当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

Abstract：

:The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, which indicates that cSOD is not essential for cell viability per se. cSODn108 confers recessive sensitivity to the superoxide anion (O2-)-generator paraquat and to the transition metal compound CuSO4, which indicates that the cSOD-null condition in fact leads to impaired O2- metabolism. The primary biological consequences of the reduced O2- dismutation capacity of cSODn108 Drosophila are realized in the adult as infertility and reduction in life-span. We conclude that the infertility and reduced life-span of cSODn108 adults arise as a consequence of the reduced capacity of embryos, larvae, and pupae to adequately protect developing preimaginal cells from O2- -initiated cytotoxic damage.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Phillips JP,Campbell SD,Michaud D,Charbonneau M,Hilliker AJ

doi

10.1073/pnas.86.8.2761

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

2761-5

issue

8

eissn

0027-8424

issn

1091-6490

journal_volume

86

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

    abstract：:ERK6, a mitogen-activated protein (MAP) kinase-related serine/threonine kinase, is highly expressed in human skeletal muscle and appears to function as a signal transducer during differentiation of myoblasts to myotubes. In transfected 293 cells, activation of the 45-kDa enzyme results in tyrosine-phosphorylated 46- a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.9.4355

    authors： Lechner C,Zahalka MA,Giot JF,Møller NP,Ullrich A

    更新日期：1996-04-30 00:00:00

  • Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain.

    abstract：:Accumulation of amyloid-beta (Aβ), which is associated with Alzheimer's disease, can be caused by excess production or insufficient clearance. Because of its β-sheet structure, fibrillar Aβ is resistant to proteolysis, which would contribute to slow degradation of Aβ plaques in vivo. Fibrillar Aβ can be internalized b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1719808115

    authors： Solé-Domènech S,Rojas AV,Maisuradze GG,Scheraga HA,Lobel P,Maxfield FR

    更新日期：2018-02-13 00:00:00

  • Separation of functional subsets of human T cells by a monoclonal antibody.

    abstract：:A monoclonal antibody was produced to human peripheral blood T cells. This hybridoma antibody, termed OKT4, was reactive by indirect immunofluorescence with only 55-60% of the peripheral blood T cell population (OKT4+) and unreactive with normal B cells, null cells, and macrophages. The OKT4- T cell population contain...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.76.8.4061

    authors： Reinherz EL,Kung PC,Goldstein G,Schlossman SF

    更新日期：1979-08-01 00:00:00

  • Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.

    abstract：:Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations. Herein, we report a strategy for the site-specific chemical attachment of ubiquitin to preassembled nucleosomes. This allowed ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1504483112

    authors： Holt MT,David Y,Pollock S,Tang Z,Jeon J,Kim J,Roeder RG,Muir TW

    更新日期：2015-08-18 00:00:00

  • Facilitating hydrogen atom migration via a dense phase on palladium islands to a surrounding silver surface.

    abstract：:The migration of species across interfaces can crucially affect the performance of heterogeneous catalysts. A key concept in using bimetallic catalysts for hydrogenation is that the active metal supplies hydrogen atoms to the host metal, where selective hydrogenation can then occur. Herein, we demonstrate that, follow...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2010413117

    authors： O'Connor CR,Duanmu K,Patel DA,Muramoto E,van Spronsen MA,Stacchiola D,Sykes ECH,Sautet P,Madix RJ,Friend CM

    更新日期：2020-09-15 00:00:00

  • Protein-binding dynamics imaged in a living cell.

    abstract：:Historically, rate constants were determined in vitro and it was unknown whether they were valid for in vivo biological processes. Here, we bridge this gap by measuring binding dynamics between a pair of proteins in living HeLa cells. Binding of a β-lactamase to its protein inhibitor was initiated by microinjection an...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1112171109

    authors： Phillip Y,Kiss V,Schreiber G

    更新日期：2012-01-31 00:00:00

  • Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum.

    abstract：:Rare nucleated fetal cells circulate within maternal blood. Noninvasive prenatal diagnosis by isolation and genetic analysis of these cells is currently being undertaken. We sought to determine if genetic evidence existed for persistent circulation of fetal cells from prior pregnancies. Venous blood samples were obtai...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.2.705

    authors： Bianchi DW,Zickwolf GK,Weil GJ,Sylvester S,DeMaria MA

    更新日期：1996-01-23 00:00:00

  • Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.

    abstract：:Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the induction of many immune and autoimmune responses. While studying the latter, we raised a T-cell line from the thymus of...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.16.7343

    authors： Ong B,Willcox N,Wordsworth P,Beeson D,Vincent A,Altmann D,Lanchbury JS,Harcourt GC,Bell JI,Newsom-Davis J

    更新日期：1991-08-15 00:00:00

  • Gravitational instabilities in binary granular materials.

    abstract：:The motion and mixing of granular media are observed in several contexts in nature, often displaying striking similarities to liquids. Granular dynamics occur in geological phenomena and also enable technologies ranging from pharmaceuticals production to carbon capture. Here, we report the discovery of a family of gra...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1820820116

    authors： McLaren CP,Kovar TM,Penn A,Müller CR,Boyce CM

    更新日期：2019-05-07 00:00:00

  • In vitro and in vivo correlation of clotting protease activity: effect of heparin.

    abstract：:The thrombogenicity of three highly purified proteases (thrombin, activated Factor X, and activated Factor IX) was determined quantitatively in an animal model. The minimal amounts required to produce a standard score 4 thrombus were 1.1 nmol for thrombin, 0.12 nmol for activated Factor X, and 0.018 nmol for activated...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.7.3028

    authors： Gitel SN,Stephenson RC,Wessler S

    更新日期：1977-07-01 00:00:00

  • Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.

    abstract：:Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCRs. Here we present ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1700891114

    authors： Ishchenko A,Wacker D,Kapoor M,Zhang A,Han GW,Basu S,Patel N,Messerschmidt M,Weierstall U,Liu W,Katritch V,Roth BL,Stevens RC,Cherezov V

    更新日期：2017-08-01 00:00:00

  • Dynamic coupling of whole-brain neuronal and neurotransmitter systems.

    abstract：:Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1921475117

    authors： Kringelbach ML,Cruzat J,Cabral J,Knudsen GM,Carhart-Harris R,Whybrow PC,Logothetis NK,Deco G

    更新日期：2020-04-28 00:00:00

  • Evidence that the Y chromosome influences autoimmune disease in male and female mice.

    abstract：:Experimental allergic encephalomyelitis (EAE), an autoimmune model of multiple sclerosis, is a complex disease influenced by genetic, intrinsic, and environmental factors. In this study, we questioned whether parent-of-origin effects influence EAE, using reciprocal F2 intercross progeny generated between EAE-susceptib...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0600536103

    authors： Teuscher C,Noubade R,Spach K,McElvany B,Bunn JY,Fillmore PD,Zachary JF,Blankenhorn EP

    更新日期：2006-05-23 00:00:00

  • Crossover from interaction to driven regimes in quantum vortex reconnections.

    abstract：:Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1818668116

    authors： Galantucci L,Baggaley AW,Parker NG,Barenghi CF

    更新日期：2019-06-18 00:00:00

  • Glucocorticoids locally disrupt an array of positioned nucleosomes on the rat tyrosine aminotransferase promoter in hepatoma cells.

    abstract：:Transcriptional activation by steroid hormones is often associated with the appearance of a DNase I hypersensitive site resulting from a local alteration of the nucleoprotein structure of the promoter. For the mouse mammary tumor virus long terminal repeat, a viral promoter under glucocorticoid control, a model has be...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.23.9300

    authors： Carr KD,Richard-Foy H

    更新日期：1990-12-01 00:00:00

  • The primary step of biotin synthesis in mycobacteria.

    abstract：:Biotin plays an essential role in growth of mycobacteria. Synthesis of the cofactor is essential for Mycobacterium tuberculosis to establish and maintain chronic infections in a murine model of tuberculosis. Although the late steps of mycobacterial biotin synthesis, assembly of the heterocyclic rings, are thought to f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2010189117

    authors： Hu Z,Cronan JE

    更新日期：2020-09-22 00:00:00

  • Isolation and mapping of plasmids containing the Salmonella typhimurium origin of DNA replication.

    abstract：:A purified EcoRI restriction endonuclease fragment that determines resistance to kanamycin and is incapable of self-replication was used to select autonomously replicating fragments from an EcoRI digest of a Salmonella typhimurium F' plasmid containing the chromosomal region believed to include the S. typhimurium orig...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.76.7.3097

    authors： Zyskind JW,Deen LT,Smith DW

    更新日期：1979-07-01 00:00:00

  • Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.

    abstract：:A cDNA containing the full coding region of human cytochrome b5 was inserted into a vaccinia virus cDNA expression vector. Infection of human thymidine kinase-minus (TK-) 143 cells in culture with this recombinant virus resulted in production of 0.3 nmol of cytochrome b5 per mg of cell lysate protein. The expressed cy...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.14.5425

    authors： Aoyama T,Nagata K,Yamazoe Y,Kato R,Matsunaga E,Gelboin HV,Gonzalez FJ

    更新日期：1990-07-01 00:00:00

  • Unanticipated regulatory roles for Arabidopsis phytochromes revealed by null mutant analysis.

    abstract：:In view of the extensive literature on phytochrome mutants in the Ler accession of Arabidopsis, we sought to secure a phytochrome-null line in the same genetic background for comparative studies. Here we report the isolation and phenotypic characterization of phyABCDE quintuple and phyABDE quadruple mutants in the Ler...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1221738110

    authors： Hu W,Franklin KA,Sharrock RA,Jones MA,Harmer SL,Lagarias JC

    更新日期：2013-01-22 00:00:00

  • Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.

    abstract：:Metal-inducible transcription of metallothionein (MT) genes involves the interaction of metal-responsive trans-acting factors with specific promoter DNA sequence elements. In this report, we present a genetic selection using the baker's yeast, Saccharomyces cerevisiae, to clone a gene from Candida glabrata encoding a ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.14.6112

    authors： Zhou PB,Thiele DJ

    更新日期：1991-07-15 00:00:00

  • Tumor induction by Agrobacterium rhizogenes involves the transfer of plasmid DNA to the plant genome.

    abstract：:The DNA from tumors of Nicotiana glauca initiated by strains of Agrobacterium rhizogenes was shown to contain sequences that are homologous to the root-inducing (Ri) plasmid of the bacterium. Two independently established tumor lines contained a similar portion of the Ri-plasmid. The Ri-plasmid also hybridized to DNA ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.10.3193

    authors： White FF,Ghidossi G,Gordon MP,Nester EW

    更新日期：1982-05-01 00:00:00

  • Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences.

    abstract：:B-lymphocyte-specific class switch recombination is known to occur between pairs of 2- to 10-kb switch regions located immediately upstream of the immunoglobulin constant heavy-chain genes. Others have shown that the recombination is temporally correlated with the induction of transcription at the targeted switch regi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.12.5625

    authors： Daniels GA,Lieber MR

    更新日期：1995-06-06 00:00:00

  • Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation.

    abstract：:Productive T cell recognition of antigen-presenting cells (APCs) is normally accompanied by the formation of a cell-cell contact called the "immunological synapse." Our understanding of the steps leading up to this formation has been limited by the absence of tools for analyzing 3D surfaces and surface distributions a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.192573999

    authors： Moss WC,Irvine DJ,Davis MM,Krummel MF

    更新日期：2002-11-12 00:00:00

  • Practical zero-shift tuning in geonium.

    abstract：:Compositeness of the electron may show up in a very small deviation of the measured electron g factor from one calculated for a point electron by quantum electrodynamics. The precision of our g measurements is currently limited by an interaction of the cyclotron motion with standing waves in the trap cavity containing...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.5.1681

    authors： Dehmelt H,Van Dyck R Jr,Palmer F

    更新日期：1992-03-01 00:00:00

  • Loss of the endothelin signal pathway in C6 rat glioma cells persistently infected with measles virus.

    abstract：:Endothelin 1 causes a strong Ca2+ signal in C6 rat glioma cells as measured by fura-2 fluorescence. This endothelin 1-induced Ca2+ signal was not observed when the cells were persistently infected with a measles virus strain of subacute sclerosing panencephalitis (SSPE, strain Lec). Binding of 125I-labeled endothelin ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.15.6736

    authors： Tas PW,Koschel K

    更新日期：1991-08-01 00:00:00

  • Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans.

    abstract：:This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial ac...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.24.11037

    authors： Ribary U,Ioannides AA,Singh KD,Hasson R,Bolton JP,Lado F,Mogilner A,Llinás R

    更新日期：1991-12-15 00:00:00

  • Functional helper activity of monoclonal T cell populations: antigen-specific and H-2 restricted cloned T cells provide help for in vitro antibody responses to trinitrophenyl-poly(LTyr,Glu)-poly(DLAla)--poly(LLys).

    abstract：:The ability of long-term cultured and monoclonal T cell populations to provide antigen-specific help was assessed in a system of Ir gene-controlled in vitro antibody responses to soluble antigens. T-cell colonies and monoclonal T-cell lines were generated which proliferated specifically in response to poly(LTyr,Glu)-p...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.10.6431

    authors： Hodes RJ,Kimoto M,Hathcock KS,Fathman CG,Singer A

    更新日期：1981-10-01 00:00:00

  • A functional peptide encoded in the Escherichia coli 23S rRNA.

    abstract：:A pentapeptide open reading frame equipped with a canonical ribosome-binding site is present in the Escherichia coli 23S rRNA. Overexpression of 23S rRNA fragments containing the mini-gene renders cells resistant to the ribosome-inhibiting antibiotic erythromycin. Mutations that change either the initiator or stop cod...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.11.5641

    authors： Tenson T,DeBlasio A,Mankin A

    更新日期：1996-05-28 00:00:00

  • CRIF1 as a potential target to improve the radiosensitivity of osteosarcoma.

    abstract：:Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expresse...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1906578116

    authors： Ran Q,Jin F,Xiang Y,Xiang L,Wang Q,Li F,Chen L,Zhang Y,Wu C,Zhou L,Xiao Y,Chen L,Wu J,Zhong JF,Li SC,Li Z

    更新日期：2019-10-08 00:00:00

  • Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis.

    abstract：:Murine endothelial cells are readily transformed in a single step by the polyomavirus oncogene encoding middle-sized tumor antigen. These cells (bEND.3) form tumors (hemangiomas) in mice which are lethal in newborn animals. The bEND.3 cells rapidly proliferate in culture and express little or no thrombospondin 1 (TS1)...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.15.6788

    authors： Sheibani N,Frazier WA

    更新日期：1995-07-18 00:00:00