Abstract:
:From a flounder pituitary cDNA library, cDNA clones encoding a 28-kDa glycoprotein produced by the pars intermedia of the pituitary were isolated and characterized. Nucleotide sequencing demonstrated a precursor of the 28-kDa protein, which consisted of 231 amino acid residues, to be cleaved into a signal peptide (24 amino acids) and a mature protein (207 amino acids) containing one N-glycosylation site. By comparison of amino acid sequences, the 28-kDa protein was found to be distantly and similarly related to growth hormone and prolactin. Consequently, it was named somatolactin. Somatolactin mRNAs were specifically expressed as 1.2 and 1.8 kb poly(A)+ RNAs in flounder pituitary.
journal_name
Proc Natl Acad Sci U S Aauthors
Ono M,Takayama Y,Rand-Weaver M,Sakata S,Yasunaga T,Noso T,Kawauchi Hdoi
10.1073/pnas.87.11.4330subject
Has Abstractpub_date
1990-06-01 00:00:00pages
4330-4issue
11eissn
0027-8424issn
1091-6490journal_volume
87pub_type
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