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The nuclear membrane organization of leukotriene synthesis.

Abstract：

:Leukotrienes (LTs) are signaling molecules derived from arachidonic acid that initiate and amplify innate and adaptive immunity. In turn, how their synthesis is organized on the nuclear envelope of myeloid cells in response to extracellular signals is not understood. We define the supramolecular architecture of LT synthesis by identifying the activation-dependent assembly of novel multiprotein complexes on the outer and inner nuclear membranes of mast cells. These complexes are centered on the integral membrane protein 5-Lipoxygenase-Activating Protein, which we identify as a scaffold protein for 5-Lipoxygenase, the initial enzyme of LT synthesis. We also identify these complexes in mouse neutrophils isolated from inflamed joints. Our studies reveal the macromolecular organization of LT synthesis.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Mandal AK,Jones PB,Bair AM,Christmas P,Miller D,Yamin TT,Wisniewski D,Menke J,Evans JF,Hyman BT,Bacskai B,Chen M,Lee DM,Nikolic B,Soberman RJ

doi

10.1073/pnas.0808211106

subject

Has Abstract

pub_date

2008-12-23 00:00:00

pages

20434-9

issue

51

eissn

0027-8424

issn

1091-6490

pii

0808211106

journal_volume

105

pub_type

杂志文章

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