Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

Abstract:

:Loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (HCC). To clarify the pathogenetic significance of allele loss on chromosome 16, we performed restriction fragment length polymorphism analysis of 70 surgically resected tumors by using 15 polymorphic DNA markers for chromosome 16. Loss of heterozygosity on chromosome 16 was detected in 36 (52%) of 69 informative cases, and the common region of allele loss in these 36 tumors was located between the HP locus (16q22.1) and the CTRB locus (16q22.3-q23.2). These losses occurred more frequently in HCCs of poor differentiation, of larger size, and with metastasis, whereas they were not detected in HCC at the earliest stage. In addition, these losses were not associated with presence or absence of hepatitis B virus DNA integration or hepatitis C virus infection. These results show that loss of heterozygosity on chromosome 16 is a late event occurring after hepatocarcinogenesis and strongly suggest that this phenomenon is involved in enhancement of tumor aggressiveness during progression of HCC.

authors

Tsuda H,Zhang WD,Shimosato Y,Yokota J,Terada M,Sugimura T,Miyamura T,Hirohashi S

doi

10.1073/pnas.87.17.6791

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

6791-4

issue

17

eissn

0027-8424

issn

1091-6490

journal_volume

87

pub_type

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