia was a major event in world prehistory. Despite the vastness of the distances covered, research suggests that prehistoric Polynesian populations maintained spheres of continuing interaction for at least some period of time in some regions. A low level of genetic variation in ancestral Poly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matisoo-Smith E,Roberts RM,Irwin GJ,Allen JS,Penny D,Lambert DM

更新日期：1998-12-08 00:00:00

abstract：:Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lima B,Lam GK,Xie L,Diesen DL,Villamizar N,Nienaber J,Messina E,Bowles D,Kontos CD,Hare JM,Stamler JS,Rockman HA

更新日期：2009-04-14 00:00:00

abstract：:Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro kinetic assays on PBMCs in 195 MS patients and 60 matched controls and quantified the phosphorylation of 17 kinases using xMAP assays. Phosphoprotein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotelnikova E,Kiani NA,Messinis D,Pertsovskaya I,Pliaka V,Bernardo-Faura M,Rinas M,Vila G,Zubizarreta I,Pulido-Valdeolivas I,Sakellaropoulos T,Faigle W,Silberberg G,Masso M,Stridh P,Behrens J,Olsson T,Martin R,Paul F

更新日期：2019-05-07 00:00:00

abstract：:Linkage analysis with restriction fragment length polymorphisms for the gene for type II procollagen (COL2A1) was carried out in a family with the Stickler syndrome, or arthro-ophthalmopathy, an autosomal dominant disorder that affects the eyes, ears, joints, and skeleton. The analysis demonstrated linkage of the dise...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmad NN,Ala-Kokko L,Knowlton RG,Jimenez SA,Weaver EJ,Maguire JI,Tasman W,Prockop DJ

更新日期：1991-08-01 00:00:00

abstract：:The genetic basis for virulence in influenza virus is largely unknown. To explore the mutational basis for increased virulence in the lung, the H3N2 prototype clinical isolate, A/HK/1/68, was adapted to the mouse. Genomic sequencing provided the first demonstration, to our knowledge, that a group of 11 mutations can c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown EG,Liu H,Kit LC,Baird S,Nesrallah M

更新日期：2001-06-05 00:00:00

abstract：:Perception and cognition in infants have been traditionally investigated using habituation paradigms, assuming that babies' memories in laboratory contexts are best constructed after numerous repetitions of the very same stimulus in the absence of interference. A crucial, yet open, question regards how babies deal wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benavides-Varela S,Siugzdaite R,Gómez DM,Macagno F,Cattarossi L,Mehler J

更新日期：2017-07-18 00:00:00

abstract：:Tissue factor (TF) plays an important role in hemostasis, inflammation, angiogenesis, and the pathophysiology of atherosclerosis and cancer. In this article we uncover a mechanism in which protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the interact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hackeng TM,Seré KM,Tans G,Rosing J

更新日期：2006-02-28 00:00:00

abstract：:The voltage-dependent gating of the colicin channel involves a substantial structural rearrangement that results in the transfer of about 35% of the 200 residues in its pore-forming domain across the membrane. This transfer appears to represent an unusual type of protein translocation that does not depend on a large, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slatin SL,Nardi A,Jakes KS,Baty D,Duché D

更新日期：2002-02-05 00:00:00

abstract：:The polymerase chain reaction was used to amplify DNA surrounding the codon 12 region of the c-Ki-ras gene from C3H/10T1/2 cells and from a number of 3-methylcholanthrene (MCA)-transformed derivatives of these cells. Sequence analysis demonstrated that tumorigenic MCAC116/39 cells, known by DNA-mediated transfection t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AC,Herschman HR

更新日期：1989-03-01 00:00:00