Myeloma proteins as tumor-specific transplantation antigens.

abstract：:Accurately estimating human mobility and gauging its relationship with virus transmission is critical for the control of COVID-19 spreading. Using mobile device location data of over 100 million monthly active samples, we compute origin-destination travel demand and aggregate mobility inflow at each US county from Mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiong C,Hu S,Yang M,Luo W,Zhang L

更新日期：2020-11-03 00:00:00

abstract：:Efficient degradation of plant cell walls by selected anaerobic bacteria is performed by large extracellular multienzyme complexes termed cellulosomes. The spatial arrangement within the cellulosome is organized by a protein called scaffoldin, which recruits the cellulolytic subunits through interactions between cohes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barth A,Hendrix J,Fried D,Barak Y,Bayer EA,Lamb DC

更新日期：2018-11-27 00:00:00

abstract：:Methionine sulfoxide reductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for the S epimer of methionine sulfoxide. The enzyme participates in defense against oxidative stresses by reducing methionine sulfoxide residues in proteins back to methionine. Because oxidation of me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lim JC,You Z,Kim G,Levine RL

更新日期：2011-06-28 00:00:00

abstract：:Fluorescence of quinacrine in the presence of different polynucleotides was studied to attempt to identify the specific nucleotides responsible for the fluorescence of stained chromosome preparations. A marked enhancement of fluorescence was seen in the presence of bihelical polynucleotides, such as poly(dA-dT), poly(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weisblum B,De Haseth PL

更新日期：1972-03-01 00:00:00

abstract：:Conventional asymmetric PCR is inefficient and difficult to optimize because limiting the concentration of one primer lowers its melting temperature below the reaction annealing temperature. Linear-After-The-Exponential (LATE)-PCR describes a new paradigm for primer design that renders assays as efficient as symmetric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez JA,Pierce KE,Rice JE,Wangh LJ

更新日期：2004-02-17 00:00:00

abstract：:Actin polymerization provides a powerful propulsion force for numerous types of cell motility. Although tremendous progress has been made in identifying the biochemical components necessary for actin-based motility, the precise biophysical mechanisms of force generation remain unclear. To probe the polymerization forc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Upadhyaya A,Chabot JR,Andreeva A,Samadani A,van Oudenaarden A

更新日期：2003-04-15 00:00:00

abstract：:We have established empirical limits for the circular dichroism spectra appropriate for aqueous solutions of the B, C, and A forms of calf-thymus DNA and have analyzed DNA conformations in biological structures. The circular dichroism spectrum above 250 nm of purified calf-thymus chromatin can be satisfactorily accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanlon S,Johnson RS,Wolf B,Chan A

更新日期：1972-11-01 00:00:00

abstract：:Chromosome 14 allelic loss is common in nasopharyngeal carcinoma (NPC) and may reflect essential tumor suppressor gene loss in tumorigenesis. An intact chromosome 14 was transferred to an NPC cell line using a microcell-mediated chromosome transfer approach. Microcell hybrids (MCHs) containing intact exogenously trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AK,Lung HL,Ko JM,Cheng Y,Stanbridge EJ,Zabarovsky ER,Nicholls JM,Chua D,Tsao SW,Guan XY,Lung ML

更新日期：2009-08-25 00:00:00

abstract：:To explore the pathogenic mechanism of dominant mutations affecting the carboxyl terminus of rhodopsin that cause retinitis pigmentosa, we generated five lines of transgenic mice carrying the proline-347 to serine (P347S) mutation. The severity of photoreceptor degeneration correlated with the levels of transgene expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li T,Snyder WK,Olsson JE,Dryja TP

更新日期：1996-11-26 00:00:00

abstract：:The chronic use of several drugs, including opiates, results in the stereotypical behaviors characteristic of addiction. Alterations in gene expression have been associated with the use of these addictive drugs. Previous studies, however, have been limited to describing changes in amounts of individual mRNAs from sing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackler SA,Eberwine JH

更新日期：1994-01-04 00:00:00

abstract：:Leukotrienes (LTs) are signaling molecules derived from arachidonic acid that initiate and amplify innate and adaptive immunity. In turn, how their synthesis is organized on the nuclear envelope of myeloid cells in response to extracellular signals is not understood. We define the supramolecular architecture of LT syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandal AK,Jones PB,Bair AM,Christmas P,Miller D,Yamin TT,Wisniewski D,Menke J,Evans JF,Hyman BT,Bacskai B,Chen M,Lee DM,Nikolic B,Soberman RJ

更新日期：2008-12-23 00:00:00

abstract：:Citrullinemia is an inborn error of metabolism due to deficiency of the urea cycle enzyme, argininosuccinate synthetase [L-citrulline:L-aspartate ligase (AMP-forming), EC 6.3.4.5]. The disease was first described in humans but was recently reported in dairy cattle in Australia. Here we report the nucleotide sequence o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennis JA,Healy PJ,Beaudet AL,O'Brien WE

更新日期：1989-10-01 00:00:00

abstract：:Cooperativity in oligonucleotide-directed sequence-specific recognition of DNA by triple helix formation can be enhanced by the addition of discrete dimerization domains. The equilibrium association constants for cooperative binding of oligonucleotides that dimerize by Watson-Crick hydrogen bonds and occupy adjacent s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Distefano MD,Dervan PB

更新日期：1993-02-15 00:00:00

abstract：:In mammalian brains, multielectrode recordings during sensory stimulation have revealed oscillations in different cortical areas that are transiently synchronous. These synchronizations have been hypothesized to support integration of sensory information or represent the operation of attentional mechanisms, but their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prechtl JC

更新日期：1994-12-20 00:00:00

abstract：:Conjugative relaxases are the proteins that initiate bacterial conjugation by a site-specific cleavage of the transferred DNA strand. In vitro, they show strand-transferase activity on single-stranded DNA, which suggests they may also be responsible for recircularization of the transferred DNA. In this work, we show t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Draper O,César CE,Machón C,de la Cruz F,Llosa M

更新日期：2005-11-08 00:00:00

abstract：:Proteins potentiated by epidermal growth factor (EGF) to induce a transformed phenotype in non-neoplastic rat kidney fibroblasts in cell culture have been isolated from many non-neoplastic tissues of the adult mouse, including submaxillary gland, kidney, liver, muscle, heart, and brain. They resemble previously descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts AB,Anzano MA,Lamb LC,Smith JM,Sporn MB

更新日期：1981-09-01 00:00:00

abstract：:Genomic RNA from the human prototype strain H of the hepatitis C virus (HCV-H) has been molecularly cloned and sequenced. The HCV-H sequence reported consists of 9416 nucleotides including the 5' and 3' untranslated regions. HCV-H shows 96% amino acid identity with the American isolate HCV-1 but only 84.9% with the Ja...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inchauspe G,Zebedee S,Lee DH,Sugitani M,Nasoff M,Prince AM

更新日期：1991-11-15 00:00:00

abstract：:The electrical block to fertilization of sea urchin eggs can be overcome by very brief periods of inside-negative egg membrane potential. Lytechinus pictus eggs whose membrane potentials have been clamped at +15 mV cannot be fertilized. If the membrane potential is repolarized to inside-negative voltages for a brief i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen SS,Steinhardt RA

更新日期：1984-03-01 00:00:00

abstract：:Brown adipose tissue (BAT) is present throughout life in rodents and plays an important role in energy balance. However, whereas BAT is clearly recognizable in the neonates of larger mammals (including dogs, cats, sheep, cattle, and humans), it is undetectable or present in only small quantities in adults of these spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Champigny O,Ricquier D,Blondel O,Mayers RM,Briscoe MG,Holloway BR

更新日期：1991-12-01 00:00:00

abstract：:Intracisternal A-particles were isolated from three different myeloma lines in BALB/c mice and from cultured neuroblastoma cells of A/J origin. All preparations contained a major structural protein with an apparent molecular weight near 70,000 as estimated by electrophoretic mobility in sodium dodecyl sulfate-containi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuff EL,Leuders KK,Ozer HL,Wivel NA

更新日期：1972-01-01 00:00:00

abstract：:Charybdotoxin (ChTX), a K+ channel blocker, depolarizes human peripheral T lymphocytes and renders them insensitive to activation by mitogen. We observed four types of K+ channels in human T cells: one voltage-activated, and three Ca(2+)-activated. To discern the mechanism by which ChTX depolarizes T cells, we examine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard RJ,Garcia ML,Slaughter RS,Reuben JP

更新日期：1992-11-01 00:00:00

abstract：:The most common monogenic cause of small-vessel disease leading to ischemic stroke and vascular dementia is the neurodegenerative syndrome cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is associated with mutations in the Notch 3 receptor. CADASIL pathology ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arboleda-Velasquez JF,Manent J,Lee JH,Tikka S,Ospina C,Vanderburg CR,Frosch MP,Rodríguez-Falcón M,Villen J,Gygi S,Lopera F,Kalimo H,Moskowitz MA,Ayata C,Louvi A,Artavanis-Tsakonas S

更新日期：2011-05-24 00:00:00

abstract：:Ecological responses to on-going climate change are numerous, diverse, and taxonomically widespread. However, with one exception, the relative roles of phenotypic plasticity and microevolution as mechanisms in explaining these responses are largely unknown. Several recent studies have uncovered evidence for temporal d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teplitsky C,Mills JA,Alho JS,Yarrall JW,Merilä J

更新日期：2008-09-09 00:00:00

abstract：:Herein, we report the identification of a unique HIV-1 integrase (IN) inhibitor-binding site using photoaffinity labeling and mass spectrometric analysis. We chemically incorporated a photo-activatable benzophenone moiety into a series of coumarin-containing IN inhibitors. A representative of this series was covalentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Al-Mawsawi LQ,Fikkert V,Dayam R,Witvrouw M,Burke TR Jr,Borchers CH,Neamati N

更新日期：2006-06-27 00:00:00

abstract：:Ribbon synapses of photoreceptor cells and second-order bipolar neurons in the retina are specialized to transmit graded signals that encode light intensity. Neurotransmitter release at ribbon synapses exhibits two kinetically distinct components, which serve different sensory functions. The faster component is deplet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaithianathan T,Matthews G

更新日期：2014-06-10 00:00:00

abstract：:The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent antineoplastic agents. Results described here demonstrate that the bryostatins may also be useful as stimulators of normal human hematopoietic cells since they can (i) directly stimulate bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： May WS,Sharkis SJ,Esa AH,Gebbia V,Kraft AS,Pettit GR,Sensenbrenner LL

更新日期：1987-12-01 00:00:00

abstract：:Biologists regularly search databases of DNA or protein sequences for evolutionary or functional relationships to a given query sequence. We describe a ranking algorithm that exploits the entire network structure of similarity relationships among proteins in a sequence database by performing a diffusion operation on a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weston J,Elisseeff A,Zhou D,Leslie CS,Noble WS

更新日期：2004-04-27 00:00:00

abstract：:In the face of antibiotics, bacterial populations avoid extinction by harboring a subpopulation of dormant cells that are largely drug insensitive. This phenomenon, termed "persistence," is a major obstacle for the treatment of a number of infectious diseases. The mechanism that generates both actively growing as well...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotem E,Loinger A,Ronin I,Levin-Reisman I,Gabay C,Shoresh N,Biham O,Balaban NQ

更新日期：2010-07-13 00:00:00

abstract：:Hox genes encode transcription factors that control spatial patterning during embryogenesis. To date, downstream targets of Hox genes have proven difficult to identify. Here, we describe studies designed to identify target genes under the control of the murine transcription factor Hoxc8. We used a mouse 16,463 gene ol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lei H,Wang H,Juan AH,Ruddle FH

更新日期：2005-02-15 00:00:00

abstract：:The recent development of HIV-1 lentiviral vectors is especially useful for gene transfer because they achieve efficient integration into nondividing cell genomes and successful long-term expression of the transgene. These attributes make the vector useful for gene delivery, mutagenesis, and other applications in mamm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Z,Han I,Park M,Brady RO

更新日期：2002-03-19 00:00:00