Synthetic human seminal alpha-inhibin-92 selectively suppresses follicle-stimulating hormone release in vivo.

abstract：:Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has been found to be a primary cause of HH. However, many individuals homozygous for the defective allele of HFE do not deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sproule TJ,Jazwinska EC,Britton RS,Bacon BR,Fleming RE,Sly WS,Roopenian DC

更新日期：2001-04-24 00:00:00

abstract：:Mutualisms between fungi and fungus-growing animals are model systems for studying coevolution and complex interactions between species. Fungal growing behavior has enabled cultivating animals to rise to major ecological importance, but evolution of farming symbioses is thought to be restricted to three terrestrial in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silliman BR,Newell SY

更新日期：2003-12-23 00:00:00

abstract：:Arsenic poisoning affects millions of people worldwide. Human arsenic intake from rice consumption can be substantial because rice is particularly efficient in assimilating arsenic from paddy soils, although the mechanism has not been elucidated. Here we report that two different types of transporters mediate transpor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma JF,Yamaji N,Mitani N,Xu XY,Su YH,McGrath SP,Zhao FJ

更新日期：2008-07-22 00:00:00

abstract：:Blood oxygen level-dependent functional MRI (fMRI) constitutes a powerful neuroimaging technology to map brain-wide functions in response to specific sensory or cognitive tasks. However, fMRI mapping of the vestibular system, which is pivotal for our sense of balance, poses significant challenges. Physical constraints...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leong ATL,Gu Y,Chan YS,Zheng H,Dong CM,Chan RW,Wang X,Liu Y,Tan LH,Wu EX

更新日期：2019-05-14 00:00:00

abstract：:In this paper we solve several boundary value problems for the Helmholtz equation on polygonal domains. We observe that when the problems are formulated as the boundary integral equations of potential theory, the solutions are representable by series of appropriately chosen Bessel functions. In addition to being analy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serkh K,Rokhlin V

更新日期：2016-08-16 00:00:00

abstract：:Portable, single-sided NMR sensors can operate under conditions inaccessible to conventional NMR while featuring lower cost, portability, and the ability to analyze arbitrary-sized objects. Such sensors can nondestructively probe the interior of samples by collecting images and measuring relaxation and diffusion const...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulsen JL,Bouchard LS,Graziani D,Blümich B,Pines A

更新日期：2008-12-30 00:00:00

abstract：:Fluorescence photobleaching recovery was used to measure the lateral diffusion coefficient and mobile fraction of surface immunoglobulin (sIg), Thy-1 antigen, and a lipid probe in the plasma membrane of mouse lymphocytes. The lipid probe (3,3'-dioctadecylindocarbocyanine) had a mean (+/-SD) diffusion coefficient of (1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dragsten P,Henkart P,Blumenthal R,Weinstein J,Schlessinger J

更新日期：1979-10-01 00:00:00

abstract：:Estrogen signaling occurs through at least two distinct molecular pathways: (i) direct binding of liganded estrogen receptors (ERs) to estrogen-responsive DNA elements (EREs) (the "ER/ERE pathway") and (ii) indirect recruitment of liganded ERs to activating protein-1 (AP-1)-responsive DNA elements via heterodimers of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung E,Acevedo ML,Cole PA,Kraus WL

更新日期：2005-01-18 00:00:00

abstract：:Curved DNA molecules and unusually small circles have been obtained by ligation of synthetic 21-base precursors: (sequence in text). The ligation resulted in the formation of double-stranded oligo-(precursor)s possessing a strong 10.5-base-pair (bp) periodicity of the runs of adenines. Two-dimensional polyacrylamide g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulanovsky L,Bodner M,Trifonov EN,Choder M

更新日期：1986-02-01 00:00:00

abstract：:Understanding the mechanisms of nanoparticle interaction with cell membranes is essential for designing materials for applications such as bioimaging and drug delivery, as well as for assessing engineered nanomaterial safety. Much attention has focused on nanoparticles that bind strongly to biological membranes or ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foreman-Ortiz IU,Liang D,Laudadio ED,Calderin JD,Wu M,Keshri P,Zhang X,Schwartz MP,Hamers RJ,Rotello VM,Murphy CJ,Cui Q,Pedersen JA

更新日期：2020-11-10 00:00:00

abstract：:Phalloidin, a toxic bicyclic peptide of rapid action from the toadstool, Amanita phalloides, gives rise to polymerization of G-actin to filamentous structures (Ph-actin) in a medium of low ionic strength. Ph-actin closely resembles the microfilaments found in liver membrane fractions (Ph-filaments) after in vivo or in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lengsfeld AM,Löw I,Wieland T,Dancker P,Hasselbach W

更新日期：1974-07-01 00:00:00

abstract：:How can collective action evolve when individuals benefit from cooperation regardless of whether they pay its participation costs? According to one influential perspective, collective action problems are common, especially when groups are large, but may be solved when individuals who have more to gain from the collect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langergraber KE,Watts DP,Vigilant L,Mitani JC

更新日期：2017-07-11 00:00:00

abstract：:Harvey and Kirsten murine sarcoma viruses each encode a structurally and functionally related 21-kilodalton protein (p21), which is the transforming protein of each virus. Using probes from the 0.9-kilobase (kb) p21-coding region of each virus (called v-Ha-ras and v-Ki-ras, respectively), we have molecularly cloned fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang EH,Gonda MA,Ellis RW,Scolnick EM,Lowy DR

更新日期：1982-08-01 00:00:00

abstract：:Experimental lemurs either were infected orally with the agent of bovine spongiform encephalopathy (BSE) or were maintained as uninfected control animals. Immunohistochemical examination for proteinase-resistant protein (prion protein or PrP) was performed on tissues from two infected but still asymptomatic lemurs, ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bons N,Mestre-Frances N,Belli P,Cathala F,Gajdusek DC,Brown P

更新日期：1999-03-30 00:00:00

abstract：:We have studied ten phenotypically similar patients with complete androgen insensitivity. All of the patients tested had significantly elevated serum luteinizing hormone and plasma androgens within or above the normal adult male range. On the basis of specific dihydrotestosterone binding by skin fibroblasts, we identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amrhein JA,Meyer WJ 3rd,Jones HW Jr,Migeon CJ

更新日期：1976-03-01 00:00:00

abstract：:Excited states of proteins may play important roles in function, yet are difficult to study spectroscopically because of their sparse population. High hydrostatic pressure increases the equilibrium population of excited states, enabling their characterization [Akasaka K (2003) Biochemistry 42:10875-85]. High-pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerch MT,Horwitz J,McCoy J,Hubbell WL

更新日期：2013-12-03 00:00:00

abstract：:Pollen tubes are highly polarized plant cells specialized in delivering sperm for fertilization. Pollen tube growth is rapid, occurs exclusively at the tip, and can reach distances thousands of times the diameter of the pollen grain without cell division, thus representing an excellent model system for studying asymme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AY,Niroomand S,Zou Y,Wu HM

更新日期：2010-09-14 00:00:00

abstract：:Functional transcription elongation complexes can be formed by adding RNA polymerase in trans to a preformed nucleic acid construct. This construct consists of a double-stranded DNA fragment that contains a noncomplementary (permanent DNA bubble) region into which an RNA primer oligonucleotide has been hybridized. By ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daube SS,Hart CR,von Hippel PH

更新日期：1994-09-27 00:00:00

abstract：:Two-phase random textures abound in a host of contexts, including porous and composite media, ecological structures, biological media, and astrophysical structures. Questions surrounding the spatial structure of such textures continue to pose many theoretical challenges. For example, can two-point correlation function...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiao Y,Stillinger FH,Torquato S

更新日期：2009-10-20 00:00:00

abstract：:We have previously shown that in neutrophils deprived of granulocyte colony-stimulating factor, apoptosis is preceded by acidification and that the protection against apoptosis conferred on neutrophils by granulocyte colony-stimulating factor is dependent upon delay of this acidification. To test the hypothesis that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gottlieb RA,Nordberg J,Skowronski E,Babior BM

更新日期：1996-01-23 00:00:00

abstract：:Murine suppressor T-cell hybridoma cells (231F1) secrete not only bioactive glycosylation-inhibiting factor (GIF) but also an inactive peptide comparable to bioactive GIF peptide in its molecular size and reactivity with anti-GIF; the amino acid sequence of the inactive peptide is identical to that of the bioactive ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano T,Liu YC,Mikayama T,Watarai H,Taniguchi M,Ishizaka K

更新日期：1995-09-26 00:00:00

abstract：:Earlier work has shown that mitochondrial proteins synthesized in the cytosol are initially made as larger precursors which are then transferred into the organelles and processed to their mature size in the absence of protein synthesis. It is now demonstrated that depletion of the mitochondrial matrix ATP in intact ye...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson N,Schatz G

更新日期：1979-09-01 00:00:00

abstract：:The "false thumb" of pandas is a carpal bone, the radial sesamoid, which has been enlarged and functions as an opposable thumb. If the giant panda (Ailuropoda melanoleuca) and the red panda (Ailurus fulgens) are not closely related, their sharing of this adaptation implies a remarkable convergence. The discovery of pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salesa MJ,Antón M,Peigné S,Morales J

更新日期：2006-01-10 00:00:00

abstract：:In mouse and human, the beta-globin genes reside in a linear array that is associated with a positive regulatory element located 5' to the genes known as the locus control region (LCR). The sequences of the mouse and human beta-globin LCRs are homologous, indicating conservation of an essential function in beta-globin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulger M,van Doorninck JH,Saitoh N,Telling A,Farrell C,Bender MA,Felsenfeld G,Axel R,Groudine M

更新日期：1999-04-27 00:00:00

abstract：:Diisopropyl fluorophosphate (DFP) causes neurotoxicity related to an irreversible inhibition of acetylcholinesterase (AChE). Management of this intoxication includes: (i) pretreatment with reversible blockers of AChE, (ii) blockade of muscarinic receptors with atropine, and (iii) facilitation of GABA(A) receptor signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pibiri F,Kozikowski AP,Pinna G,Auta J,Kadriu B,Costa E,Guidotti A

更新日期：2008-09-16 00:00:00

abstract：:The steroid cholesterol is an essential component of eukaryotic membranes, and it functionally modulates membrane proteins, including G protein-coupled receptors. To reveal insight into how cholesterol modulates G protein-coupled receptors, we have used dynamic single-molecule force spectroscopy to quantify the mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zocher M,Zhang C,Rasmussen SG,Kobilka BK,Müller DJ

更新日期：2012-12-11 00:00:00

abstract：:Injection of rat kidney cortex mRNA into Xenopus laevis oocytes leads to a stimulation of Na(+)-dependent SO4(2-) uptake. Based on this information, we have isolated from a corresponding library a cDNA (NaSi-1) that is most likely related to a Na+/SO4(2-) cotransport system. NaSi-1 cRNA leads in a time- and dose-depen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markovich D,Forgo J,Stange G,Biber J,Murer H

更新日期：1993-09-01 00:00:00

abstract：:A mathematical model is presented that describes the effects of hormone concentration on receptor saturation and biological response in systems dependent upon the generation of a secondary mediator such as cyclic AMP. The analysis makes the following assumptions: (i) the binding of hormone to its receptor is a reversi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strickland S,Loeb JN

更新日期：1981-03-01 00:00:00

abstract：:Deregulated production of nitric oxide (NO) has been implicated in the development of certain human diseases, including cancer. We sought to assess the damaging potential of NO produced under long-term conditions through the development of a suitable model cell culture system. In this study, we report that when murine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang JC,Wogan GN

更新日期：1997-10-28 00:00:00

abstract：:Aqueous gel sieving chromatography on Sephadex G-10 of the Group IA cations (Li+, Na+, K+, Rb+, Cs+) plus NH4+ as the Cl- salts, in combination with previous results for the halide anions (F-, Cl-, Br-, I-) as the Na+ salts [Washabaugh, M.W. & Collins, K.D. (1986) J. Biol. Chem. 261, 12477-12485], leads to the followi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins KD

更新日期：1995-06-06 00:00:00