Abstract:
:Previous work indicated that the light chains of a monotypic immunoglobulins G2-K and M-K from a single patient (Ti1) are identical. Our present data show that the monotypic immunoglobulins G and M share idiotypic determinants not present in their isolated light chains or in any of a large number of other immunoglobulins tested, and that amino acid sequences of the first 27 residues from the NH(2)-terminal end of the gamma- and mu-chains are identical. These results support the hypothesis that at least two genes control the synthesis of each heavy and light chain and suggest that the monotypic immunoglobulin G and monotypic immunoglobulin M of this patient share three of the four genes involved. It is proposed that, during normal immunoglobulin synthesis, different cells of a single clone synthesize immunoglobulins M and G, and that the light chains and the variable segments of the heavy chains of the proteins of the two classes are identical within the clone. A genetic switching mechanism is suggested.
journal_name
Proc Natl Acad Sci U S Aauthors
Wang AC,Wilson KS,Hopper JE,Fudenberg HH,Nisonoff Adoi
10.1073/pnas.66.2.337subject
Has Abstractpub_date
1970-06-01 00:00:00pages
337-43issue
2eissn
0027-8424issn
1091-6490journal_volume
66pub_type
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