Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.

abstract：:DNA sequences in Neurospora crassa that code for ribosomal RNA have been isolated in a highly purified state by DNA-RNA hybridization. About 100 separate ribosomal RNA genes exist in each nucleus. These genes are composed of repeated sequences that are present about 100 times per nucleus. The individual members of thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay SK,Kohne DE,Dutta SK

更新日期：1972-11-01 00:00:00

abstract：:Apolipoprotein L-1 (APOL1), the trypanolytic factor of human serum, can lyse several African trypanosome species including Trypanosoma brucei brucei, but not the human-infective pathogens T. brucei rhodesiense and T. brucei gambiense, which are resistant to lysis by human serum. Lysis follows the uptake of APOL1 into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomson R,Finkelstein A

更新日期：2015-03-03 00:00:00

abstract：:Recent scholarship suggests that the genomes of those around us affect our own phenotypes. Much of the empirical evidence for such "metagenomic" effects comes from animal studies, where the socio-genetic environment can be easily manipulated. Among humans, it is more difficult to identify such effects given the nonran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sotoudeh R,Harris KM,Conley D

更新日期：2019-08-13 00:00:00

abstract：:Bacterial intracellular symbiosis (endosymbiosis) is widespread in nature and impacts many biological processes. In holometabolous symbiotic insects, metamorphosis entails a complete and abrupt internal reorganization that creates a constraint for endosymbiont transmission from larvae to adults. To assess how endosymb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maire J,Parisot N,Galvao Ferrarini M,Vallier A,Gillet B,Hughes S,Balmand S,Vincent-Monégat C,Zaidman-Rémy A,Heddi A

更新日期：2020-08-11 00:00:00

abstract：:A discrepancy is explored regarding the spin exchange integral estimated from magnetic field effects on recombination of the bacteriochlorophyll dimer cation (Bchl)(2)+ and the bacteriopheophytin anion Bph(-) and the measured electron transfer rate between Bph and electronically excited (Bchl)(2). In one explanation c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haberkorn R,Michel-Beyerle ME,Marcus RA

更新日期：1979-09-01 00:00:00

abstract：:In epidemiological studies, both positive and negative correlations have been found between cardiovascular disease and mortality and the presence of several inorganic ions in the drinking water. In an attempt to resolve this apparent disagreement, we exposed White Carneau pigeons to drinking water containing calcium (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revis NW,Zinsmeister AR,Bull R

更新日期：1981-10-01 00:00:00

abstract：:Massive datasets that capture human movements and social interactions have catalyzed rapid advances in our quantitative understanding of human behavior during the past years. One important aspect affecting both areas is the critical role space plays. Indeed, growing evidence suggests both our movements and communicati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deville P,Song C,Eagle N,Blondel VD,Barabási AL,Wang D

更新日期：2016-06-28 00:00:00

abstract：:The tumor suppressor protein p53 plays a crucial role in coordinating cellular processes, such as cell cycle arrest, apoptosis, and senescence. The nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a homophilic adhesion molecule and involved in nerve regeneration. Interestingly, Ninj1 is found to be overexpressed i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho SJ,Rossi A,Jung YS,Yan W,Liu G,Zhang J,Zhang M,Chen X

更新日期：2013-06-04 00:00:00

abstract：:Antigenic markers associated with the major internal protein of RNA tumor viruses of the C-type have proven extremely useful in natural history studies of these viruses. This protein possesses species-specific antigenic determinants, and, in the case of mammalian C-type viruses, the protein possesses crossreactive det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilden RV,Oroszlan S

更新日期：1972-04-01 00:00:00

abstract：:The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seki T,Spurr N,Obata F,Goyert S,Goodfellow P,Silver J

更新日期：1985-10-01 00:00:00

abstract：:The self-association of gene-32 protein has been studied by sedimentation equilibrium centrifugation and polyacrylamide gel electrophoresis, in order to better understand its role in DNA replication and genetic recombination. The monomer molecular weight of gene-32 protein is 38,000 in guanidine hydrochloride and 34,0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carroll RB,Neet KE,Goldthwait DA

更新日期：1972-09-01 00:00:00

abstract：:Transport affects climate directly and indirectly through mechanisms that cause both warming and cooling of climate, and the effects operate on very different timescales. We calculate climate responses in terms of global mean temperature and find large differences between the transport sectors with respect to the size...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berntsen T,Fuglestvedt J

更新日期：2008-12-09 00:00:00

abstract：:Increasing concentrations of estradiol (E2) ranging from 0.01 to 10 nM were found to inhibit partially but significantly the lactogenic effect of ovine prolactin (oPRL) on alpha-lactalbumin production in primate mammary tissues maintained in organ culture for 9 days. E2 at 10 nM inhibited by 38% (mean) PRL-stimulated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinberg DL,Todd J,Babitsky G

更新日期：1983-07-01 00:00:00

abstract：:The kinetics for hydrogen exchange at individual base pairs in self-complementary deoxydodecanucleotide duplexes have been estimated from NMR saturation recovery measurements on the resolved imino protons as a function of temperature. The imino protons of dA . dT base pairs in the center of the fully alternating d(C-G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Ikuta S,Kozlowski S,Itakura K

更新日期：1983-04-01 00:00:00

abstract：:Oil spills can lead to irreversible environmental degradation and are a potential hazard to human health. We study how onshore oil spills affect neonatal and infant mortality by combining spatial data from the Nigerian Oil Spill Monitor with Demographic and Health Surveys. To identify a causal effect, we compare sibli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruederle A,Hodler R

更新日期：2019-03-19 00:00:00

abstract：:Whole-chromosome copy number alterations, also known as aneuploidy, are associated with adverse consequences in most cells and organisms. However, high frequencies of aneuploidy have been reported to occur naturally in the mammalian liver and brain, fueling speculation that aneuploidy provides a selective advantage in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knouse KA,Wu J,Whittaker CA,Amon A

更新日期：2014-09-16 00:00:00

abstract：:Alcohol exposure during development can cause brain malformations and neurobehavioral abnormalities. In view of the teratogenicity of ethanol, identification of molecules that could counteract the neurotoxic effects of alcohol deserves high priority. Here, we report that pituitary adenylate cyclase-activating polypept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaudry D,Rousselle C,Basille M,Falluel-Morel A,Pamantung TF,Fontaine M,Fournier A,Vaudry H,Gonzalez BJ

更新日期：2002-04-30 00:00:00

abstract：:Natural killer (NK) cells provide in vivo control of orthopoxvirus infections in association with their expansion in the draining lymph node (LN), where they are normally very rare. The mechanism of this expansion is unclear. Herein, we determined that NK-cell depletion results in enhanced infection following footpad ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pak-Wittel MA,Yang L,Sojka DK,Rivenbark JG,Yokoyama WM

更新日期：2013-01-02 00:00:00

abstract：:The Bacillus subtilis phage SP01, whose DNA contains 5-hydroxymethyluracil (hmUra) in place of thymine, codes for an abundant, small, basic protein called TF1. TF1 binds preferentially to hydroxymethyluracil-containing DNA and thereby selectively inhibits transcription of such DNA in vitro. The gene for TF1 has been s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greene JR,Brennan SM,Andrew DJ,Thompson CC,Richards SH,Heinrikson RL,Geiduschek EP

更新日期：1984-11-01 00:00:00

abstract：:The tetrodotoxin binding component of the voltage-sensitive sodium channel from Electrophorus electricus electroplax was purified by using a monoclonal antibody. An impure preparation of tetrodotoxin binding component was mixed with the pure monoclonal antibody, and the immune complex so formed was isolated by affinit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama H,Withy RM,Raftery MA

更新日期：1982-12-01 00:00:00

abstract：:Niemann-Pick C1 (NPC1) and NPC2 proteins are indispensable for the export of LDL-derived cholesterol from late endosomes. Mutations in these proteins result in Niemann-Pick type C disease, a lysosomal storage disease. Despite recent reports of the NPC1 structure depicting its overall architecture, the function of its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Lu F,Trinh MN,Schmiege P,Seemann J,Wang J,Blobel G

更新日期：2017-08-22 00:00:00

abstract：:Antibody to poly(ADP-ribose) has been covalently coupled to Sepharose and utilized to isolate selectively oligonucleosomes undergoing the poly(ADP-ribosyl)ation reaction from the bulk of chromatin. Approximately 12% of the unfractionated oligonucleosomes were bound to the immunoaffinity column and these represented es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malik N,Miwa M,Sugimura T,Thraves P,Smulson M

更新日期：1983-05-01 00:00:00

abstract：:The thymus provides multiple microenvironments that are essential for the development and repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive selection of T lymphocytes, whereas the thymic medulla establishes self-tolerance among the positively selected T lymphocytes. Cortical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohigashi I,Zuklys S,Sakata M,Mayer CE,Zhanybekova S,Murata S,Tanaka K,Holländer GA,Takahama Y

更新日期：2013-06-11 00:00:00

abstract：:Both neocortical and hippocampal networks organize the firing patterns of their neurons by prominent oscillations during sleep, but the functional role of these rhythms is not well understood. Here, we show a robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirota A,Csicsvari J,Buhl D,Buzsáki G

更新日期：2003-02-18 00:00:00

abstract：:There are certain genes on the sex chromosome of Drosophila for which the female contains twice as many copies as the male. Some of the genes in this group produce the same phenotype in each sex despite the dosage difference and are said, therefore, to manifest dosage compensation. The structural genes for glucose-6-p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seecof RL,Kaplan WD,Futch DG

更新日期：1969-02-01 00:00:00

abstract：:The calcium-dependent phosphatase calcineurin and its downstream transcriptional effector nuclear factor of activated T cells (NFAT) are important regulators of inducible gene expression in multiple cell types. In T cells, calcineurin-NFAT signaling represents a critical event for mediating cellular activation and the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bueno OF,Brandt EB,Rothenberg ME,Molkentin JD

更新日期：2002-07-09 00:00:00

abstract：:Our recent studies have shown that deregulated expression of R2, the rate-limiting component of ribonucleotide reductase, enhances transformation and malignant potential by cooperating with activated oncogenes. We now demonstrate that the R1 component of ribonucleotide reductase has tumor-suppressing activity. Stable ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan H,Huang A,Villegas C,Wright JA

更新日期：1997-11-25 00:00:00

abstract：:Insulin/Insulin-like growth factor signaling regulates homeostasis and growth in mammals, and is implicated in diseases from diabetes to cancer. In Drosophila melanogaster, as in other invertebrates, multiple Insulin-Like Peptides (DILPs) are encoded by a family of related genes. To assess DILPs' physiological roles, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Liu J,Li CR,Momen B,Kohanski RA,Pick L

更新日期：2009-11-17 00:00:00

abstract：:Two striking differences between humans and our closest living relatives, chimpanzees and gorillas, are the size of our brains (larger by a factor of three or four) and our life span (longer by a factor of about two). Our thesis is that these two distinctive features of humans are products of coevolutionary selection....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan HS,Robson AJ

更新日期：2002-07-23 00:00:00

abstract：:Genetic polymorphism in the H-2:Qa:Tla region of chromosome 17 is associated with constitutive variation of bodily odor phenotypes which permit individual olfactory recognition among mice. To determine whether known genes in the H-2:Qa:Tla complex are concerned in the constitution of odor phenotypes, mice were tested ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki K,Beauchamp GK,Egorov IK,Bard J,Thomas L,Boyse EA

更新日期：1983-09-01 00:00:00