Comparative evolution: latent potentials for anagenetic advance.

abstract：:Stimulation by isoproterenol causes large increases in the activity of rat pineal N-acetyltransferase (arylamine acetyltransferase or acetyl-CoA:arylamine N-acetyltransferase, EC 2.3.1.5) after a variable lag period. Lengthening periods of exposure to light cause rapid increases in the sensitivity of pineal N-acetyltr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romero JA,Axelrod J

更新日期：1975-05-01 00:00:00

abstract：:Intermolecular electronic coupling dictates the optical properties of molecular aggregate systems. Of particular interest are photosynthetic pigment-protein complexes that absorb sunlight then efficiently direct energy toward the photosynthetic reaction center. Two-dimensional (2D) ultrafast spectroscopy has been used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Read EL,Engel GS,Calhoun TR,Mancal T,Ahn TK,Blankenship RE,Fleming GR

更新日期：2007-09-04 00:00:00

abstract：:The polymerization of individual RecA-DNA filaments, containing either single-stranded or double-stranded DNA, was followed in real time, and their mechanical properties were characterized with force-measuring laser tweezers. It was found that the stretch modulus of a filament is dominated by its (central) DNA compone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hegner M,Smith SB,Bustamante C

更新日期：1999-08-31 00:00:00

abstract：:Recombinant human erythropoietin (rHuEpo) has been used successfully in the treatment of cancer-related anemia. Clinical observations with several patients with multiple-myeloma treated with rHuEpo has shown, in addition to the improved quality of life, a longer survival than expected, considering the poor prognostic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mittelman M,Neumann D,Peled A,Kanter P,Haran-Ghera N

更新日期：2001-04-24 00:00:00

abstract：:Erythropoietin regulates the proliferation and differentiation of erythroid precursor cells. Its effect is mediated by the erythropoietin receptor (EPOR), a member of a large family of cytokine receptors. The EPOR gene has recently been cloned, sequenced, and characterized. As shown experimentally, its intracellular C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de la Chapelle A,Träskelin AL,Juvonen E

更新日期：1993-05-15 00:00:00

abstract：:Band 3, the major intrinsic protein of the human erythrocyte membrane, was specifically labeled with the covalent fluorescent probe eosin isothiocyanate. The lateral mobility of labeled band 3 in the plane of the membrane under various conditions of ionic strength and temperature was examined by using the fluorescence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golan DE,Veatch W

更新日期：1980-05-01 00:00:00

abstract：:Protective immunity against human schistosome infection develops slowly, for reasons that are not yet fully understood. For many decades, researchers have attempted to infer properties of the immune response from epidemiological studies, with mathematical models frequently being used to bridge the gap between immunolo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell KM,Mutapi F,Savill NJ,Woolhouse ME

更新日期：2012-08-14 00:00:00

abstract：:Effects of temperature on biological processes are complex. Diffusion is less affected than the diverse enzymatic reactions that have distinct individual temperature profiles. Hence thermal fluctuations pose a formidable challenge to ectothermic organisms in which body temperature is largely dictated by the ambient te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radermacher PT,Myachina F,Bosshardt F,Pandey R,Mariappa D,Müller HA,Lehner CF

更新日期：2014-04-15 00:00:00

abstract：:T-box riboswitches control transcription of downstream genes through the tRNA-binding formation of terminator or antiterminator structures. Previously reported T-boxes were described as single-specificity riboswitches that can bind specific tRNA anticodons through codon-anticodon interactions with the nucleotide tripl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saad NY,Stamatopoulou V,Brayé M,Drainas D,Stathopoulos C,Becker HD

更新日期：2013-07-30 00:00:00

abstract：:Murine embryonic stem (ES) cells were infected with a retrovirus promoter trap vector, and clones expressing lacZ fusion genes (LacZ+) were isolated by fluorescence-activated cell sorting (FACS). Of 12 fusion genes tested, 1 was repressed when ES cells were allowed to differentiate in vitro. Two of three lacZ fusion g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy S,Rayburn H,von Melchner H,Ruley HE

更新日期：1992-08-01 00:00:00

abstract：:Local changes in conformation between the calcium-saturated and calcium-free forms of calmodulin were monitored using antisera to four peptides corresponding to three helical regions of the calcium-saturated protein. The N-terminal helix was monitored using antiserum to residues 9-19, calmodulin-(9-19); the C-terminal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariépy J,Mietzner TA,Schoolnik GK

更新日期：1986-12-01 00:00:00

abstract：:The supposition that agricultural intensification results in land sparing for conservation has become central to policy formulations across the tropics. However, underlying assumptions remain uncertain and have been little explored in the context of conservation incentive schemes such as policies for Reducing Emission...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phelps J,Carrasco LR,Webb EL,Koh LP,Pascual U

更新日期：2013-05-07 00:00:00

abstract：:The X gene product encoded by the hepatitis B virus, termed pX, is a promiscuous transactivator of a variety of viral and cellular genes under the control of diverse cis-acting elements. Although pX does not appear to directly bind DNA, pX-responsive elements include the NF-kappa B, AP-1, and CRE (cAMP response elemen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JS,Andrisani OM

更新日期：1995-04-25 00:00:00

abstract：:Interindividual differences in hepatic metabolism, which are mainly due to genetic polymorphism in its gene, have a large influence on individual drug efficacy and adverse reaction. Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells have the potential to predict interindividual...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takayama K,Morisaki Y,Kuno S,Nagamoto Y,Harada K,Furukawa N,Ohtaka M,Nishimura K,Imagawa K,Sakurai F,Tachibana M,Sumazaki R,Noguchi E,Nakanishi M,Hirata K,Kawabata K,Mizuguchi H

更新日期：2014-11-25 00:00:00

abstract：:The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. beta ARK activity is markedly stimulated by the isoprenylated beta gamma subunit complex of heterotrimeric guanine nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inglese J,Luttrell LM,Iñiguez-Lluhi JA,Touhara K,Koch WJ,Lefkowitz RJ

更新日期：1994-04-26 00:00:00

abstract：:Recent studies have indicated that mammalian cells contain a cytosolic protein disaggregation machinery comprised of Hsc70, DnaJ homologs, and Hsp110 proteins, the last of which acts to accelerate a rate-limiting step of nucleotide exchange of Hsc70. We tested the ability of transgenic overexpression of a Thy1 promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagy M,Fenton WA,Li D,Furtak K,Horwich AL

更新日期：2016-05-10 00:00:00

abstract：:The UV photodissociation kinetics of tryptophan amino acid, Trp, attached to the membrane of bacteria, Escherichia coli and Bacillus subtilis, have been studied by means of normal and synchronous fluorescence. Our experimental data suggest that the fluorescence intensity of Trp increases during the first minute of irr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li R,Dhankhar D,Chen J,Cesario TC,Rentzepis PM

更新日期：2019-09-17 00:00:00

abstract：:Persistent organic pollutants (POPs) have been associated with a wide range of adverse health effects. Our case-control study was performed to explore the association between placental levels of selected POPs and risks for neural tube defects (NTDs) in a Chinese population with a high prevalence of NTDs. Cases include...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ren A,Qiu X,Jin L,Ma J,Li Z,Zhang L,Zhu H,Finnell RH,Zhu T

更新日期：2011-08-02 00:00:00

abstract：:Magnetotactic bacteria synthesize highly uniform intracellular magnetite nanoparticles through the action of several key biomineralization proteins. These proteins are present in a unique lipid-bound organelle (the magnetosome) that functions as a nanosized reactor in which the particle is formed. A master regulator p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawlings AE,Bramble JP,Walker R,Bain J,Galloway JM,Staniland SS

更新日期：2014-11-11 00:00:00

abstract：:This paper finds that a 10-μg/m3 increase in airborne particulate matter [particulate matter smaller than 10 μm (PM10)] reduces life expectancy by 0.64 years (95% confidence interval = 0.21-1.07). This estimate is derived from quasiexperimental variation in PM10 generated by China's Huai River Policy, which provides f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ebenstein A,Fan M,Greenstone M,He G,Zhou M

更新日期：2017-09-26 00:00:00

abstract：:RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown IR

更新日期：1975-03-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterized by the accumulation of amyloid plaques in the brain. This amyloid primarily contains amyloid-beta (Abeta), a 39- to 43-aa peptide derived from the proteolytic cleavage of the endogenous amyloid precursor protein. The 42-residue-length Abeta peptide (Abe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Hu X,Khant H,Ludtke SJ,Chiu W,Schmid MF,Frieden C,Lee JM

更新日期：2009-03-24 00:00:00

abstract：:Real-world studies show that the facial expressions produced during pain and orgasm-two different and intense affective experiences-are virtually indistinguishable. However, this finding is counterintuitive, because facial expressions are widely considered to be a powerful tool for social interaction. Consequently, de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Crivelli C,Garrod OGB,Schyns PG,Fernández-Dols JM,Jack RE

更新日期：2018-10-23 00:00:00

abstract：:Protected areas are crucial for biodiversity conservation because they provide safe havens for species threatened by land-use change and resulting habitat loss. However, protected areas are only effective when they stop habitat loss within their boundaries, and are connected via corridors to other wild areas. The effe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radeloff VC,Stewart SI,Hawbaker TJ,Gimmi U,Pidgeon AM,Flather CH,Hammer RB,Helmers DP

更新日期：2010-01-12 00:00:00

abstract：:Elevated eukaryotic initiation factor 4E (eIF4E) levels frequently occur in a variety of human cancers. Overexpression of eIF4E promotes cellular transformation by selectively increasing the translation of proliferative and prosurvival mRNAs. These mRNAs possess highly structured 5'-UTRs that impede ribosome recruitme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feoktistova K,Tuvshintogs E,Do A,Fraser CS

更新日期：2013-08-13 00:00:00

abstract：:Soil bacteria and fungi play key roles in the functioning of terrestrial ecosystems, yet our understanding of their responses to climate change lags significantly behind that of other organisms. This gap in our understanding is particularly true for drylands, which occupy ∼41% of Earth´s surface, because no global, sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maestre FT,Delgado-Baquerizo M,Jeffries TC,Eldridge DJ,Ochoa V,Gozalo B,Quero JL,García-Gómez M,Gallardo A,Ulrich W,Bowker MA,Arredondo T,Barraza-Zepeda C,Bran D,Florentino A,Gaitán J,Gutiérrez JR,Huber-Sannwald E,Jan

更新日期：2015-12-22 00:00:00

abstract：:Multiple-choice examinations play a critical role in university admissions across the world. A key question is whether imposing penalties for wrong answers on these examinations deters guessing from women more than men, disadvantaging female test-takers. We consider data from a large-scale, high-stakes policy change t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coffman KB,Klinowski D

更新日期：2020-04-21 00:00:00

abstract：:Influenza virus neuraminidase (NA; EC 3.2.1.18) possesses a signal-anchor hydrophobic domain at the amino terminus. To characterize the nature of this signal-anchor domain we have introduced single amino acid changes in this domain by oligonucleotide-directed mutagenesis. Three mutant NA proteins that were synthesized...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sivasubramanian N,Nayak DP

更新日期：1987-01-01 00:00:00

abstract：:A mouse with a variant hemoglobin was discovered during electrophoretic screening of (C57BL/6J X DBA/2J)F1 progeny of females treated with ethylnitrosourea. The variant trait was transmitted as a simple Mendelian alternate at the Hbb locus in all crosses except those involving the original carrier of the mutation. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis SE,Johnson FM,Skow LC,Popp D,Barnett LB,Popp RA

更新日期：1985-09-01 00:00:00

abstract：:To study the role of low-abundance, embryonic muscle-specific gene transcripts, we have developed a method to screen cDNA clones from embryonic muscle for such sequences. The protocol involves two stages: first, partial enrichment for cDNA clones carrying possible embryo-specific sequences by selecting clones of low-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ordahl CP,Kioussis D,Tilghman SM,Ovitt CE,Fornwald J

更新日期：1980-08-01 00:00:00