Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells.

abstract：:The early detection of pathogens with epidemic potential is of major importance to public health. Most emerging infections result in dead-end "spillover" events in which a pathogen is transmitted from an animal reservoir to a human but is unable to achieve the sustained human-to-human transmission necessary for a full...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geoghegan JL,Senior AM,Di Giallonardo F,Holmes EC

更新日期：2016-04-12 00:00:00

abstract：:The integrity of the endothelial barrier between circulating blood and tissue is important for blood vessel function and, ultimately, for organ homeostasis. Here, we developed a vessel-on-a-chip with perfused endothelialized channels lined with human bone marrow stromal cells, which adopt a mural cell-like phenotype t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alimperti S,Mirabella T,Bajaj V,Polacheck W,Pirone DM,Duffield J,Eyckmans J,Assoian RK,Chen CS

更新日期：2017-08-15 00:00:00

abstract：:(2'-5')Oligoadenylate synthetase [(2'-5')A synthetase], which synthesizes a series of oligoadenylates ppp-(A2'p)n5'A [collectively referred to as (2'-5')A], has been described previously in rat liver cells, where its concentration varied with the growth status of this organ--i.e., it decreased during the early phase o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etienne-Smekens M,Vandenbussche P,Content J,Dumont JE

更新日期：1983-08-01 00:00:00

abstract：:Optimization of hydride transfer (HT) catalysts to enhance rates and selectivities of (photo)electroreduction reactions could be a crucial component of a sustainable chemical industry. Here, we analyze how ring functionalization of the adsorbed transient intermediate 2-pyridinide (2-PyH-*)-predicted to form in situ fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu S,Carter EA

更新日期：2019-11-12 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:Circumnutation and winding in plants are universal growth movements that allow plants to survive despite their sessile nature. However, the detailed molecular mechanisms controlling these phenomena remain unclear. We previously found that a gravitropic mutant of Japanese morning glory (Pharbitis nil or Ipomoea nil), S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitazawa D,Hatakeda Y,Kamada M,Fujii N,Miyazawa Y,Hoshino A,Iida S,Fukaki H,Morita MT,Tasaka M,Suge H,Takahashi H

更新日期：2005-12-20 00:00:00

abstract：:We report the successful infection of two rabbit T-cell lines and one rabbit macrophage line with human immunodeficiency virus 1 (HIV-1). One T-cell line was a herpesvirus ateles transformant, the other T-cell line was a human T-cell leukemia virus I transformant, and the macrophage line was a simian virus 40 transfor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kulaga H,Folks TM,Rutledge R,Kindt TJ

更新日期：1988-06-01 00:00:00

abstract：:2'-Deoxyadenosine 5'-O-(1-thiotriphosphate) (dATP[alpha S]) was introduced into the 3' ends of DNA restriction fragments with Escherichia coli DNA polymerase I to give phosphorothioate internucleotide linkages. Such "capped" 3' ends were found to be resistant to exonuclease III digestion. Moreover, the resistance to d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putney SD,Benkovic SJ,Schimmel PR

更新日期：1981-12-01 00:00:00

abstract：:Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly used in human medicine. Unusually, the erythromycin biosynthetic (ery) cluster lacks a pathway-specific regulatory gene. We isolated a transcriptional regulator of the ery biosynthetic genes from S. erythraea and found that this protein appears to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chng C,Lum AM,Vroom JA,Kao CM

更新日期：2008-08-12 00:00:00

abstract：:The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is removed from cullins by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein G,Ganoth D,Hershko A

更新日期：2006-08-01 00:00:00

abstract：:Mutations at the mouse limb deformity (ld) locus result in defects of growth and patterning of the limb and kidney during embryonic development. The gene responsible for this phenotype is large and complex, with the capacity to generate a number of alternatively spliced messenger RNA transcripts encoding nuclear prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogt TF,Jackson-Grusby L,Rush J,Leder P

更新日期：1993-06-15 00:00:00

abstract：:We present the complete nucleotide and deduced amino acid sequences of a mouse epidermal keratin subunit of 60,000 Da. The keratin possesses a central alpha-helical domain of four tracts (termed 1A, 1B, 2A, and 2B) that can form coiled-coils, interspersed by short linker sequences, and has non-alpha-helical terminal d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinert PM,Parry DA,Racoosin EL,Idler WW,Steven AC,Trus BL,Roop DR

更新日期：1984-09-01 00:00:00

abstract：:The yeast flora found in the major substrates of Drosophila mojavensis and in larval guts was studied both qualitatively and quantitatively. Quantitative studies show that, in four of the five substrates tested, the larvae did not contain a random sample of the yeasts present in the substrates. One widely distributed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fogleman JC,Starmer WT,Heed WB

更新日期：1981-07-01 00:00:00

abstract：:Many signaling and metabolic pathways rely on the ability of some of the proteins involved to undergo a substrate-induced transition between at least two structural states. Among the various models put forward to account for binding and activity curves of those allosteric proteins, the Monod, Wyman, and Changeux model...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fetler L,Kantrowitz ER,Vachette P

更新日期：2007-01-09 00:00:00

abstract：:Rad51 is the primary eukaryotic recombinase responsible for initiating DNA strand exchange during homologous recombination. Although the subject of intense study for over a decade, many molecular details of the reactions promoted by Rad51 and related recombinases remain unknown. Using total internal reflection fluores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granéli A,Yeykal CC,Robertson RB,Greene EC

更新日期：2006-01-31 00:00:00

abstract：:RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been known as the only slicer while Argonaute3 (AGO3) barely cleaves RNAs. Therefore, the intrinsi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park MS,Sim G,Kehling AC,Nakanishi K

更新日期：2020-11-17 00:00:00

abstract：:CD4(+) T cells expand after transfer into lymphopenic H-2(b) A(beta)-/- mice (I-A(beta)-, I-E(alpha)-deficient mice) but not after transfer into lymphopenic MHC II(Delta/Delta) mice (I-A(alpha)-, I-A(beta)-, I-E(alpha)-, and I-E(beta)-deficient mice), implying that in H-2(b) A(beta)-/- mice, A(alpha) chain and E(beta)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin B,Bourgeois C,Dautigny N,Lucas B

更新日期：2003-05-13 00:00:00

abstract：:Purified cellular retinol-binding protein (CRBP), a potential mediator of vitamin A action, was found to enable retinol to bind in a specific manner to isolated nuclei from livers of vitamin A deficient rats. Binding was followed after complexing [3H]retinol with CRBP. The binding was specific, saturable, and temperat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takase S,Ong DE,Chytil F

更新日期：1979-05-01 00:00:00

abstract：:The ability to regulate gene expression through transcription initiation underlies the adaptability and survival of all bacteria. Recent work has revealed that the transcription machinery in many bacteria diverges from the paradigm that has been established in Escherichia coliMycobacterium tuberculosis (Mtb) encodes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu DX,Garner AL,Galburt EA,Stallings CL

更新日期：2019-07-02 00:00:00

abstract：:In the primary visual cortex, neurons with similar response preferences are grouped into domains forming continuous maps of stimulus orientation and direction of movement. These properties are widely believed to result from the combination of ascending and lateral interactions in the visual system. We have tested this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galuske RA,Schmidt KE,Goebel R,Lomber SG,Payne BR

更新日期：2002-12-24 00:00:00

abstract：:Although an inverse relationship is expected in ancient DNA samples between the number of surviving DNA fragments and their length, ancient DNA sequencing libraries are strikingly deficient in molecules shorter than 40 bp. We find that a loss of short molecules can occur during DNA extraction and present an improved s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabney J,Knapp M,Glocke I,Gansauge MT,Weihmann A,Nickel B,Valdiosera C,García N,Pääbo S,Arsuaga JL,Meyer M

更新日期：2013-09-24 00:00:00

abstract：:The nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is an important coordinator of glucose homeostasis through its function in different organs such as the endocrine pancreas, adipose tissue, skeletal muscle, and liver. Recently we have demonstrated that COUP-TFII expression in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabra-Makke L,Maritan M,Planchais J,Boutant M,Pégorier JP,Even PC,Vasseur-Cognet M,Bossard P

更新日期：2013-03-12 00:00:00

abstract：:Both stem cells and mast cells express c-kit and proliferate after exposure to c-kit ligand. Mutations in c-kit may enhance or interfere with the ability of c-kit receptor to initiate the intracellular pathways resulting in cell proliferation. These observations suggested to us that mastocytosis might in some patients...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagata H,Worobec AS,Oh CK,Chowdhury BA,Tannenbaum S,Suzuki Y,Metcalfe DD

更新日期：1995-11-07 00:00:00

abstract：:Estrogen signaling occurs through at least two distinct molecular pathways: (i) direct binding of liganded estrogen receptors (ERs) to estrogen-responsive DNA elements (EREs) (the "ER/ERE pathway") and (ii) indirect recruitment of liganded ERs to activating protein-1 (AP-1)-responsive DNA elements via heterodimers of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung E,Acevedo ML,Cole PA,Kraus WL

更新日期：2005-01-18 00:00:00

abstract：:Parasponia, a woody member of the elm family, is the only nonlegume genus whose members are known to form an effective nitrogen-fixing symbiosis with a Rhizobium species. The bacterial strain RP501 is a slow-growing strain of Rhizobium isolated from Parasponia nodules. Strain RP501 also nodulates the legumes siratro (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marvel DJ,Kuldau G,Hirsch A,Richards E,Torrey JG,Ausubel FM

更新日期：1985-09-01 00:00:00

abstract：:As a master regulator of functional Ig heavy chain (IgH) expression, the IgH 3' regulatory region (3'RR) controls multiple transcription events at various stages of B-cell ontogeny, from newly formed B cells until the ultimate plasma cell stage. The IgH 3'RR plays a pivotal role in early B-cell receptor expression, ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garot A,Marquet M,Saintamand A,Bender S,Le Noir S,Rouaud P,Carrion C,Oruc Z,Bébin AG,Moreau J,Lebrigand K,Denizot Y,Alt FW,Cogné M,Pinaud E

更新日期：2016-02-09 00:00:00

abstract：:Peptidoglycan (PGN) recognition proteins (PGRPs) are pattern-recognition receptors of the innate immune system that bind and, in some cases, hydrolyze bacterial PGNs. We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan R,Roychowdhury A,Ember B,Kumar S,Boons GJ,Mariuzza RA

更新日期：2004-12-07 00:00:00

abstract：:The bacterial adaptive immune system CRISPR-Cas9 has been appropriated as a versatile tool for editing genomes, controlling gene expression, and visualizing genetic loci. To analyze Cas9's ability to bind DNA rapidly and specifically, we generated multiple libraries of potential binding partners for measuring the kine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyle EA,Andreasson JOL,Chircus LM,Sternberg SH,Wu MJ,Guegler CK,Doudna JA,Greenleaf WJ

更新日期：2017-05-23 00:00:00

abstract：:In our earlier work we showed that either spermidine or spermine could support the growth of spe2Delta or spe3Delta polyamine-requiring mutants, but it was unclear whether the cells had a specific requirement for either of these amines. In the current work, we demonstrate that spermidine is specifically required for t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay MK,Tabor CW,Tabor H

更新日期：2003-11-25 00:00:00

abstract：:Microcin B17 (MccB17) is a 3.1-kDa Escherichia coli antibiotic that contains thiazole and oxazole heterocycles in a peptide backbone. MccB17 inhibits its cellular target, DNA gyrase, by trapping the enzyme in a complex that is covalently bound to double-strand cleaved DNA, in a manner similar to the well-known quinolo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamble DB,Miller DA,Heddle JG,Maxwell A,Walsh CT,Hollfelder F

更新日期：2001-07-03 00:00:00