Effect of electron count and chemical complexity in the Ta-Nb-Hf-Zr-Ti high-entropy alloy superconductor.

abstract：:Stromal cell lines were established from canine long-term marrow cultures, cloned by limiting dilution, and maintained in stromal cell-conditioned medium. These cells grew adherent, maintained stable growth rate and morphology under standard conditions (in 20-30% conditioned medium; confluency, 70-90%), and supported ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huss R,Hong DS,McSweeney PA,Hoy CA,Deeg HJ

更新日期：1995-01-31 00:00:00

abstract：:Mutagenic specificity of 2-acetylaminofluorene (AAF) has been established in mammalian cells and several strains of bacteria by using a shuttle plasmid vector containing a single N-(deoxyguanosin-8-yl)acetylaminofluorene (C8-dG-AAF) adduct. The nucleotide sequence of the gene conferring tetracycline resistance was mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moriya M,Takeshita M,Johnson F,Peden K,Will S,Grollman AP

更新日期：1988-03-01 00:00:00

abstract：:Arf family GTP-binding proteins are best characterized as regulators of membrane traffic, but recent studies indicate an additional role in cytoskeletal organization. An Arf GTPase-activating protein of the centaurin beta family, ASAP1 (also known as centaurin beta4), binds Arf and two other known regulators of the ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randazzo PA,Andrade J,Miura K,Brown MT,Long YQ,Stauffer S,Roller P,Cooper JA

更新日期：2000-04-11 00:00:00

abstract：:The discipline-wide effort to database the fossil record at the occurrence level has made it possible to estimate marine invertebrate extinction and origination rates with much greater accuracy. The new data show that two biotic mechanisms have hastened recoveries from mass extinctions and confined diversity to a rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alroy J

更新日期：2008-08-12 00:00:00

abstract：:Actin-myosin subfragment-1 (SF-1) or actin-heavy meromyosin is dissociated by the binding of ADP and vanadate (Vi) under conditions such that ADP alone does not dissociate the complex. The association constant of the stable complex M.ADP.Vi, in which M indicates myosin [Goodno, C. C. (1979) Proc. Natl. Acad. Sci. USA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodno CC,Taylor EW

更新日期：1982-01-01 00:00:00

abstract：:Significant liquid-structure theory has been used to calculate the transport properties of the alkali metals. Unlike previous calculations, the volume and temperature dependence of the solid-like structure has been taken into consideration. Equations for the potential energy as a function of volume of the alkali metal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu CC,Eyring H

更新日期：1972-06-01 00:00:00

abstract：:Diverse motivations for preserving nature both inspire and hinder its conservation. Optimal conservation strategies may differ radically depending on the objective. For example, creating nature reserves may prevent extinctions through protecting severely threatened species, whereas incentivizing farmland hedgerows may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karp DS,Mendenhall CD,Callaway E,Frishkoff LO,Kareiva PM,Ehrlich PR,Daily GC

更新日期：2015-09-01 00:00:00

abstract：:The delta-subspecies of protein kinase C (delta PKC) was purified to near homogeneity from the Triton X-100 extract of the rat brain particulate fraction by successive chromatographies on S-Sepharose fast flow, phenyl 5PW, heparin 5PW, hydroxyapatite, and Mono Q columns. The purified enzyme was a doublet with molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogita K,Miyamoto S,Yamaguchi K,Koide H,Fujisawa N,Kikkawa U,Sahara S,Fukami Y,Nishizuka Y

更新日期：1992-03-01 00:00:00

abstract：:Cardiotoxin VII4 from Naja mossambica mossambica crystallizes in space group P61 (a = b = 73.9 A; c = 59.0 A) with two molecules of toxin (molecular mass = 6715 Da) in the asymmetric unit. The structure was solved by using a combination of multiple isomorphous replacement and density modification methods. Model buildi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rees B,Samama JP,Thierry JC,Gilibert M,Fischer J,Schweitz H,Lazdunski M,Moras D

更新日期：1987-05-01 00:00:00

abstract：:Shell shape and shell thickness of the intertidal snail Littorina obtusata changed markedly between 1871 and 1984 in northern New England. Shells collected prior to 1900 were high-spired with thin walls, whereas shells collected in 1982-84 were low-spired with thick walls. An intertidal crab (Carcinus maenas) which pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeley RH

更新日期：1986-09-01 00:00:00

abstract：:An analysis of taxonomic longevity for species of the two Cenozoic radiations of Caribbean planktonic foraminifera shows strong similarity in longevity for extinct taxa, though extant species of the latter radiation are biased towards longer-lived forms. In this case, the present is not the key to the past. A simple o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinton JS,Ginzburg L

更新日期：1984-09-01 00:00:00

abstract：:As the most prototypical G protein-coupled receptor, beta-adrenergic receptor (betaAR) regulates the pace and strength of heart beating by enhancing and synchronizing L-type channel (LCC) Ca(2+) influx, which in turn elicits greater sarcoplasmic reticulum (SR) Ca(2+) release flux via ryanodine receptors (RyRs). Howeve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou P,Zhao YT,Guo YB,Xu SM,Bai SH,Lakatta EG,Cheng H,Hao XM,Wang SQ

更新日期：2009-10-20 00:00:00

abstract：:Communities have an important role to play in biodiversity conservation. However, community-based conservation as a panacea, like government-based conservation as a panacea, ignores the necessity of managing commons at multiple levels, with vertical and horizontal interplay among institutions. The study of conservatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berkes F

更新日期：2007-09-25 00:00:00

abstract：:The gluconate (gnt) operon of Bacillus subtilis consists of four gnt genes; the second and third genes code for gluconate kinase (gluconokinase, EC 2.7.1.12) and gluconate permease, respectively. A fragment carrying the promoter of this operon (gnt promoter) and the first gene (gntR) was subcloned into a promoter prob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita Y,Fujita T

更新日期：1987-07-01 00:00:00

abstract：:It is becoming clear that steroids can be synthesized de novo by the brain and other nervous systems. Such steroids are called neurosteroids, and de novo neurosteroidogenesis from cholesterol is a conserved property of vertebrate brains. In this study, we show that the newt brain actively produces 7alpha-hydroxypregne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsunaga M,Ukena K,Baulieu EE,Tsutsui K

更新日期：2004-12-07 00:00:00

abstract：:In 1944, Freeman Dyson conjectured the existence of a "crank" function for partitions that would provide a combinatorial proof of Ramanujan's congruence modulo 11. Forty years later, Andrews and Garvan successfully found such a function and proved the celebrated result that the crank simultaneously "explains" the thre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahlburg K

更新日期：2005-10-25 00:00:00

abstract：:Networks are widely used in the biological, physical, and social sciences as a concise mathematical representation of the topology of systems of interacting components. Understanding the structure of these networks is one of the outstanding challenges in the study of complex systems. Here we describe a general techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman ME,Leicht EA

更新日期：2007-06-05 00:00:00

abstract：:We construct counterexamples to classical calculus facts such as the inverse and implicit function theorems in scale calculus-a generalization of multivariable calculus to infinite-dimensional vector spaces, in which the reparameterization maps relevant to symplectic geometry are smooth. Scale calculus is a corner sto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filippenko B,Zhou Z,Wehrheim K

更新日期：2019-04-30 00:00:00

abstract：:The role of the serum proteolytic system plasminogen/plasminogen activator as a biochemical tool used by the glia or neurons, or both, for maintaining their temporary and flexible cellular interactions during histogenesis of the nervous system is under study. The present report identifies a glia cell type, the Schwann...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalderon N

更新日期：1984-11-01 00:00:00

abstract：:The aim of the present study was to assess possible adverse effects of transgene expression in leaves of field-grown barley relative to the influence of genetic background and the effect of plant interaction with arbuscular mycorrhizal fungi. We conducted transcript profiling, metabolome profiling, and metabolic finge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kogel KH,Voll LM,Schäfer P,Jansen C,Wu Y,Langen G,Imani J,Hofmann J,Schmiedl A,Sonnewald S,von Wettstein D,Cook RJ,Sonnewald U

更新日期：2010-04-06 00:00:00

abstract：:PCSK9 encodes proprotein convertase subtilisin/kexin type 9a (PCSK9), a member of the proteinase K subfamily of subtilases. Missense mutations in PCSK9 cause an autosomal dominant form of hypercholesterolemia in humans, likely due to a gain-of-function mechanism because overexpression of either WT or mutant PCSK9 redu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rashid S,Curtis DE,Garuti R,Anderson NN,Bashmakov Y,Ho YK,Hammer RE,Moon YA,Horton JD

更新日期：2005-04-12 00:00:00

abstract：:The investigation of community structures in networks is an important issue in many domains and disciplines. This problem is relevant for social tasks (objective analysis of relationships on the web), biological inquiries (functional studies in metabolic and protein networks), or technological problems (optimization o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radicchi F,Castellano C,Cecconi F,Loreto V,Parisi D

更新日期：2004-03-02 00:00:00

abstract：:A genetic complementation system was developed in which tobacco etch virus (TEV) polymerase (NIb)-expressing transgenic plants or protoplasts were inoculated with NIb-defective TEV mutants. A beta-glucuronidase (GUS) reporter gene integrated into the genomes of parental and four mutant viruses was used to assay RNA am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li XH,Carrington JC

更新日期：1995-01-17 00:00:00

abstract：:Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking. We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenoca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SJ,Glover TW,Zhu XX,Kuick R,Thoraval D,Orringer MB,Beer DG,Hanash S

更新日期：1998-10-13 00:00:00

abstract：:Proparathyroid hormone (calcemic fraction-A) is a biosynthetic precursor of parathyroid hormone in bovine glands. Limited amounts of the isolated prohormone have been obtained for the purpose of initial structural studies. The results of automated sequence analysis on two separate preparations indicate that the N-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton JW,Niall HD,Jacobs JW,Keutmann HT,Potts JT Jr,Cohn DV

更新日期：1974-03-01 00:00:00

abstract：:A protein-free nucleic acid preparation method for electron microscopy is described. The basic procedure is very similar to the classical protein monolayer spreading techniques. The carrier protein (usually cytochrome c) is replaced by benzyldimethylalkylammonium chloride. Both the hypophase method and the microdiffus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vollenweider HJ,Sogo JM,Koller T

更新日期：1975-01-01 00:00:00

abstract：:The advent of molecular tension probes for real-time mapping of piconewton forces in living systems has had a major impact on mechanobiology. For example, DNA-based tension probes have revealed roles for mechanics in platelet, B cell, T cell, and fibroblast function. Nonetheless, imaging short-lived forces transmitted...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma R,Kellner AV,Ma VP,Su H,Deal BR,Brockman JM,Salaita K

更新日期：2019-08-20 00:00:00

abstract：:Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer to a rough (R) low-GPL producer is associated with increased virulence in zebrafish, which involves the formation of massive serpentine cords, absc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloum I,Carrère-Kremer S,Blaise M,Viljoen A,Bernut A,Le Moigne V,Vilchèze C,Guérardel Y,Lutfalla G,Herrmann JL,Jacobs WR Jr,Kremer L

更新日期：2016-07-19 00:00:00

abstract：:The body-wall muscle cells of the nematode Caenorhabditis elegans produce thick filaments during embryonic, larval, and adult stages. These thick filaments contain two myosin isoforms, A and B, which assemble into different zones along the 10-microns lengths. Paramyosin, a protein homologous to myosin rods, forms a su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honda S,Epstein HF

更新日期：1990-02-01 00:00:00

abstract：:Viperin is an IFN-inducible radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication. We determined crystal structures of an anaerobically prepared fragment of mouse viperin (residues 45-362) complexed with S-adenosylhomocysteine (SAH) or 5'-deoxyadenosine (5'-dAdo) and l-methionine (l-Met). Viperin c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fenwick MK,Li Y,Cresswell P,Modis Y,Ealick SE

更新日期：2017-06-27 00:00:00