Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration.

abstract：:Defending cellular integrity against disturbances in intracellular concentrations of ATP ([ATP](i)) is predicated on coordinating the selection of substrates and their flux through metabolic pathways (metabolic signaling), ATP transfer from sites of production to utilization (energetic signaling), and the regulation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Stewart I,Tiyyagura SR,Lin JE,Kazerounian S,Pitari GM,Schulz S,Martin E,Murad F,Waldman SA

更新日期：2004-01-06 00:00:00

abstract：:Small molecules that specifically bind with high affinity to any designated DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have been developed to rationally alter the sequence specificity of minor groove-binding polyamides containing N-methyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho J,Parks ME,Dervan PB

更新日期：1995-10-24 00:00:00

abstract：:Chaperone oligomerization is often a key aspect of their function. Irrespective of whether chaperone oligomers act as reservoirs for active monomers or exhibit a chaperoning function themselves, understanding the mechanism of oligomerization will further our understanding of how chaperones maintain the proteome. Here,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karamanos TK,Tugarinov V,Clore GM

更新日期：2020-12-01 00:00:00

abstract：:The biosynthesis of fibronectin during the in vivo development of matrix-induced endochondral bone was investigated by using [35S]methionine in rats. The dmineralized bone matrix that was implanted subcutaneously to induce local bone formation bound circulating fibronectin. This may be an important initial requirement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss RE,Reddi AH

更新日期：1980-04-01 00:00:00

abstract：:Dendritic spines are of major importance in information processing and memory formation in central neurons. Estradiol has been shown to induce an increase of dendritic spine density on hippocampal neurons in vivo and in vitro. The neurotrophin brain-derived neurotrophic factor (BDNF) recently has been implicated in ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy DD,Cole NB,Segal M

更新日期：1998-09-15 00:00:00

abstract：:High-throughput gene expression data are one of the primary resources for exploring complex intracellular dynamics in modern biology. The integration of large amounts of public data may allow us to examine general dynamical relationships between regulators and target genes. However, obstacles for such analyses are stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vandenbon A,Dinh VH,Mikami N,Kitagawa Y,Teraguchi S,Ohkura N,Sakaguchi S

更新日期：2016-04-26 00:00:00

abstract：:Our long-term goal is the in vivo expression of intrinsically colored proteins without the need for further posttranslational modification or chemical functionalization by externally added reagents. Biocompatible (Aza)Indoles (Inds)/(Aza)Tryptophans (Trp) as optical probes represent almost ideal isosteric substitutes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lepthien S,Hoesl MG,Merkel L,Budisa N

更新日期：2008-10-21 00:00:00

abstract：:Coxsackievirus causes severe disease in adult mice subjected to sustained post-weaning undernutrition (marasmus). Virus-infected marasmic mice have an increased incidence of mortality, severe lesions, and elevated and persistent viral in target organs. Transfer of immune lymphoid cells 30 min or 24 hr after viral chal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woodruff JF,Woodruff JJ

更新日期：1971-09-01 00:00:00

abstract：:Mast cells with the morphological and biochemical properties of mucosal mast cells (MMC) appear and proliferate to form the predominant cell type in rat bone marrow cultures stimulated with factors from antigen- or mitogen-activated lymphocytes. Conditioned media causing a selective proliferation of MMC were derived f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haig DM,McMenamin C,Gunneberg C,Woodbury R,Jarrett EE

更新日期：1983-07-01 00:00:00

abstract：:The requirement and influence of the peripheral nervous system on tissue replacement in mammalian appendages remain largely undefined. To explore this question, we have performed genetic lineage tracing and clonal analysis of individual cells of mouse hind limb tissues devoid of nerve supply during regeneration of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinkevich Y,Montoro DT,Muhonen E,Walmsley GG,Lo D,Hasegawa M,Januszyk M,Connolly AJ,Weissman IL,Longaker MT

更新日期：2014-07-08 00:00:00

abstract：:The marine cyanobacterium Trichodesmium is ubiquitous in tropical and subtropical seas and is an important contributor to global N and C cycling. We sought to characterize metabolic uptake patterns in individual Trichodesmium IMS-101 cells by quantitatively imaging (13)C and (15)N uptake with high-resolution secondary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finzi-Hart JA,Pett-Ridge J,Weber PK,Popa R,Fallon SJ,Gunderson T,Hutcheon ID,Nealson KH,Capone DG

更新日期：2009-04-14 00:00:00

abstract：:Previously we reported that pretreatment of rats with the substance P (SP) antagonist CP-96,345 inhibits the enterotoxic responses following administration of toxin A from Clostridium difficile into ileal loops, indicating that SP participates in the intestinal responses to this toxin. We now report that injection of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castagliuolo I,Keates AC,Qiu B,Kelly CP,Nikulasson S,Leeman SE,Pothoulakis C

更新日期：1997-04-29 00:00:00

abstract：:Ca(V)1 channels initiate excitation-contraction coupling in skeletal and cardiac muscle. During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increase muscle contractility by activation of the β-adrenergic receptor/cAMP-dependent protein k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emrick MA,Sadilek M,Konoki K,Catterall WA

更新日期：2010-10-26 00:00:00

abstract：:Infectious diseases of domesticated animals impact human well-being via food insecurity, loss of livelihoods, and human infections. While much research has focused on parasites that infect single host species, most parasites of domesticated mammals infect multiple species. The impact of multihost parasites varies acro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farrell MJ,Davies TJ

更新日期：2019-04-16 00:00:00

abstract：:The embryonic neuroepithelium gives rise to the components of the central nervous system in the mature animal. To study the early development of the murine central nervous system we have sought to isolate growth factor receptors from the neuroepithelium of the neural tube of 10-day-old mouse embryos. Because many grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid HH,Wilks AF,Bernard O

更新日期：1990-02-01 00:00:00

abstract：:Molecules of keystone significance are relatively rare, yet mediate a variety of interactions between organisms. They influence the distribution and abundance of species, the transfer of energy across multiple trophic levels, and thus they play significant roles in structuring ecosystems. Despite their potential impor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kicklighter CE,Kamio M,Nguyen L,Germann MW,Derby CD

更新日期：2011-07-12 00:00:00

abstract：:During the late Pleistocene, early anatomically modern humans coexisted in Europe with the anatomically archaic Neandertals for some thousand years. Under the recent variants of the multiregional model of human evolution, modern and archaic forms were different but related populations within a single evolving species,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caramelli D,Lalueza-Fox C,Vernesi C,Lari M,Casoli A,Mallegni F,Chiarelli B,Dupanloup I,Bertranpetit J,Barbujani G,Bertorelle G

更新日期：2003-05-27 00:00:00

abstract：:Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molecular biology to address the major limitations of standard ChIP-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dainese R,Gardeux V,Llimos G,Alpern D,Jiang JY,Meireles-Filho ACA,Deplancke B

更新日期：2020-06-16 00:00:00

abstract：:The memory for a new episode is formed immediately upon experience and can last up to a lifetime. It has been shown that the hippocampal network plays a fundamental role in the rapid acquisition of a memory of a one-time experience, in which the novelty component of the experience promotes the prompt formation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagatsuma A,Okuyama T,Sun C,Smith LM,Abe K,Tonegawa S

更新日期：2018-01-09 00:00:00

abstract：:In healthy adults, activation of γ-aminobutyric acid (GABA)(A) and glycine receptors inhibits neurons as a result of low intracellular chloride concentration ([Cl(-)](i)), which is maintained by the potassium-chloride cotransporter KCC2. A reduction of KCC2 expression or function is implicated in the pathogenesis of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bos R,Sadlaoud K,Boulenguez P,Buttigieg D,Liabeuf S,Brocard C,Haase G,Bras H,Vinay L

更新日期：2013-01-02 00:00:00

abstract：:We have shown that rat glioma tumors contain a protein that crossreacts with antibody against mouse 2.5S nerve growth factor prepared in rabbit in microcomplement fixation assays and has analogous isoelectric points to all the hybrids of 2.5S nerve growth factor (a dimer). Partially purified protein preparations from ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Longo AM,Penhoet EE

更新日期：1974-06-01 00:00:00

abstract：:The paradigm of bacterial quorum sensing (QS), which mediates cell-density-dependent gene expression, usually has been studied in high-cell-density planktonic liquid cultures or in biofilms in which signal concentrations accumulate to sufficiently high levels to induce QS. Presumably under conditions with restricted d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dulla G,Lindow SE

更新日期：2008-02-26 00:00:00

abstract：:We have screened about 1.4 million colonies of Escherichia coli K-12 for their ability to grow on nutrient agar at 30 degrees and 41 degrees. Among the 2266 temperature-sensitive mutants found, 110 were defective in DNA synthesis but not in protein synthesis at 41 degrees. Three of these dna mutations mapped at two pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sevastopoulos CG,Wehr CT,Glaser DA

更新日期：1977-08-01 00:00:00

abstract：:Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium Escherichia coli, membrane-bound sensor CusS and its response regulator CusR togeth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu B,Sengupta K,Genova LA,Santiago AG,Jung W,Krzemiński Ł,Chakraborty UK,Zhang W,Chen P

更新日期：2020-06-16 00:00:00

abstract：:The Eastern Arc Mountains of Tanzania and the Atlantic Forest of Brazil are two of the most fragmented biodiversity hotspots. Species-area relationships predict that their habitat fragments will experience a substantial loss of species. Most of these extinctions will occur over an extended time, and therefore, reconne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newmark WD,Jenkins CN,Pimm SL,McNeally PB,Halley JM

更新日期：2017-09-05 00:00:00

abstract：:Under various conditions, specific genetic areas of the phage T4 DNA molecule are preferentially and repeatedly replicated, resulting in the amplification of these areas. These areas are found to lie in the vicinity of the known origins of DNA replication. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozinski AW,Ling SK,Hutchinson N,Halpern ME,Mattson T

更新日期：1980-09-01 00:00:00

abstract：:Ultrashort light pulses can selectively excite charges, spins, and phonons in materials, providing a powerful approach for manipulating their properties. Here we use femtosecond laser pulses to coherently manipulate the electron and phonon distributions, and their couplings, in the charge-density wave (CDW) material 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Shi X,You W,Tao Z,Zhong Y,Cheenicode Kabeer F,Maldonado P,Oppeneer PM,Bauer M,Rossnagel K,Kapteyn H,Murnane M

更新日期：2020-04-21 00:00:00

abstract：:English and Russian color terms divide the color spectrum differently. Unlike English, Russian makes an obligatory distinction between lighter blues ("goluboy") and darker blues ("siniy"). We investigated whether this linguistic difference leads to differences in color discrimination. We tested English and Russian spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winawer J,Witthoft N,Frank MC,Wu L,Wade AR,Boroditsky L

更新日期：2007-05-08 00:00:00

abstract：:Ionizing radiation has been used to selectively separate the circadian oscillator function of the eye of Aplysia from some of its other functions--synchronous compound action potential (CAP) generation, the light response, synaptic transmission between photoreceptors and output neurons, and the bursting pacemaker mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woolum JC,Strumwasser F

更新日期：1980-09-01 00:00:00

abstract：:Erythroid Krüppel-like factor (EKLF), which binds to the CACCC box in the beta-globin promoter, is required for the expression of the beta-globin gene in adult erythroid cells. It was recently demonstrated that EKLF is also required for the activity of the beta-globin locus control region (LCR) 5'HS3. Some evidence su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JS,Lee CH,Chung JH

更新日期：1999-08-31 00:00:00