DNA-mediated redox signaling for transcriptional activation of SoxR.

abstract：:Despite the increasing number of regulatory proteins identified in clathrin-independent endocytic (CIE) pathways, our understanding of the exact functions of these proteins and the sequential manner in which they function remains limited. In this study, using the Caenorhabditis elegans intestine as a model, we observe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen S,Li L,Li J,Liu B,Zhu X,Zheng L,Zhang R,Xu T

更新日期：2014-10-28 00:00:00

abstract：:It is generally thought that an effective vaccine to prevent HIV-1 infection should elicit both strong neutralizing antibody and cytotoxic T lymphocyte responses. We recently demonstrated that potent, boostable, long-lived HIV-1 envelope (Env)-specific cytotoxic T lymphocyte responses can be elicited in rhesus monkeys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Letvin NL,Montefiori DC,Yasutomi Y,Perry HC,Davies ME,Lekutis C,Alroy M,Freed DC,Lord CI,Handt LK,Liu MA,Shiver JW

更新日期：1997-08-19 00:00:00

abstract：:Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the function of distinct ion-transport mechanisms at the cell plasma membrane. Active Na(+) and K(+) exchange in sperm is under the control of the Na,K-ATPase. Two mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jimenez T,McDermott JP,Sánchez G,Blanco G

更新日期：2011-01-11 00:00:00

abstract：:Murine embryonal carcinoma (EC) cells are refractory to infection by retroviruses because retroviral long terminal repeat (LTR) enhancers have little activity in EC cells. A previous report described the isolation of clonal EC cell lines that express the integrated neomycin-resistance gene (neo) linked to the Moloney ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taketo M,Tanaka M

更新日期：1987-06-01 00:00:00

abstract：:In confluent fibroblast monolayers, an increase in the selective uptake of free cholesterol (FC) from plasma low density lipoprotein (LDL) was accompanied by an increase in FC efflux. The rate of FC efflux was proportional to the FC content of the cell surface caveolae and to mRNA levels of caveolin, an FC-binding pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fielding CJ,Bist A,Fielding PE

更新日期：1997-04-15 00:00:00

abstract：:Most paleo-episodes of ocean acidification (OA) were either too slow or too small to be instructive in predicting near-future impacts. The end-Cretaceous event (66 Mya) is intriguing in this regard, both because of its rapid onset and also because many pelagic calcifying species (including 100% of ammonites and more t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tyrrell T,Merico A,Armstrong McKay DI

更新日期：2015-05-26 00:00:00

abstract：:Model compositions of Earth, Venus, and Mercury are calculated from the premise that planets and chondrites underwent four identical fractionation processes in the solar nebula. Because elements of similar properties stay together in these processes, five constraints suffice to define the composition of a planet: mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan JW,Anders E

更新日期：1980-12-01 00:00:00

abstract：:Conditional mutations such as temperature-sensitive (ts) mutations are important for the analysis of protein function but are often difficult, or impossible, to obtain. Here we present a simple method for generating conditional mutations based on the use of a protein-destabilizing genetic element in combination with s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park EC,Finley D,Szostak JW

更新日期：1992-02-15 00:00:00

abstract：:Fetal pancreatic beta cells demonstrate a deficient insulin release in response to glucose, but the underlying mechanism at the cellular level is unknown. By using beta cells from 21-day fetal rats we made an attempt to clarify the mechanism(s) behind this reduced glucose response. In addition to measuring insulin rel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rorsman P,Arkhammar P,Bokvist K,Hellerström C,Nilsson T,Welsh M,Welsh N,Berggren PO

更新日期：1989-06-01 00:00:00

abstract：:Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G1/S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray-Bablin J,Zalvide J,Fox MP,Knickerbocker CJ,DeCaprio JA,Keyomarsi K

更新日期：1996-12-24 00:00:00

abstract：:To explore the basis for the template specificities of the bacteriophage T3 and T7 RNA polymerases (EC 2.7.7.6), we determined the nucleotide sequences of six promoters recognized by the T3 RNA polymerase and compared them with the previously determined promoter sequences recognized by the bacteriophage T7 RNA polymer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailey JN,Klement JF,McAllister WT

更新日期：1983-05-01 00:00:00

abstract：:Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes. MHC-I-bound peptides originate from protein degradation by the proteasome, suggesting that stably folded, long-lived proteins could evade monitoring. Here, we investigate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trentini DB,Pecoraro M,Tiwary S,Cox J,Mann M,Hipp MS,Hartl FU

更新日期：2020-02-25 00:00:00

abstract：:The modern Old World Monkeys (Superfamily Cercopithecoidea, Family Cercopithecidae) can be traced back into the late Miocene, but their origin and subsequent diversification is obscured by the scarcity of terrestrial fossil sites in Africa between 15 and 6 Ma. Here, we document the presence of cercopithecids at 12.5 M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rossie JB,Gilbert CC,Hill A

更新日期：2013-04-09 00:00:00

abstract：:Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal development despite its high expression in neurons. Several lines of evidence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reinicke AT,Laban K,Sachs M,Kraus V,Walden M,Damme M,Sachs W,Reichelt J,Schweizer M,Janiesch PC,Duncan KE,Saftig P,Rinschen MM,Morellini F,Meyer-Schwesinger C

更新日期：2019-04-16 00:00:00

abstract：:Telomere syndromes have their most common manifestation in lung disease that is recognized as idiopathic pulmonary fibrosis and emphysema. In both conditions, there is loss of alveolar integrity, but the underlying mechanisms are not known. We tested the capacity of alveolar epithelial and stromal cells from mice with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder JK,Barkauskas CE,Limjunyawong N,Stanley SE,Kembou F,Tuder RM,Hogan BL,Mitzner W,Armanios M

更新日期：2015-04-21 00:00:00

abstract：:DNA and protein determinants of nucleosome positioning have been examined after in vitro reconstitutions of native or modified histone octamers onto tandem repeats of 207- and 172-base-pair DNA sequences containing the Lytechinus variegatus 5S rRNA gene and onto monomeric sequences derived from these by digestion with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong F,Hansen JC,van Holde KE

更新日期：1990-08-01 00:00:00

abstract：:Metastasis of solid tumors is a key determinant of cancer patient survival. Targeting micrometastases using nanoparticles could offer a way to stop metastatic tumor growth before it causes excessive patient morbidity. However, nanoparticle delivery to micrometastases is difficult to investigate because micrometastases...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kingston BR,Syed AM,Ngai J,Sindhwani S,Chan WCW

更新日期：2019-07-23 00:00:00

abstract：:A 2.9-kilobase Acc I fragment of the DNA of the pneumococcal bacteriophage Cp-1, containing the cpl gene, hybridizes with the lytA gene encoding the pneumococcal amidase. The nucleotide sequence of the cpl gene of Cp-1, encoding a muramidase (CPL), has been determined. The 3' regions of the cpl and lytA coding sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García E,García JL,García P,Arrarás A,Sánchez-Puelles JM,López R

更新日期：1988-02-01 00:00:00

abstract：:CD4+ T cells recognize major histocompatibility complex (MHC) class II-bound peptides that are primarily obtained from extracellular sources. Endogenously synthesized proteins that readily enter the MHC class I presentation pathway are generally excluded from the MHC class II presentation pathway. We show here that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanderson S,Frauwirth K,Shastri N

更新日期：1995-08-01 00:00:00

abstract：:Ultrastructural immunocytochemical studies of the expression of major histocompatibility complex class I antigens in the placentas of inbred rats were performed using placentas derived from natural matings and from embryo transfers into females made pseudopregnant by mechanical stimulation. The studies utilized the WF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanbour-Shakir A,Zhang X,Rouleau A,Armstrong DT,Kunz HW,Macpherson TA,Gill TJ 3rd

更新日期：1990-01-01 00:00:00

abstract：:After more than two decades of study, many fundamental questions remain unanswered about the dynamics of glass-forming materials confined to thin films. Experiments and simulations indicate that free interfaces enhance dynamics over length scales larger than molecular sizes, and this effect strengthens at lower temper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivancic RJS,Riggleman RA

更新日期：2020-10-13 00:00:00

abstract：:Neuronal remodeling is a fundamental process by which the brain responds to environmental influences, e.g., during stress. In the hippocampus, chronic stress causes retraction of dendrites in CA3 pyramidal neurons. We have recently identified the glycoprotein M6a as a stress-responsive gene in the hippocampal formatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alfonso J,Fernández ME,Cooper B,Flugge G,Frasch AC

更新日期：2005-11-22 00:00:00

abstract：:The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood. Previously, we noted that the expression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He H,Li W,Liyanarachchi S,Srinivas M,Wang Y,Akagi K,Wang Y,Wu D,Wang Q,Jin V,Symer DE,Shen R,Phay J,Nagy R,de la Chapelle A

更新日期：2015-05-12 00:00:00

abstract：:The delivery of AMPA receptors to the plasma membrane is a critical step both for the synaptic delivery of these receptors and for the regulation of synaptic transmission. To directly visualize fusion events of transport vesicles containing the AMPA receptor GluA2 subunit with the plasma membrane we used pHluorin-tagg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araki Y,Lin DT,Huganir RL

更新日期：2010-06-15 00:00:00

abstract：:The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2',5'-linked RNA molecules (2-5A) that activate regulated RNA decay in mammalian tissues. Differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donovan J,Whitney G,Rath S,Korennykh A

更新日期：2015-03-31 00:00:00

abstract：:Bacteria in the human oral cavity often grow in an attached multispecies biofilm community. Members of this community display defined interactions that have an impact on the physiology of the individual and the group. Here, we show that during coculture growth with streptococci, the oral pathogen Aggregatibacter actin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsey MM,Whiteley M

更新日期：2009-02-03 00:00:00

abstract：:DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao P,LeBlanc SJ,Case BC,Elston TC,Hingorani MM,Erie DA,Weninger KR

更新日期：2020-07-28 00:00:00

abstract：:The ability of cocaine to inhibit the dopamine transporter (DAT) appears to be crucial for its reinforcing properties. The potential use of drugs that produce long-lasting inhibition of the DAT as a mean of preventing the "high" and reducing drug-seeking behavior has become a major strategy in medication development. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkow ND,Wang GJ,Fowler JS,Gatley SJ,Ding YS,Logan J,Dewey SL,Hitzemann R,Lieberman J

更新日期：1996-09-17 00:00:00

abstract：:Immobilizing a protein, that is fully compatible with the patient, on the surface of a biomedical device should make it possible to avoid adverse responses such as inflammation, rejection, or excessive fibrosis. A surface that strongly binds and does not denature the compatible protein is required. Hydrophilic surface...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bilek MM,Bax DV,Kondyurin A,Yin Y,Nosworthy NJ,Fisher K,Waterhouse A,Weiss AS,dos Remedios CG,McKenzie DR

更新日期：2011-08-30 00:00:00

abstract：:Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation and likely contribute to the remarkable diversity of placental structures. Independent capture events have been identified in primates, rodents, lagomorphs, and carnivores, where they are involved in the formation of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornelis G,Heidmann O,Degrelle SA,Vernochet C,Lavialle C,Letzelter C,Bernard-Stoecklin S,Hassanin A,Mulot B,Guillomot M,Hue I,Heidmann T,Dupressoir A

更新日期：2013-02-26 00:00:00