F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase.

abstract：:The cell surface of embryonic peripheral neurons provides a mitogenic stimulus for Schwann cells. We report (i) the solubilization of this mitogenic activity from rat dorsal root ganglion neurons grown in tissue culture and (ii) the solubilization and partial purification of mitogenic activity from neonatal rat brains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratner N,Hong DM,Lieberman MA,Bunge RP,Glaser L

更新日期：1988-09-01 00:00:00

abstract：:By using the maximum likelihood method, we made a genome-wide comparison of the evolutionary rates in the lineages leading to the laboratory strain (S288c) and a wild strain (YJM789) of Saccharomyces cerevisiae and found that genes in the laboratory strain tend to evolve faster than in the wild strain. The pattern of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu Z,David L,Petrov D,Jones T,Davis RW,Steinmetz LM

更新日期：2005-01-25 00:00:00

abstract：:Contractile forces are essential for many developmental processes involving cell shape change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the major component of the contractile machinery, have shown that active contractility occurs above a threshold motor concentration and within a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Wolynes PG

更新日期：2012-04-24 00:00:00

abstract：:Rifamycin antibiotics, which inhibit RNA-directed DNA polymerase of Rauscher leuckemia virus, prevent the leukemogenic activity of the virus, and the effect of leukemogenesis correlates with the magnitude of inhibition of the purified enzyme. This inhibition of enzyme activity by rifamycin SV derivatives is due to a r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu AM,Ting RC,Gallo RC

更新日期：1973-05-01 00:00:00

abstract：:The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2',5'-linked RNA molecules (2-5A) that activate regulated RNA decay in mammalian tissues. Differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donovan J,Whitney G,Rath S,Korennykh A

更新日期：2015-03-31 00:00:00

abstract：:Protein-mediated electron transfer is an essential event in many biochemical processes. Efficient electron transfer requires the reorganization energy of the redox event to be minimized, which is ensured by the presence of rigid donor and acceptor sites. Electron transfer copper sites are present in the ubiquitous cup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaballa ME,Abriata LA,Donaire A,Vila AJ

更新日期：2012-06-12 00:00:00

abstract：:Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-1, miR-133 and miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao PK,Kumar RM,Farkhondeh M,Baskerville S,Lodish HF

更新日期：2006-06-06 00:00:00

abstract：:The ciliary epithelium in the eye consists of pigmented epithelial cells that express the α1β1 isoform of Na,K-ATPase and nonpigmented epithelial cells that express mainly the α2β3 isoform. In principle, a Na,K-ATPase inhibitor with selectivity for α2β3 that penetrates the cornea could effectively reduce intraocular p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katz A,Tal DM,Heller D,Habeck M,Ben Zeev E,Rabah B,Bar Kana Y,Marcovich AL,Karlish SJ

更新日期：2015-11-03 00:00:00

abstract：:The kinetics of the reduction of horseheart ferricytochrome c by sodium dithionite (phosphate buffer-sodium chloride; pH 6.5, mu = 1.0, 25 degrees ) features two reaction pathways; one with the rate constant k(3) = 1.17 x 10(4) M(-1) sec(-1), the other with the rate constant k(1)k(2)/k(-1) = 6.0 x 10(4) M(-1) sec(-1)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Creutz C,Sutin N

更新日期：1973-06-01 00:00:00

abstract：:Tropical cyclones have massive economic, social, and ecological impacts, and models of their occurrence influence many planning activities from setting insurance premiums to conservation planning. Most impact models allow for geographically varying cyclone rates but assume that individual storm events occur randomly w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mumby PJ,Vitolo R,Stephenson DB

更新日期：2011-10-25 00:00:00

abstract：:Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) protein interactions at the synaptic vesicle/plasma membrane interface play an essential role in neurotransmitter release. The membrane-proximal region (amino acids 77-90) of the v-SNARE vesicle-associated membrane protein 2 (VAMP 2,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Haro L,Ferracci G,Opi S,Iborra C,Quetglas S,Miquelis R,Lévêque C,Seagar M

更新日期：2004-02-10 00:00:00

abstract：:The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimulating activity. We have raised rabbit antisera to a bacterially synthe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeClue JE,Cohen BD,Lowy DR

更新日期：1991-11-15 00:00:00

abstract：:Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse. Heterozygotes carry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge C,Stanley P

更新日期：2008-02-05 00:00:00

abstract：:Systemic anthrax, caused by inhalation or ingestion of Bacillus anthracis spores, is characterized by rapid microbial growth stages that require iron. Tightly bound and highly regulated in a mammalian host, iron is scarce during an infection. To scavenge iron from its environment, B. anthracis synthesizes by independe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abergel RJ,Wilson MK,Arceneaux JE,Hoette TM,Strong RK,Byers BR,Raymond KN

更新日期：2006-12-05 00:00:00

abstract：:The temporal dynamics of electrical activity in an olfactory organ, the procerebral lobe of the terrestrial mollusc Limax maximus, is studied. The lobe exhibits intrinsic oscillations in its field potential. Intracellular recordings show that the lobe contains two classes of neurons, both with activity phase-locked to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaney KR,Gelperin A,Fee MS,Flores JA,Gervais R,Tank DW,Kleinfeld D

更新日期：1994-01-18 00:00:00

abstract：:Certain types of human papillomaviruses (HPVs) are etiologically linked to cervical cancer. Their transforming capacity is encoded by a polycistronic premRNA, where alternative splicing leads to the translation of functional distinct proteins such as E6, E6*, and E7. Here we show that splicing of HPV16 E6/E7 ORF casse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberger S,De-Castro Arce J,Langbein L,Steenbergen RD,Rösl F

更新日期：2010-04-13 00:00:00

abstract：:The human malaria parasite Plasmodium falciparum can cause infected red blood cells (iRBC) to form rosettes with uninfected RBC, a phenotype associated with severe malaria. Rosetting is mediated by a subset of the Plasmodium falciparum membrane protein 1 (PfEMP1) variant adhesins expressed on the infected host-cell su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juillerat A,Lewit-Bentley A,Guillotte M,Gangnard S,Hessel A,Baron B,Vigan-Womas I,England P,Mercereau-Puijalon O,Bentley GA

更新日期：2011-03-29 00:00:00

abstract：:Truncation selection is known to be the most efficient form of directional selection. When this is modified so that the fitness increases linearly over a range of one or two standard deviations of the value of the selected character, the efficiency is reduced, but not greatly. When truncation selection is compared to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crow JF,Kimura M

更新日期：1979-01-01 00:00:00

abstract：:Modern practice for training classification deepnets involves a terminal phase of training (TPT), which begins at the epoch where training error first vanishes. During TPT, the training error stays effectively zero, while training loss is pushed toward zero. Direct measurements of TPT, for three prototypical deepnet a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papyan V,Han XY,Donoho DL

更新日期：2020-10-06 00:00:00

abstract：:When the human cDNA, isolated on the basis of homology to the murine carbonic anhydrase (CA) "Y" was expressed in COS cells, the human CA was targeted to and processed in mitochondria, as expected for CA-V. However, tissue distribution reported for the corresponding mouse CA Y mRNA was much more limited than that repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagao Y,Srinivasan M,Platero JS,Svendrowski M,Waheed A,Sly WS

更新日期：1994-10-25 00:00:00

abstract：:An antibody (anti-p21ser) was raised against a ras p21-related synthetic peptide and was able to recognize specifically the substitution of serine for glycine at amino acid 12 of p21. This substitution causes oncogenic activation of p21. Anti-p21ser was found to immunoprecipitate v-Ki-ras p21 and to strongly inhibit i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark R,Wong G,Arnheim N,Nitecki D,McCormick F

更新日期：1985-08-01 00:00:00

abstract：:In both human patients and murine models, the progression from insulitis to diabetes is neither immediate nor inevitable, as illustrated by the innocuous versus destructive infiltrates of BDC2.5 transgenic mice on the nonobese diabetic (NOD) versus C57BL/6.H-2g7 genetic backgrounds. Natural killer (NK)-cell-specific t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poirot L,Benoist C,Mathis D

更新日期：2004-05-25 00:00:00

abstract：:The Golgi apparatus is a membrane-bounded organelle with the characteristic shape of a series of stacked flat cisternae. During mitosis in mammalian cells, the Golgi apparatus is once fragmented into small vesicles and then reassembled to form the characteristic shape again in each daughter cell. The mechanism and det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tachikawa M,Mochizuki A

更新日期：2017-05-16 00:00:00

abstract：:It has been postulated that, in the adult visual cortex, visual inputs modulate levels of mRNAs coding for neurotransmitter receptors in an activity-dependent manner. To investigate this possibility, we performed a monocular enucleation in adult rabbits and, 15 days later, collected their left and right visual cortice...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen QT,Matute C,Miledi R

更新日期：1998-03-17 00:00:00

abstract：:The global financial crisis has precipitated an increasing appreciation of the need for a systemic perspective toward financial stability. For example: What role do large banks play in systemic risk? How should capital adequacy standards recognize this role? How is stability shaped by concentration and diversification...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arinaminpathy N,Kapadia S,May RM

更新日期：2012-11-06 00:00:00

abstract：:The phosphatidylinositol phosphate kinase (PIPK) family of enzymes is primarily responsible for converting singly phosphorylated phosphatidylinositol derivatives to phosphatidylinositol bisphosphates. As such, these kinases are central to many signaling and membrane trafficking processes in the eukaryotic cell. The th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muftuoglu Y,Xue Y,Gao X,Wu D,Ha Y

更新日期：2016-08-02 00:00:00

abstract：:Porphyromonas gingivalis is the major causative agent of periodontitis, and it may also be involved in the development of systemic diseases (atherosclerosis, rheumatoid arthritis). P. gingivalis is found on and within oral and gingival epithelial cells following binding to surface components of host cells, which serve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boisvert H,Lorand L,Duncan MJ

更新日期：2014-04-08 00:00:00

abstract：:RS67333 is a partial serotonin subtype 4 receptor (5-HT4R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the neurotrophic protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lecoutey C,Hedou D,Freret T,Giannoni P,Gaven F,Since M,Bouet V,Ballandonne C,Corvaisier S,Malzert Fréon A,Mignani S,Cresteil T,Boulouard M,Claeysen S,Rochais C,Dallemagne P

更新日期：2014-09-09 00:00:00

abstract：:A (Mg(2+) + Ca(2+))ATPase (ATP phosphohydrolase, EC 3.6.1.3) has been purified from sarcoplasmic reticulum using a single step centrifugation procedure. The preparation is >95% pure by weight and contains only 25-30% of the lipid associated with the enzyme in native sarcoplasmic reticulum. The purified enzyme is unabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren GB,Toon PA,Birdsall NJ,Lee AG,Metcalfe JC

更新日期：1974-03-01 00:00:00

abstract：:This paper explores the explanations for, and consequences of, the early appearance of food production outside the Fertile Crescent of Southwest Asia, where it originated in the 10th/9th millennia cal BC. We present evidence that cultivation appeared in Central Anatolia through adoption by indigenous foragers in the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird D,Fairbairn A,Jenkins E,Martin L,Middleton C,Pearson J,Asouti E,Edwards Y,Kabukcu C,Mustafaoğlu G,Russell N,Bar-Yosef O,Jacobsen G,Wu X,Baker A,Elliott S

更新日期：2018-04-03 00:00:00