Measles virus-specific IgD antibodies in patients with subacute sclerosing panencephalitis.

abstract：:The regulatory mechanisms that use signals of low levels of reactive oxygen species (ROS) could be obscured by ROS produced under stress and thus are better investigated under homeostatic conditions. Previous studies showed that the chloroplastic atypical thioredoxin ACHT1 is oxidized by 2-Cys peroxiredoxin (2-Cys Prx...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eliyahu E,Rog I,Inbal D,Danon A

更新日期：2015-10-13 00:00:00

abstract：:MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising nanofiller in multifunc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling Z,Ren CE,Zhao MQ,Yang J,Giammarco JM,Qiu J,Barsoum MW,Gogotsi Y

更新日期：2014-11-25 00:00:00

abstract：:The sensitive and accurate quantification of protein biomarkers plays important roles in clinical diagnostics and biomedical research. Sandwich ELISA and its variants accomplish the capture and detection of a target protein via two antibodies that tightly bind at least two distinct epitopes of the same antigen and hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee T,Knappik A,Sandford E,Tewari M,Choi SW,Strong WB,Thrush EP,Oh KJ,Liu N,Walter NG,Johnson-Buck A

更新日期：2020-09-15 00:00:00

abstract：:Diminished Sonic Hedgehog (Shh) signaling is associated with the most common forebrain defect in humans, holoprosencephaly (HPE), which includes cyclopia, a phenotype also seen in mice and other vertebrates with defective Shh signaling. The secreted protein Shh acts as a crucial factor that patterns the ventral forebr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roessler E,Du YZ,Mullor JL,Casas E,Allen WP,Gillessen-Kaesbach G,Roeder ER,Ming JE,Ruiz i Altaba A,Muenke M

更新日期：2003-11-11 00:00:00

abstract：:Loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (HCC). To clarify the pathogenetic significance of allele loss on chromosome 16, we performed restriction fragment length polymorphism analysis of 70 surgically resected tumors by using 15 polymorphic DNA markers f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuda H,Zhang WD,Shimosato Y,Yokota J,Terada M,Sugimura T,Miyamura T,Hirohashi S

更新日期：1990-09-01 00:00:00

abstract：:DNA vaccines, comprised of plasmid DNA encoding proteins from pathogens, allergens, and tumors, are being evaluated as prophylactic vaccines and therapeutic treatments for infectious diseases, allergies, and cancer; plasmids encoding normal human proteins are likewise being tested as vaccines and treatments for autoim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Acres B,Balloul JM,Bizouarne N,Paul S,Slos P,Squiban P

更新日期：2004-10-05 00:00:00

abstract：:From a flounder pituitary cDNA library, cDNA clones encoding a 28-kDa glycoprotein produced by the pars intermedia of the pituitary were isolated and characterized. Nucleotide sequencing demonstrated a precursor of the 28-kDa protein, which consisted of 231 amino acid residues, to be cleaved into a signal peptide (24 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ono M,Takayama Y,Rand-Weaver M,Sakata S,Yasunaga T,Noso T,Kawauchi H

更新日期：1990-06-01 00:00:00

abstract：:The traditional disciplines of science are grounded in the observation and measurement of object properties. Recent advances in digital computer technology have spawned numerous computer-based imaging systems that extend the range of observation and measurement into realms that would otherwise be inaccessible. More im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck RN

更新日期：1993-11-01 00:00:00

abstract：:The mechanisms that regulate the ubiquitin (Ub)-proteasome system's own components, although critically important, are largely unknown. Ub, a principal component of the system, must be maintained at adequate levels to support cellular homeostasis under basal and stressed conditions. It was suggested that Ub is degrade...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shabek N,Herman-Bachinsky Y,Ciechanover A

更新日期：2009-07-21 00:00:00

abstract：:Functional recovery after stroke has been associated with brain plasticity; however, the exact relationship is unknown. We performed behavioral tests, functional MRI, and histology in a rat stroke model to assess the correlation between temporal changes in sensorimotor function, brain activation patterns, cerebral isc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dijkhuizen RM,Ren J,Mandeville JB,Wu O,Ozdag FM,Moskowitz MA,Rosen BR,Finklestein SP

更新日期：2001-10-23 00:00:00

abstract：:Data drawn from a global compilation of studies quantitatively confirm the long-articulated contention that erosion rates from conventionally plowed agricultural fields average 1-2 orders of magnitude greater than rates of soil production, erosion under native vegetation, and long-term geological erosion. The general ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montgomery DR

更新日期：2007-08-14 00:00:00

abstract：:It has recently been demonstrated that coupled enzymatic processes may possess, for a particular choice of the state variables, multidimensional inflection points in thermodynamic force-flow space. The conditions for reciprocity in the linear region near such a reference state, which may be far from equilibrium, are o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caplan SR

更新日期：1981-07-01 00:00:00

abstract：:The type II cell of the alveolar epithelium of adult rats has been studied by electron microscopy to determine its ability to endocytose electron-dense tracers of differing molecular charge and size. The tracers studied were native (anionic) ferritin, cationic ferritin, 70-kilodalton dextran, and colloidal carbon. Alv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams MC

更新日期：1984-10-01 00:00:00

abstract：:Accurate calculations of force generated and of ATP flux, in steady isotonic contractions, are made on a simple, two-state muscle model of the sliding filament type. The objective is to illustrate the proper formulation and use of a complete and self-consistent molecular model of muscle. Otherwise, the model is not me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1974-05-01 00:00:00

abstract：:Clones of embryonic chick chondrocytes have been isolated and collagen biosynthesis has been followed as the clones grow and eventually lose division capacity. Analysis of collagen type at each successive subculture until the time of cellular senescence has shown that a change in synthesis occurs from the cartilage-sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayne R,Vail MS,Mayne PM,Miller EJ

更新日期：1976-05-01 00:00:00

abstract：:Acetyl-CoA synthase from Clostridium thermoaceticum (ACS(Ct)) is an alpha(2)beta(2) tetramer containing two novel Ni-X-Fe(4)S(4) active sites (the A and C clusters) and a standard Fe(4)S(4) cluster (the B cluster). The acsA and acsB genes encoding the enzyme were cloned into Escherichia coli strain JM109 and overexpre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loke HK,Bennett GN,Lindahl PA

更新日期：2000-11-07 00:00:00

abstract：:The local conformations of proteins and peptides are determined by the amino acid sequence. However, the 20 amino acids encoded by the genome allow the peptide backbone to fold into many conformations, so that even for a small peptide it becomes very difficult to predict the three-dimensional structure. By using empir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burgess AW

更新日期：1994-03-29 00:00:00

abstract：:The powerful optogenetic pharmacology method allows the optical control of neuronal activity by photoswitchable ligands tethered to channels and receptors. However, this approach is technically demanding, as it requires the design of pharmacologically active ligands. The development of versatile technologies therefore...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lemoine D,Habermacher C,Martz A,Méry PF,Bouquier N,Diverchy F,Taly A,Rassendren F,Specht A,Grutter T

更新日期：2013-12-17 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-regulated gene expression is stimulated independently by the cellular trans-activator NF-kappa B and the viral protein Tat. Noncytotoxic concentrations of the drug pentoxifylline (PTX) inhibited interaction of NF-kappa B with its motif and the stim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biswas DK,Ahlers CM,Dezube BJ,Pardee AB

更新日期：1993-12-01 00:00:00

abstract：:Although the F-specific ssRNA phage MS2 has long had paradigm status, little is known about penetration of the genomic RNA (gRNA) into the cell. The phage initially binds to the F-pilus using its maturation protein (Mat), and then the Mat-bound gRNA is released from the viral capsid and somehow crosses the bacterial e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harb L,Chamakura K,Khara P,Christie PJ,Young R,Zeng L

更新日期：2020-10-13 00:00:00

abstract：:Polymorphism in materials often leads to significantly different physical properties--the rutile and anatase polymorphs of TiO2 are a prime example. Polytypism is a special type of polymorphism, occurring in layered materials when the geometry of a repeating structural layer is maintained but the layer-stacking sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo H,Xie W,Tao J,Inoue H,Gyenis A,Krizan JW,Yazdani A,Zhu Y,Cava RJ

更新日期：2015-03-17 00:00:00

abstract：:Overproduction or deficiency of many chaperones and other cellular components cure the yeast prions [PSI+] (formed by Sup35p) or [URE3] (based on Ure2p). However, at normal expression levels, Btn2p and Cur1p eliminate most newly arising [URE3] variants but do not cure [PSI+], even after overexpression. Deficiency or o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorkovskiy A,Reidy M,Masison DC,Wickner RB

更新日期：2017-05-23 00:00:00

abstract：:The discovery of RNAi has revolutionized loss-of-function genetic studies in mammalian systems. However, significant challenges still remain to fully exploit RNAi for mammalian genetics. For instance, genetic screens and in vivo studies could be broadly improved by methods that allow inducible and uniform gene express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meerbrey KL,Hu G,Kessler JD,Roarty K,Li MZ,Fang JE,Herschkowitz JI,Burrows AE,Ciccia A,Sun T,Schmitt EM,Bernardi RJ,Fu X,Bland CS,Cooper TA,Schiff R,Rosen JM,Westbrook TF,Elledge SJ

更新日期：2011-03-01 00:00:00

abstract：:Antibody-secreting plasma cells (PCs) arise rapidly during adaptive immunity to control infections. The early PCs are retained within the reactive lymphoid organ where their localization and homeostasis rely on extrinsic factors, presumably produced by local niche cells. While myeloid cells have been proposed to form ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang HY,Rivas-Caicedo A,Renevey F,Cannelle H,Peranzoni E,Scarpellino L,Hardie DL,Pommier A,Schaeuble K,Favre S,Vogt TK,Arenzana-Seisdedos F,Schneider P,Buckley CD,Donnadieu E,Luther SA

更新日期：2018-07-17 00:00:00

abstract：:Lung adenocarcinomas harboring activating mutations in the epidermal growth factor receptor (EGFR) represent a common molecular subset of non-small cell lung cancer (NSCLC) cases. EGFR mutations predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs) and thus represent a dependency in NSCLCs harboring these alte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharifnia T,Rusu V,Piccioni F,Bagul M,Imielinski M,Cherniack AD,Pedamallu CS,Wong B,Wilson FH,Garraway LA,Altshuler D,Golub TR,Root DE,Subramanian A,Meyerson M

更新日期：2014-12-30 00:00:00

abstract：:Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation through the acetylation of cyclooxygenase II. These aspirin-triggered lipoxins (ATL) may mediate some of ASA's beneficial actions and therefore are of interest in the search...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clish CB,O'Brien JA,Gronert K,Stahl GL,Petasis NA,Serhan CN

更新日期：1999-07-06 00:00:00

abstract：:The heme-copper oxidases constitute a superfamily of terminal dioxygen-reducing enzymes located in the inner mitochondrial or in the bacterial cell membrane. The presence of a mechanistically important covalent bond between a histidine ligand of the copper ion (Cu(B)) in the active site and a generally conserved tyros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rauhamäki V,Baumann M,Soliymani R,Puustinen A,Wikström M

更新日期：2006-10-31 00:00:00

abstract：:The mechanisms underlying analgesia related to social touch are not clear. While recent research highlights the role of the empathy of the observer to pain relief in the target, the contribution of social interaction to analgesia is unknown. The current study examines brain-to-brain coupling during pain with interpers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein P,Weissman-Fogel I,Dumas G,Shamay-Tsoory SG

更新日期：2018-03-13 00:00:00

abstract：:The photoproduct of carbon monoxide myoglobin generated at 4 K and lower has a resonance Raman spectrum characteristic of a high-spin heme but in which the high-frequency core size-sensitive lines are at lower frequency than those in the deoxy preparation. Such differences are not detected in the photoproduct generate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousseau DL,Argade PV

更新日期：1986-03-01 00:00:00

abstract：:Rabbit corneas denuded of their endothelium were coated with bovine corneal endothelial cells (from steers) previously maintained in tissue culture for short (20 generations) or prolonged (200 generations) periods. When grafted back into female rabbits, the corneal buttons remained clear and showed no edema. In contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gospodarowicz D,Greenburg G,Alvarado J

更新日期：1979-01-01 00:00:00