An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.

abstract：:The M2 protein of influenza A virus forms a transmembrane proton channel important for viral infection and replication. Amantadine blocks this channel, thus inhibiting viral replication. Elucidating the high-resolution structure of the M2 protein and its change upon amantadine binding is crucial for designing antivira...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cady SD,Hong M

更新日期：2008-02-05 00:00:00

abstract：:One of the principles that has emerged from experimental evolutionary studies of microorganisms is that polymorphic alleles or new mutations can sometimes possess a latent potential to respond to selection in different environments, although the alleles may be functionally equivalent or disfavored under typical condit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stebbins GL,Hartl DL

更新日期：1988-07-01 00:00:00

abstract：:There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal disease and to overcome the growing problem of resistance to current therapies. F901318, the leading representative of a novel class of drug, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliver JD,Sibley GEM,Beckmann N,Dobb KS,Slater MJ,McEntee L,du Pré S,Livermore J,Bromley MJ,Wiederhold NP,Hope WW,Kennedy AJ,Law D,Birch M

更新日期：2016-11-08 00:00:00

abstract：:Cumulative distributions of the number of doublings undergone by mixed megakaryocytic/erythroblastic colonies and by pure megakaryocytic colonies were determined from plasma clot cultures of bone marrow (from C57BL/6 mice) supplemented with erythropoietin. Analysis of these distributions suggests that these colonies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulus JM,Prenant M,Deschamps JF,Henry-Amar M

更新日期：1982-07-01 00:00:00

abstract：:The plasmid construct pSVO-CAT has been used to test adenovirus promoter activities in the unmethylated or methylated state. We have now observed that the E2A late promoter of adenovirus type 2 (Ad2) DNA also activated the chloramphenicol acetyltransferase (CAT) gene upon transfection of the pAd2E2A-CAT construct into...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langner KD,Weyer U,Doerfler W

更新日期：1986-03-01 00:00:00

abstract：:We have identified a 10-kDa stress-inducible mitochondrial protein. The protein is synthesized at elevated rates in cultured rat hepatoma cells challenged with heat shock or amino acid analogues and, therefore, designated heat shock protein 10 (Hsp10). Hsp10 was purified to homogeneity from rat liver and found to exhi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartman DJ,Hoogenraad NJ,Condron R,Høj PB

更新日期：1992-04-15 00:00:00

abstract：:When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burakoff SJ,Ratnofsky SE,Benacerraf B

更新日期：1977-10-01 00:00:00

abstract：:Cell type in Saccharomyces yeasts is regulated by two transposable blocks of DNA, the a and alpha cassettes. There are three loci where either cassette can exist. At the HML and HMR loci the cassettes are not expressed. The cassette at the MAT locus is expressed and controls the cell type. Changes of cell type involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strathern JN,Spatola E,McGill C,Hicks JB

更新日期：1980-05-01 00:00:00

abstract：:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen KL,Eberli D,Yoo JJ,Atala A

更新日期：2010-02-23 00:00:00

abstract：:Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes increase the production of the highly amyloidogenic 42-residue form of amyloid beta-protein (Abeta42) in a variety of cell lines and transgenic mice. To elucidate the molecular mechanism of this effect, wild-type (wt) or mutant PS1 and PS2 genes were sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia W,Zhang J,Perez R,Koo EH,Selkoe DJ

更新日期：1997-07-22 00:00:00

abstract：:We have recently purified calorigen, the natural trigger for heat production in the inflorescences of Sauromatum guttatum Schott (voodoo lily), a thermogenic plant, and identified it as salicylic acid. Since then an analytical assay was developed that allows the quantitation of salicylic acid in plant tissues. This as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raskin I,Turner IM,Melander WR

更新日期：1989-04-01 00:00:00

abstract：:Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. Formation of rose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hicks AM,Riedlinger G,Willingham MC,Alexander-Miller MA,Von Kap-Herr C,Pettenati MJ,Sanders AM,Weir HM,Du W,Kim J,Simpson AJ,Old LJ,Cui Z

更新日期：2006-05-16 00:00:00

abstract：:Without a fully developed initial segment, the most proximal region of the epididymis, male infertility results. Therefore, it is important to understand the development and regulation of this crucial region. In addition to distinctively high activity levels of the components of the ERK pathway, which are essential fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu B,Washington AM,Hinton BT

更新日期：2014-12-30 00:00:00

abstract：:Siglecs are a recently discovered family of animal lectins that belong to the Ig superfamily and recognize sialic acids (Sias). CD33-related Siglecs (CD33rSiglecs) are a subgroup with as-yet-unknown functions, characterized by sequence homology, expression on innate immune cells, conserved cytosolic tyrosine-based sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angata T,Margulies EH,Green ED,Varki A

更新日期：2004-09-07 00:00:00

abstract：:Tibetans have adapted to the chronic hypoxia of high altitude and display a distinctive suite of physiologic adaptations, including augmented hypoxic ventilatory response and resistance to pulmonary hypertension. Genome-wide studies have consistently identified compelling genetic signatures of natural selection in two...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song D,Navalsky BE,Guan W,Ingersoll C,Wang T,Loro E,Eeles L,Matchett KB,Percy MJ,Walsby-Tickle J,McCullagh JSO,Medina RJ,Khurana TS,Bigham AW,Lappin TR,Lee FS

更新日期：2020-06-02 00:00:00

abstract：:Human nociceptive voltage-gated sodium channel (Na(v)1.7), a target of significant interest for the development of antinociceptive agents, is blocked by low nanomolar concentrations of (-)-tetrodotoxin(TTX) but not (+)-saxitoxin (STX) and (+)-gonyautoxin-III (GTX-III). These findings question the long-accepted view th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker JR,Novick PA,Parsons WH,McGregor M,Zablocki J,Pande VS,Du Bois J

更新日期：2012-10-30 00:00:00

abstract：:A number of eukaryotic viruses have evolved mechanisms to downregulate activity of the interferon-induced, double-stranded RNA-activated protein kinase (referred to as P68 based on its Mr of 68,000 in human cells). This control is essential because once activated, the P68 kinase phosphorylates its natural substrate, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee TG,Tomita J,Hovanessian AG,Katze MG

更新日期：1990-08-01 00:00:00

abstract：:Recent studies have shown that the genes of the gibberellin (GA) biosynthesis pathway in the fungus Gibberella fujikuroi are organized in a cluster of at least seven genes. P450-1 is one of four cytochrome P450 monooxygenase genes in this cluster. Disruption of the P450-1 gene in the GA-producing wild-type strain IMI ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojas MC,Hedden P,Gaskin P,Tudzynski B

更新日期：2001-05-08 00:00:00

abstract：:We use quantized molecular dynamics simulations to characterize the role of enzyme vibrations in facilitating dihydrofolate reductase hydride transfer. By sampling the full ensemble of reactive trajectories, we are able to quantify and distinguish between statistical and dynamical correlations in the enzyme motion. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boekelheide N,Salomón-Ferrer R,Miller TF 3rd

更新日期：2011-09-27 00:00:00

abstract：:The Landau spectrum of bismuth is complex and includes many angle-dependent lines in the extreme quantum limit. The adequacy of single-particle theory to describe this spectrum in detail has been an open issue. Here, we present a study of angle-resolved Nernst effect in bismuth, which maps the angle-resolved Landau sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Z,Fauqué B,Malone L,Antunes AB,Fuseya Y,Behnia K

更新日期：2012-09-11 00:00:00

abstract：:Drosophila melanogaster is a powerful model organism for dissecting the neurogenetic basis of appetitive and aversive behaviors. However, some methods used to assay food preference require or cause starvation. This can be problematic for fly ethanol research because it can be difficult to dissociate caloric preference...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park A,Tran T,Atkinson NS

更新日期：2018-09-04 00:00:00

abstract：:The labeled inorganic phosphate formed by enzymatic hydrolysis of [gamma-18O]ATP in normal water was derivatized to trimethyl phosphate and analyzed for the proportions of [18O3]Pi, [18O2]Pi, [18O1]Pi, and [18O0]Pi. The proportions observed were correlated with the kinetics of intermediate exchange by using a kinetic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Midelfort CF

更新日期：1981-04-01 00:00:00

abstract：:Factor XI (plasma thromboplastin antecedent) deficiency is a blood coagulation abnormality occurring in high frequency in Ashkenazi Jews. Three independent point mutations that result in a blood coagulation abnormality have been identified in the factor XI gene of six unrelated Ashkenazi patients. These mutations eith...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asakai R,Chung DW,Ratnoff OD,Davie EW

更新日期：1989-10-01 00:00:00

abstract：:Nucleosomes are the fundamental structural unit of chromatin. In addition to stabilizing the DNA polymer, nucleosomes are modified in ways that reflect and affect gene expression in their vicinity. It has long been assumed that nucleosomes can transmit memory of gene expression through their covalent posttranslational...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlissel G,Rine J

更新日期：2019-10-08 00:00:00

abstract：:We show that a 2-step phospho/dephosphorylation cycle for the alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid receptor (AMPAR), as used in in vivo learning experiments to assess long-term potentiation (LTP) induction and establishment, exhibits bistability for a wide range of parameters, consistent with val...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castellani GC,Bazzani A,Cooper LN

更新日期：2009-08-18 00:00:00

abstract：:The conservation of endangered fish is of critical importance. Cryobanking could provide an effective backup measure for use in conjunction with the conservation of natural populations; however, methodology for cryopreservation of fish eggs and embryos has not yet been developed. The present study established a method...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Iwasaki Y,Shikina S,Yoshizaki G

更新日期：2013-01-29 00:00:00

abstract：:Physiological and evolutionary adaptations operate at very different time scales. Nevertheless, there are reasons to believe there should be a strong relationship between the two, as together they modify the phenotype. Physiological adaptations change phenotype by altering certain microscopic parameters; evolutionary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milo R,Hou JH,Springer M,Brenner MP,Kirschner MW

更新日期：2007-10-23 00:00:00

abstract：:The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is removed from cullins by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein G,Ganoth D,Hershko A

更新日期：2006-08-01 00:00:00

abstract：:The blind Mexican cave tetra, Astyanax mexicanus, is a unique model system for the study of parallelism and the evolution of cave-adapted traits. Understanding the genetic basis for these traits has recently become feasible thanks to production of a genome-wide linkage map and quantitative trait association analyses. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross JB,Protas M,Conrad M,Scheid PE,Vidal O,Jeffery WR,Borowsky R,Tabin CJ

更新日期：2008-12-23 00:00:00

abstract：:Chromosomal RNA was isolated from several rat tissues by a new technique. It is shown by RNA-DNA hybridization that each tissue contains a distinct population of chromosomal RNA sequences. This finding is compatible with the proposal that chromosomal RNA is involved in the process of gene activation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayfield JE,Bonner J

更新日期：1971-11-01 00:00:00