当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

Abstract：

:The structural and functional organization of the cell nucleus has been investigated using three-dimensional reconstruction, immunoelectron microscopy, and high-resolution in situ autoradiography. Nuclear regions enriched in small nuclear ribonucleoprotein particles (snRNPs) form a reticular network within the nucleoplasm that extends between the nucleolar surface and the nuclear envelope. The snRNPs occupy approximately 18% of the volume of CHOC 400 cell nuclei. The in situ sites of DNA replication and transcription are complementary to, rather than coincident with, the nuclear regions concentrated in snRNPs. Based on these data a three-dimensional model of the organization of the mammalian cell nucleus is presented.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Spector DL

doi

10.1073/pnas.87.1.147

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

147-51

issue

1

eissn

0027-8424

issn

1091-6490

journal_volume

87

pub_type

杂志文章

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