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Corticoinsular circuits encode subjective value expectation and violation for effortful goal-directed behavior.

Abstract：

:We are presented with choices each day about how to invest our effort to achieve our goals. Critically, these decisions must frequently be made under conditions of incomplete information, where either the effort required or possible reward to be gained is uncertain. Such choices therefore require the development of potential value estimates to guide effortful goal-directed behavior. To date, however, the neural mechanisms for this expectation process are unknown. Here, we used computational fMRI during an effort-based decision-making task where trial-wise information about effort costs and reward magnitudes was presented separately over time, thereby allowing us to model distinct effort/reward computations as choice-relevant information unfolded. We found that ventromedial prefrontal cortex (vmPFC) encoded expected subjective value. Further, activity in dorsal anterior cingulate (dACC) and anterior insula (aI) reflected both effort discounting as well as a subjective value prediction error signal derived from trial history. While prior studies have identified these regions as being involved in effort-based decision making, these data demonstrate their specific role in the formation and maintenance of subjective value estimates as relevant information becomes available.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Arulpragasam AR,Cooper JA,Nuutinen MR,Treadway MT

doi

10.1073/pnas.1800444115

subject

Has Abstract

pub_date

2018-05-29 00:00:00

pages

E5233-E5242

issue

22

eissn

0027-8424

issn

1091-6490

pii

1800444115

journal_volume

115

pub_type

杂志文章

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