Antarctic birds breed later in response to climate change.

abstract：:The replication of simian virus 40 (SV40) DNA is dependent upon a single viral protein [tumor (T) antigen] and multiple cellular proteins. To define the required cellular proteins, we have made use of a cell-free system that supports the replication of plasmid DNA molecules containing the SV40 origin of replication. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Virshup DM,Kelly TJ

更新日期：1989-05-01 00:00:00

abstract：:The unicellular green alga Chlamydomonas swims with two flagella that can synchronize their beat. Synchronized beating is required to swim both fast and straight. A long-standing hypothesis proposes that synchronization of flagella results from hydrodynamic coupling, but the details are not understood. Here, we presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geyer VF,Jülicher F,Howard J,Friedrich BM

更新日期：2013-11-05 00:00:00

abstract：:The family of WD40-repeat (WDR) proteins is one of the largest in eukaryotes, but little is known about their function in brain development. Among 26 WDR genes assessed, we found 7 displaying a major impact in neuronal morphology when inactivated in mice. Remarkably, all seven genes showed corpus callosum defects, inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kannan M,Bayam E,Wagner C,Rinaldi B,Kretz PF,Tilly P,Roos M,McGillewie L,Bär S,Minocha S,Chevalier C,Po C,Sanger Mouse Genetics Project.,Chelly J,Mandel JL,Borgatti R,Piton A,Kinnear C,Loos B,Adams DJ,Hérault Y,

更新日期：2017-10-31 00:00:00

abstract：:Questions that still surround the origin and early dispersals of maize (Zea mays L.) result in large part from the absence of information on its early history from the Balsas River Valley of tropical southwestern Mexico, where its wild ancestor is native. We report starch grain and phytolith data from the Xihuatoxtla ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piperno DR,Ranere AJ,Holst I,Iriarte J,Dickau R

更新日期：2009-03-31 00:00:00

abstract：:Deuterium Fourier-transform nuclear magnetic resonance spectra have been obtained of 1-myristoyl 2-(14,14,14-trideutero)myristoyl phosphatidylcholine bilayers at 34.1 MHz by using the quadrupole echo pulse technique. Thereby, we have investigated the effects upon the deuterated dimyristoyl phosphatidylcholine bilayers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldfield E,Gilmore R,Glaser M,Gutowsky HS,Hshung JC,Kang SY,King TE,Meadows M,Rice D

更新日期：1978-10-01 00:00:00

abstract：:Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR), but there have been few studies of the interactions between these two proteins. In this study, recombinant human MS (hMS) and MSR (hMSR) were expressed in baculovirus-infected insect cells and purified to homogeneity. hMSR maintained...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamada K,Gravel RA,Toraya T,Matthews RG

更新日期：2006-06-20 00:00:00

abstract：:Recent research links diet-induced obesity (DIO) with impaired immunity, although the underlying mechanisms remain unclear. We find that the induction of inducible NO synthase (iNOS) and cytokines is suppressed in mice with DIO and in bone marrow macrophages (BMMPhi) from mice with DIO exposed to an oral pathogen, Por...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Q,Leeman SE,Amar S

更新日期：2009-06-30 00:00:00

abstract：:Ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid have been attached covalently to the 5' terminus of the deoxynucleotide sequence C-A-C-A-A-T-T-C-C-A-C-A-C-A-A-C (16-mer) via an ethylenediamine linker. In the presence of Fe2+ and dithiothreitol, these reagents bring about the hybridization-depend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu BC,Orgel LE

更新日期：1985-02-01 00:00:00

abstract：:Two independently arising alpha heavy chain mutants have been found to synthesize heavy chains with CH1 deletions of approximately equal extent. Both were isolated from heavy chain-producing variants of the mouse myeloma W3129 and demonstrate that it is possible to arrive at the heavy chain disease phenotype by the pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dackowski W,Morrison SL

更新日期：1981-11-01 00:00:00

abstract：:Mach bands, the illusory brightness maxima and minima perceived at the initiation and termination of luminance gradients, respectively, are generally considered a direct perceptual manifestation of lateral inhibitory interactions among retinal or other lower order visual neurons. Here we examine an alternative explana...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotto RB,Williams SM,Purves D

更新日期：1999-04-27 00:00:00

abstract：:To attempt to locate functionally important regions of the interferon (IFN) molecule, recombinant human IFN-alpha 2 was subjected to proteolytic digestion. The bacterial proteinase thermolysin produced two major complementary fragments, HuIFN-alpha 2-(1-110) and HuIFN-alpha 2-(111-153). After reduction with 2-mercapto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ackerman SK,Zur Nedden D,Heintzelman M,Hunkapiller M,Zoon K

更新日期：1984-02-01 00:00:00

abstract：:A significant improvement in molecular hydrogen uptake properties is revealed by our ab initio calculations for Li-decorated metal-organic framework 5. We have found that two Li atoms are strongly adsorbed on the surfaces of the six-carbon rings, one on each side, carrying a charge of +0.9e per Li atom. Each Li can cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blomqvist A,Araújo CM,Srepusharawoot P,Ahuja R

更新日期：2007-12-18 00:00:00

abstract：:Reinstatement of neural activity is hypothesized to underlie our ability to mentally travel back in time to recover the context of a previous experience. We used intracranial recordings to directly examine the precise spatiotemporal extent of neural reinstatement as 32 participants with electrodes placed for seizure m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaffe RB,Kerr MS,Damera S,Sarma SV,Inati SK,Zaghloul KA

更新日期：2014-12-30 00:00:00

abstract：:In the rhesus monkey (Macaca mulatta), the frequency of pulsatile gonadotropic hormone release is relatively constant in the face of widely varying levels of estradiol (E2) in the peripheral circulation--e.g., in the course of the follicular phase of the menstrual cycle and after ovariectomy. This suggests that modula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kesner JS,Wilson RC,Kaufman JM,Hotchkiss J,Chen Y,Yamamoto H,Pardo RR,Knobil E

更新日期：1987-12-01 00:00:00

abstract：:Gene expression networks are complicated by the assortment of regulatory factors that bind DNA and modulate transcription combinatorially. Single-cell measurements can reveal biological mechanisms hidden by population averages, but their value has not been fully explored in the context of mRNA regulation. Here, we ada...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Brugge JS,Janes KA

更新日期：2011-10-04 00:00:00

abstract：:Excited states of proteins may play important roles in function, yet are difficult to study spectroscopically because of their sparse population. High hydrostatic pressure increases the equilibrium population of excited states, enabling their characterization [Akasaka K (2003) Biochemistry 42:10875-85]. High-pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerch MT,Horwitz J,McCoy J,Hubbell WL

更新日期：2013-12-03 00:00:00

abstract：:Given their relatively small area, mangroves and their organic sediments are of disproportionate importance to global carbon sequestration and carbon storage. Peat deposition and preservation allows some mangroves to accrete vertically and keep pace with sea-level rise by growing on their own root remains. In this stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ezcurra P,Ezcurra E,Garcillán PP,Costa MT,Aburto-Oropeza O

更新日期：2016-04-19 00:00:00

abstract：:The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here, we show that Kif26b, a kinesin family gene, is a downst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchiyama Y,Sakaguchi M,Terabayashi T,Inenaga T,Inoue S,Kobayashi C,Oshima N,Kiyonari H,Nakagata N,Sato Y,Sekiguchi K,Miki H,Araki E,Fujimura S,Tanaka SS,Nishinakamura R

更新日期：2010-05-18 00:00:00

abstract：:Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardol P,Bailleul B,Rappaport F,Derelle E,Béal D,Breyton C,Bailey S,Wollman FA,Grossman A,Moreau H,Finazzi G

更新日期：2008-06-03 00:00:00

abstract：:The sequence of the transforming region of simian sarcoma virus (SSV) has been determined by using molecularly cloned viral DNA. This region encompassed the 1.0-kilobase pair woolly monkey cell-derived insertion sequence, v-sis, and flanking simian sarcoma-associated viral (SSAV) sequences. A 675-nucleotide-long open ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devare SG,Reddy EP,Robbins KC,Andersen PR,Tronick SR,Aaronson SA

更新日期：1982-05-01 00:00:00

abstract：:The idea that the first living systems on earth were based on self-replicating RNA molecules has recently become popular as a result of the discovery of ribozymes. However, there are several major problems associated with the prebiotic synthesis of ribonucleotides. In addition, there is the newly recognized problem of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joyce GF,Schwartz AW,Miller SL,Orgel LE

更新日期：1987-07-01 00:00:00

abstract：:The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood. Previously, we noted that the expression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He H,Li W,Liyanarachchi S,Srinivas M,Wang Y,Akagi K,Wang Y,Wu D,Wang Q,Jin V,Symer DE,Shen R,Phay J,Nagy R,de la Chapelle A

更新日期：2015-05-12 00:00:00

abstract：:Although antibodies to HLA play a role in the pathogenesis of diseases processes such as rejection of transplanted organs, the precise mechanisms by which antibodies cause tissue injury are not completely understood. We hypothesized that antibodies to host tissues cause inflammation in part by activating endothelial e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamakuchi M,Kirkiles-Smith NC,Ferlito M,Cameron SJ,Bao C,Fox-Talbot K,Wasowska BA,Baldwin WM 3rd,Pober JS,Lowenstein CJ

更新日期：2007-01-23 00:00:00

abstract：:Protein interactions with the collagen triple helix play a critical role in collagen fibril formation, cell adhesion, and signaling. However, structural insight into sequence-specific collagen recognition is limited to an integrin-peptide complex. A GVMGFO motif in fibrillar collagens (O denotes 4-hydroxyproline) bind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohenester E,Sasaki T,Giudici C,Farndale RW,Bächinger HP

更新日期：2008-11-25 00:00:00

abstract：:The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papahadjopoulos D,Allen TM,Gabizon A,Mayhew E,Matthay K,Huang SK,Lee KD,Woodle MC,Lasic DD,Redemann C

更新日期：1991-12-15 00:00:00

abstract：:The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental Origins of Health and Disease hypothesis. However, our understanding of the underlying mechanisms remains ill-defined. We have developed a mouse paternal low-protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watkins AJ,Dias I,Tsuro H,Allen D,Emes RD,Moreton J,Wilson R,Ingram RJM,Sinclair KD

更新日期：2018-10-02 00:00:00

abstract：:A structural and functional model of bacterial nitric oxide reductase (NOR) has been designed by introducing two glutamates (Glu) and three histidines (His) in sperm whale myoglobin. X-ray structural data indicate that the three His and one Glu (V68E) residues bind iron, mimicking the putative Fe(B) site in NOR, while...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin YW,Yeung N,Gao YG,Miner KD,Tian S,Robinson H,Lu Y

更新日期：2010-05-11 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) patients carry a missense mutation in ACVR1 [617G > A (R206H)] that leads to hyperactivation of BMP-SMAD signaling. Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) generation. This positiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayashi Y,Hsiao EC,Sami S,Lancero M,Schlieve CR,Nguyen T,Yano K,Nagahashi A,Ikeya M,Matsumoto Y,Nishimura K,Fukuda A,Hisatake K,Tomoda K,Asaka I,Toguchida J,Conklin BR,Yamanaka S

更新日期：2016-11-15 00:00:00

abstract：:Human chorionic gonadotropin (hCG) preparations contain activity against HIV type 1 (HIV-1). However, there has been controversy about whether some biological activities of hCG beta-subunit (hCGbeta) preparations are caused by the beta-subunit itself or other proteins present in the preparations. We report here the pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee-Huang S,Huang PL,Sun Y,Huang PL,Kung HF,Blithe DL,Chen HC

更新日期：1999-03-16 00:00:00

abstract：:Lesion of the sciatic nerve caused a rapid increase in c-fos and c-jun mRNA that was followed about 2 hr later by an increase in nerve growth factor (NGF) mRNA. To evaluate whether the initial increase in c-fos mRNA is causally related to the subsequent increase in NGF mRNA, we performed experiments with fibroblasts o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hengerer B,Lindholm D,Heumann R,Rüther U,Wagner EF,Thoenen H

更新日期：1990-05-01 00:00:00