Deuterium nuclear magnetic resonance investigation of the effects of proteins and polypeptides on hydrocarbon chain order in model membrane systems.

abstract：:The regulatory mechanisms that use signals of low levels of reactive oxygen species (ROS) could be obscured by ROS produced under stress and thus are better investigated under homeostatic conditions. Previous studies showed that the chloroplastic atypical thioredoxin ACHT1 is oxidized by 2-Cys peroxiredoxin (2-Cys Prx...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eliyahu E,Rog I,Inbal D,Danon A

更新日期：2015-10-13 00:00:00

abstract：:Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane excitability and myocardial dysfunction remain uncertain. Failing human cardiomyocytes exhibit increased CaMKII and voltage-gated Ca(2+) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koval OM,Guan X,Wu Y,Joiner ML,Gao Z,Chen B,Grumbach IM,Luczak ED,Colbran RJ,Song LS,Hund TJ,Mohler PJ,Anderson ME

更新日期：2010-03-16 00:00:00

abstract：:The quantitative autoradiographic 2-deoxy-[14C]glucose technique has been used with conscious rats to investigate the functional consequences (reflected as alterations in local rates of glucose utilization) of unilateral intrastriatal administration of vasoactive intestinal polypeptide. Intrastriatal administration of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCulloch J,Kelly PA,Uddman R,Edvinsson L

更新日期：1983-03-01 00:00:00

abstract：:Beckwith-Wiedemann syndrome (BWS) involves fetal overgrowth and predisposition to a wide variety of embryonal tumors of childhood. We have previously found that BWS is genetically linked to 11p15 and that this same band shows loss of heterozygosity in the types of tumors to which children with BWS are susceptible. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoovers JM,Kalikin LM,Johnson LA,Alders M,Redeker B,Law DJ,Bliek J,Steenman M,Benedict M,Wiegant J,Lengauer C,Taillon-Miller P,Schlessinger D,Edwards MC,Elledge SJ,Ivens A,Westerveld A,Little P,Mannens M,Feinberg AP

更新日期：1995-12-19 00:00:00

abstract：:In this contribution, we study situations in which nanoparticles in a fluid are strongly heated, generating high heat fluxes. This situation is relevant to experiments in which a fluid is locally heated by using selective absorption of radiation by solid particles. We first study this situation for different types of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merabia S,Shenogin S,Joly L,Keblinski P,Barrat JL

更新日期：2009-09-08 00:00:00

abstract：:The subcellular localization of cathepsin B activity (EC 3.4.22.1) in three murine melanomas of increasing metastatic potential (Cloudman less than B16-F1 less than B16 amelanotic) was determined. Cathepsin B activity was localized in the heavy mitochondrial fraction of normal murine liver but in the light mitochondri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sloane BF,Rozhin J,Johnson K,Taylor H,Crissman JD,Honn KV

更新日期：1986-04-01 00:00:00

abstract：:The Arabidopsis DEMETER (DME) DNA glycosylase demethylates the maternal genome in the central cell prior to fertilization and is essential for seed viability. DME preferentially targets small transposons that flank coding genes, influencing their expression and initiating plant gene imprinting. DME also targets interg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Hung YH,Rim HJ,Zhang D,Frost JM,Shin H,Jang H,Liu F,Xiao W,Iyer LM,Aravind L,Zhang XQ,Fischer RL,Huh JH,Hsieh TF

更新日期：2019-08-27 00:00:00

abstract：:Defining prospective pathways by which zoonoses evolve and emerge as human pathogens is critical for anticipating and controlling both natural and deliberate pandemics. However, predicting tenable pathways of animal-to-human movement has been hindered by challenges in identifying reservoir species, cultivating zoonoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker MM,Graham RL,Donaldson EF,Rockx B,Sims AC,Sheahan T,Pickles RJ,Corti D,Johnston RE,Baric RS,Denison MR

更新日期：2008-12-16 00:00:00

abstract：:Thirty percent of the 189 tumors studied to date express DNA polymerase beta variants. One of these variants was identified in a prostate carcinoma and is altered from isoleucine to methionine at position 260, within the hydrophobic hinge region of the protein. Another variant was identified in a colon carcinoma and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sweasy JB,Lang T,Starcevic D,Sun KW,Lai CC,Dimaio D,Dalal S

更新日期：2005-10-04 00:00:00

abstract：:Insulin activates sterol regulatory element-binding protein-1c (SREBP-1c) in liver, thereby increasing fatty acid and triglyceride synthesis. We created a line of transgenic rats that produce epitope-tagged human SREBP-1c in liver under control of the constitutive apolipoprotein E promoter/enhancer. This system allows...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen JL,Zhang Y,Bae SH,Farooqi MS,Liang G,Hammer RE,Goldstein JL,Brown MS

更新日期：2012-10-02 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00

abstract：:To study the structure and function of the gene for parathyroid hormone, we obtained recombinant plasmids containing bovine parathyroid hormone cDNA. The nucleotide sequence at the 5' terminus (relative to the sense strand) of the cDNA insert in a recombinant plasmid, pPTHi4, was different from that previously reporte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weaver CA,Gordon DF,Kemper B

更新日期：1981-07-01 00:00:00

abstract：:Androgens and the androgen receptor (AR) play important roles in the testes. Previously we have shown that male total AR knockout (T-AR-/y) mice revealed incomplete germ cell development and lowered serum testosterone levels, which resulted in azoospermia and infertility. However, the consequences of AR loss in partic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Yeh S,Chen YT,Wu CC,Chuang KH,Lin HY,Wang RS,Chang YJ,Mendis-Handagama C,Hu L,Lardy H,Chang C

更新日期：2006-11-21 00:00:00

abstract：:Song syntax, defined as orderly temporal arrangements of acoustic units within a bird song, is a conspicuous feature of the songs of many species of passerine birds. While syntactical features play a role in interspecific song recognition by males of many bird species, syntax variation within species and female respon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balaban E

更新日期：1988-05-01 00:00:00

abstract：:Cancer vaccines genetically engineered to produce interleukin 2 have been investigated intensively in a series of animal models and are at the point of entering into clinical trials. In this study we demonstrate a strong correlation between the rate of interleukin 2 production and the protection efficiency of murine S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt W,Schweighoffer T,Herbst E,Maass G,Berger M,Schilcher F,Schaffner G,Birnstiel ML

更新日期：1995-05-09 00:00:00

abstract：:The method of evolutionary stable strategies (ESS), in its current form, is confronted with a difficulty when it tries to explain how some social behaviors initiate their evolution. We show that this difficulty may be removed by changing the assumption made tacitly in game theory (and in ESS) of randomness of meetings...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eshel I,Cavalli-Sforza LL

更新日期：1982-02-01 00:00:00

abstract：:Reducing monosaccharides and oligosaccharides, after reductive amination, were separated and detected as their 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde (CBQCA) derivatives by capillary electrophoresis/laser-induced fluorescence. Under optimized conditions, the minimum detectable quantities for monosaccharide sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu JP,Shirota O,Wiesler D,Novotny M

更新日期：1991-03-15 00:00:00

abstract：:Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein. To examine the physical basis for the apparent disproportion between LDL cholesterol and apoB characteristic of this syndrome, we used density...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng B,Thompson GR,Sniderman AD,Forte TM,Krauss RM,Kwiterovich PO Jr

更新日期：1983-11-01 00:00:00

abstract：:The role of rising atmospheric CO2 in modulating estuarine carbonate system dynamics remains poorly characterized, likely due to myriad processes driving the complex chemistry in these habitats. We reconstructed the full carbonate system of an estuarine seagrass habitat for a summer period of 2.5 months utilizing a co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pacella SR,Brown CA,Waldbusser GG,Labiosa RG,Hales B

更新日期：2018-04-10 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a mediator of host immunity and functions as a high, upstream activator of cells within the innate and the adaptive immunological systems. Recent studies have suggested a potentially broader role for MIF in growth regulation because of its ability to antagonize p53-media...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fingerle-Rowson G,Petrenko O,Metz CN,Forsthuber TG,Mitchell R,Huss R,Moll U,Müller W,Bucala R

更新日期：2003-08-05 00:00:00

abstract：:Aged rats, displaying impairments in spatial learning and memory associated with marked cellular atrophy of forebrain cholinergic neurons, received intracerebroventricular infusions of one of the four neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), or neurotrop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer W,Sirevaag A,Wiegand SJ,Lindsay RM,Björklund A

更新日期：1994-08-30 00:00:00

abstract：:A cyclic AMP-binding protein (CAP protein), cyclic AMP, and RNA polymerase holoenzyme are shown to initiate lac transcription at the lac promoter. Lac repressor appears to control transcription by preventing RNA polymerase and/or CAP protein from binding to the lac promoter. Results support the idea that the lac promo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eron L,Block R

更新日期：1971-08-01 00:00:00

abstract：:A convenient technique for the partial purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described. The method depends upon annealing poly(adenylic acid)-rich mRNA to oligothymidylic acid-cellulose columns and its elution with buffers of low ionic strength. Biologically active rabbit glo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aviv H,Leder P

更新日期：1972-06-01 00:00:00

abstract：:The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyons RP,Scholz CA,Cohen AS,King JW,Brown ET,Ivory SJ,Johnson TC,Deino AL,Reinthal PN,McGlue MM,Blome MW

更新日期：2015-12-22 00:00:00

abstract：:A solid-phase immunoadsorbent capable of binding mouse interferon has been prepared. Starting from crude tissue-culture material, interferon could be purified 1990 times in a single step of affinity chromatography. Overall recovery ranged from 55 to 103% with tissue culture and mouse-brain interferon; however, only 5%...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sipe JD,de Maeyer-Guignard J,Fauconnier B,de Maeyer E

更新日期：1973-04-01 00:00:00

abstract：:Sympatric speciation has been controversial since it was first proposed as a mode of speciation. Subterranean blind mole rats (Spalacidae) are considered to speciate allopatrically or peripatrically. Here, we report a possible incipient sympatric adaptive ecological speciation in Spalax galili (2n = 52). The study mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadid Y,Tzur S,Pavlícek T,Šumbera R,Šklíba J,Lövy M,Fragman-Sapir O,Beiles A,Arieli R,Raz S,Nevo E

更新日期：2013-02-12 00:00:00

abstract：:A molecular assembly based on derivatized polystyrene is described, which mimics both the light-harvesting and energy-conversion steps of photosynthesis. The system is unique in that the two key parts of a photosynthetic system are incorporated in a functional assembly constructed from polypyridine complexes of Ru(II)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sykora M,Maxwell KA,DeSimone JM,Meyer TJ

更新日期：2000-07-05 00:00:00

abstract：:RNA interference (RNAi) is a widely used method for analysis of gene function in tissue culture cells. However, to date there has been no reliable method for testing the specificity of any particular RNAi experiment. The ideal experiment is to rescue the phenotype by expression of the target gene in a form refractory ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kittler R,Pelletier L,Ma C,Poser I,Fischer S,Hyman AA,Buchholz F

更新日期：2005-02-15 00:00:00

abstract：:HLA class II gene polymorphism was investigated in 100 patients with clinically definite multiple sclerosis (MS) by restriction fragment length polymorphism analysis of Taq I-digested DNA using DRB, DQA, and DQB cDNA probes. Twenty-six patients had primarily chronic progressive MS and 74 had relapsing/remitting MS. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olerup O,Hillert J,Fredrikson S,Olsson T,Kam-Hansen S,Möller E,Carlsson B,Wallin J

更新日期：1989-09-01 00:00:00

abstract：:Linkage analysis with restriction fragment length polymorphisms for the gene for type II procollagen (COL2A1) was carried out in a family with the Stickler syndrome, or arthro-ophthalmopathy, an autosomal dominant disorder that affects the eyes, ears, joints, and skeleton. The analysis demonstrated linkage of the dise...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmad NN,Ala-Kokko L,Knowlton RG,Jimenez SA,Weaver EJ,Maguire JI,Tasman W,Prockop DJ

更新日期：1991-08-01 00:00:00