Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

abstract：:A 92-amino acid polypeptide, alpha-inhibin-92 (alpha-IB-92), has been isolated and characterized from human seminal plasma and found to be active in suppressing follicle-stimulating hormone (FSH) release in vitro. In the present in vivo study, intravenous injection of synthetic alpha-IB-92 (4 and 20 micrograms) signif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu WH,McCann SM,Li CH

更新日期：1988-01-01 00:00:00

abstract：:Homing endonucleases stimulate gene conversion by generating site-specific DNA double-strand breaks that are repaired by homologous recombination. These enzymes are potentially valuable tools for targeted gene correction and genome engineering. We have engineered a variant of the I-AniI homing endonuclease that nicks ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McConnell Smith A,Takeuchi R,Pellenz S,Davis L,Maizels N,Monnat RJ Jr,Stoddard BL

更新日期：2009-03-31 00:00:00

abstract：:The molecular and cellular basis of selective motor neuron (MN) vulnerability in amyotrophic lateral sclerosis (ALS) is not known. In genetically distinct mouse models of familial ALS expressing mutant superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS), we demonstrate select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalancette-Hebert M,Sharma A,Lyashchenko AK,Shneider NA

更新日期：2016-12-20 00:00:00

abstract：:A neuroethological approach to human and nonhuman primate behavior and cognition predicts biological specializations for social life. Evidence reviewed here indicates that ancestral mechanisms are often duplicated, repurposed, and differentially regulated to support social behavior. Focusing on recent research from no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SW,Brent LJ,Adams GK,Klein JT,Pearson JM,Watson KK,Platt ML

更新日期：2013-06-18 00:00:00

abstract：:Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after nonselective growth. Rifampicin-resistant (Rif(r)) isolates were stable, suggesting that they had arisen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sánchez-Romero MA,Casadesús J

更新日期：2014-01-07 00:00:00

abstract：:Benthic foraminifers inhabit a wide range of aquatic environments including open marine, brackish, and freshwater environments. Here we show that several different and diverse foraminiferal groups (miliolids, rotaliids, textulariids) and Gromia, another taxon also belonging to Rhizaria, accumulate and respire nitrates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piña-Ochoa E,Høgslund S,Geslin E,Cedhagen T,Revsbech NP,Nielsen LP,Schweizer M,Jorissen F,Rysgaard S,Risgaard-Petersen N

更新日期：2010-01-19 00:00:00

abstract：:Genetically obese (ob/ob) mice, mice that became obese after treatment with gold thioglucose, and lean animals were studied in the euthyroid state, after induction of hypothyroidism, and after treatment with triiodothyronine. The activity of glycerol 3-phosphate dehydrogenase (sn-glycerol-3-phosphate:(acceptor) oxidor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： York DA,Bray GA,Yukimura Y

更新日期：1978-01-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor, a subtype of excitatory amino acid receptor, mediates synaptic responses in many regions of the central nervous system. This receptor plays a critical role in the mechanisms of both synaptic plasticity and excitotoxicity. Although these receptors were generally thought to be a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monaghan DT,Olverman HJ,Nguyen L,Watkins JC,Cotman CW

更新日期：1988-12-01 00:00:00

abstract：:The basolateral membranes of Aplysia californica foregut absorptive cells contain both Cl(-)-stimulated ATPase and ATP-dependent Cl- transport activities, and each was inhibited by orthovanadate. Both of these orthovanadate-sensitive activities were reconstituted into proteoliposomes. The reaction sequence kinetics we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerencser GA,Zelezna B

更新日期：1993-09-01 00:00:00

abstract：:Go is a specific class ("other") of signal-transducing heterotrimeric GTP-binding proteins (G proteins) that is expressed in high levels in mammalian brain. We have cloned two different rat cDNAs encoding the alpha subunit of Go (Go alpha-1 and Go alpha-2) and a human Go alpha chromosomal gene. The human Go alpha gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsukamoto T,Toyama R,Itoh H,Kozasa T,Matsuoka M,Kaziro Y

更新日期：1991-04-15 00:00:00

abstract：:Amplitude-modulated phosphorescence/microwave double-resonance (AM-PMDR) spectra are reported for complexes of methylmercury(II) cation, designated CH3Hg(II), with tryptophan and glyceraldehyde-3-phosphate dehydrogenase (GPDHase; from rabbit muscle). Wavelength shifts are observed in the AM-PMDR spectra of CH3Hg(II)-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JM,Maki AH

更新日期：1982-07-01 00:00:00

abstract：:Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of "druggable" targets, and the access-limiting blood-retinal barrier (BRB) present major hurdles toward eff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vighi E,Trifunović D,Veiga-Crespo P,Rentsch A,Hoffmann D,Sahaboglu A,Strasser T,Kulkarni M,Bertolotti E,van den Heuvel A,Peters T,Reijerkerk A,Euler T,Ueffing M,Schwede F,Genieser HG,Gaillard P,Marigo V,Ekström P,Pa

更新日期：2018-03-27 00:00:00

abstract：:The tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) has been defined by its ability to promote tumorigenesis on carcinogen-initiated mouse skin. Activation of Wnt/β-catenin signaling has a decisive role in mouse skin carcinogenesis, but it remains unclear how TPA activates Wnt/β-catenin signaling in mouse s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su Z,Song J,Wang Z,Zhou L,Xia Y,Yu S,Sun Q,Liu SS,Zhao L,Li S,Wei L,Carson DA,Lu D

更新日期：2018-08-07 00:00:00

abstract：:We have constructed and cloned, in bacteria, recombinant plasmids containing DNA complementary to mRNA coding for a pancreatic pre-prosomatostatin, a product of the cell-free translation of pancreatic islet mRNAs shown previously by immunoprecipitation to be a precursor of somatostatin. A clone containing a nearly ful...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodman RH,Jacobs JW,Chin WW,Lund PK,Dee PC,Habener JF

更新日期：1980-10-01 00:00:00

abstract：:The role of missense changes in BRCA1 in breast cancer susceptibility has been difficult to establish. We used comparative evolutionary methods to identify potential functionally important amino acid sites in exon 11 and missense changes likely to disrupt gene function, aligning sequences from 57 eutherian mammals and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming MA,Potter JD,Ramirez CJ,Ostrander GK,Ostrander EA

更新日期：2003-02-04 00:00:00

abstract：:Vertebrate remains recovered from a limestone fissure filling on Antigua, Lesser Antilles, are associated with radiocarbon dates ranging from 4300 to 2500 yr B.P., contemporaneous with the earliest aboriginal human occupation of the island. Nine taxa of lizards, snakes, birds, bats, and rodents (one-third of the total...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steadman DW,Pregill GK,Olson SL

更新日期：1984-07-01 00:00:00

abstract：:Cdc7 is an essential kinase required for the initiation of eukaryotic DNA replication. Previous studies in many species showed that the minichromosome maintenance complex is a major physiological target of this kinase. In this study, we have mapped the sites in human Mcm2 protein that are phosphorylated by Cdc7. The i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho WH,Lee YJ,Kong SI,Hurwitz J,Lee JK

更新日期：2006-08-01 00:00:00

abstract：:Natural killer (NK) cells are key players in the innate response to viruses, including herpesviruses. In particular, the variety of viral strategies to modulate the recognition of certain herpesviruses witnesses the importance of NK cells in the control of this group of viruses. Still, NK evasion strategies have remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grauwet K,Cantoni C,Parodi M,De Maria A,Devriendt B,Pende D,Moretta L,Vitale M,Favoreel HW

更新日期：2014-11-11 00:00:00

abstract：:Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential role...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spees JL,Olson SD,Whitney MJ,Prockop DJ

更新日期：2006-01-31 00:00:00

abstract：:Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone deacetylase inhibitors are currently in clinical trials for the treatment of cancer. These and other inhibitors also affect microtubule acetylation. A multidimensional, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haggarty SJ,Koeller KM,Wong JC,Grozinger CM,Schreiber SL

更新日期：2003-04-15 00:00:00

abstract：:Although antibodies to HLA play a role in the pathogenesis of diseases processes such as rejection of transplanted organs, the precise mechanisms by which antibodies cause tissue injury are not completely understood. We hypothesized that antibodies to host tissues cause inflammation in part by activating endothelial e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamakuchi M,Kirkiles-Smith NC,Ferlito M,Cameron SJ,Bao C,Fox-Talbot K,Wasowska BA,Baldwin WM 3rd,Pober JS,Lowenstein CJ

更新日期：2007-01-23 00:00:00

abstract：:Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta I,Ganguly S,Rozanas CR,Stuehr DJ,Panda K

更新日期：2016-07-19 00:00:00

abstract：:The p2b domain of Rous sarcoma virus (RSV) Gag and the p6 domain of HIV-1 Gag contain late assembly (L) domains that engage the ESCRT membrane fission machinery and are essential for virus release. We now show that the PPXY-type RSV L domain specifically recruits the BAR domain protein PACSIN2 into virus-like particle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popov S,Popova E,Inoue M,Wu Y,Göttlinger H

更新日期：2018-07-03 00:00:00

abstract：:Posttranslational modifications (PTMs) are important physiological means to regulate the activities and structures of central regulatory proteins in health and disease. Small GTPases have been recognized as important molecules that are targeted by PTMs during infections of mammalian cells by bacterial pathogens. The e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barthelmes K,Ramcke E,Kang HS,Sattler M,Itzen A

更新日期：2020-03-17 00:00:00

abstract：:In Xenopus oocytes injected with rat brain mRNA, as in neurons, glycine greatly potentiated responses of the N-methyl-D-aspartate (NMDA) type of excitatory amino acid receptor. Injected oocytes generated a partially desensitizing inward current in response to NMDA with 30 nM added glycine. As the added glycine concent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerma J,Zukin RS,Bennett MV

更新日期：1990-03-01 00:00:00

abstract：:Monotremes have left a poor fossil record, and paleontology has been virtually mute during two decades of discussion about molecular clock estimates of the timing of divergence between the platypus and echidna clades. We describe evidence from high-resolution x-ray computed tomography indicating that Teinolophos, an E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe T,Rich TH,Vickers-Rich P,Springer M,Woodburne MO

更新日期：2008-01-29 00:00:00

abstract：:The pathophysiology of systemic inflammation and sepsis involves peripheral organs, causing gastrointestinal, renal, and cardiovascular alterations, as well as the central nervous system (CNS), affecting sleep, temperature regulation, behavior, and neuroendocrine function. The molecular basis of the CNS effects of sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong ML,Bongiorno PB,Rettori V,McCann SM,Licinio J

更新日期：1997-01-07 00:00:00

abstract：:Sheep antibodies directed against an AMP-bovine serum albumin conjugate exhibit highly specific binding toward AMP. These antibodies bind to the AMP moiety of adenylylated glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] from Escherichia coli and to no other antigenic determinant on the prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohman RJ,Rhee SG,Stadtman ER

更新日期：1980-12-01 00:00:00

abstract：:Protein kinase C (PKC) and Syk protein tyrosine kinase play critical roles in immune cell activation including that through the high-affinity IgE receptor, FcepsilonRI. Mechanisms by which PKC activation leads to the activation of Ras, a family of GTPases essential for immune cell activation, have been elusive. We pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami Y,Kitaura J,Yao L,McHenry RW,Kawakami Y,Newton AC,Kang S,Kato RM,Leitges M,Rawlings DJ,Kawakami T

更新日期：2003-08-05 00:00:00

abstract：:Environmental stress often leads to an increased production of reactive oxygen species that are involved in plastid-to-nucleus retrograde signaling. Soon after the release of singlet oxygen ((1)O(2)) in chloroplasts of the flu mutant of Arabidopsis, reprogramming of nuclear gene expression reveals a rapid transfer of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simková K,Moreau F,Pawlak P,Vriet C,Baruah A,Alexandre C,Hennig L,Apel K,Laloi C

更新日期：2012-10-02 00:00:00