Pyochelin: novel structure of an iron-chelating growth promoter for Pseudomonas aeruginosa.

abstract：:The role of protein farnesylation in lamin A biogenesis and the pathogenesis of progeria has been studied in considerable detail, but the importance of farnesylation for the B-type lamins, lamin B1 and lamin B2, has received little attention. Lamins B1 and B2 are expressed in nearly every cell type from the earliest s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung HJ,Nobumori C,Goulbourne CN,Tu Y,Lee JM,Tatar A,Wu D,Yoshinaga Y,de Jong PJ,Coffinier C,Fong LG,Young SG

更新日期：2013-05-21 00:00:00

abstract：:From within an albino melanocyte line grown in vitro we identified and cloned cells that apparently had reverted to wild type. We sequenced a part of the tyrosinase gene, encompassing a candidate mutation, from wild-type, albino, and revertant cell DNAs. The revertant cells contain, on one chromosome, a perfect base r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson IJ,Bennett DC

更新日期：1990-09-01 00:00:00

abstract：:Cardiolipin is important for bacterial and mitochondrial stability and function. The final step in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically between prokaryotes and eukaryotes. To study the importance of cardiolipin synthesis for mitochondrial integrity, membrane protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serricchio M,Bütikofer P

更新日期：2012-04-17 00:00:00

abstract：:Infection of the mouse trigeminal ganglia (TG) is the most commonly used model for the study of herpes simplex virus type 1 (HSV-1) latency. Its popularity is caused, at least in part, by the perception that latent infection can be studied in this system in the absence of spontaneous viral reactivation. However, this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman LT,Ellison AR,Voytek CC,Yang L,Krause P,Margolis TP

更新日期：2002-01-22 00:00:00

abstract：:We propose a model for DNA polymerase fidelity in which free energy differences, delta delta G, between matched and mismatched nucleotides are magnified at the enzyme's active site. Both hydrogen bonding and stacking components of the interaction energy are amplified, with the most profound effect being on the magnitu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petruska J,Sowers LC,Goodman MF

更新日期：1986-03-01 00:00:00

abstract：:The functional architecture of mammalian visual cortex has been elucidated in impressive detail by experimental work of the past 20-25 years. The origin of many of the salient features of this architecture, however, has remained unexplained. This paper is the first of three (the others will appear in subsequent issues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linsker R

更新日期：1986-10-01 00:00:00

abstract：:The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghendler Y,Teng MK,Liu JH,Witte T,Liu J,Kim KS,Kern P,Chang HC,Wang JH,Reinherz EL

更新日期：1998-08-18 00:00:00

abstract：:Administration of beta-sitosterol (42 mg/kg per day) for 3 weeks to 8-month-old male LXRbeta-/- mice resulted in the death of motor neurons in the lumbar region of the spinal cord and loss of tyrosine hydroxylase-positive dopaminergic neurons in the substantia nigra. In mice at 5 months of age, beta-sitosterol had no ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HJ,Fan X,Gabbi C,Yakimchuk K,Parini P,Warner M,Gustafsson JA

更新日期：2008-02-12 00:00:00

abstract：:Attention allows animals to respond selectively to competing stimuli, enabling some stimuli to evoke a behavioral response while others are ignored. How the brain does this remains mysterious, although it is increasingly evident that even animals with the smallest brains display this capacity. For example, insects res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulk AC,Stacey JA,Pearson TW,Taylor GJ,Moore RJ,Srinivasan MV,van Swinderen B

更新日期：2014-04-01 00:00:00

abstract：:Alphavirus envelope proteins, organized as trimers of E2-E1 heterodimers on the surface of the pathogenic alphavirus, mediate the low pH-triggered fusion of viral and endosomal membranes in human cells. The lack of specific treatment for alphaviral infections motivates our exploration of potential antiviral approaches...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeng X,Mukhopadhyay S,Brooks CL 3rd

更新日期：2015-02-17 00:00:00

abstract：:Selection of mammalian cells in progressively increasing concentrations of methotrexate results in selective amplification of DNA sequences coding for dihydrofolate reductase (tetrahydrofolate dehydrogenase, 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3). In some cell variants the amplified genes are stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman RJ,Brown PC,Schimke RT

更新日期：1979-11-01 00:00:00

abstract：:The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the sa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein A,Fischli W,Lowney LI,Hunkapiller M,Hood L

更新日期：1981-11-01 00:00:00

abstract：:Two adjacent, divergently transcribed, developmentally regulated genes of the maize chloroplast chromosome have different superhelical density/transcriptional activation profiles when transcribed in vitro by the homologous DNA-dependent RNA polymerase. Promoter-specific transcription of the gene for the beta and epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stirdivant SM,Crossland LD,Bogorad L

更新日期：1985-08-01 00:00:00

abstract：:The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo formation of ONOO- has been demonstrated in shock and inflammation. Herein we provide evidence that cytotoxicity in cells exposed to ONOO- is mediated by DNA strand breakage and the subseque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szabó C,Zingarelli B,O'Connor M,Salzman AL

更新日期：1996-03-05 00:00:00

abstract：:Poliovirus mRNA and mRNA transcribed from vesicular stomatitis virus and reovirus genomes efficiently direct protein synthesis in vivo under experimental conditions where the initiation of host protein synthesis is selectively blocked. The selective blockage of host peptide chain initiation after exposure to hypertoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nuss DL,Oppermann H,Koch G

更新日期：1975-04-01 00:00:00

abstract：:The Ly-6 locus encodes several cell surface proteins whose functions are unknown. Although it is hypothesized that these proteins may be receptors, there is no direct evidence that they bind a ligand. Herein we present evidence that Ly-6A.2, a Ly-6 protein expressed on T lymphocytes, binds a ligand expressed on normal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamezai A,Rock KL

更新日期：1995-05-09 00:00:00

abstract：:Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug TNP-470 displays striking cell-type specificity insofar as it induces the expression of p21(CIP/WAF), a cyclin-dependent ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh JR,Mohan R,Crews CM

更新日期：2000-11-07 00:00:00

abstract：:One goal of regenerative medicine is to repair damaged tissue. This requires not only generating new cells of the proper phenotype, but also selecting for those that properly integrate into sites of injury. In our laboratory we are using a cell-migration-based in vivo selection system to generate antibodies that induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han KH,Arlian BM,Macauley MS,Paulson JC,Lerner RA

更新日期：2018-01-16 00:00:00

abstract：:The basic theory of a newly discovered physical technique, steady-state electrophoresis, is described followed by analyses of several representative macro-ion systems with the technique. This method measures apparent moments of molar diminished charge (defined below) of solvated macro-ions from an analysis of a concen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Godfrey JE

更新日期：1989-06-01 00:00:00

abstract：:By double indirect immunofluorescence, using primary rabbit antibodies to tubulin and guinea pig antibodies to vimentin, we have simultaneously labeled microtubules and intermediate filaments in several types of cultured normal fibroblasts. With well-spread interphase cells there was an extensive but not complete corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ball EH,Singer SJ

更新日期：1981-11-01 00:00:00

abstract：:The voltage-dependent gating of the colicin channel involves a substantial structural rearrangement that results in the transfer of about 35% of the 200 residues in its pore-forming domain across the membrane. This transfer appears to represent an unusual type of protein translocation that does not depend on a large, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slatin SL,Nardi A,Jakes KS,Baty D,Duché D

更新日期：2002-02-05 00:00:00

abstract：:Saposin A, a heat-stable 16-kDa glycoprotein, was isolated from Gaucher disease spleen and purified to homogeneity. Chemical sequencing from its amino terminus and of peptides obtained by digestion with protease from Staphylococcus aureus strain V-8 demonstrated that saposin A is derived from proteolytic processing of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morimoto S,Martin BM,Yamamoto Y,Kretz KA,O'Brien JS,Kishimoto Y

更新日期：1989-05-01 00:00:00

abstract：:The Paramyxoviridae family of enveloped viruses enters cells through the concerted action of two viral glycoproteins. The receptor-binding protein, hemagglutinin-neuraminidase (HN), H, or G, binds its cellular receptor and activates the fusion protein, F, which, through an extensive refolding event, brings viral and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bose S,Zokarkar A,Welch BD,Leser GP,Jardetzky TS,Lamb RA

更新日期：2012-09-25 00:00:00

abstract：:Peptide-protein interactions are important mediators of cellular-signaling events. Consensus binding motifs (also known as short linear motifs) within these contacts underpin molecular recognition, yet have poor pharmacological properties as discrete species. Here, we present methods to transform intact peptides into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawson KV,Rose TE,Harran PG

更新日期：2013-10-01 00:00:00

abstract：:We report the optical conductivity in high-quality crystals of the chiral topological semimetal CoSi, which hosts exotic quasiparticles known as multifold fermions. We find that the optical response is separated into several distinct regions as a function of frequency, each dominated by different types of quasiparticl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu B,Fang Z,Sánchez-Martínez MÁ,Venderbos JWF,Ni Z,Qiu T,Manna K,Wang K,Paglione J,Bernhard C,Felser C,Mele EJ,Grushin AG,Rappe AM,Wu L

更新日期：2020-11-03 00:00:00

abstract：:High-affinity nuclear binding sites for 17 beta-estradiol (17 beta E2) were recently found in bone cells; however, the mechanism by which estrogen exerts its effect on bone in vivo is still unknown. To study if estrogen acts on bone directly, we used an experimental model in which test substances are infused locally i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takano-Yamamoto T,Rodan GA

更新日期：1990-03-01 00:00:00

abstract：:Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced glucocorticoid-dependent social dominance ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tada H,Miyazaki T,Takemoto K,Takase K,Jitsuki S,Nakajima W,Koide M,Yamamoto N,Komiya K,Suyama K,Sano A,Taguchi A,Takahashi T

更新日期：2016-11-08 00:00:00

abstract：:Oscillatory activity is widespread in dynamic neuronal networks. The main paradigm for the origin of periodicity consists of specialized pacemaking elements that synchronize and drive the rest of the network; however, other models exist. Here, we studied the spontaneous emergence of synchronized periodic bursting in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penn Y,Segal M,Moses E

更新日期：2016-03-22 00:00:00

abstract：:High-entropy alloys are made from random mixtures of principal elements on simple lattices, stabilized by a high mixing entropy. The recently discovered body-centered cubic (BCC) Ta-Nb-Hf-Zr-Ti high-entropy alloy superconductor appears to display properties of both simple crystalline intermetallics and amorphous mater...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Rohr F,Winiarski MJ,Tao J,Klimczuk T,Cava RJ

更新日期：2016-11-15 00:00:00

abstract：:Matching ATP:NADPH provision and consumption in the chloroplast is a prerequisite for efficient photosynthesis. In terms of ATP:NADPH ratio, the amount of ATP generated from the linear electron flow does not meet the demand of the Calvin-Benson-Bassham (CBB) cycle. Several different mechanisms to increase ATP availabi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voon CP,Guan X,Sun Y,Sahu A,Chan MN,Gardeström P,Wagner S,Fuchs P,Nietzel T,Versaw WK,Schwarzländer M,Lim BL

更新日期：2018-11-06 00:00:00