The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.

abstract：:The up-regulation of the 25-hydroxyvitamin D(3)-24-hydroxylase by 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] is well established and occurs at the transcriptional level through two vitamin D response elements in the promoter of the gene. However, the mechanism of down-regulation of the 24-hydroxylase by parathyroid ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zierold C,Mings JA,DeLuca HF

更新日期：2001-11-20 00:00:00

abstract：:A single mutation altering the transmembrane domain of the receptor-like p185 protein encoded by the rat neu gene converts the normal neu gene into a potent oncogene. The biochemical consequences of this mutation were studied by examining phosphorylation of the normal and transforming p185 molecules in membrane prepar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bargmann CI,Weinberg RA

更新日期：1988-08-01 00:00:00

abstract：:DNA sequences in Neurospora crassa that code for ribosomal RNA have been isolated in a highly purified state by DNA-RNA hybridization. About 100 separate ribosomal RNA genes exist in each nucleus. These genes are composed of repeated sequences that are present about 100 times per nucleus. The individual members of thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay SK,Kohne DE,Dutta SK

更新日期：1972-11-01 00:00:00

abstract：:A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and ferti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansing JS,Watkins JC,Hallmark B,Cox MP,Karafet TM,Sudoyo H,Hammer MF

更新日期：2008-08-19 00:00:00

abstract：:Contractile forces are essential for many developmental processes involving cell shape change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the major component of the contractile machinery, have shown that active contractility occurs above a threshold motor concentration and within a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Wolynes PG

更新日期：2012-04-24 00:00:00

abstract：:During sporulation of the Gram-positive bacterium Bacillus subtilis, transcription of genes encoding spore coat proteins in the mother-cell compartment of the sporangium is controlled by RNA polymerase containing the sigma subunit called sigma K. Based on comparison of the N-terminal amino acid sequence of sigma K wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu S,Halberg R,Kroos L

更新日期：1990-12-01 00:00:00

abstract：:The serological properties of the gag gene products p15 and p12 of N- and B-tropic viruses of C57BL mice have been examined. Although these viruses were serologically identical by competition assays for proteins gp71 and p30, they were readily distinguishable in competition assays for proteins p15 and p12. Two isolate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benade LE,Ihle JN,Declève A

更新日期：1978-09-01 00:00:00

abstract：:The genomic basis of primate phenotypic uniqueness remains obscure, despite increasing genome and transcriptome sequence data availability. Although factors such as segmental duplications and positive selection have received much attention as potential drivers of primate phenotypes, single-copy primate-specific genes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tay SK,Blythe J,Lipovich L

更新日期：2009-07-21 00:00:00

abstract：:Pregnant mothers often report a special awareness of and bonding with their unborn child. Little is known about this relationship although it may offer potential for the assessment of the fetal condition. Recently we found evidence of short epochs of fetal-maternal heart rate synchronization under uncontrolled conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Leeuwen P,Geue D,Thiel M,Cysarz D,Lange S,Romano MC,Wessel N,Kurths J,Grönemeyer DH

更新日期：2009-08-18 00:00:00

abstract：:The adzuki bean beetle, Callosobruchus chinensis, is triple-infected with distinct lineages of Wolbachia endosymbiont, wBruCon, wBruOri, and wBruAus, which were identified by their wsp (Wolbachia surface protein) gene sequences. Whereas wBruCon and wBruOri caused cytoplasmic incompatibility of the host insect, wBruAus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo N,Nikoh N,Ijichi N,Shimada M,Fukatsu T

更新日期：2002-10-29 00:00:00

abstract：:Across phyla, the ribosomes-the central molecular machines for translation of genetic information-exhibit an overall preserved architecture and a conserved functional core. The natural heterogeneity of the ribosome periodically phases a debate on their functional specialization and the tissue-specific variations of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbeigiarab S,Kiani P,Velazquez Sanchez A,Krisp C,Kazantsev A,Fester L,Schlüter H,Ignatova Z

更新日期：2019-11-05 00:00:00

abstract：:Mobile ectothermic animals can control their body temperatures by selecting specific thermal conditions in the environment, but embryos--trapped within an immobile egg and lacking locomotor structures--have been assumed to lack that ability. Falsifying that assumption, our experimental studies show that even early sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du WG,Zhao B,Chen Y,Shine R

更新日期：2011-06-07 00:00:00

abstract：:Lymphatic vessel growth or lymphangiogenesis occurs during embryonic development and wound healing and plays an important role in tumor metastasis and inflammatory diseases. However, the possibility of noninvasive detection and quantification of lymphangiogenesis has been lacking. Here, we present the Vegfr3(EGFPLuc) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martínez-Corral I,Olmeda D,Diéguez-Hurtado R,Tammela T,Alitalo K,Ortega S

更新日期：2012-04-17 00:00:00

abstract：:Molecular recognition by proteins is fundamental to molecular biology. Dissection of the thermodynamic energy terms governing protein-ligand interactions has proven difficult, with determination of entropic contributions being particularly elusive. NMR relaxation measurements have suggested that changes in protein con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caro JA,Harpole KW,Kasinath V,Lim J,Granja J,Valentine KG,Sharp KA,Wand AJ

更新日期：2017-06-20 00:00:00

abstract：:Antisense oligodeoxyribonucleotides targeted to the epidermal growth factor (EGF) receptor were encapsulated into liposomes linked to folate via a polyethylene glycol spacer (folate-PEG-liposomes) and efficiently delivered into cultured KB cells via folate receptor-mediated endocytosis. The oligonucleotides were a pho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Lee RJ,Cauchon G,Gorenstein DG,Low PS

更新日期：1995-04-11 00:00:00

abstract：:To determine which of seven library design algorithms best introduces new protein function without destroying it altogether, seven combinatorial libraries of green fluorescent protein variants were designed and synthesized. Each was evaluated by distributions of emission intensity and color compiled from measurements ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Treynor TP,Vizcarra CL,Nedelcu D,Mayo SL

更新日期：2007-01-02 00:00:00

abstract：:The oxygen isotope record of the last million years, as provided by a deep sea core sediment, is analyzed by a method recently developed in the theory of dynamical systems. The analysis suggests that climatic variability is the manifestation of a chaotic dynamics described by an attractor of fractal dimensionality. A ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicolis C,Nicolis G

更新日期：1986-02-01 00:00:00

abstract：:FtsZ, the ancestral homolog of eukaryotic tubulins, is a GTPase that assembles into a cytokinetic ring structure essential for cell division in prokaryotic cells. Similar to tubulin, purified FtsZ polymerizes into dynamic protofilaments in the presence of GTP; polymer assembly is accompanied by GTP hydrolysis. We used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Margalit DN,Romberg L,Mets RB,Hebert AM,Mitchison TJ,Kirschner MW,RayChaudhuri D

更新日期：2004-08-10 00:00:00

abstract：:The generalized seizures of status epilepticus (SE) trigger a series of molecular and cellular events that produce cognitive deficits and can culminate in the development of epilepsy. Known early events include opening of the blood-brain barrier (BBB) and astrocytosis accompanied by activation of brain microglia. Wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varvel NH,Neher JJ,Bosch A,Wang W,Ransohoff RM,Miller RJ,Dingledine R

更新日期：2016-09-20 00:00:00

abstract：:Increased clouds and precipitation normally decrease the diurnal temperature range (DTR) and thus have commonly been offered as explanation for the trend of reduced DTR observed for many land areas over the last several decades. Observations show, however, that the DTR was reduced most in dry regions and especially in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou L,Dickinson RE,Tian Y,Vose RS,Dai Y

更新日期：2007-11-13 00:00:00

abstract：:Na(+)-channel inactivation is proposed to occur by binding of an intracellular inactivation gate to a hydrophobic inactivation gate receptor in the intracellular mouth of the pore. Amino acid residues in transmembrane segment S6 of domain IV (IVS6) that are critical for fast inactivation were identified by alanine-sca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McPhee JC,Ragsdale DS,Scheuer T,Catterall WA

更新日期：1994-12-06 00:00:00

abstract：:In our earlier work we showed that either spermidine or spermine could support the growth of spe2Delta or spe3Delta polyamine-requiring mutants, but it was unclear whether the cells had a specific requirement for either of these amines. In the current work, we demonstrate that spermidine is specifically required for t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay MK,Tabor CW,Tabor H

更新日期：2003-11-25 00:00:00

abstract：:Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearse RV 2nd,Drolet DW,Kalla KA,Hooshmand F,Bermingham JR Jr,Rosenfeld MG

更新日期：1997-07-08 00:00:00

abstract：:We describe a new computer program, trilogy, for the automated discovery of sequence-structure patterns in proteins. trilogy implements a pattern discovery algorithm that begins with an exhaustive analysis of flexible three-residue patterns; a subset of these patterns are selected as seeds for an extension process in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradley P,Kim PS,Berger B

更新日期：2002-06-25 00:00:00

abstract：:Despite considerable interest in the forces shaping the relationship between brain size and cognitive abilities, it remains controversial whether larger-brained animals are, indeed, better problem-solvers. Recently, several comparative studies have revealed correlations between brain size and traits thought to require...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benson-Amram S,Dantzer B,Stricker G,Swanson EM,Holekamp KE

更新日期：2016-03-01 00:00:00

abstract：:The genetic coupling hypothesis of signal-preference evolution, whereby the same genes control male signal and female preference for that signal, was first inspired by the evolution of cricket acoustic communication nearly 50 years ago. To examine this hypothesis, we compared the genomic location of quantitative trait...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw KL,Lesnick SC

更新日期：2009-06-16 00:00:00

abstract：:We describe a fractionation and purification scheme for the Drosophila RNA polymerase II general transcription factors. Drosophila TFIIE, TFIIF, TFIIH, and RNA polymerase II have been purified to greater than 50% homogeneity from Drosophila embryo nuclear extracts. TFIID has been purified 80-fold and is not significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austin RJ,Biggin MD

更新日期：1996-06-11 00:00:00

abstract：:The ganglioside pattern of both SV40- and polyoma virus-transformed mouse cell lines differs from that of the parent cell lines or of cell lines that have transformed spontaneously in tissue culture. This is manifested by a dramatic decrease of gangliosides with an oligosaccharide chain larger than sialyllactose. Pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cumar FA,Brady RO,Kolodny EH,McFarland VW,Mora PT

更新日期：1970-10-01 00:00:00

abstract：:Previous work indicated that the light chains of a monotypic immunoglobulins G2-K and M-K from a single patient (Ti1) are identical. Our present data show that the monotypic immunoglobulins G and M share idiotypic determinants not present in their isolated light chains or in any of a large number of other immunoglobul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang AC,Wilson KS,Hopper JE,Fudenberg HH,Nisonoff A

更新日期：1970-06-01 00:00:00

abstract：:Myoglobin-mediated oxygen delivery to intracellular mitochondria is demonstrated in cardiac myocytes isolated from the hearts of mature rats. Myocytes are held at high ambient oxygen pressure, 40-340 torr (5-45 kPa); sarcoplasmic myoglobin is fully oxygenated. In this condition oxygen availability does not limit respi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wittenberg BA,Wittenberg JB

更新日期：1987-11-01 00:00:00