The differential effects of ionizing radiation on the circadian oscillator and other functions in the eye of Aplysia.

abstract：:The emergence of antibiotic resistance among nosocomial pathogens has reemphasized the need for effective infection control strategies. The spread of resistant pathogens within hospital settings proceeds along various routes of transmission and is characterized by large fluctuations in prevalence, which are typical fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pelupessy I,Bonten MJ,Diekmann O

更新日期：2002-04-16 00:00:00

abstract：:The presence of substance P-immunoreactive (SPI) varicose nerve networks and nerve fiber bundles in guinea pig prevertebral sympathetic ganglia has been confirmed by fluorescence immunohistochemistry. No SPI neurons have been found in sympathetic ganglia, including lumbar paravertebral ganglia. Peroxidase-antiperoxida...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matthews MR,Cuello AC

更新日期：1982-03-01 00:00:00

abstract：:In response to various pathological stresses, the heart undergoes a pathological remodeling process that is associated with cardiomyocyte hypertrophy. Because cardiac hypertrophy can progress to heart failure, a major cause of lethality worldwide, the intracellular signaling pathways that control cardiomyocyte growth ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Appert-Collin A,Cotecchia S,Nenniger-Tosato M,Pedrazzini T,Diviani D

更新日期：2007-06-12 00:00:00

abstract：:DNA was extracted from the remains of 35 ground sloths from various parts of North and South America. Two specimens of Mylodon darwinii, a species that went extinct at the end of the last glaciation, yielded amplifiable DNA. However, of the total DNA extracted, only approximately 1/1000 originated from the sloth, wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Höss M,Dilling A,Currant A,Pääbo S

更新日期：1996-01-09 00:00:00

abstract：:We report a combined thermodynamic and structural characterization of a DNA tetraplex. Using spectroscopic and calorimetric techniques, we demonstrate that d(TG3T) and d(TG3T2G3T), in the presence of K+, form stable tetramolecular complexes. From differential scanning calorimetry measurements, we obtain the following ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin R,Gaffney BL,Wang C,Jones RA,Breslauer KJ

更新日期：1992-09-15 00:00:00

abstract：:Tomato plants overexpressing a prosystemin gene that encodes the precursor of a mobile wound signal called systemin have been shown previously to constitutively synthesize extraordinarily high levels of two defensive proteinase inhibitor proteins in leaves in the absence of wounding. We herein report that leaves of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Constabel CP,Bergey DR,Ryan CA

更新日期：1995-01-17 00:00:00

abstract：:The sense of hearing is remarkable for its auditory dynamic range, which spans more than 10(12) in acoustic intensity. The mechanisms that enable the cochlea to transduce high sound levels without damage are of key interest, particularly with regard to the broad impact of industrial, military, and recreational auditor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Housley GD,Morton-Jones R,Vlajkovic SM,Telang RS,Paramananthasivam V,Tadros SF,Wong AC,Froud KE,Cederholm JM,Sivakumaran Y,Snguanwongchai P,Khakh BS,Cockayne DA,Thorne PR,Ryan AF

更新日期：2013-04-30 00:00:00

abstract：:Antiapoptotic Bcl-2 family members interact with inositol trisphosphate receptor (InsP3R) Ca(2+)release channels in the endoplasmic reticulum to modulate Ca(2+)signals that affect cell viability. However, the molecular details and consequences of their interactions are unclear. Here, we found that Bcl-xL activates sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Vais H,Gu W,Foskett JK

更新日期：2016-03-29 00:00:00

abstract：:Photosystem II (PSII) is an intrinsic membrane protein complex that functions as a light-driven water:plastoquinone oxidoreductase in oxygenic photosynthesis. Electron transport in PSII is associated with formation of reactive oxygen species (ROS) responsible for oxidative modifications of PSII proteins. In this study...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Prasad A,Sedlářová M,Kale R,Frankel LK,Sallans L,Bricker TM,Pospíšil P

更新日期：2021-01-26 00:00:00

abstract：:Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful method of identifying high-affinity ligands for a broad range of molecular targets. Nevertheless, a sizeable fraction of proteins remain difficult targets due to inherently limited chemical diversity of nucleic acids. We have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davies DR,Gelinas AD,Zhang C,Rohloff JC,Carter JD,O'Connell D,Waugh SM,Wolk SK,Mayfield WS,Burgin AB,Edwards TE,Stewart LJ,Gold L,Janjic N,Jarvis TC

更新日期：2012-12-04 00:00:00

abstract：:The study of the metabolome presents numerous challenges, first among them being the cataloging of its constituents. A step in this direction will be the development of tools to identify metabolites that share common structural features. The importance of sulfated molecules in cell-cell communication motivated us to d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mougous JD,Leavell MD,Senaratne RH,Leigh CD,Williams SJ,Riley LW,Leary JA,Bertozzi CR

更新日期：2002-12-24 00:00:00

abstract：:The lack of efficient mechanisms for stable genetic transformation of medically important insects, such as anopheline mosquitoes, is the single most important impediment to progress in identifying novel control strategies. Currently available techniques for foreign gene expression in insect cells in culture lack the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsubara T,Beeman RW,Shike H,Besansky NJ,Mukabayire O,Higgs S,James AA,Burns JC

更新日期：1996-06-11 00:00:00

abstract：:The accumulation of metal ions and amyloid-β (Aβ) aggregates found in the brain of patients with Alzheimer's disease (AD) has been suggested to be involved in AD pathogenesis. To investigate metal-Aβ-associated pathways in AD, development of chemical tools to target metal-Aβ species is desired. Only a few efforts, how...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JS,Braymer JJ,Nanga RP,Ramamoorthy A,Lim MH

更新日期：2010-12-21 00:00:00

abstract：:Pollen tubes are highly polarized plant cells specialized in delivering sperm for fertilization. Pollen tube growth is rapid, occurs exclusively at the tip, and can reach distances thousands of times the diameter of the pollen grain without cell division, thus representing an excellent model system for studying asymme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AY,Niroomand S,Zou Y,Wu HM

更新日期：2010-09-14 00:00:00

abstract：:Natal dispersal, the process through which immature individuals permanently depart their natal area in search of new sites, is integral to the ecology and evolution of animals. Insights about the underlying causes of natal dispersal arise mainly from research on species whose short dispersal distances or restricted di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Studds CE,Kyser TK,Marra PP

更新日期：2008-02-26 00:00:00

abstract：:Leaflets of Samanea saman open and close rhythmically, driven by an endogenous circadian clock. Light has a rapid, direct effect on the movements and also rephases the rhythm. We investigated whether light signals might be mediated by increased inositolphospholipid turnover, a mechanism for signal transduction that is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse MJ,Crain RC,Satter RL

更新日期：1987-10-01 00:00:00

abstract：:We have assayed carbonic anhydrase activity (carbonate dehydratase, carbonate hydro-lyase, EC 4.2.1.1) and bicarbonate permeability in suspensions of broken and intact guinea pig mitochondria by monitoring the disappearance of C16O18O. We found significant activity in preparations from liver and skeletal muscle, but n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodgson SJ,Forster RE 2nd,Storey BT,Mela L

更新日期：1980-09-01 00:00:00

abstract：:Photoadaptation, the ability to attenuate a light response on prolonged light exposure while remaining sensitive to escalating changes in light intensity, is essential for organisms to decipher time information appropriately, yet the underlying molecular mechanisms are poorly understood. In Neurospora crassa, VIVID (V...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CH,DeMay BS,Gladfelter AS,Dunlap JC,Loros JJ

更新日期：2010-09-21 00:00:00

abstract：:In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation of endocardial cells and that its deletion therein results in fully penetrant, dose-dependent atria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadeau M,Georges RO,Laforest B,Yamak A,Lefebvre C,Beauregard J,Paradis P,Bruneau BG,Andelfinger G,Nemer M

更新日期：2010-11-09 00:00:00

abstract：:Changes in the amount, intensity, and timing of precipitation are increasing hydrologic variability in many regions, but we have little understanding of how these changes are affecting freshwater species. Stream-breeding amphibians-a diverse group in North America-may be particularly sensitive to hydrologic variabilit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lowe WH,Swartz LK,Addis BR,Likens GE

更新日期：2019-09-24 00:00:00

abstract：:Indirect immunofluorescent analysis revealed that sera from five patients with subacute sclerosing panencephalitis possessed IgD antibodies directed against measles virus components in persistently infected HeLa cells. IgD levels in these sera were within the normal range. Control studies indicated that the reaction w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luster MI,Armen RC,Hallum JV,Leslie GA

更新日期：1976-04-01 00:00:00

abstract：:The kinetics of hepatic uptake and degradation of sphingomyelin/cholesterol (2:1, M/M) small unilamellar liposomes were investigated in a BALB/c mouse. The tissue distribution of liposomes was determined by scintillation spectrometry. The percentage of intact liposomes in tissues was estimated by the technique of gamm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang KJ,Luk KF,Beaumier PL

更新日期：1980-07-01 00:00:00

abstract：:Polysomes (S-20) from homogenates of guinea pig liver synthesized serum albumin and a precursor of the fourth component of guinea pig complement (C4) in vitro. The C4 precursor (pro-C4) accounted for approximately 0.2% and albumin 4% of the radiolabeled protein precipitable by trichloroacetic acid and not bound to pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hall RE,Colten HR

更新日期：1977-04-01 00:00:00

abstract：:Exposure of Chinese hamster cells to reduced oxygen partial pressure results in a marked enhancement in the frequency of methotrexate resistance and dihydrofolate reductase gene amplification. The frequency of enhanced resistance is a function of the length of exposure to hypoxic conditions and the time after recovery...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice GC,Hoy C,Schimke RT

更新日期：1986-08-01 00:00:00

abstract：:Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If cell shape fluctuations are active enough, the aggregate sponta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marmottant P,Mgharbel A,Käfer J,Audren B,Rieu JP,Vial JC,van der Sanden B,Marée AF,Graner F,Delanoë-Ayari H

更新日期：2009-10-13 00:00:00

abstract：:We show that epidermal growth factor (EGF) receptor can be transferred in a biologically active orientation from donor hepatic membranes to recipient receptorless fibroblast cells. The recipient cells (NR-6) normally lack EGF receptors and are biologically unresponsive to EGF. The transfer of receptors from donor plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishayee S,Feinman J,Pittenger M,Michael H,Das M

更新日期：1982-03-01 00:00:00

abstract：:Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) is an eight-carbon sugar mostly confined to Gram-negative bacteria. It is often involved in attaching surface polysaccharides to their lipid anchors. α-Kdo provides a bridge between lipid A and the core oligosaccharide in all bacterial LPSs, whereas an oligosaccharide of β-Kdo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ovchinnikova OG,Mallette E,Koizumi A,Lowary TL,Kimber MS,Whitfield C

更新日期：2016-05-31 00:00:00

abstract：:Rapid electrical conduction in the His-Purkinje system tightly controls spatiotemporal activation of the ventricles. Although recent work has shed much light on the regulation of early specification and morphogenesis of the His-Purkinje system, less is known about how transcriptional regulation establishes impulse con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang SS,Kim KH,Rosen A,Smyth JW,Sakuma R,Delgado-Olguín P,Davis M,Chi NC,Puviindran V,Gaborit N,Sukonnik T,Wylie JN,Brand-Arzamendi K,Farman GP,Kim J,Rose RA,Marsden PA,Zhu Y,Zhou YQ,Miquerol L,Henkelman RM,Sta

更新日期：2011-08-16 00:00:00

abstract：:FIP-3 (14.7K interacting protein) was discovered during a search for cell proteins that could interact with an adenovirus protein (Ad E3-14.7K) that had been shown to prevent tumor necrosis factor (TNF)-alpha-induced cytolysis. FIP-3, which contains leucine zippers and a zinc finger domain, inhibits both basal and ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Kang J,Friedman J,Tarassishin L,Ye J,Kovalenko A,Wallach D,Horwitz MS

更新日期：1999-02-02 00:00:00

abstract：:Spatio-temporal studies on the growth of capillary blood vessels and capillary lymphatic vessels in tissue remodeling have suggested that lymphangiogenesis is angiogenesis-dependent. We revisited this concept by using fibroblast growth factor 2 (FGF-2) (80 ng) to stimulate the growth of both vessel types in the mouse ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang LK,Garcia-Cardeña G,Farnebo F,Fannon M,Chen EJ,Butterfield C,Moses MA,Mulligan RC,Folkman J,Kaipainen A

更新日期：2004-08-10 00:00:00