Protective immunity to Schistosoma haematobium infection is primarily an anti-fecundity response stimulated by the death of adult worms.

abstract：:The ecology of microbes in the gut has been shown to play important roles in the health of the host. To better understand microbial growth and population dynamics in the proximal colon, the primary region of bacterial growth in the gut, we built and applied a fluidic channel that we call the "minigut." This is a chann...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cremer J,Segota I,Yang CY,Arnoldini M,Sauls JT,Zhang Z,Gutierrez E,Groisman A,Hwa T

更新日期：2016-10-11 00:00:00

abstract：:The combination of lutropin (LH; luteinizing hormone) alpha and beta subunits was examined in rat pituitaries incubated with [35S]methionine or [35S]sulfate. Combination was assessed by using antiserum directed against the beta subunit. The data show that combination of most of the subunits proceeds rapidly, well befo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshina H,Boime I

更新日期：1982-12-01 00:00:00

abstract：:Flagellin and several other external components of the bacterial flagellum are thought to be exported, not by the general N-terminal signal peptide-dependent pathway, but by a flagellum-specific pathway involving a central channel in the flagellum itself. We have constructed a variety of mutant alleles of the Escheric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuwajima G,Kawagishi I,Homma M,Asaka J,Kondo E,Macnab RM

更新日期：1989-07-01 00:00:00

abstract：:Herpesvirus extracted from a naturally occurring frog renal carcinoma (Lucké tumor) induced virus-free Lucké tumors in developing frogs. Herpesvirus recovered from an induced tumor after incubation at low temperature of tumor fragments cultured in vitro was oncogenic when injected into developing frog embryos. With th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naegele RF,Granoff A,Darlington RW

更新日期：1974-03-01 00:00:00

abstract：:Here, we describe the identification and characterization of a nuclear body (matrix-associated deacetylase body) whose formation and integrity depend on deacetylase activity. Typically, there are 20-40 0.5-microM bodies per nucleus, although the size and number can vary substantially. The structure appears to contain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Downes M,Ordentlich P,Kao HY,Alvarez JG,Evans RM

更新日期：2000-09-12 00:00:00

abstract：:Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) cause ∼2% of all human cancers. RNase R-resistant RNA sequencing revealed that both gammaherpesviruses encode multiple, uniquely stable, circular RNAs (circRNA). EBV abundantly expressed both exon-only and exon-intron circRNAs from the BamHI A rightward ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toptan T,Abere B,Nalesnik MA,Swerdlow SH,Ranganathan S,Lee N,Shair KH,Moore PS,Chang Y

更新日期：2018-09-11 00:00:00

abstract：:Apoptotic cells contain nuclear autoantigens that may initiate a systemic autoimmune response. To explore the mechanism of antibody binding to apoptotic cells, 3H9, a murine autoantibody with dual specificity for phospholipids and DNA, was used. H chain mutants of 3H9 were constructed, expressed as single-chain Fv (sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cocca BA,Seal SN,D'Agnillo P,Mueller YM,Katsikis PD,Rauch J,Weigert M,Radic MZ

更新日期：2001-11-20 00:00:00

abstract：:Cachectin (tumor necrosis factor) is a powerful macrophage hormone released during infection, which circulates in blood to produce diverse effects in the organism. We examined the effect of cachectin on release of anterior pituitary hormones from either hemipituitaries or dispersed pituitary cells incubated in vitro. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milenkovic L,Rettori V,Snyder GD,Beutler B,McCann SM

更新日期：1989-04-01 00:00:00

abstract：:The effects of epinephrine (as low as 0.1 muM) on guanosine 3':5'-cyclic monophosphate (cGMP) and adenosine 3':5'-cyclic monophosphate (cAMP) in isolated fat cells were examined. Epinephrine increased both cGMP and cAMP levels, with the elevation of cAMP preceding the rise of cGMP. Maximal elevation was obtained with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asakawa T,Ruiz J,Ho RJ

更新日期：1978-06-01 00:00:00

abstract：:In contrast with speciation in terrestrial organisms, marine plankton frequently display gradual morphological change without lineage division (e.g., phyletic gradualism or gradual evolution), which has raised the possibility that a different mode of evolution dominates within pelagic environments. Here, we reexamine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hull PM,Norris RD

更新日期：2009-12-15 00:00:00

abstract：:αβ T-cell repertoire selection is mediated by peptide-MHC complexes presented by thymic epithelial or myeloid cells, and by lipid-CD1 complexes expressed by thymocytes. γδ T-cell repertoire selection, by contrast, is largely unresolved. Mice mutant for Skint-1, a unique Ig superfamily gene, do not develop canonical Vγ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbee SD,Woodward MJ,Turchinovich G,Mention JJ,Lewis JM,Boyden LM,Lifton RP,Tigelaar R,Hayday AC

更新日期：2011-02-22 00:00:00

abstract：:The atmospheric and deep sea reservoirs of carbon dioxide are linked via physical, chemical, and biological processes. The last of these include photosynthesis, particle settling, and organic matter remineralization, and are collectively termed the "biological carbon pump." Herein, we present results from a 13-y (1992...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karl DM,Church MJ,Dore JE,Letelier RM,Mahaffey C

更新日期：2012-02-07 00:00:00

abstract：:In vivo electroporation is a powerful technique for the introduction of genes into organisms. Temporal and spatial regulation of expression of introduced genes, or of RNAi, would further enhance the utility of this method. Here we demonstrate conditional regulation of gene expression from electroporated plasmids in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuda T,Cepko CL

更新日期：2007-01-16 00:00:00

abstract：:Spatial working memory or short-term place memory is impaired in schizophrenia. The efficiency of antipsychotic drugs, particularly of typical antipsychotics, on cognitive deficit in schizophrenia remains disputable. Inhibition of serotonin (5-HT) 2A/2C receptors is important for cognitive improvement in schizophrenic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bubenikova-Valesova V,Stuchlik A,Svoboda J,Bures J,Vales K

更新日期：2008-01-22 00:00:00

abstract：:Recently, hepatic peroxisome proliferator-activated receptor (PPAR)γ has been implicated in hepatic lipid accumulation. We found that the C3H mouse strain does not express PPARγ in the liver and, when subject to a high-fat diet, is resistant to hepatic steatosis, compared with C57BL/6 (B6) mice. Adenoviral PPARγ2 inje...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YJ,Ko EH,Kim JE,Kim E,Lee H,Choi H,Yu JH,Kim HJ,Seong JK,Kim KS,Kim JW

更新日期：2012-08-21 00:00:00

abstract：:The induction of heat shock proteins in three species of Leishmania, L. tropica, L. enrietti, and L. donovani is reported. When cultures of promastigotes are shifted from 26 degrees C to 37 degrees C or 40 degrees C, the synthesis of proteins with apparent molecular weights of 88,000, 74,000, and 54,000 is stimulated....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawrence F,Robert-Gero M

更新日期：1985-07-01 00:00:00

abstract：:The plant hormone ethylene is involved in many developmental processes, including fruit ripening, abscission, senescence, and leaf epinasty. Tomato contains a family of ethylene receptors, designated LeETR1, LeETR2, NR, LeETR4, and LeETR5, with homology to the Arabidopsis ETR1 ethylene receptor. Transgenic plants with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tieman DM,Taylor MG,Ciardi JA,Klee HJ

更新日期：2000-05-09 00:00:00

abstract：:WE REEXAMINED TWO QUESTIONS CONCERNING LYT ANTIGENS OF CYTOTOXIC T CELLS OF THE MOUSE: is Lyt-1 antigen expressed on cytotoxic effector cells and can cytotoxicity be blocked by antibody to Lyt antigens in the absence of added complement? A 3-hr (51)Cr-release assay with splenic effector cells and leukemia or myeloma t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama E,Shiku H,Stockert E,Oettgen HF,Old LJ

更新日期：1979-04-01 00:00:00

abstract：:Covalent attachment of myristic acid (C14:0) to the NH2-terminal glycine residue of a number of cellular, viral, and oncogene-encoded proteins is essential for full expression of their biological function. Substitution of oxygen for methylene groups in this fatty acid does not produce a significant change in chain len...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson DR,Cox AD,Solski PA,Devadas B,Adams SP,Leimgruber RM,Heuckeroth RO,Buss JE,Gordon JI

更新日期：1990-11-01 00:00:00

abstract：:Heme is a common factor linking several metabolic perturbations in Alzheimer's disease (AD), including iron metabolism, mitochondrial complex IV, heme oxygenase, and bilirubin. Therefore, we determined whether heme metabolism was altered in temporal lobes obtained at autopsy from AD patients and age-matched nondemente...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atamna H,Frey WH 2nd

更新日期：2004-07-27 00:00:00

abstract：:Liver fibrosis interferes with normal liver function and facilitates hepatocellular carcinoma (HCC) development, representing a major threat to human health. Here, we present a comprehensive perspective of microRNA (miRNA) function on targeting the fibrotic microenvironment. Starting from a murine HCC model, we identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winkler I,Bitter C,Winkler S,Weichenhan D,Thavamani A,Hengstler JG,Borkham-Kamphorst E,Kohlbacher O,Plass C,Geffers R,Weiskirchen R,Nordheim A

更新日期：2020-01-07 00:00:00

abstract：:The effects of selected heme analogues on heme oxygenase activity in tissues and on human and rabbit bone marrow hematopoietic colony growth were examined. Zinc protoporphyrin (ZnPP) and zinc mesoporphyrin (ZnMP), at concentrations ranging between 1 and 20 microM, produced significant inhibition of human and rabbit bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lutton JD,Abraham NG,Drummond GS,Levere RD,Kappas A

更新日期：1997-02-18 00:00:00

abstract：:Rev-Erbβ is a nuclear receptor that couples circadian rhythm, metabolism, and inflammation. Heme binding to the protein modulates its function as a repressor, its stability, its ability to bind other proteins, and its activity in gas sensing. Rev-Erbβ binds Fe3+-heme more tightly than Fe2+-heme, suggesting its activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar A,Carter EL,Harland JB,Speelman AL,Lehnert N,Ragsdale SW

更新日期：2021-01-19 00:00:00

abstract：:In this paper we introduce the network histogram, a statistical summary of network interactions to be used as a tool for exploratory data analysis. A network histogram is obtained by fitting a stochastic blockmodel to a single observation of a network dataset. Blocks of edges play the role of histogram bins and commun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olhede SC,Wolfe PJ

更新日期：2014-10-14 00:00:00

abstract：:Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering switches in migratory behavior, whereby vertically migrating cells can actively invert their direction of migration upon e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrara F,Sengupta A,Behrendt L,Vardi A,Stocker R

更新日期：2021-02-02 00:00:00

abstract：:It is generally believed that serial passage at high multiplicity of infection (moi) is required for the generation of defective interfering (DI) particles. High levels of DI RNAs are found associated with persistent infections initiated with laboratory cultures of cucumber necrosis virus (CNV). Two synthetic CNV tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rochon DM

更新日期：1991-12-15 00:00:00

abstract：:beta-catenin has functions as both an adhesion and a signaling molecule. Disruption of these functions through mutations of the beta-catenin gene (CTNNB1) may be important in the development of colorectal tumors. We examined the entire coding sequence of beta-catenin by reverse transcriptase-PCR (RT-PCR) and direct se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ilyas M,Tomlinson IP,Rowan A,Pignatelli M,Bodmer WF

更新日期：1997-09-16 00:00:00

abstract：:Hierarchical cellular structures are ubiquitous in nature because of their low-density, high-specific properties, and multifunctionality. Inspired by these systems, we created lightweight ceramic architectures composed of closed-cell porous struts patterned in the form of hexagonal and triangular honeycombs by direct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muth JT,Dixon PG,Woish L,Gibson LJ,Lewis JA

更新日期：2017-02-21 00:00:00

abstract：:Inhomogeneous ab initio molecular dynamics simulations show that vaporization of MgSiO3 is incongruent and that the vapor phase is dominated by SiO and O2 molecules. The vapor is strongly depleted in Mg at low temperature and approaches the composition of the liquid near the critical point. We find that the liquid-vap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao B,Stixrude L

更新日期：2018-05-22 00:00:00

abstract：:Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The popul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trivedi U,Madsen JS,Everett J,Fell C,Russel J,Haaber J,Crosby HA,Horswill AR,Burmølle M,Rumbaugh KP,Sørensen SJ

更新日期：2018-12-11 00:00:00